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Peptide capable of reducing blood pressure, protein capable of reducing blood pressure, and application of peptide capable of reducing blood pressure

A blood pressure-lowering peptide and blood-pressure-lowering technology, which is applied in blood-pressure-lowering peptides and blood-pressure-lowering proteins and their application fields, can solve problems such as blood pressure rise, and achieve a synergistic blood pressure-lowering effect

Active Publication Date: 2019-07-19
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Bradykinin has the function of dilating blood vessels, but when bradykinin is in an inactive state, it loses the ability to dilate blood vessels, thereby increasing blood pressure

Method used

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  • Peptide capable of reducing blood pressure, protein capable of reducing blood pressure, and application of peptide capable of reducing blood pressure
  • Peptide capable of reducing blood pressure, protein capable of reducing blood pressure, and application of peptide capable of reducing blood pressure
  • Peptide capable of reducing blood pressure, protein capable of reducing blood pressure, and application of peptide capable of reducing blood pressure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0103] Embodiment 1: antihypertensive drug tablet

[0104] The antihypertensive drug tablet of this embodiment contains 5wt% of hypotensive peptide and 95wt% of excipients. The hypotensive peptide is the first hypotensive peptide, and the excipients are starch and magnesium stearate.

[0105] In fact, the hypotensive peptide can also be any one or several of the second hypotensive peptide, the third hypotensive peptide and the hypotensive protein. The auxiliary material can be any one or more of starch, sucrose and maltodextrin. The content of hypotensive peptide can be 1-20wt% and the content of auxiliary materials can be 80wt-99wt%.

Embodiment 2

[0106] Embodiment 2: antihypertensive health product

[0107] The antihypertensive drug tablet of this embodiment contains 15wt% of hypotensive peptide and 85wt% of excipients. The hypotensive peptide is the third hypotensive peptide, and the auxiliary materials are starch, honey, dietary fiber, arginine, and glutathione.

[0108] Wherein, the hypotensive peptide can also be any one or several of the first hypotensive peptide, the second hypotensive peptide and the hypotensive protein. The content of hypotensive peptide can be 1-20wt% and the content of auxiliary materials can be 80wt-99wt%.

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Abstract

The invention discloses peptide capable of reducing blood pressure, protein capable of reducing blood pressure, and an application of the peptide capable of reducing blood pressure. The amino acid sequence of the peptide capable of reducing blood pressure is VHW, and the amino acid sequence of the protein capable of reducing blood pressure contains VHW. The peptide capable of reducing blood pressure and the protein capable of reducing blood pressure can restrain the activity of angiotensin converting enzymes, so that the effect of reducing blood pressure can be achieved, and the peptide capable of reducing blood pressure and the protein capable of reducing blood pressure can be used for preparing various medicines or health-care products capable of reducing blood pressure.

Description

technical field [0001] The invention belongs to the technical field of food or medicine, and relates to blood pressure lowering peptides, blood pressure lowering proteins and applications thereof. Background technique [0002] Angiotensin converting enzyme (ACE) is an enzyme that can cause blood pressure to increase, and it has the following two regulatory pathways. [0003] First, angiotensin-converting enzyme can cut off two amino acids (His-Leu) at the end of angiotensin I (AngiotensinI), thereby converting angiotensin I into angiotensin II (AngiotensinII). Wherein, the amino acid sequence of angiotensin I is Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu, abbreviated as DRVYIHPFHL. The amino acid sequence of angiotensin II is Asp-Arg-Val-Tyr-Ile-His-Pro-Phe, abbreviated as DRVYIHPF. Angiotensin II is a vasoconstrictor that promotes constriction of blood vessels, thereby raising blood pressure. [0004] Second, angiotensin-converting enzyme can excise two amino acids (Phe-Arg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K5/083A61K38/06A61P9/12A23L33/18
CPCA61K38/00A23V2002/00A61P9/12A23L33/18C07K5/1019A23V2200/326A61K38/06A61K38/07
Inventor 谢静莉陈绪军朱巧莎吴俊杰周淡魏东芝
Owner EAST CHINA UNIV OF SCI & TECH
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