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Pharmaceutical composition for lowering blood pressure

A composition and blood pressure lowering technology, applied in the field of medicine, can solve problems that have not been introduced to the application

Inactive Publication Date: 2014-02-12
JIANGSU CAREFREE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it did not introduce the application of azilsartan, a single chemical component, in combination with antihypertensive drugs
Chinese patent CN201210072267.2, a pharmaceutical composition containing azilsartan, introduces that the combination of azilsartan and diuretics has the effect of lowering blood pressure, but only involves indapamide, a diuretic, for other The drug is not specified

Method used

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  • Pharmaceutical composition for lowering blood pressure
  • Pharmaceutical composition for lowering blood pressure
  • Pharmaceutical composition for lowering blood pressure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1 Azilsartan Hydrochlorothiazide Tablets

[0029] Prescription:

[0030]

[0031] Process: Mix azilsartan, hydrochlorothiazide, microcrystalline cellulose, pregelatinized starch and hydroxypropyl methylcellulose evenly, use 5% PVP absolute ethanol as binder to granulate, dry at 40°C for granulation, add Magnesium stearate is obtained by mixing and pressing into tablets.

Embodiment 2

[0032] Embodiment 2 Azilsartan and Nebivolol Tablets

[0033] prescription

[0034]

[0035]

[0036] Process: Mix azilsartan, nebivolol, microcrystalline cellulose, pregelatinized starch and hydroxypropyl methylcellulose evenly, use 5% PVP absolute ethanol as binder to granulate, dry at 40°C Granules, add magnesium stearate, mix well and press into tablets.

Embodiment 3

[0037] Embodiment 3 Azilsartan and Amlodipine Tablets

[0038] prescription

[0039]

[0040] Process: Mix azilsartan, amlodipine, microcrystalline cellulose, pregelatinized starch and hydroxypropyl methylcellulose evenly, use 5% PVP absolute ethanol as binder to granulate, dry at 40°C for granulation , add magnesium stearate, mix well and press into tablets.

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PUM

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Abstract

The invention relates to a pharmaceutical composition containing azilsartan. The pharmaceutical composition particularly comprises azilsartan and at least one other antihypertensive medicine. The collaborative antihypertensive effect can be effectively played. The pharmaceutical composition for lowering blood pressure, which has a good antihypertensive effect, stable pressure reduction, and good tolerance, is provided.

Description

technical field [0001] The invention relates to a blood pressure lowering pharmaceutical composition containing azilsartan, which belongs to the technical field of medicine. Background technique [0002] Hypertension is currently the most common cardiovascular and cerebrovascular disease in the world. According to reports, the number of hypertensive patients worldwide has exceeded 1 billion. At present, the number of hypertensive patients in China has exceeded 1.6, and there is an increasing trend of hypertensive patients. The etiology of hypertension is very complicated, and the specific pathogenic factors cannot be completely determined at present. Generally, hypertensive patients need life-long treatment to maintain blood pressure stability. In addition, a series of complications such as heart, brain, kidney and other organs accompanied by high blood pressure have made high blood pressure a major factor that endangers human health and seriously affects the living standar...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K31/4245A61P9/12
Inventor 秦引林
Owner JIANGSU CAREFREE PHARM CO LTD
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