246results about How to "Improve transport" patented technology

The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.

The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.

The present invention provides synthetic 5′UTRs comprising a first polynucleotide fragment and a second polynucleotide fragment, wherein the first polynucleotide fragment comprises at least one splice site of a first eukaryotic gene, the second polynucleotide fragment comprises at least a portion of 5′ untranslated region of a second eukaryotic gene, and the first polynucleotide fragment is located 5′ of the second polynucleotide fragment. In one embodiment, the first polynucleotide fragment comprises the second intron of a sarcoplasmic/endoplasmic reticulum calcium ATPase gene and the second polynucleotide fragment comprises at least a portion of the 5′ untranslated region (5′UTR) of a eukaryotic casein gene. The synthetic 5′UTRs are useful for increasing the expression of a transgene when positioned between a promoter and a transgene within an expression vector. The present invention also provides vectors comprising synthetic 5′UTRs and methods for increasing the expression of a transgene using synthetic 5′UTRs.

This invention features permeability enhancer molecules, and methods, to increase membrane permeability of various molecules, such as nucleic acids, polynucleotides, oligonucleotides, enzymatic nucleic acid molecules, antisense nucleic acid molecules, 2-5A antisense chimeras, triplex forming oligonucleotides, decoy RNAs, dsRNAs, siRNAs, aptamers, or antisense nucleic acids containing nucleic acid cleaving chemical groups, peptides, polypeptides, proteins, carbohydrates, steroids, metals and small molecules, thereby facilitating cellular uptake of such molecules.

Provided is a conducting polymer composition including a conducting polymer and an ionic conjugated polymer. The conducting polymer composition includes the ionic conjugated polymer having a conjugated structure, in addition to the conducting polymer, and thus, can enhance hole injection and transport capability. Furthermore, ionization potential and work function can be easily adjusted by chemically tuning the backbone of the ionic conjugated polymer. In addition, the conducting polymer composition can be dissolved in water, alcohol, or a polar organic solvent, thereby enabling a solution process and rendering spin-coating easier.

A draper header for a combine harvester includes two side drapers each running from an outer end guide roller at a first end of the header to an inner end guide roller adjacent the discharge location of the header and a central feed draper located at the discharge location and including a front guide roller just behind the cutter bar and running to a rear guide roller in front of the feeder house of the combine harvester. Each inner end guide roller is associated with a respective discharge roller immediately adjacent and parallel to it with a stripper blade in contact with the peripheral surface of the discharge roller so as to strip the crop from the peripheral surface along the full length of the roller. Each stripper blade is inclined downwardly and inwardly to a bottom edge closely adjacent the upper run of the feed draper. The stripper roller or in another arrangement the draper itself has rows of projections across the surface which pass through corresponding shaped recesses in the edge of the stripper blade so that the crop material is discharged onto the blade while the projections are shaped to prevent the crop from being driven into the recesses. An auger is located between the discharge rollers with a front edge of the flight forward of the rear end of the discharge rollers to feed the material inwardly and underneath the auger to the inlet of the feeder house.

An integrated process for production and upgrading of heavy and extra-heavy crude oil, comprising (a) reforming of hydrocarbons such as natural gas to produce hydrogen, CO2 and steam (b) separating the produced hydrogen from the CO2, steam and any other gases to give a hydrogen rich fraction and a CO2 rich fraction and steam, (c) injecting the steam alone or in combination with the CO2 rich fraction into a reservoir containing heavy or extra heavy oil to increase the oil recovery, and (d) upgrading/refining of the heavy or extra heavy oil to finished products by extensive hydroprocessing, comprising several steps of hydrocracking and hydrotreating (sulfur, nitrogen and metals removal as well as hydrogenation of olefins and aromatics), using the hydrogen rich fraction.

Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering compounds of the general formula:

wherein the variables are defined in the specification.

Disclosed are compositions for collecting, storing, and transporting populations of nucleic acids from biological specimens, and clinical, forensic, or environmental samples. Also disclosed are methods for using these compositions as one-step formulations for killing pathogens, inactivating nucleases, and releasing polynucleotides from other cellular components within the sample, and stabilizing the nucleic acids prior to further processing or assay. In particular embodiments, the invention provides a single, one-step, sample collection/transport/storage formulation containing a known quantity of a non-genomic, nucleic acid carrier molecule that serves as an internal reference control to monitor the fidelity of the collection/transportation medium, and measure the integrity of nucleic acids subsequently isolated and purified from the processed sample.

The position of intra-osseous implants and abutments to analogs is enabled and enhanced by using the longitudinal axial locked position of a post (12a) of an implant (12) having a locking taper in a bore (10a) of an implant (10) having a generally matching locking taper as a reference to determine the position of a stop surface (14c) on impression posts, abutment analog posts and the like received in the bore of an implant and implant analog. In another embodiment the bore (16) of an implant analog (16) is provided with a shelf (16c) located at a position determined by the axial distance of the locked position of the abutment post to prevent over-seating. Controlled retentive resistance and stability of a post is provided by using flats formed in the bore of an implant analog and by forming rings on a post receivable in the bore of an implant or implant analog. One such ring (18c) is formed with an outer periphery sized and configured to allow bending of the outer peripheral portion in a direction opposite to the direction of insertion in a bore to provide greater retentive resistance than insertion resistance.

Cosmetics comprising at least one isoflavone aglycone, particularly genistein and/or daidzein, in a biologically active form as active component which is incorporated into liposomes are effective in the treatment of cellulitis, in the treatment of female or male skin after the climacteric, particularly of female skin after the menopause, for increasing the size and firmness of female breasts, and for whitening the skin. Preferably, said isoflavone aglycones incorporated into liposomes are combined with algal extract.

The present invention provides a passive inhaler for use in treating a number of diseases. The inventor has shown that the compositions comprised in the inhaler can be delivered to the lungs and to the brain in pharmacological relevant dosages, to treat a number of diseases in the lungs and the brain. Further, the inhaler is also able to deliver substances to the brain which may enhance transport across the blood brain barrier.

A method and device are described for applying a microprotrusion member (44) including a plurality of microprotrusions (90) to the stratum corneum with impact. The method and device are used to improve transport of an agent across the skin for agent delivery or sampling. The applicator (10, 60, 80) causes the microprotrusion member (44) to impact the stratum corneum with a certain amount of impact determined to effectively pierce the skin with the microprotrusions (90). The preferred applicator (10, 60, 80) impacts the stratum corneum with the microprotrusion member (44) with an impact of at least 0.05 joules per cm² of the microprotrusion member (44) in 10 msec or less.

Disclosed are methods and systems for improved information transfer across networks, including network protocols with invariant structure, topological addressing, and recursive network structures.

Mixed-phase TiO₂ nanofibers prepared via a sol-gel technique followed by electrospinning and calcination are provided as photocatalysts. The calcination temperature is adjusted to control the rutile phase fraction in TiO₂ nanofibers relative to the anatase phase. Post-calcined TiO₂ nanofibers composed of 38 wt % rutile and 62 wt % anatase exhibited the highest initial rate constant of UV photocatalysis. This can be attributed to the combined influences of the fibers' specific surface areas and their phase compositions.

A vessel storing or transporting a low temperature fluid includes an insulating material disposed between an inner tank and an outer shell. The insulating material is volumetrically compressed so that it exerts a reaction force that is equal to or exceeds an ambient pressure at the outer shell and/or supports at least some of the weight of the inner tank. Manufacturing processes and methods of using the vessel also are described.

The present invention relates to the field of electrotherapy and measuring by means of electric currents for diagnostic purposes, and more particularly to an electrode arrangement for facilitating wound healing, a method for measuring wound healing and a wound dressing having an electrode arrangement. A wound dressing according to the present invention comprises at least two impedance reference electrodes, a frame like counter-electrode and stimulation electrodes in a form of an array; and a bioadhesive affinity layer surrounding the stimulation electrodes; said wound dressing being suited for applying on top of the wound so that the stimulation electrode array is on the wound area, and that the at least two impedance reference electrodes and the frame like counter-electrode are suited for placing in contact with the healthy skin surrounding the wound area; which electrodes, are suited for applying LIDC type electrical stimulation current to the wound area and for bioimpedance measurement. The wound dressing according to the present invention provide a continuous, non-invasive and objective solution for monitoring chronic wound healing without disturbing the delicate healing process.

Electrodes in an organic thin film transistor based on single component organic semiconductors may be chemically modified to realize ambipolar transport. Electronic circuits may be assembled which include at least two such organic thin film transistors wherein at least one transistor is configured as a pmos transistor and at least on other transistor is configured as a nmos transistor.

There is provided a method for improving the efficacy and/or transdermal transport of topically administered pharmaceuticals and pharmacologically active compounds, said method comprising the step of incorporating the pharmaceutical or pharmacologically active compound in a carrier comprising an effective amount of one or more complexes of a phosphate derivative of a lipophilic pharmaceutically acceptable compound.

The present invention generally relates to electrochemical devices, such as electrochromic (EC) devices and thin film batteries (TFB), and in particular to anodes of electrochemical devices with improved intercalation and/or transport properties. Some embodiments of the invention include anodes, such as nickel oxide, doped with Si, Sn, SiO₂ and/or SnO₂, which may be in the form of nanoparticles or even substituted atoms/molecules. These nanoparticles/substituted atoms, which have higher lithium intercalation capability, distort the lattice of the anode, improving movement and intercalation of Li ions. In some other embodiments, the anode may be formed of silicon oxide and/or tin oxide, which materials have good transport and intercalation of Li ions.

A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. Cleavage of X allows separation of A from B, unmasking the normal ability of the basic amino acids in B to drag cargo C into cells near the cleavage event. X is cleaved extracellularly, preferably under physiological conditions. D-amino acids are preferred for the A and B portions, to minimize immunogenicity and nonspecific cleavage by background peptidases or proteases.

A microchannel contactor and methods of contacting substances in microchannel apparatus are described. Some preferred embodiments are combined with microchannel heat exchange.

The present invention relates to novel hepatitis C virus (“HCV”) protease inhibitors or other flavivirus protease inhibitors having the general structure (I) or (II), pharmaceutical compositions containing one or more such inhibitors, methods for preparing such inhibitors, uses of these compounds to treat hepatitis C and related disorders together with their use for their activity towards NS3 serine protease, intermediary compounds for the method of preparation of said compounds and screening methods. The invention specifically discloses novel chemical compounds as inhibitors of the HCV serine protease.

An organic photovoltaic cell structure and a method for fabricating the organic photovoltaic cell structure are each predicated upon an organic photovoltaic material layer located and formed interposed between an anode and a cathode. The organic photovoltaic cell structure and the method for fabricating the organic photovoltaic cell structure also include for the anode a nickel and indium doped tin oxide material layer (Ni-ITO) that has a nickel doping sufficient to provide a work function of the nickel and indium doped tin oxide material layer (Ni-ITO) anode preferably no more positive than about −5.0 eV. Such a composition of the nickel and indium doped tin oxide material layer (Ni-ITO) anode provides for a superior bandgap matching to a B3HT p-type donor component within a B3HT:BPCM BHJ organic photovoltaic material layer while also providing a greater bandgap separation of an aluminum material layer (Al) cathode to provide for enhanced electric field and charge carrier transport and collection capabilities of an organic photovoltaic cell device that derives from the organic photovoltaic cell structure.