Compositions and methods for treating cardiovascular, cerebrovascular and other vascular disease patients

Abstract

Disclosed are compositions having one or more statins from two different groups, 1) one or more lipophilic statins and 2) one or more hydrophilic statins. The present invention is also directed towards methods of treating patients with cardiovascular diseases and other vascular diseases, including but not limited to Diabetes Mellitus type I and / or II (DM), coronary artery diseases (CAD), peripheral vascular diseases (PVD), cerebrovascular disease, post myocardial infarctions (post MI), post cerebrovascular accidents (post CVA), Hypertriglyceridemia, Hypercholesterolemia, and abdominal aortic aneurysms (AAA) using the composition of the present invention.

Description

[0001] This application claims priority under 35 USC §119(e) to US Provisional Application 60 / 763,308, filed January 30, 2006, which is incorporated herein in its entirety. technical field [0002] The present invention relates to compositions comprising one or more statins selected from two different groups: 1) one or more lipophilic statins and 2) one or more hydrophilic statins kind. The present invention also relates to methods of using the compositions of the present invention to treat patients suffering from cardiovascular disease and other vascular diseases, including but not limited to type I and / or type II diabetes (DM), coronary artery disease (CAD), Peripheral vascular disease (PVD), cerebrovascular disease, post-myocardial infarction (post-MI), post-stroke syndrome (post-CVA), hypertriglyceridemia, hypercholesterolemia, and abdominal aortic aneurysm (AAA). Background technique [0003] Low-density lipoprotein (LDL) carries cholesterol around in the blood. Measu...

AI Technical Summary

Problems solved by technology

However, this dose increase resulted in a small reduction in LDL cholesterol (6% to possibly a maximum of 10%)

Also, when higher doses of statins are taken, the incidence of side effects is undoubtedly doubled (varies with each statin and patient)

[0010] However, to date, the inventors believe that no one has prepared a composition comprising one or more statins selected from two different groups: 1) one or more lipophilic statins and 2) ) one or more hydrophilic statins

However, because combination therapies are not yet available, methods for treating patients with cardiovascular disease and other vascular-related diseases to achieve the goal