42 results about "Peripheral Blood Vessel" patented technology

The invention relates to the technical field of medical monitoring and intelligent decision making, and particularly discloses an intraoperative noninvasive real-time blood flow monitoring and medication intervention analysis system. Pulse wave oscillation harmonic component characteristics and diastolic attenuation characteristic characteristics are extracted by using variational mode decomposition and a polynomial fitting algorithm; the multi-dimensional features are fused and then input into a deep learning classification model, and accurate recognition of insufficient heart pump efficiency, abnormal peripheral vascular tension and circulation capacity imbalance states is achieved; time sequence prediction and grading early warning are carried out based on the hidden Markov model and the individualized baseline safety interval, and finally a targeted medication scheme is output through the intervention strategy knowledge base.

The invention provides an intraoperative path optimization method and system based on solid tumor preoperative image analysis, and the method comprises the steps: constructing a three-dimensional model of a tumor and peripheral blood vessels and nerves according to a preoperative image, and carrying out the dissection risk marking of the three-dimensional model through a deep learning model, generating an anatomical risk image with risk gradient value distribution; taking the minimum intraoperative bleeding amount and the highest tumor excision rate as a reward function, combining the three-dimensional model, an anatomical risk image and historical similar case data, and simulating multiple operation paths based on an adversarial reinforcement learning algorithm to obtain an optimal operation path; the method comprises the following steps: acquiring the pose, ultrasonic image and fluorescence image of a surgical instrument in real time during surgery, matching the preoperative image with the intraoperative image based on a biomechanical model driven non-rigid registration algorithm, predicting organ displacement, and correcting an optimal surgical path, thereby avoiding accidental injury of key tissues, ensuring that an infiltration area is brought into the surgical path in time, and improving the surgical efficiency. Residues are reduced, and static planning failure is avoided.

This utility model relates to an innovation of a carotid artery vasodilator that can be used at home and in the emergency room as a supplement to drug treatment for conditions such as carotid artery obstruction in the neck region. It increases the production of nitric oxide mediated by endothelial nitric oxide synthase in the intact endothelial layer of the carotid artery, which is located on the inner surface of the neck brace. It can be applied for a certain period of time for each patient. The intermittent or continuous operation function can be selected through an adjustable power circuit. It only affects the lesion area and does not affect the patient's peripheral blood vessels. It can be used in situations where nitrates may be prohibited. It prevents the reduction of blood flow to the brain tissue that may occur due to jugular venous constriction. The flexible structure of the applicator neck brace (9) can be maintained in the application area for a long time and includes a pulsed magnetic field (PMF).

The application discloses a peripheral blood vessel intervention thrombus-removing catheter with a distal embolism protection structure and relates to the technical field of blood vessel thrombus-removing catheters.The peripheral blood vessel intervention thrombus-removing catheter with the distal embolism protection structure comprises a catheter body, one end of the catheter body is provided with a thrombus-removing assembly, the surface of the catheter body is provided with a thrombus-removing assembly, the inside of the catheter body is provided with a transmission assembly, the thrombus-removing assembly comprises a protection pipe network fixedly installed on one side of the catheter body.The transmission assembly is arranged, in the process of use, the rotation of a lead screw can drive one end of the lead screw to move the one side of the filter screen plate to the inside of the protection pipe network, so that the protection pipe network is expanded, and the air bag piece can be inflated, the catheter is placed into in the process of use, the preparation time of catheter operation is reduced, the catheter is convenient to operate, the thrombus-removing and protection operation of the catheter are improved, and the use convenience of the catheter is improved.

The embodiment of the invention provides a PID self-adaptive control ultrasonic imaging method and system based on direct-current motor constant-speed driving. The method comprises the steps that an acquisition signal of a target position is acquired; wherein the target position is a target blood vessel in peripheral blood vessels; based on the acquired signal, controlling an ultrasonic probe of the catheter to perform rotary scanning through a motor to obtain ultrasonic echoes; processing the ultrasonic echo through a preset ultrasonic imaging module to obtain an ultrasonic signal image; and performing coordinate transformation on the ultrasonic signal image to obtain a cross section image and a longitudinal section image of a target blood vessel corresponding to the target position. According to the scheme, the ultrasonic imaging stability of the system can be improved, so that the image quality of the cross section image and the longitudinal section image of the target blood vessel is improved.

The invention discloses hydrogel microspheres capable of loading radioactive isotopes and a preparation method of the hydrogel microspheres. The microsphere is formed by copolymerizing a macrocyclic ligand structure, a hydrophilic monomer and a cross-linking agent, and a macrocyclic ligand is connected with a polymer main chain through a bridging structure containing p-aminobenzoic acid and aliphatic diamine and can efficiently and stably complex various radioactive isotopes. The microspheres have the characteristics of being close to water in density, good in suspension property, smooth in surface and rich in elasticity, and are easily and uniformly distributed in tumor peripheral blood vessels. The preparation method comprises the following two routes: firstly synthesizing the functional monomer and then copolymerizing, or firstly preparing the microspheres and then gradually grafting. The problems that existing microsphere nuclides are prone to falling off, high in density and poor in suspension property are effectively solved, and the microsphere is suitable for interventional radioactive embolism treatment.

The invention discloses a peripheral vessel interventional catheter fixing device which comprises a mounting mechanism, a catheter clamping mechanism used for fixing an interventional catheter is arranged on the side face of the mounting mechanism, an adjusting mechanism is arranged between the catheter clamping mechanism and the mounting mechanism and used for steering adjustment of the catheter clamping mechanism, and the catheter clamping mechanism is connected with the mounting mechanism through the adjusting mechanism; a driving seat is slidably connected to the inner side of the mounting mechanism, the end, away from the pipe clamping mechanism, of the adjusting mechanism is connected with the driving seat, and a driving assembly used for driving the driving seat is further arranged in the mounting mechanism. According to the peripheral vessel interventional catheter fixing device, the interventional catheter can be fixed through the mounting mechanism and the catheter clamping mechanism, the driving seat can be driven to move through the adjusting knob, then the adjusting mechanism is driven to adjust the position of the catheter clamping mechanism, and meanwhile the adjusting mechanism can achieve steering adjustment of the catheter clamping mechanism; and the fixing requirements of the peripheral vascular intervention catheter in different use scenes are met.

Described herein are compounds of Formula I,wherein the variables are defined herein, their use as activators from AMPK, pharmaceutical compositions containing such compounds and their use to treat, for example, heart failure or peripheral vascular disease.

The application discloses a preparation method of a far-infrared moisture-absorbing and heat-generating blanket, and particularly relates to the technical field of blanket manufacturing, which comprises the following steps: pretreating fiber materials, giving the mixed fibers with far-infrared function, moisture-absorbing and heat-generating treatment of the mixed fibers, weaving the mixed fibers into a fabric, and post-finishing the fabric; the far-infrared moisture-absorbing and heat-generating capability is given to the blanket, after the human body absorbs far-infrared rays, the water molecules in the human body can resonate, the vibration energy level of the water molecules can be activated, and then the blood circulation of the human body can be accelerated; long-term use of the blanket can help to improve the microcirculation system of the human body, enhance metabolism, and improve the immunity of the human body; for example, for some people with weak physique and easy to feel cold in hands and feet, use of the blanket can promote the expansion of peripheral blood vessels, make the body warmer, and enhance the self-regulation ability of the body; the thermal effect of the far-infrared rays can also play a certain physiotherapy role.

This invention discloses a 3D-printed helical biodegradable anti-inflammatory vascular stent and its preparation method, belonging to the field of vascular stents. The invention uses multiple helical support wires arranged into a tubular shape, with the ends connected in a serpentine transitional manner. The helical support wires are connected by connecting ribs, and the surface is coated. This invention is biodegradable after use, avoiding the harm caused by permanent retention in the body, and has a lower restenosis rate compared to metal stents. The surface of the vascular stent is coated with a spermidine-containing coating to prevent immune rejection of the implanted vascular stent, thereby addressing the problems of inflammation and intimal hyperplasia. The helical structure facilitates contraction and expansion, has good bending flexibility, and the added connecting ribs increase the radial support performance of the vascular stent, better achieving the effect of vascular remodeling. This invention has significant implications in terms of biodegradability, anti-immune rejection, and mechanical properties, and can be used for treatment in different locations such as peripheral and coronary vessels.

An ultrasonic balloon catheter (1), which is introduced into the cardiovascular system and treats stenosis or occlusion of the heart or peripheral blood vessels, is provided with: a flexible catheter tube (11); the balloon (12) is made of an elastic material and provided with an expansion part (121) for expanding and contracting and neck parts (122) arranged at the two ends of the expansion part (121) respectively, the balloon (12) is fixedly arranged on the outer side of the catheter hose (11) through the neck parts (122), and the expansion part (121) and the neck parts (122) form an expansion space on the outer tube wall of the catheter hose (11) so that the fluid composition can be injected into the expansion space from the opening in the outer tube wall; and the ultrasonic probe (13) is arranged in the expansion part (121) of the balloon (12), is sleeved outside the inner pipe fitting (111) and at the opening in the outer pipe wall, and is used for emitting ultrasonic waves and inducing microbubbles in the fluid composition in the expansion space to generate a cavitation erosion effect.

The application belongs to the technical field of ultrasonic blood vessel imaging, and particularly relates to a peripheral blood vessel imaging method and system based on ultrasonic tomography and a storage medium. An ultrasonic tomography system is used to collect images of a to-be-measured part, and a plurality of three-dimensional cross-sectional image sequences are obtained. A pulse signal is synchronously collected. A target detection neural network is used to process the three-dimensional cross-sectional image sequences, and preliminary observation values of blood vessel positions are output. An optimal state estimation is sequentially performed on the blood vessel positions of each three-dimensional cross-sectional image based on a Kalman filtering algorithm, and optimal blood vessel position estimations of each frame are output. The preliminary observation values of the blood vessel positions are taken as observation values of the Kalman filtering, and a state transition equation of the Kalman filtering algorithm is constructed according to the blood vessel positions, blood flow velocities and the pulse signal. According to the optimized three-dimensional cross-sectional image sequences, a dynamic three-dimensional blood vessel model is reconstructed. The application realizes dynamic artifact suppression and state smoothing based on the pulse signal, and provides image clarity.

The invention belongs to the technical field of biological medicines, and particularly relates to a compound Atovaquone for treating cardiomyopathy, and the cardiomyopathy refers to all diseases causing myocardial structure and dysfunction, including secondary cardiac hypertrophy / heart failure and primary hypertrophic cardiomyopathy. The compound can be prepared into granules, capsules, powder, tablets and injection preparations together with another active ingredient which is different from the compound shown in the formula I and has the functions of enhancing the heart function, expanding peripheral blood vessels, reducing myocardial oxygen consumption and the like, and pharmaceutically acceptable auxiliary materials are added.

Methods for non-invasively measuring blood pressure using multi-wavelength photoplethysmography (PPG) signals obtained from peripheral blood vessels. A wearable device is calibrated using PPG signals measured distal to the wearable device and analyzed in order to create a cardiovascular profile of a wearer. After calibration, windows of PPG signals are analyzed to provide a blood pressure estimation, based on the created profile. The current invention utilizes single-site measured PPG signals in order to make a prediction of the wearer's blood pressure. By using a combination of multi-wavelength PPG waveform features and a range of vital signs calculated by the wearable device, the device is able to provide a more accurate and robust prediction of blood pressure compared to existing methods. This has important implications for clinical settings where frequent and remote monitoring of blood pressure is necessary for managing a range of health conditions.

Provided are an extravasation detection device, extravasation detection system, and program, which are capable of more easily detecting extravasation even when detection in a peripheral blood vessel is difficult. An extravasation detection device 1 acquires, from a blood flow measurement device 4, a measurement value related to a blood flow state in the heart H of a patient P with an indwelling needle inserted at a predetermined site 7 of the body before and after administration of an infusion solution trough the indwelling needle, determines whether or not the infusion solution is correctly administered on the basis of the acquired measurement value, and outputs a determination result.

The application discloses a kind of human peripheral blood vessel photoacoustic three-dimensional imaging device and imaging method thereof, belong to blood vessel imaging field.The application provides detailed blood vessel structure and blood flow dynamic information by high resolution and functional monitoring ability of photoacoustic imaging, promote early identification and treatment effect evaluation to common pathological changes such as diabetic foot and peripheral arterial disease;Meanwhile, the application adopts mechanical system, and the detection front end of higher quality can be carried and stably operated, to obtain better photoacoustic imaging result;The application has highly stable precision scanning imaging mode, and various imaging modes are convenient for clinical application;Through the arrangement of imaging tank and its lifting structure, it is ensured that the switching of imaging mode can be applied in limited space, so as to be suitable for gantry type three-dimensional mobile device layout.The application is expected to promote the portability of equipment, reduce equipment development cost, be widely applied in clinical practice and community medical treatment, and improve disease management level.

The utility model relates to medical instrument technical field provides a kind of catheter assembly and steam ablation equipment for peripheral blood vessel steam ablation, and the catheter assembly for peripheral blood vessel steam ablation includes central catheter, balloon catheter, balloon structure and steam generating device, balloon catheter is sleeved outside central catheter, balloon catheter is suitable for liquid and gas to be introduced;Balloon structure is located outside balloon catheter, and balloon structure is communicated with the space in the tube of balloon catheter, and balloon structure is suitable for expansion and contraction;Steam generating device is located in balloon catheter, and steam generating device is used to convert liquid into steam, and steam is used to fill balloon structure.The utility model's catheter assembly for peripheral blood vessel steam ablation, liquid is converted into steam by steam generating device to fill balloon structure, while multilayer balloon catheter structure and pressure monitoring design effectively reduce the risk of blood vessel rupture, with the advantages of accurate controllable, minimally invasive efficient, reduce the risk of blood vessel rupture.

The present application relates to the technical field of image reconstruction, in particular to a liver tumor interventional preoperative blood vessel three-dimensional model reconstruction system, which can realize the following steps through the mutual cooperation between multiple modules: obtaining a liver CTA three-dimensional matrix of a target patient before liver tumor intervention; determining the blood vessel confidence corresponding to each voxel in the tumor peripheral region and the normal liver region; determining the gradient distortion degree corresponding to each voxel in the tumor peripheral region; determining the effective blood vessel proportion in the tumor peripheral region; performing adaptive blood vessel fracture completion screening processing according to the gradient distortion degree and the blood vessel confidence to obtain the tumor peripheral blood vessel region; and performing blood vessel reconstruction based on the effective blood vessel proportion in the tumor peripheral region and the gray value corresponding to the voxel in the tumor peripheral blood vessel region. The present application realizes the identification of the tumor peripheral blood vessel region and improves the accuracy of identification, thereby improving the rationality of liver tumor interventional preoperative blood vessel three-dimensional model reconstruction.

The application discloses a method, device and storage medium for segmenting an aneurysm. The method comprises the following steps: generating a blood vessel graph structure according to a blood vessel segmentation mask, wherein the blood vessel graph structure at least comprises leaf nodes containing radius attributes; determining an initial path node inside the aneurysm according to a positioning point; screening a target path from the initial path node to the leaf node, and sorting the target path according to an average radius to form a path pair; restoring a path through the aneurysm based on the path pair to obtain a restored path; and segmenting the aneurysm based on the restored path to obtain an aneurysm segmentation result. The scheme can guarantee stable segmentation of a large aneurysm, stably obtain the peripheral blood vessel condition of the aneurysm, and improve the accuracy and reliability of aneurysm segmentation.

A perfusion angiography for peripheral vascular disease assessment in combination with photoplethysmographic imaging. An apparatus (13) and method for performing perfusion imaging receives image sequences concurrently acquired by an X-ray imaging device (2) and by a photoplethysmographic imaging device (3). When temporally aligned, the perfusion status of perfused organ tissue is extracted from both image sequences over time and images are generated for display on a display unit (5) that indicate changes in perfusion status at various locations of the perfused organ tissue, thereby capturing both deep and superficial organ tissue perfusion properties. A reduction in image signal intensity in the photoplethysmographic images caused by a bolus of previously administered contrast agent (10) passing through can be used to temporally align the two concurrently acquired image sequences.

This invention provides an extravasation detection device, an extravasation detection system, and a program that enable easier detection of extravasation, even in cases where detection in peripheral blood vessels is difficult. [Solution] The extravasation detection device 1 includes: a first measurement value acquisition unit 11 that acquires a first measurement value related to the blood flow state during the administration of intravenous fluid from the indwelling needle 5 at a first measurement position B1 in the blood vessel L near the insertion position A1 where the indwelling needle 5 is inserted into the blood vessel L of patient P; a second measurement value acquisition unit 12 that acquires a second measurement value related to the blood flow state before and after the administration of intravenous fluid from the indwelling needle 5 at a second measurement position B2 corresponding to the first measurement position B1; a determination unit 14 that determines whether or not intravenous fluid administration is being performed normally by comparing the first measurement value acquired by the first measurement value acquisition unit 11 and the second measurement value acquired by the second measurement value acquisition unit 12; and a determination result output unit 15 that outputs the determination result from the determination unit 14.

This invention discloses a method for monitoring cardiovascular data in cardiology, comprising the following steps: S1, Non-invasive collaborative acquisition of multimodal cardiovascular data: Constructing a multimodal non-invasive sensor array, fitting sensitive points on the wrist, chest, and behind the ear, to simultaneously acquire photoplethysmography (PPG) pulse wave signals, multi-lead electrocardiogram (ECG) signals, and bioimpedance signals, completing preliminary data encapsulation and synchronous transmission. This invention employs multimodal non-invasive sensor collaborative acquisition technology to simultaneously acquire multi-dimensional cardiovascular data such as ECG, pulse wave, and bioimpedance, breaking the limitations of single-dimensional monitoring and comprehensively covering core monitoring indicators such as cardiac electrophysiology, peripheral vascular function, and cardiac function, providing complete data support for disease assessment and effectively avoiding missed diagnoses of early cardiovascular abnormalities.

This application relates to the field of physiological signal detection and health monitoring technology, and provides a wearable device and method for microcirculation status assessment and multi-physiological parameter monitoring. The wearable device includes: a signal acquisition unit, a feature extraction unit, and a status assessment unit. The signal acquisition unit is used to acquire at least one physiological signal characterizing the hemodynamic characteristics and related microcirculatory physiological processes within peripheral blood vessels. The feature extraction unit is used to obtain feature parameters based on the physiological signals. The status assessment unit is used to analyze and calculate based on the feature parameters using a machine learning model and / or a physiological mechanism model to obtain a status assessment result characterizing the peripheral vascular microcirculation status. This application transforms the palpation assessment process, which relies on human experience, into an engineered, parameterized, and objective assessment process, reducing reliance on human experience and improving the objectivity, consistency, accuracy, and repeatability of the assessment results.

This invention provides an extravasation detection device, an extravasation detection system, and a program that enable easier detection of extravasation, even in cases where detection in peripheral blood vessels is difficult. [Solution] The extravasation detection device 1 acquires measurements from the blood flow measuring device 4 regarding the blood flow state in the heart H of patient P, in which an indwelling needle has been inserted at a predetermined site 7 in the body, before and after the administration of intravenous fluid from the indwelling needle. Based on the acquired measurements, it determines whether or not the intravenous fluid administration is being performed normally and outputs the determination result.

We propose a photoacoustic imaging device and method capable of generating highly reproducible three-dimensional photoacoustic wave images of peripheral blood vessels in deep regions of a target area, with significantly higher accuracy and while ensuring the safety of the subject, for target tissues or organs within the subject. [Solution] The control unit sets the scan path of the light source probe unit to encompass the target area specified by the vision unit, and guides and controls the tip of the robot tube according to the scan path.

The invention relates to the field of biomedical materials, in particular to cyanoacrylate medical blood vessel blocking glue and a preparation method thereof.The cyanoacrylate medical blood vessel blocking glue is prepared from, by mass, 30-35 parts of 2-octyl cyanoacrylate, 7-8 parts of lactide modified hydroxyethyl methylacrylate, 0.02-0.03 part of polymerization inhibitor propyl gallate, 0.02-0.03 part of initiator, 0.02-0.03 part of initiator, 0.02-0.03 part of initiator, 0.02-0.03 part of initiator and the balance water. By innovatively adopting various functional components and carrying out synergistic compatibility and precise preparation, compared with the prior art, the comprehensive performance of the product is remarkably improved, and the plugging agent has the advantages of rapid and reliable plugging effect, good plugging effect, good plugging effect, good plugging effect, good plugging effect, good plugging effect, good plugging effect, good plugging effect, good plugging effect and the like. Meanwhile, good biocompatibility, intraoperative developing capacity and a potential drug sustained release function are achieved, operation is easy and convenient, performance is stable, a safer and more efficient choice is provided for clinical vascular interventional therapy, and wide application prospects are achieved in the fields of cardiovascular and neurological intervention, peripheral vascular embolism and the like.

The invention discloses a thrombus rotary cutting catheter system suitable for multiple lesions, and belongs to the technical field of interventional medical instruments. The system includes a catheter assembly and a powered handle assembly. A composite tool bit, an integrated spiral star-shaped grinding head, a rotary cutting tool bit and a flexible scraper tool bit are arranged at the head end of the catheter assembly and can be selectively used according to thrombus properties; a spiral steel cable with a spiral blade is arranged in the catheter and used for power transmission and thrombus delivery. A driving device, a thrombus outflow pipeline and a guide wire assembly are arranged in the power handle assembly, and the scraper is controlled to be opened and closed through the flexible scraper trigger button. Through the design of the integrated composite tool bit structure, the built-in guide wire and the waste liquid channel, efficient removal of multiple types of thrombus is achieved, catheter replacement in an operation is avoided, and operation continuity and safety are improved. The system is a disposable consumable, is compact in structure, is simple and convenient to operate, and is suitable for interventional therapy of peripheral blood vessel and other thrombotic diseases.

To provide a photoacoustic imaging apparatus and a photoacoustic imaging method capable of generating a simple and highly reproducible three dimensional photoacoustic image of a surface layer peripheral blood vessel for the entire foot of a subject.SOLUTION: A light source probe unit is provided so as to be movable along a two dimensional coordinate system in which a longitudinal direction and a vertical direction of an apparatus main body are axes orthogonal to each other in a tank of the apparatus main body, and the light source probe unit is driven and controlled so as to slide along outer surfaces of a sole side and a back side of a foot of a subject in a non-contact manner with reference to a height position of a limb end holding portion.SELECTED DRAWING: Figure 1