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Treatment of post-bariatric hypoglycemia using mini-dose stable glucagon

A technology of glucagon and hypoglycemia, which is applied in the field of treating hypoglycemia after weight loss, and can solve problems such as inability to relieve symptoms

Pending Publication Date: 2020-11-13
XERIS PHARMA INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unlike dumping, nutritional manipulation does not alleviate symptoms of postprandial hypoglycemia (PPH)

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] Randomized, placebo-controlled, double-blind, two-way crossover study followed by open-label crossover extension with standard of care to assess the incidence and duration of postprandial hypoglycemia in patients following bariatric surgery

[0081] The primary objective of the described study was to assess the incidence and duration of postprandial hypoglycemia (PG below 70 mg / dL). To assess (i) prevention of postprandial hypoglycemic episodes (defined as glucose levels below 70 mg / dl); (ii) prevention of severe hypoglycemic episodes (defined as glucose levels below 54 mg / dl); prevention of Rebound hyperglycemia (defined as glucose levels above 180 mg / dl) was used as a secondary goal. Time in target range (defined as glucose levels of 70 mg / dl to 180 mg / dl), reported in minutes, should also be assessed; and the neurologicity of hypoglycemia recorded using the Edinburgh Hypoglycemia Symptoms Score Originating symptoms (if present).

[0082]Additional objectives includ...

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PUM

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Abstract

Post-bariatric hypoglycemia (PBH) is an increasingly-recognized complication of gastric bypass surgery. Current therapeutic options have suboptimal efficacy. Small doses of stable liquid glucagon canbe used to treat or prevent post-bariatric hypoglycemia.

Description

[0001] Statement Regarding Federally Funded Research [0002] This invention was made with Government support under Grant No. R44DK107114 awarded by the U.S. Department of Health and Human Services. The government has certain rights in this invention. technical field [0003] The present invention relates to the fields of bariatric medicine and surgery. In particular aspects, the invention relates to methods for treating post-bariatric hypoglycemia (PBH). Background technique [0004] An abnormal increase in insulin secretion can lead to severe hypoglycemia, or low blood sugar, a state that can lead to serious illness including seizures and brain damage. Drug-induced hypoglycemia may be due to overdose of sulfonylureas or insulin. Many medical conditions are characterized by non-drug-induced endogenous hyperinsulinemic hypoglycemia, such as hyperinsulinemic hypoglycemia following gastric bypass surgery. [0005] Hypoglycemia can lead to a variety of symptoms, including l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/26A61K9/00A61K9/08A61K47/02A61K47/20A61K47/26A61P1/18A61P3/08A61P5/48
CPCA61K38/26A61K9/0019A61K9/0021A61K47/20A61K47/26A61K9/08A61P3/08A61P5/48A61P1/18A61K47/02A61K47/10
Inventor 布雷特·纽尼斯万格史蒂夫·J·普莱斯特斯基玛丽-伊丽莎白·帕蒂
Owner XERIS PHARMA INC
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