109 results about "Peripheral Blood Vessel" patented technology

Systems and methods can facilitate wide broad-band IVUS for peripheral vascular applications with simultaneous improved resolution and penetration depth. A custom analog front end interface can withstand large voltages and recover to receive a sub-mV pulse from less than one mm away. The custom analog front end interface can be on an interface chip that can be sized to be integrated within a tip of the IVUS catheter to connect micro-cables within the IVUS catheter to the broad-band transducer. The interface chip can also include a dual-stage amplifier having a pulse mode configured to withstand voltage pulses greater than 30 VPP during pulsing and an echo reception mode configured to receive sub-mV echoes during echo reception.

The invention provides a non-invasive blood pressure estimation method, device and equipment, a storage medium and a product, and belongs to the technical field of biomedicine, and the method comprises the steps that an ECG signal and an ICG signal are preprocessed; generating physiological feature indexes, wherein the physiological feature indexes comprise conventional indexes and special indexes; determining an incidence relation between the conventional index and the basic peripheral vascular resistance parameter as well as the basic artery compliance parameter; inputting the conventional indexes into a pre-trained machine learning model, and outputting basic peripheral vascular resistance prediction parameters and basic artery compliance prediction parameters; performing dynamic correction according to the special indexes, and generating a target peripheral vascular resistance parameter and a target artery compliance parameter; and calculating and generating a blood pressure estimation result. According to the non-invasive blood pressure estimation method, device and equipment, the storage medium and the product, the accuracy, dynamic nature and stability of non-invasive blood pressure estimation can be improved.

The invention relates to the technical field of medical monitoring and intelligent decision making, and particularly discloses an intraoperative noninvasive real-time blood flow monitoring and medication intervention analysis system. Pulse wave oscillation harmonic component characteristics and diastolic attenuation characteristic characteristics are extracted by using variational mode decomposition and a polynomial fitting algorithm; the multi-dimensional features are fused and then input into a deep learning classification model, and accurate recognition of insufficient heart pump efficiency, abnormal peripheral vascular tension and circulation capacity imbalance states is achieved; time sequence prediction and grading early warning are carried out based on the hidden Markov model and the individualized baseline safety interval, and finally a targeted medication scheme is output through the intervention strategy knowledge base.

The invention discloses a human body peripheral blood vessel photoacoustic three-dimensional imaging device and an imaging method thereof, and belongs to the field of blood vessel imaging. Through high resolution and functional monitoring capability of photoacoustic imaging, detailed blood vessel structure and blood flow dynamic information are provided, and early recognition and treatment effect evaluation of common lesions such as diabetic foot and peripheral artery diseases are promoted; meanwhile, a mechanical system is adopted, so that the detection front end with relatively high quality can be borne, and stable operation is realized, and a relatively good photoacoustic imaging result is obtained; the system has a highly stable accurate scanning imaging mode, and is convenient for multiple imaging modes of clinical application; through the arrangement of the imaging water tank and the lifting structure of the imaging water tank, switching of imaging modes in a limited space can be ensured, so that the device can be suitable for the layout of a portal type three-dimensional moving device. The system is expected to promote the portability of equipment, reduce the research and development cost of the equipment, be widely applied to clinical practice and community medical treatment, and improve the disease management level.

The invention provides an intraoperative path optimization method and system based on solid tumor preoperative image analysis, and the method comprises the steps: constructing a three-dimensional model of a tumor and peripheral blood vessels and nerves according to a preoperative image, and carrying out the dissection risk marking of the three-dimensional model through a deep learning model, generating an anatomical risk image with risk gradient value distribution; taking the minimum intraoperative bleeding amount and the highest tumor excision rate as a reward function, combining the three-dimensional model, an anatomical risk image and historical similar case data, and simulating multiple operation paths based on an adversarial reinforcement learning algorithm to obtain an optimal operation path; the method comprises the following steps: acquiring the pose, ultrasonic image and fluorescence image of a surgical instrument in real time during surgery, matching the preoperative image with the intraoperative image based on a biomechanical model driven non-rigid registration algorithm, predicting organ displacement, and correcting an optimal surgical path, thereby avoiding accidental injury of key tissues, ensuring that an infiltration area is brought into the surgical path in time, and improving the surgical efficiency. Residues are reduced, and static planning failure is avoided.

The invention provides a nicking guide wire, a nicking balloon assembly and an intervention device. The nicking guide wire comprises a guide wire shaft and a cutting unit. The cutting unit has an expansion state and a compression state, the far end of the cutting unit is fixed to the guide wire shaft, and the near end of the cutting unit is of an expandable annular structure. The nick guide wire is configured such that when the nick guide wire cooperates with the balloon catheter, at least part of the distal end of the balloon catheter enters the interior of the cutting unit through the annular structure. The indented guide wire is provided with the cutting unit, the cutting unit is combined with a balloon catheter to achieve the balloon cutting function, due to the fact that the indented guide wire is separated from a balloon body, the trafficability and flexibility of the product are better than those of products such as a cutting balloon, and when the indented guide wire is applied to treatment of intracranial vessel moderate calcification lesions, blood vessel injuries are not likely to be caused; and operative complications are reduced. For serious calcification lesions of cardiovascular and peripheral blood vessels, plaque expansion can be achieved without additionally using a CTO balloon for pre-expansion, and the operation cost and the operation difficulty are reduced.

The invention discloses a curative effect evaluation system for treating liver cancer by combining HDRBT with thermal ablation in multi-modal radiomics, and relates to the field of liver cancer treatment, and the system comprises a multi-modal image data acquisition module which is used for collecting multi-modal image data; the three-dimensional visual model construction module is used for reconstructing a three-dimensional structure of liver tumors, peripheral blood vessels and bile ducts through an image segmentation algorithm, and generating a visual model by fusing radiomics characteristics; the combined treatment plan generation module is used for integrating the dosimetry parameters of the HDRBT and the process parameters of the thermal ablation, optimizing a catheter implanting path, the position of a thermal ablation electrode and a treatment sequence, and generating a combined treatment scheme; and the curative effect evaluation module is used for quantitatively analyzing tumor volume change, ablation boundary integrity and residual tumor activity through accurate registration of multi-modal images before and after treatment. According to the scheme, the problems of incomplete thermal ablation and high recurrence rate of hepatocellular carcinoma can be solved, and full-chain technical support is provided for clinical precise application.

The invention relates to the technical field of medical instruments, and discloses an intelligent pressure feedback type peripheral blood vessel thrombus removal and autoblood transfusion system which comprises a negative pressure pump, one-way valves symmetrically arranged at one end of a negative pressure pump cabin, and a blood storage bag arranged on the outer side of the one-way valve at the outlet end of the negative pressure pump cabin. The separation mechanism is arranged on the outer side of the one-way valve at the inlet section of the negative pressure pump, and the bubble discharging mechanism is arranged in the separation mechanism and used for discharging bubbles from blood; the separating mechanism comprises a shell, a sliding groove formed in the top of the shell, a sliding block arranged in the sliding groove, and a reset spring arranged on the side, close to the negative pressure pump, of the sliding block, the sliding block moves along the sliding groove, and the sliding groove limits the moving range of the sliding block. By arranging the separating mechanism, the filtering part is divided into different working spaces, and the different working spaces can be switched, so that the situation that the whole equipment cannot be used due to blockage of a single filtering part is avoided.

The peripheral blood vessel perfusion catheter comprises a catheter body, a head end plugging unit and a side hole plugging unit, the far end of the catheter body is open, and the catheter body is provided with a plurality of side holes; the head end plugging unit comprises a plugging block, an abutting circular ring and a spring connecting the plugging block and the abutting circular ring. The side hole plugging unit comprises a first circular ring, a second circular ring, a flexible connecting cylinder connected with the first circular ring and the second circular ring and a plurality of connecting rods connected between the first circular ring and the second circular ring, the second circular ring is connected with a pushing rod through a connecting frame, and a pull rope is connected between the connecting frame and the plugging block; the abutting circular ring, the first circular ring and the second circular ring are all located in the guide pipe body. The peripheral blood vessel perfusion catheter has good pushing performance, and better thrombus elimination can be achieved.

This utility model relates to an innovation of a carotid artery vasodilator that can be used at home and in the emergency room as a supplement to drug treatment for conditions such as carotid artery obstruction in the neck region. It increases the production of nitric oxide mediated by endothelial nitric oxide synthase in the intact endothelial layer of the carotid artery, which is located on the inner surface of the neck brace. It can be applied for a certain period of time for each patient. The intermittent or continuous operation function can be selected through an adjustable power circuit. It only affects the lesion area and does not affect the patient's peripheral blood vessels. It can be used in situations where nitrates may be prohibited. It prevents the reduction of blood flow to the brain tissue that may occur due to jugular venous constriction. The flexible structure of the applicator neck brace (9) can be maintained in the application area for a long time and includes a pulsed magnetic field (PMF).

Exemplary embodiments described herein are directed to a vascular access catheter device with an inline needle, the device having a needle portion that is linearly displaceable relative to a catheter portion, and vice versa, and to methods of performing blood transfer procedures using said device. Retraction of the needle portion relative to the catheter portion allows the catheter of the catheter portion to cover the needle tip during a blood transfer procedure, thereby preventing needle damage to a fistula / graft or peripheral vessel of a patient, as well as possible needle stick injuries to health care workers during removal / disposal of a used device. Because the needle still remains largely within the catheter after retraction, there is no risk of catheter collapse, kinking, etc., during use, which could compromise blood flow during a hemodialysis or other vascular access procedure.

The invention discloses a peripheral vascular punctiform stent system comprising a punctiform stent unit and a delivery assembly unit. The dotted stent unit comprises a plurality of mutually independent dotted stents; the point-shaped supports are sequentially arranged in the length direction of the conveying assembly units. A radial supporting force range associated with the compression ratio is preset for each point-shaped stent unit; when the value of the compression ratio is 10%-55%, the value domain of the radial supporting force of the dotted stent units is 0.15-0.5 N / mm, and the value of the radial supporting force of any dotted stent does not exceed the endpoint value of the value domain of the radial supporting force of the dotted stent units. The radial supporting force range is designed in advance, so that the dotted stent units have redundancy, the stability defect of the dotted stent units after being unfolded in the blood vessel is overcome, unexpected displacement and restenosis of one or more dotted stent units are inhibited, and the original position is maintained for a long time.

The invention provides a pressure adjusting system and a method for adjusting the pressure of fluid in an inner cavity of medical equipment, and relates to a method for controlling a pressure control pump to enable the pressure of the fluid in the inner cavity of the medical equipment to change within a period of time. A coronary artery blood vessel remodeling catheter, a peripheral balloon dilatation catheter, a peripheral blood vessel remodeling catheter, an intracranial laser balloon dilatation catheter, a drug coating balloon dilatation catheter, a photodynamic balloon catheter, a mastoid balloon catheter, a constraint type balloon dilatation catheter and a spinous process balloon can be made. Expansion and contraction of a balloon body in a balloon catheter such as a drug delivery balloon catheter are regularly changed within a period of time, and therefore the treatment effect is better achieved.

The present invention relates to a peripheral vascular stent, which comprises a plurality of support units arranged at intervals and a membrane. Each support unit is formed by a silk thread and is a closed ring shape. Each support unit comprises a plurality of peaks and valleys that are centered on the axis of the peripheral vascular stent and are arranged periodically in the circumferential direction. Two adjacent peak tops form one cycle. The membrane is covered on the plurality of support units. The flexibility of the membrane is greater than that of the support unit. A plurality of hollowed-out areas are formed on the silk threads of the same support unit and / or on the membrane between two adjacent support units. Two adjacent support units are connected only through the membrane outside the hollowed-out areas. The vascular stent of the present invention can meet the mechanical property requirements under various deformation states of the lower limb artery, has appropriate radial supporting force and good flexibility, can well reduce the chronic outward expansion force in the vascular stent. The vascular stent of the present invention has little influence on blood flow, little damage to the inner wall of the blood vessel, and is not easy to cause secondary thrombosis formation.

The application discloses a peripheral blood vessel intervention thrombus-removing catheter with a distal embolism protection structure and relates to the technical field of blood vessel thrombus-removing catheters.The peripheral blood vessel intervention thrombus-removing catheter with the distal embolism protection structure comprises a catheter body, one end of the catheter body is provided with a thrombus-removing assembly, the surface of the catheter body is provided with a thrombus-removing assembly, the inside of the catheter body is provided with a transmission assembly, the thrombus-removing assembly comprises a protection pipe network fixedly installed on one side of the catheter body.The transmission assembly is arranged, in the process of use, the rotation of a lead screw can drive one end of the lead screw to move the one side of the filter screen plate to the inside of the protection pipe network, so that the protection pipe network is expanded, and the air bag piece can be inflated, the catheter is placed into in the process of use, the preparation time of catheter operation is reduced, the catheter is convenient to operate, the thrombus-removing and protection operation of the catheter are improved, and the use convenience of the catheter is improved.

The invention belongs to the technical field of ultrasonic angiography, and particularly relates to a peripheral angiography method and system based on ultrasonic tomography and a storage medium. Acquiring an image of a to-be-detected part through an ultrasonic tomography system to obtain a plurality of frames of three-dimensional cross section image sequences; synchronously acquiring pulse signals; processing the three-dimensional cross section image sequence by adopting a target detection neural network, and outputting a preliminary observation value of the blood vessel position; sequentially performing optimal state estimation on the blood vessel position of each frame of three-dimensional cross section image based on a Kalman filtering algorithm, and outputting the optimal blood vessel position estimation of each frame; wherein the initial observation value of the blood vessel position serves as an observation value of Kalman filtering, and a state transition equation of a Kalman filtering algorithm is constructed according to the blood vessel position, the blood flow speed and the pulse signal; and according to the optimized three-dimensional cross section image sequence, reconstructing to obtain a dynamic three-dimensional blood vessel model. Dynamic artifact suppression and state smoothing are achieved based on the pulse signals, and image definition is provided.

The application discloses a kind of peripheral blood vessel tension measurement method and device based on ultrasound, it is related to the technical field of hemodynamics monitoring.The application collects the ultrasound image and arterial spectrum data of peripheral artery, obtains the pressure gradient variation characteristic parameter of peripheral artery from the ultrasound image of peripheral artery;According to the arterial spectrum data of continuous multiple heart cycles in the time period set according to peripheral artery, the resistance characteristic parameter of the rise and fall of blood flow velocity and the forward blood flow of peripheral artery are obtained;The pressure gradient variation characteristic parameter, resistance characteristic parameter and forward blood flow are used, which comprehensively reflect the peripheral arterial vessel tension situation.The application can use ultrasound to realize non-invasive, convenient and dynamic real-time reflection of peripheral vessel tension, and the hemodynamic changes can be fed back through the peripheral vessel tension waveform diagram, which is beneficial to early warning and helpful for health management and clinical guidance.

The present application relates to the technical field of medical diagnosis, and discloses a blood oxygen real-time monitoring system based on a photoelectric volume pulse wave, which comprises the following steps: inducing a vasomotor response through periodic thermal excitation, and demodulating a physiological pulse wave from a thermal modulation signal by using a synchronous phase-locked amplification technology. The present application solves the signal acquisition problem in a silent low perfusion state, converts background signals regarded as invalid noise in traditional monitoring into a resolvable vital sign carrier, and realizes non-invasive evaluation of microcirculation function through a thermal response index, thereby providing an early screening means for peripheral vascular diseases. The system maintains medical-grade precision while realizing the engineering feasibility of a consumer-grade device with an extremely simple hardware architecture.

Systems and methods can include wearable, non-invasive ultrasound modalities for treating a variety of medical conditions, including but not limited to peripheral vascular disease. The modality could be therapeutic ultrasound (TUS), and be configured to promote angiogenesis within a patient via stimulation of cavitation and shear stress, among other mechanisms.

Superficial Temporal Artery Retrograde (STAR) access processes, systems and devices to deliver therapies retrograde, namely (up the body) via the Branches of the External and internal carotid arteries; or antegrade (down the body) to Face; Heart; Organs and extremities of the peripheral vasculature.

The embodiment of the invention provides a PID self-adaptive control ultrasonic imaging method and system based on direct-current motor constant-speed driving. The method comprises the steps that an acquisition signal of a target position is acquired; wherein the target position is a target blood vessel in peripheral blood vessels; based on the acquired signal, controlling an ultrasonic probe of the catheter to perform rotary scanning through a motor to obtain ultrasonic echoes; processing the ultrasonic echo through a preset ultrasonic imaging module to obtain an ultrasonic signal image; and performing coordinate transformation on the ultrasonic signal image to obtain a cross section image and a longitudinal section image of a target blood vessel corresponding to the target position. According to the scheme, the ultrasonic imaging stability of the system can be improved, so that the image quality of the cross section image and the longitudinal section image of the target blood vessel is improved.

The invention discloses hydrogel microspheres capable of loading radioactive isotopes and a preparation method of the hydrogel microspheres. The microsphere is formed by copolymerizing a macrocyclic ligand structure, a hydrophilic monomer and a cross-linking agent, and a macrocyclic ligand is connected with a polymer main chain through a bridging structure containing p-aminobenzoic acid and aliphatic diamine and can efficiently and stably complex various radioactive isotopes. The microspheres have the characteristics of being close to water in density, good in suspension property, smooth in surface and rich in elasticity, and are easily and uniformly distributed in tumor peripheral blood vessels. The preparation method comprises the following two routes: firstly synthesizing the functional monomer and then copolymerizing, or firstly preparing the microspheres and then gradually grafting. The problems that existing microsphere nuclides are prone to falling off, high in density and poor in suspension property are effectively solved, and the microsphere is suitable for interventional radioactive embolism treatment.

The embodiment of the invention provides a carotid artery peripheral blood vessel monitoring method and system.The method comprises the steps that a carotid artery blood vessel is positioned through a probe of transcranial Doppler equipment, the probe is fixed to the corresponding position, and blood flow signals are collected; the probe comprises two array elements, and the two array elements are in a pulse wave PW mode when combined and are in a continuous wave CW mode when separated. After a section of stable blood flow signal is collected, operating power and transmitting power parameters of transcranial Doppler equipment are optimized; and monitoring the quality of the blood flow signal in real time, and if the quality of the blood flow signal is lower than a preset threshold value, performing power parameter optimization again. The power consumption of equipment can be reduced, and long-term monitoring is facilitated; the operation power of the equipment is reduced, the transmitting power is reduced, and the minimum harm to the human body caused by ultrasonic radiation to a subject is reduced.

The utility model discloses a novel peripheral nerve and blood vessel protection device, and particularly relates to the field of nerve and blood vessel protection for osteotomy, the novel peripheral nerve and blood vessel protection device comprises a metal sheet, first limiting grooves are symmetrically formed in the middles of the two ends of the metal sheet, a handle rod is fixedly connected to one side of the top of the metal sheet, and a barrier strip is fixedly connected to the other side of the top of the metal sheet. According to the utility model, the metal sheet is inserted into the gap between the osteotomy bone surface and the peripheral blood vessels and nerves, so that the osteotomy bone surface can be separated from the peripheral blood vessels and nerves, and after the osteotomy tools such as a fret saw, an electric swing saw and the like cut off the bone surface, the metal sheet is touched firstly and osteotomy is stopped; by means of the first limiting groove, an osteotomy fret saw can be conveniently inserted, so that the position of the osteotomy fret saw is kept stable, the position of an osteotomy surface is not prone to sliding in the osteotomy process, and accurate osteotomy is achieved.

The invention discloses a peripheral vessel interventional catheter fixing device which comprises a mounting mechanism, a catheter clamping mechanism used for fixing an interventional catheter is arranged on the side face of the mounting mechanism, an adjusting mechanism is arranged between the catheter clamping mechanism and the mounting mechanism and used for steering adjustment of the catheter clamping mechanism, and the catheter clamping mechanism is connected with the mounting mechanism through the adjusting mechanism; a driving seat is slidably connected to the inner side of the mounting mechanism, the end, away from the pipe clamping mechanism, of the adjusting mechanism is connected with the driving seat, and a driving assembly used for driving the driving seat is further arranged in the mounting mechanism. According to the peripheral vessel interventional catheter fixing device, the interventional catheter can be fixed through the mounting mechanism and the catheter clamping mechanism, the driving seat can be driven to move through the adjusting knob, then the adjusting mechanism is driven to adjust the position of the catheter clamping mechanism, and meanwhile the adjusting mechanism can achieve steering adjustment of the catheter clamping mechanism; and the fixing requirements of the peripheral vascular intervention catheter in different use scenes are met.

The present invention provides the application of the secretory protein CTSB (cathepsin B) in predicting the risk of vascular lesions in patients with diabetic foot ulcers (DFUs), belonging to the field of biomedicine technology. Through single-cell sequencing studies, the present invention found that the secretory protein CTSB is significantly enriched in vascular endothelial cells in the blood vessels of DFU patients, with high PPI connectivity and low expression; CTSB overexpression / knockout experiments found that CTSB is associated with the proliferation and tubulogenesis of vascular endothelial cells in human blood vessels; ELISA experiments also found that the level of secretory protein CTSB in serum can be used as a marker for predicting the risk of vascular lesions in DFU patients, and that the expression level of CTSB is negatively correlated with the Wanger grade of diabetic foot; the method can predict the risk of peripheral vascular lesions in DFU patients, has the advantages of simple operation and high sensitivity, can reduce false detection and missed detection, and has stable and reliable test results, making it suitable for large-scale detection.

The present invention discloses a test tube adapter applicable to immunoassay, comprising: a support part for placing and supporting the peripheral blood vessel; a clamping part integrally fixed to the lower part of the support part, and the clamping part is used for facilitating the clamping of the peripheral blood vessel by a clamp; and a fixing part integrally fixed to the lower part of the clamping part at the end of the adapter, and the fixing part is used for fixing and positioning the adapter. Wherein, a positioning hole is formed on the side wall of the fixing part, and an induction hole is formed on the side wall opposite to the positioning hole. According to the present invention, the structure is simple and effective, enabling the peripheral blood collection tube to be placed on the detection instrument for detection. The adapter is provided with a positioning hole, which can be positioned and locked when the adapter is placed on the detection instrument. Moreover, an induction hole is formed at the lower end position of the adapter where the peripheral blood collection tube is located, so that the peripheral blood collection tube can be exposed for the detection instrument to sense the peripheral blood collection tube.

Described here are devices, systems, and methods for cannulating a vessel. Generally, the method may comprise advancing a stent into a first vessel and deploying the stent in the first vessel to hold open one or more valves. This may permit retrograde blood flow through the blood vessel in peripheral vasculature and aid in cannulation of the blood vessel.

Described herein are compounds of Formula I,wherein the variables are defined herein, their use as activators from AMPK, pharmaceutical compositions containing such compounds and their use to treat, for example, heart failure or peripheral vascular disease.

Disclosed in the present invention are a long-acting functionalized double-layer bionic small-caliber vascular prosthesis, and a preparation method therefor and use thereof. The preparation method therefor comprises: separately synthesizing degradable polyurethane elastomers PCHU-DSeSe and PCHU-DTA using a three-step solution polymerization method, and carrying out near-field direct-writing electrospinning of PCHU-DSeSe on a stainless steel mandrel with an axial groove to obtain an axially oriented fibrous vascular inner layer; assembling the axially oriented fibrous vascular inner layer together with the mandrel into a polytetrafluoroethylene mold having radially oriented patterns on the inner wall of the housing; rapidly casting a PCHU-DTA / DMSO solution into the mold for phase separation to obtain a vascular outer layer of an axis-aligned topological microstructure, and carrying out freeze-drying to obtain the long-acting functionalized double-layer bionic small-caliber vascular prosthesis. The long-acting functionalized double-layer bionic small-caliber vascular prosthesis has the functions of continuous release of DSS, NO and H2S, and in-situ dynamic regulation and repair of a vascular tissue microenvironment, can be used for arteriovenous fistula creation, and coronary artery and peripheral vascular bypass therapy, and thus has good application prospects.