190results about How to "Effective carry" patented technology

The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.

The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.

Methods and systems for providing necessary and sufficient quality-of-service (QoS), in a packet-based core transport network that utilizes dynamic setting of bandwidth management pipes or thresholds to obviate link congestion are disclosed. Congestion avoidance is a necessary and sufficient requirement in order to guarantee Quality of Service (QoS) in packet-based core networks.

A typical network is composed of a plurality of backbone links connecting edge nodes where backhaul links are aggregated. The backhaul links connect the backbone links to the remote sites serving the subscribers. In order to enforce bandwidth management policies, Access Controllers, which perform traffic shaping, are situated on each remote site.

In the event of a violation of certain link threshold settings, dynamic adjustment of the bandwidth management policies on affected Access Controllers is enforced. Various algorithms in determining the correlation between the link nearing congestion and the source or destination of traffic streams are also discussed. This invention implements a feedback control loop wherein probes at various points in the network checks for congestion states to guide bandwidth management threshold decisions in order to maintain the condition of non-congestion throughout the network. Capacity planning and congestion avoidance mechanisms work hand-in-hand to fulfill Service Level Agreements (SLA).

Examples of local communication systems are disclosed, based on a ring of point-to-point links, providing for transport of fixed rate synchronous, fixed rate asynchronous data and variable rate data in a flexible format. Different segments of the ring network can carry data at different bit rates, while remaining synchronized to a common frame rate and having a common control channel structure, for compatibility with earlier systems. Parallel channels are provided, either permanently or when required, for signalling errors of source data, data validity/padding, flow control. Parallel variable width channels are defined with free content (stream or packet). Null data symbols are defined for padding on a byte-by-byte basis. The allocation of capacity among variable width channels is revised block by block, and a transition period is defined to allow for ring latency. Calculations for allocation of capacity are performed during one block for the next block, locally at each source station, according to predetermined rules. Information as to bandwidth requirements is exchanged prior to the calculation via a special connection signalling channel and message format.

Integrally stiffened and formed, load carrying structures comprising a plurality of elongated thin-walled tubes placed co-extensively in a complementary side-by-side fashion which together form a hollow structure having a desired external contour. Integral skins forming the external and internal surfaces of the structure cooperatively therewith. The structure can be formed with an underlying internal support member spanning the interior of the load carrying structure, thereby connecting opposite sides of the structure together. Also, each of the tubes are wound with fibers in controlled orientations generally paralleling the direction of the loads applied to the tubes to optimize the strength to weight ratio of the tubes.

The present invention relates to a composition for the delivery of active agents that are protected from environmental oxidation and are resistant to ruminal fermentation degradation but not intestinal digestion and adsorption. The composition may contain biologically active ingredients such as for example, vitamins, minerals, proteins, amino acids, fatty acids, nutritional supplements, and pharmaceuticals together with natural and/or synthetic lecithin phospholipids.

An aircraft light assembly comprises a light apparatus configured to be supported in a space on the body of an aircraft. The apparatus has one or more light emitting diodes (13) generating visible light and an outer structure overlying the LEDs. The outer structure includes a light transmission portion through which visible light from the LEDs can pass, and a metallic portion with an outer surface exposed to the external airflow. A heat-transmitting connection thermally links the LEDs to the metallic portion so that heat from the LEDs flows to the outer surface and is dissipated to the external airflow. The light assembly is configured to be secured in a conventional socket for an incandescent navigation light bulb and to receive the electrical current supplied thereto by the aircraft electrical system. Civilian applications of the unit have only visible LEDs. When the unit is for a military aircraft, it has electric circuitry connected with a visible light source and an IR light source, and the electric circuitry is configured to process the input current from the socket and based thereon operate in either a visible mode or covert IR mode. Where the current is in one electrical state, such as for example a certain voltage, the electric circuit sends power only to the visible light source. When the current is in a different electrical state, e.g., a different voltage level, the circuitry sends power only to the IR source, and no visible light is emitted. Different input current voltages or characteristics are also used to cause the IR emitter to flash in various patterns that can be programmed into the unit. All control may be accomplished over a single pair of wires, as in existing systems that do not have IR mode capability. To upgrade existing aircraft, light source units a shaped to fit in the apertures for existing lenses over incandescent navigational fixtures.

A transparent routing device disposed within an access network configured in accordance with one or more lower-layer protocols is disclosed herein. The device includes a set of subscriber-side ports. Each of the subscriber-side ports is associated with a plurality of virtual subscriber-side interfaces disposed to effectively terminate a corresponding plurality of subscriber-side connections with subscriber host devices served by the access network. The device further includes at least one network-side port through which communication occurs with an external network in accordance with a higher-layer protocol. A routing table is configured to establish a correspondence between network addresses of the subscriber host devices and the plurality of virtual subscriber-side interfaces. During operation of the device, packets received through the at least one network-side port are forwarded to corresponding ones of the virtual subscriber-side interfaces based upon network addresses of the packets.

An electromechanical linear actuator assembly having in-line axial load support of its screw drive shaft is provided. The bearing support structure provides a single in-line ball bearing accommodated within a hardened end fitting and a screw pivot recess in the axial screw drive shaft. For axial loading in an opposite direction, a number of smaller ball bearings are provided around the outer periphery of the screw shaft in a groove, and are retained within the hardened end fitting by a bearing retainer. End rod support bearings providing heat compensation and lubrication fluid transfer are also provided. A braking mechanism having increased life and more consistent load engagement is also provided. Further, integrated electronics may be provided for position sensing and power efficiency control.

A transparent routing device disposed within an access network configured in accordance with one or more lower-layer protocols is disclosed herein. The device includes a set of subscriber-side ports. Each of the subscriber-side ports is associated with a plurality of virtual subscriber-side interfaces disposed to effectively terminate a corresponding plurality of subscriber-side connections with subscriber host devices served by the access network. The device further includes at least one network-side port through which communication occurs with an external network in accordance with a higher-layer protocol. A routing table is configured to establish a correspondence between network addresses of the subscriber host devices and the plurality of virtual subscriber-side interfaces. During operation of the device, packets received through the at least one network-side port are forwarded to corresponding ones of the virtual subscriber-side interfaces based upon network addresses of the packets.

An oil separator usable with a welder and air compressor combination unit. The oil separator includes a cylindrical housing having an inlet that receives the stream of compressed air containing oil from the air compressor. Within the oil separator, there is a deflector baffle that redirects the flow of the oil to a swirling, downwardly directed path along the inner surface of the cylindrical housing where the air is separated out therefrom and passes upwardly to exit through a fluid outlet formed in the cover of the separator. The swirling oil flows downwardly through an annular slot formed between a circular plate and the inner surface of the cylindrical housing into a lower chamber where the oil is channeled by radially directed baffles into radial channels to redirect that oil toward an oil outlet at the center of the circular bottom where that oil exits to be re-circulated in the combination unit or for disposal.

A suspension system for carrying a compressed gas fuels in vehicle. The suspensions arms and springs are configured to maximize the space between the wheels while providing a high degree of suspension stiffness to maintain proper wheel alignment during cornering, braking and in rough terrain. The suspension arms have two broadly-spaced attachment points to the chassis that provides structural rigidity to the rear suspension subassembly.

A navigation apparatus is obtained that can reduce as much as possible to blank interval during the navigation even when a route deviation has occurred. In order to structure a navigation apparatus that includes a guided vehicle position determining means 3c that finds the position of a guided vehicle and a recommended route searching means 3i that searches for a recommended route to a destination point, a problem condition identifying means 3f is provided that identifies the presence or absence of a problem condition that makes the travel along the recommended route Ro difficult when viewed in terms of the current condition of the guided vehicle with respect to the recommended route Ro forward travel side of the position of the guided vehicle, and a route deviation plan means 3h is provided that sets a point that the guided vehicle is anticipated to reach under the presence of the problem condition to the starting point, activates the recommended route searching means 3i, and searches for a new recommended route Rn from the starting point to a destination point in the case in which the problem condition identifying means 3f has identified that a problem condition is present.

The invention provides a double disc gate valve where the discs are movable in a casing by a disc manipulation structure which can change an orientation of at least one of the valve discs relative to the centre plane away from an initial orientation by movement of an outer disc carrier relative to an inner disc carrier. The relative movement between the disc carriers is initiated automatically during opening and closing of the valve. The change in orientation facilitates sealing between the discs and valve seats by a gradually established contact between the discs and the seats and the required opening and closing force may therefore be reduced.

The vertical data center module is a multistory compact footprint data center unit that exploits vertical air movements, both downward and upward, to efficiently sustain conventional low-cost air-cooled computing systems. It integrates a hybrid cooling system that can benefit from an air-side economizer without compromising its compact footprint. For polluted urban environments, this air-side economizer comprises an air-to-air heat exchanger to effectively limit the amount of outside air that can enter the module and come into contact with sensitive computing systems. Through side-to-side, side-to-back or back-to-back juxtaposition, multiple units can be assembled in clusters on a colocation site to create large-scale vertical data center complexes, effectively maximizing real estate use and cost effectiveness by fully exploiting all three dimensions.

Shrink-wrap packaging is provided with at least one reinforced integral handle. Each handle is formed by an opening formed in the shrink-wrap material, and a reinforced area that surrounds the opening. Preferably two handles are located at opposite ends or sides of the package. The reinforced areas include an additional layer of the shrink-wrap film, or may include other material such as other types of thermoplastics, paper/fiber composites, or combinations thereof. Shading may be applied to the reinforced areas in order that a consumer can more easily recognize the openings in the shrink-wrap as designated handles. Other embodiments include handles formed by use of a paperbound element in combination with openings in the shrink-wrap material, and webbing secured to a plurality of the containers along with a handle loop integral with the webbing that is orientated to extend through the opening in the shrink wrap material.

An automated rule-based system for facilitating delivery of a fax document from a source to a destination over a network where an initial delivery attempt has been unsuccessful. Actions to be taken are based upon a time-variable set of input conditions which may be determined from one or more of the destination, the source, a database of past delivery attempts, and a human analyst. The actions may include one or more of resubmitting the fax document to the network for a next delivery attempt, canceling the document, sending a request to the source or destination for additional delivery information, and identifying the destination as a technical problem. The input conditions may include an identification of non-business days and non-business hours.

A utility table and storage apparatus for use in vehicles such as pickup trucks having a truck bed includes three main parts: a main frame, a rail system, and a tool storage system. The main frame is made up of a frame assembly with four collapsible legs. The legs have wheels, and are adjustable in height. The main frame forms the support structure for the work table, the top of which is preferably covered by a 4 ft. by 8 ft. piece of metal, plywood, or other suitable material. When the main frame/table portion is outside the truck bed, it rests on the four legs with the wheels attached, allowing it to be moved around. The rail system consists of three components, the anchor frame, the guide frame, and the transfer frame. The anchor frame is bolted down to the bed of the truck. The guide frame guides the transfer frame during movements of the main frame, and is temporarily bolted to the anchor frame, but can be removed if needed to allow the full use of the truck bed. Bearings such as V-groove cam followers or other sliding mechanisms between the transfer frame and the main frame enable the back and forth motion and pull-out of the table. The tool storage system consists of toolboxes and storage compartments arranged in an orderly manner on the main frame/table.

A feed additive composition includes a protective agent, lecithin in an amount of 0.05 to 6% by weight relative to a total weight of the composition, a basic amino acid in an amount of at least 40% by weight and less than 65% by weight relative to the total weight of the composition, and water. A method of producing a feed additive composition includes preparing a molten mixture of at least one protective agent, lecithin and at least one basic amino acid, and solidifying the molten mixture by immersing the molten mixture in water or an aqueous liquid. The protective agent includes hydrogenated vegetable oils and/or hydrogenated animal oils having melting points of greater than 50° C. and less than 90° C.