Analyzing cartridge and liquid feed control device

一种液体、溶液的技术，应用在分析盒领域，能够解决喷嘴堵塞、污染、结构复杂等问题，达到减少限制、简单内部结构、低廉生产的效果

Inactive Publication Date: 2002-09-18
ASAHI KASEI KK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, problems can arise in the following situations: for example, in the case of liquid overflow, clogging of the nozzle of the automatic pipette and contamination due to insufficient cleaning. In the case of POC analyzes in the medical field Saying this is a great burden
The holes described above are always open outwards, and the delivery of liquids is controlled by applying the pressure loss of the reaction channels connected to the holes and forming the pressure relief openings by rupturable seals, resulting in a very complex structure The problem

Method used

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  • Analyzing cartridge and liquid feed control device
  • Analyzing cartridge and liquid feed control device
  • Analyzing cartridge and liquid feed control device

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0307] (Experimental example 1: Measurement of the backwater pressure of the hydrophobic membrane)

[0308] Backwater pressure is measured for each average pore size of hydrophobic membranes of various materials. For the laboratory setup for the measurements, the setup in which the removable filter holder 810 with the membrane 800 is placed is connected to the tip of a syringe 820 with an internal diameter of 5 mm. The effective diameter of membrane 800 is 3 millimeters. In addition, in the attached Figure 10 Figure (b) in FIG. 1 shows a cross-sectional view of the filter holder 810 and the tip of the syringe 820.

[0309] To measure backwater pressure, the syringe 820 is first placed in the test solution 830, and the measurement is taken by pushing the syringe 820 against the dial 840 while the syringe 820 is held upright with its tip pointing up. The air in the syringe 820 is pushed to the outside through the membrane 800 , by pushing the syringe further to gradually inc...

example 2

[0371] Another example of quantitative analysis of total cholesterol in serum performed using the same cartridge as that in Example 1 will now be described. However, in this example, an air pressure method is applied as a method of transferring liquid.

[0372] As for the analysis box 5, except that electrodes and lead wires are not provided, the same analysis box as that used in the accompanying drawings 11, 12 and 13 (Example 1) is applied, so this example will be described using the accompanying drawings 11, 12 and 13 . In addition, various operations and procedures are also almost the same as those in Example 1, so only analysis procedures that are different from Example 1 will be described below.

[0373] to 3)

[0374] The procedure is the same as that of the example.

[0375] 4) Preparation of reagent solution

[0376] The procedure is the same as that of the example, but the operation of wetting the tank m is not carried out.

[0377] Filtration and measurement of...

example 3

[0384] The method of manufacturing the cartridge 4 as described above and the method of dissolving the reagents in the cartridge 4 are described in detail below.

[0385] Description of planar component 900

[0386] Injection molding using PMMA resin was performed to form the planar member 900 constituting the analysis cartridge 4 . This planar part 900 is 2 mm thick and has the attached figure 1 Model of the slot shown. The width and depth of the grooves a to m are both 50 micrometers. And, it comprises a well with a diameter of 2 mm and a depth of 50 micrometers, which constitutes the measuring conduit A. In addition, it has through holes each having a diameter of 2 mm, which constitute the containers 901 to 912 .

[0387] 2) Squeeze the exhaust film

[0388] Using a ring die with an outer diameter of 4 mm and an inner diameter of 3 mm (1 mm in width), the PTFE porous membrane membrane 940 was extruded to remove the porosity of the extruded part. Squeezing is performed...

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PUM

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Abstract

The analytical cartridge of the present invention has a plurality of containers and connected capillary tubes for communication between the containers. Furthermore, there are reagents for analysis in the analytical cartridge, the container having an opening to the outside of the analytical cartridge, wherein the opening is covered with a vent membrane, each vent membrane being made of gas permeable / liquid Composed of impermeable hydrophobic porous membrane. The analysis box requires only a small amount of samples and reagents, requires no maintenance, and is suitable for POC analysis, etc. In addition, in this analysis cartridge, a non-liquid reagent is provided in a container with a vent, so that a very small amount of reagent solution can be prepared in this analysis cartridge by injecting a reagent solution into the container immediately before analysis. In addition, a liquid delivery control device is connected to the analysis box to allow or regulate the entry / exhaust of gas through the vent, thereby controlling the delivery of liquid through the capillary tube between any containers.

Description

technical field [0001] The present invention relates to an analysis cartridge capable of convenient analysis and detection, which is used in the analysis of micro-sample, and a method of manufacturing the same. The present invention also relates to an analysis method using the analysis cartridge. Furthermore, the present invention relates to a fluid delivery control device connected to an assay cartridge and controlling the delivery of fluid in the assay cartridge. Background technique [0002] Attention has been paid to the importance of performing analysis and measurement on or near a place where analysis and measurement (hereinafter collectively referred to as "POC (Point of Concern) analysis, etc.") are required, such as where medical diagnosis is required to be performed near a patient Point-of-care diagnostic analysis (POC analysis) of required measurements, analysis of hazardous substances in rivers and waste water at sites such as river and waste water treatment pla...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00G01N33/487G01N33/49G01N35/10
CPCB01L3/502715B01L3/502723B01L3/50273B01L3/502738B01L3/523B01L2200/027B01L2200/0621B01L2200/0684B01L2200/148B01L2200/16B01L2300/047B01L2300/0672B01L2300/0816B01L2300/0864B01L2300/0867B01L2300/087B01L2300/0887B01L2400/0415B01L2400/0418B01L2400/0481B01L2400/0487B01L2400/0683B01L2400/0694G01N2035/1044Y10T436/2575G01N35/10
Inventor 北口畅哉木口昌
Owner ASAHI KASEI KK
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