98results about How to "Improve dose accuracy" patented technology

The invention relates to: A portable medication delivery device (1) comprising a medication cartridge (11) having an outlet (111) and a movable piston (112), and a housing (12) for holding said cartridge, and a flexible piston rod (13) being operable to engage and displace said piston along an axis (113) of said cartridge, and guiding means (14) for bending said piston rod away from said axis, and actuating means (15), and driving means (16, 17) for transferring movement from said actuating means to said piston rod, said driving means including a driving wheel (17) for displacing the piston rod (13), said flexible piston rod comprising regularly spaced first members (330; 331; 332) adapted to mechanically cooperate with corresponding second members (171) on said driving wheel. The object of the present invention is to provide a medication delivery system that combines compactness with an improved accuracy. The problem is solved in that said flexible piston rod (13) exhibits a linear or approximately linear path between said driving wheel (17) and said piston (112). This has the advantage of yielding a compact, low-weight device with an improved dose accuracy. The invention may e.g. be used in injection or infusion devices for a person's self-treatment of a disease such as diabetes.

A pharmaceutical cartridge piston including a rigid core to resist compression of the piston. The resistance to compression contributes to the piston providing dose accuracy and dynamic recovery advantages.

The invention relates to a contaminated soil ex-situ medicating, mixing and restoring system. The system consists of a soil warehouse, a quantitative feeder, a solid medicament bin, a weighing screw feeder, a liquid medicament box, a medicament pump, a spraying device, a soil crusher, a feeding belt machine, a cutting, crushing and mixing device, a soil stirrer, a discharge belt machine and a scattering, crushing and mixing device. Contaminated soil can be rapidly restored by adopting a solid or liquid remediation medicament according to different contaminated soil characteristics, and the contaminated soil ex-situ medicating, mixing and restoring system is mainly suitable for ex-situ remediation occasions of heavy metal or organic matter contaminated soil. The contaminated soil ex-situ medicating, mixing and restoring system is wide in application range, high in processing capacity and medicating and measuring precision, good in crushing and mixing effect, is high in automation degree for contaminated soil, can be used for solidification stability of heavy metal contaminated soil and chemical and oxidation remediation treatment of organic matter polluted soil, also can be used for the crushing and mediation mixing operation of other similar materials, and has favorable environment-friendly and social benefits.

The invention relates to: A medication delivery device (1) for delivering a specific dose comprising a medication cartridge (11) having an outlet (111) and a piston (112), and means (12) for holding said cartridge, and a piston rod (13) being operable to engage and displace said piston, and electrically driven actuating means (15), and driving means (161, 162) for transferring movement from said actuating means to said piston rod, and memory means (17) for storing data, and processing means (18) for evaluating said data and for controlling said actuating means. The object of the present invention is to provide a medication delivery system that combines a relatively high dose accuracy with the use of relatively low quality mechanical components and which enables compensation for built-in non-linearities. The problem is solved in that a first set of data (19) describing the actual movement (130) of said piston rod (13) relative to said medication cartridge (11) as a function of the movement (150) of said actuating means (15) is stored in said memory means (17), and the movement (130) of the piston rod (13) governing the delivered dose is controlled by the processing means (18) on the basis of said first set of data (19). This has the advantage of allowing compensation for mechanical inaccuracies and built-in non-linearities linearities. The invention may e.g. be used in injection or infusion devices for a person's self-treatment of a disease such as diabetes.

A method and apparatus is provided for the efficient and controllable delivery of cryogen liquid droplets into thin walled containers before they are sealed, the pressurization of the sealed container caused by the evaporation of the liquid cryogen causing the walls of the container to stiffen. Discharge of the droplets immediately upstream of the container sealing station is facilitated using a horizontal displacement assembly to transport metered droplets from a liquid dosing unit to the point of injection above the container. The horizontal displacement assembly may be provided with internal heaters to prevent freeze up, and a sensor to confirm droplet discharge. It may also be provided with a separate source of heated nitrogen gas, which can be used to back purge the dispensing unit should it become clogged, to melt any frozen liquid occlusions which may have formed in the cryogen supply line. In one embodiment, the solenoid used to actuate the piston regulating the opening and closing of the needle valve, which meters the dispensing of droplets, is mounted in thermal contact with said piston, this placement of the solenoid serving to cool the piston and thus prevent overheating in the case of rapid cycling.

A chain conveyor for gravimetrically measuring/dosing materials, especially bulk materials. The conveyor includes a housing/trough in which at least two chain conveyors with strip-shaped driving elements attached thereto rotate, wherein a measuring bridge that is supported on at least one force measuring device is arranged between the inlet and an outlet hole. The driving elements are mounted with multiple articulations on the conveyor chains, more particularly, said driving elements are inserted with positive-fit by lateral hinge bolts in the chain links located on the upper edge and configured to be placed flatly in the measuring bridge.

The present invention relates to methods for the treatment of exacerbation periods of pulmonary diseases, particularly chronic obstructive pulmonary diseases, by administering alpha-1 antitrypsin (AAT) to a subject in need thereof. Particularly, the present invention discloses the efficient treatment of exacerbation periods of pulmonary diseases by administering AAT via inhalation.

The invention discloses a phenylboronic acid hydrogel-based sugar-sensitive microneedle pad and a preparation method thereof. The phenylboronic acid hydrogel-based sugar-sensitive microneedle pad comprises a base and a microneedle array which is located on the base, wherein the base and microneedles are mainly prepared from a vinyl phenylboronic acid monomer and a vinyl monomer through free radical copolymerization; microneedle bodies and the base can both be used for embedding insulin drugs; the phenylboronic acid monomer is selected from 3-acrylamidophenylboronic acid, and the vinyl monomeris selected from N-isopropyl acrylamide and N-vinyl pyrrolidone. The preparation method disclosed by the invention is simple; the obtained phenylboronic acid hydrogel-based sugar-sensitive microneedlepad is regular in structure, has good mechanical performance, is capable of effectively piercing the skin, has stimulus responsiveness to glucose concentration, and is capable of regulating the release rate and the dosage of insulin according to blood sugar concentrations and effectively preventing a risk of hypoglycemia caused by excessive release of the insulin.

The present invention claims and discloses a pharmaceutical composition suitable for oral administration, in form of an emulsion pre-concentrate, comprising (i) a compound of formula (I); (ii) one or more surfactants; (iii) optionally an oil or semi-solid fat; said composition forming an in-situ oil-in-water emulsion upon contact with aqueous media such as gastrointestinal fluids. The composition may optionally also comprise one or more short-chain alcohols. The pharmaceutical composition is useful in the treatment of pain and inflammation.

The invention discloses an automatic calibration device and calibration method for an online water quality analyzer, comprising a host computer, a first control module A, a second control module B, a third control module C, a circuit control board, a solution mixing pool (1), Mixing tank inlet pipe (2), Y-shaped tee (3), first syringe pump (4), second syringe pump (5), peristaltic pump (6), electromagnetic stirrer (7), detection liquid pipe ( 8), the present invention not only has high liquid dosing precision, but also can automatically calibrate the water quality online analyzer.

A system and method removing air from a reservoir, the system comprising the reservoir that carries a medicament, a first pump connected to the reservoir that draws the medicament out of the reservoir, an air removal device connected to the first pump that releases air from the medicament, and a second pump connected to the air removal device that delivers the medicament.

The present invention relates to the novel vortioxetine salts, solvates and crystalline forms thereof, specifically, vortioxetine hemihydrobromide and a crystalline form thereof, and isopropanol solvate of vortioxetine hydrobromide and a crystalline form thereof. Compared to the known vortioxetine hydrobromide, the vortioxetine salts, solvates and crystalline forms of the present invention have improved features in stability, hygroscopicity and purity. The present invention also relates to preparation methods of the vortioxetine salts, solvates and crystalline forms, pharmaceutical compositions thereof and their uses in the manufacture of antidepressant drugs.

The invention discloses a drug delivery device.The drug delivery device is characterized by comprising a shell (1), an installation sleeve (2), a regulating barrel (3), a regulating rod (4) and a mandrel (5).The tail of the regulating rod is rotated, the regulating rod is in threaded connection with the mandrel, the mandrel only can slide relative to a separation piece, and therefore the regulating rod cannot rotate in the rotating process due to the mandrel but moves axially; one end of the regulating rod is connected with the separation piece in an abutting mode, and therefore the regulating rod only can move towards one side of the regulating barrel; the regulating barrel is in threaded connection with the installation sleeve, and the regulating barrel is driven by a limit ring to rotatably slide along with rotatable sliding of the regulating rod; when the regulating barrel slides to a certain position, the tail of the regulating rod is pushed, so that the mandrel which is in threaded connected with the regulating rod slides towards the near end to push against a plug in a regulating barrel to move a certain distance to deliver a drug from a drug barrel.

A method for filling a container to be filled with a fill product is described. The method includes connecting the container to be filled with a product fill pipe, determining the initial pressure in the container to be filled, filling the container to be filled, and stopping the filling of the container when a predetermined cut-off pressure is reached in the container.

The invention relates to a filling device for filling a container, in particular with a pharmaceutical liquid, comprising a first filling unit (10), which carries out a partial filling of the container and only partially fills the container, a second filling unit (11), which carries out final filling of the container and completely fills the container, at least one scale (3), which weighs the empty container (21), the partially filled container (22) and the completely filled container (23), and a control unit (6), which is connected to the first filling unit (10), the second filling unit (11) and the scale (3) and is designed to control the first and second filling units (10, 11) on the basis of the values of the weighing processes determined by the scale (3).

A method for handling a liquid, in particular for the metered transfer of a liquid that is viscous at room temperature from a reservoir to a receiving container for the purpose of further processing the viscous liquid. In the method the receiving container is filled with the liquid. In this arrangement the liquid is present in a plurality of individual portions. Furthermore, the liquid is cooled such that the individual portions are present in a predominantly solid state of aggregation. Preferably, the individual portions are sufficiently small so that the transferred liquid is a frozen granulate.

The invention concerns a calibration pipette comprising an actuated electronic display (3) and a calibration function. The calibration function is such that at least one real volume obtained with an indicated volume is input via a user interface into the control system and that the control system calculates calibration settings and stores them in a memory, by means of which settings the stroke length of the piston or the volume indicated on the display is corrected so that the volume indicated on the display equals the real dosing volume.

The invention provides a needleless injector. The needleless injector is composed of a dosage medicine tube and a thruster, wherein the thruster is composed of an upper shell component, an adjusting compression component, an unlocking injection component and a lower shell. The rear end of the dosage medicine tube is in threaded connection with the front end of the upper shell component of the thruster, and a piston push rod in the dosage medicine tube is in gapless clamping connection with a spring pull rod of the upper shell component of the thruster; the adjusting compression component is screwed into the upper shell component through rectangular threads; the lower shell is fixed at the tail part of the adjusting compression component through self-tapping screws; and the unlocking injection component is clamped and fixed at the rear end of the lower shell. The needleless injector of the invention has the advantages that: a gapless clamping connection design is adopted for the dosagemedicine tube, so high dosage precision of an injected liquid medicine is ensured; a dosage adjusting function, a pressurizing function and a medicine pumping function are integrated, so the needleless injector is more convenient to use and convenient for taking out; and unlocking and injection are integrally designed, so safety is ensured, and operation is convenient.