Application of Adamtsl3 as diagnosis and treatment marker for abdominal aortic aneurysm

An abdominal aortic aneurysm and drug technology, which is applied in the application field of abdominal aortic aneurysm diagnosis and treatment markers

Inactive Publication Date: 2020-05-26
PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no clear drug that can delay the progression of abdominal aortic aneurysm

Method used

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  • Application of Adamtsl3 as diagnosis and treatment marker for abdominal aortic aneurysm
  • Application of Adamtsl3 as diagnosis and treatment marker for abdominal aortic aneurysm
  • Application of Adamtsl3 as diagnosis and treatment marker for abdominal aortic aneurysm

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Example 1 Correlation between Adamtsl3 gene expression and abdominal aortic aneurysm

[0047] 1. Animals and Handling

[0048] Male wild-type C57BL / 6J was obtained from Jackson Laboratories (Bar Harbor, Me). All mice were housed in pathogen-free isolation cages as littermate controls. Mice received a normal laboratory diet. Mice aged 10-12 weeks were subcutaneously injected with normal saline or angiotensin II (AngII) using Alzet osmotic minipumps (2004, Durect Corporation), and the injection dose was 1000ng.kg-1.min-1 (Sigma-Aldrich , St. Louis, MO). AAA mice and normal control mice were anesthetized with 10% chloral hydrate, and sterilized by soaking in 75% alcohol for 2 minutes. The chest cavity and abdominal cavity were opened, the organs were pushed aside, the heart and aorta were exposed, and the blood was sucked away with gauze. Carefully cut the full length of the heart and aorta up to the bifurcation of the abdominal aorta, and immediately put it in 0.01M ...

Embodiment 2

[0064] Example 2 The effect of Adamtsl3 gene expression on the function of aortic smooth muscle cells

[0065] 1. Adamtsl3 gene overexpression

[0066] 1. Culture of human aortic smooth muscle cells

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Abstract

The invention discloses an application of Adamtsl3 as a diagnosis and treatment marker for abdominal aortic aneurysm, and also discloses a reagent and a kit for detecting Adamtsl3. The invention further discloses a method and a medicine for treating abdominal aortic aneurysm. The above research achievements provide a new strategy and thought for clinically treating abdominal aortic aneurysm.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of Adamtsl3 as a marker for diagnosis and treatment of abdominal aortic aneurysm. Background technique [0002] Abdominal aortic aneurysm (AAA) is a common chronic aortic degenerative disease, which is common in elderly men over 60 years old. Currently, the prevalence of abdominal aortic aneurysm is 5%-10% in the elderly male population over 60 years old. The incidence of abdominal aortic aneurysm gradually increases with age, the maximum diameter of the aneurysm gradually increases, and the risk of rupture gradually increases. Abdominal aortic aneurysm continues to progress, and may be complicated by rupture and bleeding in the late stage, and the emergency mortality rate is as high as 90%. Therefore, abdominal aortic aneurysm has the characteristics of high morbidity and high mortality, which seriously threatens the health of middle-aged and elderly people. [0003...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886G01N33/68G01N33/577G01N33/574A61K45/00A61K48/00A61K38/17A61P35/00
CPCA61K38/1709A61K45/00A61K48/005A61P35/00C12Q1/6886C12Q2600/158G01N33/57407G01N33/57484G01N33/577G01N33/68G01N2333/47
Inventor 张慧李方达陈思良杨丹郑月宏
Owner PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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