Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Methods for treating endoleaks during endovascular repair of abdominal aortic aneurysms

a technology for abdominal aortic aneurysms and endovascular repair, which is applied in the direction of blood vessels, biocide, applications, etc., can solve the problems of increased diastolic volume of left ventricular end, increased morbidity of aneurysms, and inability to open surgery

Inactive Publication Date: 2002-03-21
RICCI CHARLIE +3
View PDF1 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0041] endovascularly repairing said aneurysm by catheter delivery of an endovascular prosthesis to the site of said aneurysm thereby inhibiting blood flow into the aneursym;
[0112] The methods described herein are useful in reducing or eliminating blood flow through an endoleak into an endovascularly repaired aneurysm thereby reducing or eliminating the possible rupture of the aneurysm. Accordingly, these methods find use in human and other mammalian subjects requiring closure of such endoleaks. Additionally, when a water insoluble contrast agent is employed, the stability of the closure can be monitored weeks, months or even years after sealing by non-invasive fluoroscopic techniques. Resealing of the endoleak is also facilitated by the presence of the water insoluble contrast agent which permits the clinician to readily identify the site of treated endoleaks.

Problems solved by technology

Abdominal aortic aneurysms (AAA) represents a serious medical challenge and, when left untreated, eventual rupture of the aneurysm has significant morbidity associated therewith.
When feasible, open surgery to repair the aortic aneurysm has been shown to be clinically successful..sup.1 However, open surgery is often not feasible especially in patients suffering from severe cardiac disease, renal disease or other conditions which contraindicate open surgery.
Infrarenal aortic clamping is also associated with an increased cardiac demand including an increase in left ventricular end diastolic volume and may be related to cardiac mortality.
Endoleaks arising after such grafting may be caused by incomplete sealing between the endovascular prosthesis and the aortic wall or by defects within the endovascular prosthesis.
However, the mortality rates for open surgery of endoleaks is higher than either initial open surgery for the abdominal aortic aneurysm or for the initial endovascular repair of the aneurysm.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0116] The purpose of this example is to demonstrate the preparation of a fluid polymer composition useful in the methods of this invention.

[0117] Specifically, an EVOH polymer composition was prepared as follows:

Composition

[0118] A) 8 g EVOH;

[0119] B) 30 g tantalum having an average particle size of about 3 .mu.m (narrow size distribution); and

[0120] C) 100 mL DMSO.

[0121] Component A) was added to Component C) at 50.degree. C. and stirred for 2 hrs on a hot plate under an argon blanket. To this resulting composition was added Component B and the resulting mixture was mixed until homogeneous.

example 2

[0122] This example illustrates sealing of endoleaks arising from endo-vascular repair of an abdominal aortic aneurysm in a dog model. The following illustrates the protocol employed:

Equipment Used

[0123] 0.035 / 0.038 3J Guide Wires (Cook, Bloomington, Ind.)

[0124] 10-14F Introducer Sheaths (Daig, Minnetonka, Minn.)

[0125] Angioplasty Balloon Catheters (10.times.2 / 10.times.4 / 10.times.6 / 16.-times.2 / 16.times.4 18.times.2 / 18.times.4)-(Blue Max and XXL; Meditech, Mass.)

[0126] 4 mm Aortic Punch (Medtronic, Minneapolis, Minn.)

[0127] Palmaz Stents: P4014, P5014 (Johnson and Johnson Interventional Systems, New Jersey)

[0128] Infusion Catheters (Easy Rider.TM. 3F, Micro Therapeutics, Irvine, Calif.)

[0129] Microguide Wire (Silver Speed.TM., Micro Therapeutics, Irvine, Calif.)

[0130] Composition of Example 1

[0131] Contrast Media-Hypaque-76.TM. (Nycomed, Princeton, N.J.)

[0132] 7 and 8F Guiding Catheters (Medtronics, Minneapolis, Minn.)

[0133] 10 mm and 12 mm diameter polyethylene terephthalate Wallgra...

example 3

[0156] This example illustrates the procedures used to access a simulated endoleak within the aneurysm sac after placement of the prosthesis within the AAA. Specifically, this example employs the following protocol.

[0157] A 25 kg male dog was prepared and anesthetized per Example 2 above. An abdominal midline incision was then made and the descending aorta exposed. A 15 mm arteriotomy was made in the aorta and a patch of fascia was sutured onto this opening creating an aneurysm of a size of about 4.5.times.3.5.times.4.0 cm. Three 4F Fogarty balloon catheters were placed into the aneursym via the carotid artery under fluoroscopy and each balloon catheter was then filled with contrast solution comprising 1:1 saline:Hypaque 76 (0.25 cc, 0.25 cc and 0.5 cc respectively). A 12 mm.times.5 cm Wall stent graft was placed within the aorta and over the aneurysm opening. To access the aneurysm sac through the graft, a 6 F guide catheter was placed into the aorta to the graft via the femoral ar...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
viscosityaaaaaaaaaa
weight percentaaaaaaaaaa
Login to View More

Abstract

Disclosed are methods for treating endoleaks arising from endovascular repair of abdominal aortic aneurysms. The disclosed methods involve the in situ sealing of endoleaks after placement of an endovascular prostheses in the abdominal aorta. Sealing of endoleaks is achieved by injection of either a biocompatible polymer or prepolymer fluid composition into the endoleak which composition in situ solidifies to seal the leak. Preferably, the biocompatible fluid composition comprises a contrast agent to allow the clinician to visualize the sealing process.

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS[0002] This application is a continuation-in-part of U.S. patent application Ser. No. 09 / 273,120 filed Mar. 19, 1999 which application is incorporated herein by reference in its entirety.[0003] 1. Field of the Invention[0004] This invention is directed to methods for treating endoleaks arising from endovascular repair of abdominal aortic aneurysms. Specifically, the methods of this invention involve the in situ sealing of endoleaks after placement of an endovascular prostheses in the abdominal aorta. Sealing of endoleaks is achieved by injection of a biocompatible fluid composition at the site of the endoleak which composition in situ solidifies and adheres to the vascular and / or prosthetic wall to seal the leak. Preferably, the biocompatible fluid composition comprises a contrast agent to allow the clinician to visualize the sealing process.[0005] 2. References[0006] The following publications, patent applications and patents are cited ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(United States)
IPC IPC(8): A61B17/00A61B17/12A61B19/00A61F2/06A61L24/00A61L24/06A61L24/08
CPCA61B17/00491A61B17/0057A61B2017/00575A61B2019/5433A61B2019/5437A61F2/06A61L24/001A61L24/06A61L24/08A61L2430/36C08L29/04C08L33/04C08L1/12Y10S524/916A61B2090/3933A61B2090/3937
Inventor RICCI, CHARLIEDOLMATCH, BARTCRAGG, ANDREW H.GREFF, RICHARD J.
Owner RICCI CHARLIE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products