34 results about "Microdosing" patented technology

The invention provides a microdosimetry-based evaluation method for a targeted alpha radionuclide treatment biological effective dose, and the method comprises the steps: carrying out the integration of a time activity curve of alpha radionuclide in an organ, obtaining the cumulative activity, and calculating the physical absorbed dose and dose rate of the organ through Monte Carlo simulation; based on micro-dose Monte Carlo simulation, constructing a micro-dose spectrum of the alpha radionuclide to obtain saturation correction dose average linear energy for representing radiation quality; obtaining biological effect parameters of the alpha radionuclide by fitting saturation correction dose average line energy and cell experiment data by using a micro-dose kinetic model; and evaluating the biological effective dose of the target organ in combination with the physical absorbed dose, the dose rate and the biological effect parameter. According to the method, the problem that a biological effective dose evaluation method is lacked in dose evaluation of targeted alpha radionuclide treatment is solved.

An applicator, including a body, an applicator surface having two or more nozzles configured to apply two or more formulas to skin, one or more reservoirs configured to hold the two or more formulas, a position sensor configured to map the skin as the applicator surface applies the two or more formulas, wherein the position sensor is configured to transmit position data, where the applicator is configured to adjust a dosage of each formula of the two or more formulas based on the position data.

A nozzle is provided herein for ophthalmic dispensers which is configured to accommodate microdosing. The nozzle includes a converging pathway. Preferably, the pathway converges so as to impart momentum to liquid passing therethrough through an increase of velocity. A tapered portion may be provided flared openly from the inlet to best accept liquid flow thereinto and provide a funneling effect into the flowpath. Preferably, the flowpath terminates at an outlet which is internally un-radiused and circumscribed by a chamfered surface.

A microdosing device and a method for dispensing droplets from a plurality of nozzles are presented. The microdosing device comprises a cartridge in which at least part of a dosing chamber and the plurality of nozzles are formed, the dosing chamber being fluidically connected to a fluid inlet and the plurality of nozzles. The microdosing device further comprises an actuator configured to change the volume of the dosing chamber in order to eject a droplet from each of the plurality of nozzles, and a pressure sensor configured to generate a pressure signal dependent on a pressure in the dosing chamber. The microdosing device also includes a fluid reservoir fluidically connected to the fluid inlet and a pressure control device separately from the actuator, configured to control the pressure in the fluid reservoir based on the pressure signal.

Microdosing system (100, 300) for dosing a quantity of fluid to be dispensed, comprising: a micropump (101) having an inlet (102) and an outlet (103) and designed to draw in the fluid (104, 105, 109) to be discharged through the inlet (102) and to discharge at least part of the fluid (104, 105, 109) from the outlet (103), a first flow sensor (106a, 106b) arranged on the inlet or outlet side, which has an opening (107a, 107b) and a flow meter (108a, 108b), wherein the flow meter (108a, 108b) is configured to determine the flow rate of the fluid (104, 105) passing through this opening (107a, 107b), and means (113, 313) for calibrating and / or interfering detection of the microdosing system (100, 300), wherein the means (113, 313) for calibrating and / or detecting disturbances of the microdosing system (100, 300) comprise a control device (302) configured to detect an actual sensor signal of the first flow sensor (106a, 106b) when the micropump (101) is inactive, and to correct subsequent sensor signals of the first flow sensor (106a, 106b) based on this in order to counteract sensor drift of the first flow sensor (106a, 106b) and to calibrate the microdosing system (100, 300).

The invention provides a method for calculating micro-dosimetry parameters and statistical errors thereof in alpha radiopharmaceutical radiation biological effect prediction under a microscopic heterogeneity condition. The method comprises the following steps: (1) constructing a stylized cell community model with microstructure heterogeneity, and describing heterogeneity spatial distribution of alpha radiopharmaceutical source items; (2) using a Monte Carlo method to simulate energy deposition information generated by each region source item to a cell nucleus target region; (3) calculating key micro-dosimetry parameters and statistical errors of the cell nucleus and the intranuclear radiation sensitive domain under the complex source item based on a micro-dosimetry principle and a probability method; and (4) predicting the survival score in the cell community based on the microdosimetry radiobiologic effect model, and performing error control and relative biological efficiency calculation. The method is used in the field of alpha radiopharmaceutical dose evaluation, can realize composite analysis and error control of micro-dosimetry parameters in a more real scene model, and provides technical support for research, development and conversion of alpha radiopharmaceuticals.

The present invention relates to compositions and methods for treating aging-related diseases. The present invention provides a composition comprising at least three substances selected from the group consisting of alpha-ketoglutaric acid, malic acid, pterostilbene, micro-dose lithium, glycine, ginger, Rhodiola rosea, acetylglucosamine, vitamin C, glucosamine, fisetin, L-theanine, oxaloacetic acid, fumaric acid, succinic acid, hyaluronic acid, butyric acid, anthocyanins, piper longum amide, quercetin, curcumin, and a pharmaceutically acceptable salt thereof. And caffeine, trehalose and spermidine. The present invention also provides related pharmaceutical compositions, methods for improving senescence profiles, and articles of manufacture.

The invention relates to the technical field of medicine feeders, and discloses a novel medicine feeder which comprises a main body assembly. The main body assembly comprises a main pipe and a main pipe; the air bag is arranged on the connector; a cleaning assembly is arranged on the main pipe; according to the cleaning assembly, a connecting rod is fixedly connected to the outer side of the main pipe; the supporting rod is arranged on the inner side of the connecting rod; the side pipe is connected into the supporting rod in a sliding mode. The spraying head is arranged at one end of the side pipe; the ring body is slidably connected to the inner side of the main pipe; the double-tube type medicine feeding mode of the main tube and the side tube is adopted, residues and waste of medicine on the tube wall are reduced, medicine feeding is more accurate, and the novel medicine feeder has the advantages that medicine residues on the tube wall of the medicine feeder are reduced, accurate medicine feeding of small and micro-dose medicine for infants is facilitated, and medicine waste and side effects of excessive medicine are avoided. The problem that an existing medicine feeder does not have a good cleaning function is solved.

The application provides a piston driving device for a continuous micro-dosing device and a working method, which comprises the following steps: under the action of a control device, a force storage and release device releases a specified piston stroke, and a force storage device outputs a linear thrust to push a piston push rod device to move in a specified direction for a specified piston stroke. By adding a sufficient amount of liquid medicine into a medicine storage device, the control device obtains an injection instruction or an injection program inputted from outside, and the control device starts to control the force storage and release device to release the specified piston stroke, and the force storage device outputs a linear moment to push the piston push rod device to move in the specified direction for the specified piston stroke. The force storage device is used as a power source to push the piston by a direct pushing mode, the required pulse number is calculated according to the required dose or the distance of the piston movement, the control device is used to accurately control the force storage and release device to release the specified piston stroke, the accuracy of the dosing dose is improved, and the structure is simple and the cost is low.

A microdosing device and a method for dispensing droplets from a plurality of nozzles are presented. The microdosing device comprises a cartridge, in which at least a part of a dosing chamber and the plurality of nozzles are formed, wherein the dosing chamber is fluidically connected to a fluid inlet and the plurality of nozzles. The microdosing device further comprises an actuator which is configured to change a volume of the dosing chamber to thereby eject a droplet from each of the plurality of nozzles, and a pressure sensor which is configured to generate a pressure signal dependent on a pressure in the dosing chamber. In addition, the microdosing device comprises a liquid reservoir which is fluidically connected to the fluid inlet, and a pressure control device provided separately from the actuator which is configured to control a pressure in the liquid reservoir on the basis of the pressure signal.

The present invention concerns a microdosing test device comprising: 1) a layer impermeable to aqueous liquids wherein the layer comprises a biocompatible and biodegradable adhesive for a mucosal surface of an animal, and 2) a carrier adapted for bringing a test compound in a non-therapeutic concentration in physical contact with the mucosal surface; wherein the layer when applied to the mucosal surface forms a microdosing compartment between the layer and the mucosal surface which compartment contains the carrier.

A method for coupling a microdosimetry model with a Monte Carlo neutron transport model comprises the following steps: conducting an in vitro cell survival experiment to obtain experimental data; establishing a microdosimetry model based on microdosimetry and experimental data, and correcting the influence of overkill effect, dose rate effect and intracellular boron distribution heterogeneity on the microdosimetry model; calculating the physical absorption dose through a Monte Carlo transport model; and coupling the microdosimetry model with the Monte Carlo transport to calculate the biological effective dose. The present invention establishes a set of RBE models suitable for BNCT based on microdosimetry, greatly improves the calculation accuracy and speed, and realizes the coupling calculation of the microdosimetry model with the Monte Carlo transport model to calculate the biological effective dose.

The invention discloses a system and a method for measuring equivalent biological dose of targeted alpha nuclide therapy based on a voxel model. According to the system, a patient-specific three-dimensional voxel anatomical model and an activity distribution diagram are constructed through an image processing module; the intelligent energy item module calls a pre-established dose point core database according to decay characteristics of the selected alpha nuclide to generate an equivalent total dose point core; the dose calculation module performs fast convolution calculation based on the cumulative activity and the equivalent total dose point kernel to obtain a three-dimensional physical absorbed dose; the biological dose module is integrated with a micro-dose dynamic model and converts physical dose into a three-dimensional biological dose distribution diagram equivalent to conventional external radiation therapy. The technical defects that a standard model is large in error, Monte Carlo simulation consumes time, depends on multi-time-point dynamic imaging, and the physical dose cannot reflect the alpha particle biological effect are overcome, efficient, accurate and clinically practical individualized biological dose evaluation is achieved, and the accuracy and safety of a treatment scheme are remarkably improved.

Described are compositions, kits and methods for preventing, minimizing the risk of, or treating a microbial infection at a wound or surgical site. The method comprises injecting a combination of a therapeutically effective microdose of a microbial agent and a local anesthetic into the dermis layer of the skin. The composition can be administered by medical personnel, provided by non-clinical personnel, or self-administered.

A dosing system for transferring an aseptic fluid in dosages into a container, comprising a peristaltic pump configured such that the filling accuracy for fill volumes of the aseptic fluid<100 μL is ±3 μL.

A nozzle is provided herein for ophthalmic dispensers which is configured to accommodate microdosing. The nozzle includes a converging pathway. Preferably, the pathway converges so as to impart momentum to liquid passing therethrough through an increase of velocity. A tapered portion may be provided flared openly from the inlet to best accept liquid flow thereinto and provide a funneling effect into the flowpath. Preferably, the flowpath terminates at an outlet which is internally un-radiused and circumscribed by a chamfered surface.

The present invention provides a method of determining the amount of a psilocybin in a sample, the method comprising contacting a cell which expresses ABCF1 with the sample, comparing the expression of ABCF1 with a standard to determine the amount of psilocybinin in the sample. Also provided are methods of microdosing based on ABCF1 expression.

This invention discloses a voxel-based system and method for determining the equivalent biological dose of targeted alpha nuclide therapy. The system constructs a patient-specific three-dimensional voxel anatomical model and activity distribution map through an image processing module; an intelligent source term module, based on the decay characteristics of the selected alpha nuclide, calls a pre-built dose point kernel database to generate an equivalent total dose point kernel; a dose calculation module performs rapid convolution calculation based on cumulative activity and the equivalent total dose point kernel to obtain the three-dimensional physical absorbed dose; and a biological dose module integrates a micro-dose kinetic model to convert the physical dose into a three-dimensional biological dose distribution map equivalent to conventional external beam radiotherapy. This invention overcomes the technical shortcomings of standard models, such as large errors, time-consuming Monte Carlo simulations, reliance on multi-timepoint dynamic imaging, and the inability of physical dose to reflect the biological effects of alpha particles. It achieves efficient, accurate, and clinically practical individualized biological dose assessment, significantly improving the accuracy and safety of treatment plans.

An applicator, including a body, an applicator surface having two or more nozzles configured to apply two or more formulas to skin, one or more reservoirs configured to hold the two or more formulas, a position sensor configured to map the skin as the applicator surface applies the two or more formulas, wherein the position sensor is configured to transmit position data, where the applicator is configured to adjust a dosage of each formula of the two or more formulas based on the position data.

The present invention discloses a method for predicting the relative biological effect of boron neutron capture therapy, comprising the steps of: conducting an in vitro cell survival experiment to provide data support for the establishment of a relative biological effect model; establishing a relative biological effect model based on microdosimetry; and optimizing the relative biological effect model. The present invention uses the Monte Carlo method to establish a cell matrix to simulate the intracellular energy distribution of tissue cells under different types of boron drugs and different boron concentrations, taking into account the effects of different boron drugs on tissue cells, so that the simulation calculation is closer to the experimental results; fully considering the influence of biological effects, introducing saturation parameters in the biophysical model established based on microdosimetry to solve the overkill effect, introducing evaluation parameters for the dose rate effect under long-term irradiation, and fully considering the heterogeneous distribution of different boron drugs on tissue cells. Compared with the existing RBE model, the calculation accuracy of the model of the present invention is significantly improved, and it can meet the RBE prediction of different boron drugs.

This invention relates to a micro-dose insecticidal aerosol composition for controlling disease-transmitting insects, whether flying or crawling. The micro dose insecticidal aerosol composition in one single actuation, comprises pyrethroid insecticide in hydrocarbon solvent, capable of generating particles in the air and in the environment with particle diameter D50 ≤ 0,15 µm corresponding to 500 to 800 mg of the composition applied every 5 m3.

This invention provides a piston motion system and operating method for a continuous micro-dose delivery device. The system includes a power-release device releasing a specified piston stroke under the action of a control device. The power-release device outputs a rotational torque to drive the piston body of the piston pusher device to move along a specified direction for the specified piston stroke. Sufficient drug solution is added to the drug storage device. The control device receives an externally input injection command or injection program. The control device initiates control of the power-release device to release the specified piston stroke, and the power-release device outputs a rotational torque to drive the piston body of the piston pusher device to move along a specified direction for the specified piston stroke. By driving the piston through the output rotational torque, the required number of pulses can be calculated based on the required infusion dose or piston movement distance. The control device precisely controls the power-release device to release the specified piston stroke, which helps improve the accuracy of drug delivery. Furthermore, the system is simple in structure and low in cost.

The invention discloses a burn wound repair system based on a bionic nano-material, and relates to the technical field of intelligent wound therapy, the system comprises a bionic nano-material application layer used for covering a burn wound and providing a biocompatible stent, the surface of the bionic nano-material application layer is loaded with controllably released drugs or growth factors; the intelligent drug delivery module is connected with the bionic nano material application layer and used for releasing specific drugs or bioactive factors in a micro-dose mode under the control instruction; the multi-mode environment sensor array is arranged on the application layer or below the application layer and used for collecting wound surface environment data in real time, and the wound surface environment data comprise the pH value, the temperature, the humidity, percolate and the like; the closed-loop control and algorithm unit is in communication connection with the multi-mode environment sensor array and the intelligent drug delivery module, performs wound healing stage classification based on the collected environment data, and generates adjustment parameters and drug administration instructions through a reinforcement learning algorithm and a self-adaptive PID control strategy; the invention discloses a flexible integrated packaging and pasting module.

The disclosed embodiments are directed to a wearable automatic drug delivery device configured to provide basal-only dosing of insulin. In a primary embodiment, the wearable drug delivery device is configured to provide automatic operation and provides audible alerts and visual status indicators to the patient. In other embodiments, the patient may have some degree of control over the operation of the device by providing tapping gestures on housing of the device. In yet another embodiment, the patient may provide input and receive status from the device via an application executing on a portable computing device in wireless communication with the wearable drug delivery device.

Devices, systems, and methods are provided herein for delivering medication (e.g., insulin) via a wearable pump having a patch-style form factor for adhesion to a user's body. The reusable pump may be coupled to a disposable cap housing a microdosing system for delivering precise, repeatable doses of medication to a cannula configured to deliver medication to a target infusion area beneath the user's outer skin layer. The system further may include an applicator for inserting the cannula into the user's skin and / or applying an adhesive pad to the skin.

A nutraceutical composition, consisting of at least of Berberine in a range of 500-1500 mg, Trimethylglycine (TMG) in a range of 500-2000 mg, Microdose Lithium in range of 1-5 mg, Epigallocatechin-3-gallate (EGCG) in a range of 100-500 mg, Fisetin in a range of 100-1000 mg, Resveritrol in a range of 150-1000 mg, Glutathione in a range of 250-1000 mg, Nicotinamide Mononucleotide (NMN) in a range of 250-1000 mg or Nicotinamide Riboside (NR) in a range of 100-2000 mg, Calcium Alphaketoglutarate (CaAKG) in a range of 300-2000 mg, Spermidine in a range of 0.5-10 mg, Urolithin A in a range of 250-2000 mg, Hyaluronic acid in a range of 100-240 mg, Fucoidan in a range of 100-4000 mg, and Sodium Butyrate in a range of 100-3000 mg.

A continuous micro-dose administration apparatus includes a needle apparatus, a drug storage apparatus, a piston push rod apparatus, a force accumulating apparatus, an accumulated force release apparatus, and a control apparatus. Under the action of the control apparatus, the accumulated force release apparatus releases a specified piston stroke, the force accumulating apparatus pushes the piston push rod apparatus to move into the drug storage apparatus by the specified piston stroke, and drug liquid in the drug storage apparatus is discharged through the needle apparatus. With the force accumulating apparatus as a power source, the piston body is pushed by means of rotation or direct pushing, a required number of pulses is calculated according to a dose to be infused or a distance moved by the piston, and the control apparatus accurately controls the accumulated force release apparatus to release the specified piston stroke, thereby improving the dose administration accuracy.

The invention discloses a push type injection pump for micro-administration, and relates to the technical field of medical instruments. The supporting seat is mounted on one side of the top end of the injection pump table; the clamping mechanism is mounted on the other side of the top end of the injection pump table; the propelling mechanism is mounted between the opposite surfaces of the supporting seat and the clamping mechanism; through cooperative work of the precise screw rod, the propelling driving assembly, the propelling nut, the ball return groove, the multiple ball bodies, the mounting frame and the cleaning block, the precise screw rod is matched with a ball raceway on the inner wall of the propelling nut, and rolling transmission of the ball bodies and circulating guiding of the ball return groove are combined, so that the gap problem of a traditional transmission structure is thoroughly solved; meanwhile, the cleaning block on the mounting frame synchronously cleans impurities on the surface of the lead screw in the propelling process, the situation that the impurities affect the transmission precision is avoided, and then the strict requirement for clinical precise micro-dosage can be met.