Medicine composition including active substrates extracted from Sang Huang, the preparing method and the application in the producing of medicine thereof

A technology of active substances and compositions, which can be applied to pharmaceutical compositions of active substances, preparation of anticancer drugs, hypotensive drugs and hypoglycemic drugs, and the field of immunomodulatory drugs, can solve the problem that the efficacy and activity of heteropolysaccharides need to be improved problem, to achieve significant anti-tumor activity, simple process, and the effect of enhancing immune activity

Inactive Publication Date: 2007-09-12
广州鸿华桑黄生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the medicinal activity of heteropolysaccharides extracted from Phellinus mycelia needs to be improved

Method used

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  • Medicine composition including active substrates extracted from Sang Huang, the preparing method and the application in the producing of medicine thereof
  • Medicine composition including active substrates extracted from Sang Huang, the preparing method and the application in the producing of medicine thereof
  • Medicine composition including active substrates extracted from Sang Huang, the preparing method and the application in the producing of medicine thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A method for preparing active substances extracted from Phellinus Phellinus comprises the following steps:

[0038] i. The preparation method of the water extract of the fruiting body of Phellinus Phellinus: crush 400 g of the fruiting body of Phellinus Phellinus, pass through a 60-mesh sieve, use 3000 ml of water to reflux extract at a temperature of 90 ° C for 8 hours, filter, and repeat the above extraction process for the solid residue After 3 times, the filtrates were combined, concentrated under reduced pressure to a volume of 50ml, added 200ml of ethanol, placed at 4°C for 24 hours, filtered, washed with 30ml of acetone and 30ml of ethanol, and freeze-dried to obtain 28g; The polysaccharide content is 65%.

[0039] ii. Polysaccharide PT 1 and proteoglycan PT 2 The preparation method of Phellinus Phellinus fruiting body: take the water extract of Phellinus chinensis fruiting body and add 15ml of sodium phosphate (5mmol) buffer solution with a pH of 7.7 to 5g of ...

Embodiment 2

[0059] The method for preparing the active substance extracted from Phellinus Phellinus is basically the same as that in Example 1, except that the method used to measure the protein content is the Folin phenol reagent method.

Embodiment 3

[0061] A tablet containing a mixture of active substances extracted from Phellinus Phellinus, the active substance is PT 1 and PT 2 A mixture of 1:3 by weight (PT1 and PT 2 Preparation method is as embodiment 1), and prescription is as follows:

[0062] Phellinus active substance 200g

[0063] Lactose 200g

[0064] Appropriate amount of starch slurry

[0065] Sodium carboxymethyl starch 10g

[0066] Magnesium Stearate 6g

[0067] Total production of 1000 pieces

[0068] Preparation method: Phellinus active substance, lactose, and sodium carboxymethyl starch are ground separately and passed through a 60-mesh sieve, weighed according to the above prescription, and the ingredients are mixed evenly. Under stirring, the starch slurry is used to make a soft material, and passed through a 18-mesh Sieve to make wet granules and dry at 60°C for 4 hours, then sieve and granulate, add magnesium stearate, mix evenly, and press into tablets.

[0069] Usage and dosage of the present...

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Abstract

The present invention is one kind of medicine composition containing active matter extracted from male agaric, and its preparation process and application in preparing anticancer medicine, immunity regulating medicine, hypotensor and hypoglycemic. The medicine composition includes active matter extracted from male agaric and pharmaceutically acceptable carrier, and the active matter is mixture of polysaccharide PT1 of molecular weight 11-15 KDa and proteoglycan PT2 of molecular weight 17-23 KDa in the weight ratio of 1 to 1.5-4.

Description

technical field [0001] The invention relates to a pharmaceutical composition, a preparation method and its application in the preparation of medicines, in particular to a pharmaceutical composition containing active substances extracted from Regulating drugs, antihypertensive drugs and hypoglycemic drugs. Background technique [0002] Phellinus as a traditional Chinese medicinal material has been recorded in China for a long time. Its fruiting bodies are used as medicine, with a slightly bitter taste, which can benefit the five internal organs, soften and harden, detoxify, stop bleeding, and promote blood circulation; disease. In South Korea, Japan and Southeast Asian countries, it is also used as a khan to treat gastrointestinal diseases, lymphatic diseases and various cancers. The anti-tumor effect of Phellinus was first studied in Japan, Ikekawa T, Nakanishi et al (Chem. Basidiomycete fungi, including Coriolus versicolor and Phellinus, etc., used Sarcoma 180 to conduct...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/06A61K38/00A61P35/00A61P37/02A61P9/12A61P3/10
Inventor 王洪权王毅民窦媛媛丁建新窦茜茜王京燕王海燕张敏郑成贵纪晓光何伟庭郑文俊
Owner 广州鸿华桑黄生物技术有限公司
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