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Biological dose calculation method for boron neutron capture therapy

A technology of boron neutron capture and biological dose, which is applied in the fields of therapy, X-ray/γ-ray/particle irradiation therapy, radiotherapy, etc., and can solve the problems of model accuracy controversy and lack of wide applicability

Active Publication Date: 2021-04-09
NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
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Problems solved by technology

In addition, some researchers proposed to use the MKM model, the accuracy of which is controversial and lacks wide applicability

Method used

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  • Biological dose calculation method for boron neutron capture therapy
  • Biological dose calculation method for boron neutron capture therapy
  • Biological dose calculation method for boron neutron capture therapy

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Embodiment 1

[0121] See attached figure 1 , the present embodiment provides a biological dose calculation method for boron neutron capture therapy, comprising the following steps:

[0122] Step 101: Based on neutron autoradiography and cell structure imaging technology, obtain accurate determination of boron concentration distribution in tumor / normal tissues and organs;

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Abstract

The invention relates to a biological dose calculation method for boron neutron capture therapy (BNCT). According to the method disclosed by the invention, accurate measurement of the tumor cell scale and tumor / normal tissue vessel boron concentration distribution is realized based on a neutron autography technology; according to different boron drug distribution characteristics, neutron energy spectra and tissue material characteristics, the corresponding relationship between boron distribution and neutron energy and the relative biological effect (RBE) or the complex biological effect (CBE) of all ray components of the BNCT is constructed through Monte Carlo simulation and a microdosimetry physical model; a radiation simulation human body model of patient individualization is constructed based on the medical image data, and then, three-dimensional dose distribution is obtained; and according to contouring of a gross tumor volume and normal structures, the equivalent biological dose is acquired by combining three-dimensional physical dose distribution and biological effect factors, and the dose volume histogram (DVH) of tumors and normal structures are obtained by calculation, so that a theoretical basis is provided for the design of novel targeted drugs and biological conversion of the accurate BNCT clinical treatment plan.

Description

technical field [0001] The present invention relates to the technical field of radiation therapy, in particular to a method for calculating biological dose of boron neutron capture therapy. Background technique [0002] According to China's latest cancer data "China Cancer Report" released by the National Cancer Center, about 10,000 people are diagnosed with cancer every day, and cancer has become the number one killer threatening the health of our people. As one of the three main methods of cancer treatment, radiotherapy has always pursued the goal of increasing the radiation dose to the tumor area during radiotherapy to kill the tumor, and at the same time reducing the radiation dose to normal tissues to reduce damage to normal tissues . An ideal precision radiotherapy technology should kill tumor cells with high selectivity and high lethality at the micron scale, and BNCT is a radiotherapy technology with this characteristic. It injects a boron-containing compound into t...

Claims

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Application Information

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IPC IPC(8): A61N5/10
CPCA61N5/1071A61N5/1075A61N2005/109
Inventor 耿长冉齐婕汤晓斌田锋刘渊豪
Owner NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
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