Methods for treating endoleaks during endovascular repair of abdominal aortic aneurysms
a technology for abdominal aortic aneurysms and endovascular repair, which is applied in the direction of blood vessels, biocide, applications, etc., can solve the problems of increased diastolic volume of left ventricular end, increased morbidity of aneurysms, and inability to open surgery
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example 1
[0116] The purpose of this example is to demonstrate the preparation of a fluid polymer composition useful in the methods of this invention.
[0117] Specifically, an EVOH polymer composition was prepared as follows:
Composition
[0118] A) 8 g EVOH;
[0119] B) 30 g tantalum having an average particle size of about 3 .mu.m (narrow size distribution); and
[0120] C) 100 mL DMSO.
[0121] Component A) was added to Component C) at 50.degree. C. and stirred for 2 hrs on a hot plate under an argon blanket. To this resulting composition was added Component B and the resulting mixture was mixed until homogeneous.
example 2
[0122] This example illustrates sealing of endoleaks arising from endo-vascular repair of an abdominal aortic aneurysm in a dog model. The following illustrates the protocol employed:
Equipment Used
[0123] 0.035 / 0.038 3J Guide Wires (Cook, Bloomington, Ind.)
[0124] 10-14F Introducer Sheaths (Daig, Minnetonka, Minn.)
[0125] Angioplasty Balloon Catheters (10.times.2 / 10.times.4 / 10.times.6 / 16.-times.2 / 16.times.4 18.times.2 / 18.times.4)-(Blue Max and XXL; Meditech, Mass.)
[0126] 4 mm Aortic Punch (Medtronic, Minneapolis, Minn.)
[0127] Palmaz Stents: P4014, P5014 (Johnson and Johnson Interventional Systems, New Jersey)
[0128] Infusion Catheters (Easy Rider.TM. 3F, Micro Therapeutics, Irvine, Calif.)
[0129] Microguide Wire (Silver Speed.TM., Micro Therapeutics, Irvine, Calif.)
[0130] Composition of Example 1
[0131] Contrast Media-Hypaque-76.TM. (Nycomed, Princeton, N.J.)
[0132] 7 and 8F Guiding Catheters (Medtronics, Minneapolis, Minn.)
[0133] 10 mm and 12 mm diameter polyethylene terephthalate Wallgra...
example 3
[0156] This example illustrates the procedures used to access a simulated endoleak within the aneurysm sac after placement of the prosthesis within the AAA. Specifically, this example employs the following protocol.
[0157] A 25 kg male dog was prepared and anesthetized per Example 2 above. An abdominal midline incision was then made and the descending aorta exposed. A 15 mm arteriotomy was made in the aorta and a patch of fascia was sutured onto this opening creating an aneurysm of a size of about 4.5.times.3.5.times.4.0 cm. Three 4F Fogarty balloon catheters were placed into the aneursym via the carotid artery under fluoroscopy and each balloon catheter was then filled with contrast solution comprising 1:1 saline:Hypaque 76 (0.25 cc, 0.25 cc and 0.5 cc respectively). A 12 mm.times.5 cm Wall stent graft was placed within the aorta and over the aneurysm opening. To access the aneurysm sac through the graft, a 6 F guide catheter was placed into the aorta to the graft via the femoral ar...
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