The invention discloses a vehicle route optimization processing method, comprising the following steps: a, collecting order quantity, network point quantity, network point distance matrix and vehicleinformation; B, setting whether the time window and/or the line template are open; (c) the order quantity, the number of dot, the distance matrix of dots, the vehicle information, whether the time window is open, and whether the route template is open are taken as constraint conditions, the ant colony genetic fusion algorithm is adopted to iteratively calculate the optimal path, and the dot pheromone is updated; Reasonable use of constraints in this design, ant colony genetic fusion algorithm iterative calculation after replication and transformation, the shortest path, and the results of performance indicators are good.