Patents
Literature
Patsnap Eureka AI that helps you search prior art, draft patents, and assess FTO risks, powered by patent and scientific literature data.

69 results about "Intestinal digestion" patented technology

Intestinal Phase of Digestion. The bulk of carbohydrate and fat digestion, as well as the remainder of protein digestion, occurs in the intestinal phase. Your pancreas releases a buffer into your small intestine to reduce the acidity of the food coming from your stomach.

South sea decapterus kurroides uric acid-lowering and antioxidant polypeptide and application thereof

PendingCN122647556ADPPHXanthine
The application discloses a South China Sea Decapterus maruadsi polypeptide with uric acid reducing and antioxidant activities and an application thereof, and relates to the technical field of biology. The polypeptide with high uric acid reducing activity and antioxidant activity is screened through activity prediction and molecular docking, and the amino acid sequence is FYDWWK. The polypeptide can be stably combined with the active center of xanthine oxidase, forms multiple hydrogen bonds and hydrophobic interaction, significantly inhibits the generation of uric acid, and has an in-vitro xanthine oxidase inhibition IC 50 of 3.068±0.2547 mmol / L. Meanwhile, the polypeptide has excellent DPPH free radical scavenging capacity, and an IC 50 of 5.033±0.5476 mmol / L. The polypeptide has good stability, still has high efficient inhibitory activity after simulated gastrointestinal digestion, and has oral development potential. The polypeptide is a natural marine small molecule active peptide, is safe and easy to absorb, and can be applied to the preparation of products related to uric acid reducing and / or antioxidant.
Owner:SOUTH CHINA SEA FISHERIES RES INST CHINESE ACAD OF FISHERY SCI

Ultrasound Digestive Endoscope

1. The name of the design product: ultrasonic digestive endoscope. 2. The use of the design product: for gastrointestinal digestive examination diagnosis and treatment. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.
Owner:CHANGZHOU UNITED IMAGING HEALTHCARE SURGICAL TECH CO LTD

Packaging product of micronutrient supplement for promoting digestive function of intestinal tract of body

The present invention provides a package of a micronutrient supplement for promoting the digestive function of the intestinal tract of a body, the micronutrient supplement consisting of two types of unit dosage forms in one package for sale to a purchaser wherein the first type of unit dosage form contains VB6 and a compound thereof, and the second type of unit dosage form contains VB6 and a compound thereof. The first type of unit dosage form contains Zn and compounds thereof, the second type of unit dosage form contains Zn and compounds thereof or VD and compounds thereof, and the first type of unit dosage form does not contain Zn and VD, and the second type of unit dosage form does not contain VB6, the micronutrient supplement being provided in a manner of administration twice a day, the first type of unit dosage form is taken in an awakening period, and the second type of unit dosage form is taken in a sleep period. The packaging product can be matched with the biological clock rhythm of an organism, the absorption and utilization rate of micronutrients is increased, and then the intestinal digestion function is improved.
Owner:JIMEI UNIV

Preparation method of high-immunocompetence low-sensitization hydrolyzed whey protein digestion product

The invention belongs to the technical field of whey protein processing, and particularly relates to a preparation method of a hydrolyzed whey protein digestion product with high immunocompetence and low sensitization. The preparation method comprises the following steps: by taking hydrolyzed whey protein as a raw material, carrying out simulated gastrointestinal digestion treatment under specific conditions to obtain a whey protein digestion product; the product can effectively exert immunoregulation and anti-inflammatory effects, solves the problem of sensitization of a traditional whey protein product, and has a good application prospect.
Owner:GUOZHEN HEALTH TECH (BEIJING) CO LTD

Preparation method of whey protein / pullulan / sugar astaxanthin nano dispersion

The invention discloses a preparation method of a whey protein / pullulan / sugar astaxanthin nano-dispersion, WPC / PUL compounds are adopted to construct different carriers to embed AST, the carriers are respectively a nano-dispersion loaded with AST, emulsion gel and microcapsule powder, the three carriers have good embedding efficiency and protection effect on AST, the simulated gastrointestinal digestion stability of AST is remarkably improved, and the stability of AST is improved. And the method has great significance in expanding the preparation of an AST embedding delivery system and the application of AST in industries such as food and the like.
Owner:JILIN AGRICULTURAL UNIV

Composition containing black pepper extract and capable of promoting intestinal digestion and absorption and cat food

The invention discloses a black pepper extract-containing composition capable of promoting intestinal digestion and absorption and a cat food, and relates to the technical field of animal foods.The composition is prepared by compounding fish oil, krill oil, sunflower seed oil and linseed oil according to a specific proportion based on compound functional grease and natural plant extracts in a scientific proportion; according to the invention, the ratio of omega6 fatty acid to omega3 fatty acid is optimized to an ideal range of (2.5-3.2): 1, black pepper extract with functions of promoting digestion and regulating flora is synergistically added, and through combination of scientifically proportioned functional components and an advanced process, an'intestinal tract-microorganism-metabolism 'experiment verifies that digestion and absorption of cat nutrition are realized, and the effect of promoting digestion and regulating flora is achieved. Meanwhile, the multi-dimensional and systematic improvement of oxidation resistance, inflammation resistance, immunity improvement and metabolism functions is achieved.
Owner:ANFU CHAOWEI DAILY CHEM CO LTD

Preparation method and application of astaxanthin emulsion gel

The invention belongs to the technical field of food processing, and relates to a preparation method and application of astaxanthin emulsion gel. The invention provides a preparation method of astaxanthin emulsion gel, which comprises the following steps: taking an ovalbumin and beet pectin compound solution obtained through electrostatic interaction under a specific pH value as a water phase, taking medium-chain fatty acid containing astaxanthin as an oil phase, and mixing the oil phase with the ovalbumin and beet pectin compound solution to obtain the astaxanthin emulsion gel. The preparation method comprises the following steps: carrying out homogenization treatment on a blend of a water phase and an oil phase by using a high-speed dispersion machine to obtain a primary emulsion, carrying out ultrasonic treatment on the primary emulsion to obtain an emulsion, adding calcium ions into the emulsion, uniformly mixing, and carrying out crosslinking and phase change on the emulsion to obtain the astaxanthin emulsion gel. According to the astaxanthin emulsion gel disclosed by the invention, the storage stability of the astaxanthin can be remarkably improved, so that more astaxanthin is migrated to a water phase in an intestinal digestion process, the bioavailability of the astaxanthin is improved, and the antioxidant activity in vivo is remarkably improved compared with that of free astaxanthin.
Owner:GUANGDONG OCEAN UNIVERSITY

Gastrointestinal ultrasound contrast agent without scattering echoes as well as preparation method and application of gastrointestinal ultrasound contrast agent

The invention discloses a gastrointestinal ultrasound contrast agent without scattering echoes as well as a preparation method and application thereof, and relates to the technical field of biomedical ultrasound. The gastrointestinal ultrasound contrast agent comprises a thickening agent, a sound velocity regulator and water, the thickening agent comprises an edible gum thickening agent, and the edible gum thickening agent is selected from one or more of xanthan gum, guar gum, konjac gum, gellan gum, sodium carboxymethyl cellulose, Arabic gum, modified starch and natural starch; the sound velocity regulator is selected from one or more of skim milk powder, polyethylene glycol and mannitol. The gastrointestinal ultrasound contrast agent disclosed by the invention has the characteristics of no scattering echo and relatively low sound attenuation, and is suitable for clinical requirements of ultrasound examination and screening of gastrointestinal digestive tracts. For focuses, with high echoes, of all layers of the stomach wall or gaps of the stomach wall in the stomach wall, the gastrointestinal ultrasound contrast agent without scattering echoes has a very good contrast imaging effect.
Owner:SECOND MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL +1

A method for evaluating the bioavailability of soybean oil based on an in vitro digestion / cell co-culture model

ActiveCN116121328BMicrobiological testing/measurementMaterial analysisGastric digestionIn vitro digestion
This invention discloses a method for evaluating the bioavailability of soybean oil based on an in vitro digestion / cell co-culture model. Soybean oil is emulsified using WPI emulsifier and then digested sequentially through simulated gastric and intestinal fluids to obtain the gastric digestion products of soybean oil. Fatty acids are extracted from the intestinal digestion products of soybean oil, dissolved in dimethyl sulfoxide, and linked to fatty acid-free bovine serum albumin to obtain in vitro digestion products of soybean oil that can be absorbed by the intestines. These are then added to a cell co-culture model for cell incubation and transport. HepG2 cells from the cell co-culture model are collected, and Oil Red O staining and total triglyceride content are measured to obtain lipid deposition, thereby evaluating the bioavailability of soybean oil. The in vitro digestion / cell co-culture model of this invention is specifically designed for soybean oil digestion. This method objectively and scientifically evaluates the bioavailability of soybean oil at different metabolic stages, providing a standard basis for the scientific and healthy consumption of soybean oil and possessing significant practical value.
Owner:JIANGSU UNIV

Antibacterial peptide for inhibiting food-borne pathogens as well as acquisition method and application of antibacterial peptide

The invention provides an antibacterial peptide for inhibiting food-borne pathogens as well as an acquisition method and application of the antibacterial peptide, and relates to the technical field of bioactive peptides and biomedical engineering. The amino acid sequence of the antibacterial peptide is as follows: Gly-Leu-Thr-Leu-Lys-His-Leu-Lys-Lys-Leu-Phe, and the antibacterial peptide can be used for effectively inhibiting the growth of food-borne pathogens such as staphylococcus aureus, salmonella, escherichia coli, pseudomonas aeruginosa, listeria monocytogenes and the like. The defects in the prior art are overcome, the antibacterial peptide with antibacterial activity is found and identified through a screening method combining a gastrointestinal digestive enzyme-peptide omics technology and an experiment, and a new natural antibacterial agent is provided for food, medicine and other related fields.
Owner:BEE RES INST CHINESE ACAD OF AGRI SCI

A slowly digestible quinoa flour-concentrated milk protein composite gel food and a preparation method thereof

This invention discloses a slow-digesting quinoa flour-concentrated milk protein composite gel food and its preparation method, belonging to the field of food processing technology. The invention first protects the composition as a gel food prepared from raw materials containing concentrated milk protein and quinoa flour; the preparation includes premixing quinoa flour and a portion of concentrated milk protein, hydrating them to obtain a premix with a starch-protein network, adding the remaining raw materials, stirring to form a slurry, and then shaping it. The gel food of this invention constructs a dense and continuous starch-protein network. This network, on the one hand, acts as a physical barrier to prevent effective contact between gastrointestinal digestive enzymes and internal proteins, maintaining the stability of the protein's secondary structure, thereby slowing down the rate of protein digestion and hydrolysis in the gastrointestinal tract to achieve slow digestion; on the other hand, it directly improves the product's hardness, chewiness, and other textural parameters, enhances water-holding capacity, reduces water separation rate, optimizes color and flavor, and achieves a synergistic improvement in multiple indicators of edible quality.
Owner:PEKING UNIV INST OF ADVANCED AGRI SCI +1

Saccharomyces cerevisiae SY and application of saccharomyces cerevisiae SY in preparation of codonopsis pilosula leavening with high in-vivo and in-vitro bioavailability and capable of improving gastrointestinal motility

The invention belongs to the technical field of microbial fermentation, and particularly relates to saccharomycetes SY and application thereof in preparation of a codonopsis pilosula fermentation product which is high in in-vivo and in-vitro bioavailability and capable of improving gastrointestinal motility. The codonopsis pilosula fermented product is prepared by fermenting codonopsis pilosula with saccharomycetes SY. The content of lobetyolin in the pilose asiabell root leavening prepared by fermenting pilose asiabell root through the saccharomycetes SY is high, in-vitro digestion experiments prove that the removal rate of lobetyolin, total flavonoids and superoxide anion free radicals and the bioaccessibility of the total reducing capacity are remarkably improved, and rat experiments find that the pilose asiabell root leavening can promote gastrointestinal motility and improve the bioavailability of the pilose asiabell root. Intestinal mucosa regeneration and barrier repair are promoted; the content of effective components such as luteolin 7-glucosid-3 '-xyloside capable of enhancing immune cell activity, regulating inflammatory factor balance, protecting cells from oxidative stress injury and improving gastrointestinal digestion and absorption functions and energy metabolism in serum is increased, and absorption of the effective components in blood is promoted.
Owner:江苏菌钥生命科技发展有限公司 +2

Probiotic fermented traditional Chinese medicine preparation and preparation method thereof

The invention relates to the technical field of traditional Chinese medicine preparations, and particularly discloses a preparation method of a probiotic fermented traditional Chinese medicine preparation, which comprises the following steps: carrying out aerobic fermentation on part of traditional Chinese medicine raw materials to obtain aerobic fermentation liquor and aerobic fermentation residues; performing anaerobic fermentation on the other part of the traditional Chinese medicine raw materials to obtain anaerobic fermentation liquid and anaerobic fermentation residues; mixing the aerobic and anaerobic fermentation residues and carrying out solid-state fermentation to prepare functional mycoplasm; and mixing the aerobic and anaerobic fermentation broth with the functional mycoplasm to obtain the microbial inoculum. According to the preparation method, a segmented fermentation process is combined with a fermentation inducer compounded by tea polyphenol and yeast extract, so that the problems of poor taste and low utilization rate of active ingredients of a traditional Chinese medicine preparation are effectively solved. The probiotic fermented traditional Chinese medicine preparation prepared by the preparation method disclosed by the invention is mellow in taste, palatable in sourness and sweetness and high in utilization rate of active ingredients, has the effects of strengthening the spleen and stomach and promoting digestion and removing food stagnation, and can be used for remarkably improving the gastrointestinal function, effectively reducing gastric emptying hysteresis and improving the small intestine propulsion capability and the overall gastrointestinal digestion capability.
Owner:SHAANXI WUDING BIOTECHNOLOGY CO LTD

A method for preparing highly immunologically active ovotransferrin hydrolysate based on an adult gastrointestinal simulated digestive system

This invention belongs to the field of food nutrition and functional factors, specifically relating to a method for preparing highly immunomodulatory ovotransferrin (OVT) hydrolysates based on an adult gastrointestinal simulated digestive system. The method involves processing OVT using a simulated adult gastrointestinal tract to prepare OVT hydrolysates containing HTEGSTT, TTSY, and / or RTAGWVIPMG. This invention reveals that OVT exhibits enhanced immunomodulatory activity after gastrointestinal digestion and hydrolysis, and is more readily hydrolyzed in simulated adult digestive fluids than in infant digestive fluids. Comparative experiments show that nutritional intervention with OVT simulated digestive products from adults and infants can promote the production of short-chain fatty acids such as acetic acid, propionic acid, and butyric acid, effectively alleviate swelling and damage to the small intestinal mucosa caused by inflammation, significantly improve intestinal barrier immune function, and OVT IA exhibits higher intestinal immune activity than OVT IB.
Owner:WUHAN MILAI BIOTECHNOLOGY CO LTD +2

Method for simulating taste characteristics of novel umami peptide in gastrointestinal digestion in Xuanwei ham

The invention relates to the technical field of food science and biology, and particularly discloses a method for measuring taste characteristics of novel umami peptide in simulated gastrointestinal digestion of Xuanwei ham. The method comprises the following steps: sequentially carrying out in-vitro simulated digestion on an oral phase, a stomach phase and an intestinal phase on Xuanwei ham homogenate to obtain a digestion product, carrying out centrifugation, filtration and freeze-drying treatment, and carrying out gel filtration chromatography separation to obtain main elution peaks, preferably selecting components with the strongest umami activity. Peptide fragment sequences are identified by using nano-liter liquid chromatography-mass spectrometry, candidate peptide fragments are screened by combining molecular weight, amino acid residue composition and toxicity prediction, and a variety of machine learning models are further adopted to predict umami potential. And performing chemical synthesis on the optimized peptide, determining a threshold value by a taste dilution method, and completing sensory evaluation. According to the method, the novel flavor peptide which is free of bitter taste and has a flavor threshold lower than that of monosodium glutamate can be efficiently screened out, and a technical support is provided for flavor enhancement of functional flavoring agents and fermented meat products.
Owner:KUNMING UNIV OF SCI & TECH

Anti-epileptic stiff silkworm polypeptide as well as preparation method and application thereof

The invention belongs to the technical field of biological medicines, and provides an anti-epileptic stiff silkworm polypeptide as well as a preparation method and application thereof. The bombyx batryticatus polypeptide is a peptide fragment with an amino acid sequence as shown in SEQ ID No.1, and is RFAFPAWI (PP6). The method comprises the following steps: preparing a peptide extract in stiff silkworm by simulating gastrointestinal digestion, identifying peptide in stiff silkworm polypeptide by using Nano LC-MS / MS, and carrying out difference analysis; differential peptides with potential anti-epileptic activity are obtained through virtual screening, and the anti-epileptic stiff silkworm polypeptide PP6 with potential anti-epileptic activity is synthesized. PP6 has a neuroprotection effect on PC12 cell neurotoxicity damaged by glutamic acid (Glu) by adjusting a GABA signal channel, and has an anti-epileptic effect on an epileptic mouse induced by pentaerythrityl tetrazole (PTZ). Therefore, PP6 may be a new leading peptide compound for developing epileptic drugs, and the anti-epileptic polypeptide can be widely applied to the fields of medicines, foods and the like to achieve the anti-epileptic target.
Owner:SHANXI UNIV OF CHINESE MEDICINE

Application of nutritional composition in preparation of immunoregulation product

The invention discloses an application of a nutritional composition in preparation of an immunoregulation product. The nutritional composition comprises a lactoferrin gastrointestinal digest and a selenium gastrointestinal digest, wherein in the nutritional composition, the content of the lactoferrin gastrointestinal digests is 80 to 180 [mu] g / mL; in terms of selenium element, the content of selenium gastrointestinal digests is 12-28 ng / mL. The nutritional composition provided by the invention contains digestive juice compounded by lactoferrin and selenium, and compared with single lactoferrin and selenium, the nutritional composition has a better synergistic anti-inflammatory effect.
Owner:MEAD JOHNSON PEDIATRIC NUTRITION TECH (GUANGZHOU) CO LTD +1

Bifidobacterium animalis subsp. Animalis BN16 capable of stabilizing emotion and relieving anxiety, metagen and preparation method and application of bifidobacterium animalis subsp. Animalis BN16 and metagen

The invention discloses bifidobacterium animalis subsp. Animalis BN16 for stabilizing emotion and relieving anxiety and a metagen, the metagen is prepared by fermenting a bifidobacterium animalis subsp. Animalis BN16 and probiotic fermentation composition, and the composition is prepared from the following materials in parts by weight: 35 parts of milled rice with embryo, 30 parts of corn kernels, 17 parts of lotus seeds, 10 parts of walnut kernels and 8 parts of white granulated sugar. And 400 parts of purified water. The bifidobacterium animalis subsp. Animalis BN16 is fermented and then processed to prepare the metagen, nutritional ingredients in the metagen are directly, effectively and fully biotransformed, tryptophan absorption can be promoted, the situations of insufficient nutrition transformation, insufficient absorption and the like caused by poor intestinal digestion ability of people with sub-health emotions are avoided, emotion stabilization is facilitated, and the health-care effect is achieved. Anxiety is relieved, and the anxiety period is shortened.
Owner:湖南益百益优生物科技有限公司

A betalain-loaded chitosan-sodium alginate hydrogel bead

The application discloses a betalain-loaded chitosan oligosaccharide-sodium alginate hydrogel bead, and belongs to the technical field of pharmaceutical preparations. The betalain-chitosan oligosaccharide-sodium alginate hydrogel bead (Bt-COS-SA) is prepared by adopting an ionic gel method with sodium alginate and chitosan oligosaccharide as carriers, and the optimal preparation conditions of the hydrogel bead are as follows: the betalain concentration is 2 mg / mL, the sodium alginate concentration is 1.5%, the chitosan oligosaccharide concentration is 0.75%, and the CaCl2 concentration is 1.5%. Under the conditions, the embedding rate of the hydrogel bead to the betalain is 74.33+ / -2.31%. The in-vitro simulation gastrointestinal digestion experiment shows that the hydrogel bead has certain pH sensitivity and good sustained-release property; meanwhile, the antioxidation result shows that the antioxidation capacity of the betalain-loaded hydrogel bead is improved to a certain extent, and the hydrogel bead exhibits good application potential in the active substance delivery field.
Owner:GUANGDONG OCEAN UNIVERSITY

Method for simulating in-vitro gastrointestinal digestion of breast milk under different digestive abilities of infants

The invention relates to the technical field of in-vitro simulated digestion, in particular to a method for simulating in-vitro gastrointestinal digestion of breast milk under different digestive abilities of infants, which comprises the steps of reagent preparation, breast milk pretreatment, in-vitro simulated digestion, quantitative detection, protein electrophoretic analysis and the like. The method is derived from deep insight of infant digestive ability diversity, breast milk sample scarcity and efficiency and precision defects in the prior art, and a set of in-vitro digestion model with physiological correlation, high efficiency and economical efficiency is constructed through a technical combination of individual difference simulation by gradient parameters, sample saving by micro operation and reliability improvement by a standardized process. A quantifiable and repeatable tool is provided for research on the digestive mechanism of breast milk, the scientific problem of how the digestive ability difference affects nutrient absorption and infant health is disclosed in an assisting mode, and accurate nutrition is promoted from the concept to practice.
Owner:FIRST AFFILIATED HOSPITAL OF KUNMING MEDICAL UNIV

Intestinal absorption of hematin chloride

The present application relates to a kind of intestinal absorption hemin, belong to biological medicine technical field, the intestinal absorption hemin, including hemin and gamma-cyclodextrin;The molar ratio of hemin and cyclodextrin is 1:2;The preparation method of the intestinal absorption hemin, comprising the following steps: (1) hemin is mixed with ammonia water, to obtain hemin solution;Cyclodextrin is mixed with water, to obtain cyclodextrin aqueous solution;(2) the hemin solution is mixed with the cyclodextrin aqueous solution, to obtain mixed solution;(3) the mixed solution is stirred, and dried for 5h, to obtain intestinal absorption hemin.The intestinal absorption hemin prepared in the present application has the advantages of water solubility and stability, high bioavailability after gastrointestinal digestion, and can be used as a raw material for preparing nutritional fortifier for iron supplementation.
Owner:BEIJING TECH & BUSINESS UNIV

Preparation method of functional protein for shrimp feed, functional protein and application

PendingCN122623756APectinasePhytase
The application provides a preparation method of functional protein for shrimp feed and the functional protein and application, wherein the steps of the preparation method of the application include three steps of raw material compounding, fermentation and enzymolysis and post-treatment. The raw material compounding is uniformly mixing composite plant protein raw materials containing corn gluten meal, cottonseed protein and peanut meal to obtain a mixture; the fermentation and enzymolysis is inoculating composite bacteria liquid containing lactobacillus plantarum and bacillus subtilis into the mixture, adding composite enzyme preparation containing protease, phytase, pectinase, hemicellulase and cellulase, and then performing solid-state fermentation and enzymolysis after adjusting the moisture content of the material to obtain a fermentation product; and the post-treatment is drying and crushing the fermentation product to finally obtain the functional protein synergized by bacteria and enzymes. Adding the prepared functional protein to low-fish meal shrimp feed can reduce the inhibition of protein synthesis and metabolism of shrimp caused by low-fish meal feeding, improve the intestinal digestion capacity of shrimp and the antioxidant level of the body, and thus optimize the overall growth performance of shrimp.
Owner:SHENZHEN AOHUA GRP CO LTD

Method for testing influence of magnesium potassium sulfate on growth of weaned piglets

The invention discloses a method for testing the influence of magnesium potassium sulfate on the growth of weaned piglets, which comprises the steps of in-vitro simulated digestive tract test and in-vivo animal test, preparation of simulated stomach and intestine digestive juice, detection of the dissociation rate of magnesium potassium sulfate in the simulated digestive juice, selection of 216 21-day-old weaned piglets, and random division of the 216 21-day-old weaned piglets into 6 groups, and relates to the technical field of livestock breeding. According to the method for testing the influence of the magnesium potassium sulfate on the growth of the weaned piglets, the dissociation and absorption rules of potassium and magnesium ions in the magnesium potassium sulfate in duodenum, jejunum and ileum of the weaned piglets are defined through in-vitro tests, and a theoretical basis is provided for dose design of in-vivo tests.
Owner:ANIMAL SCI RES INST GUANGDONG ACADEMY OF AGRI SCI

Ganoderma lucidum polysaccharide-fish scale peptide compound with high reducing power as well as preparation method and application thereof

The invention discloses a ganoderma lucidum polysaccharide-fish scale peptide compound with high reducing power as well as a preparation method and application thereof, and belongs to the field of biological medicines. According to the method, firstly, by designing different test combinations, correlation between factors and test results (response values) is fitted through polynomials, the relation between the factors and the test results is functionalized, the interaction relation between the factors and the response values and the interaction relation between the factors are researched, the contribution degrees of the important factors to target values are further optimized, and the target values are optimized; and determining an optimal extraction process. The extracted ganoderan-fish scale peptide compound has a certain effect of high oxidation resistance or high reducing power, and has a better application effect in the aspects of oral digestion, stomach digestion, small intestine digestion and the like.
Owner:SHANDONG AGRICULTURAL UNIVERSITY

Preparation method of thymol microemulsion and application of thymol microemulsion in margarine

The invention belongs to the technical field of food processing, and particularly relates to a preparation method of thymol microemulsion and application of the thymol microemulsion in margarine. According to the thymol microemulsion provided by the invention, the water solubility and stability of edible oil and the utilization rate of unsaturated fatty acid can be improved, the edible oil is encapsulated in the form of microemulsion, and polyunsaturated fatty acid is embedded through a food delivery system, so that the dispersity of the polyunsaturated fatty acid in a water phase is improved, and oxidation of oil drops is inhibited; therefore, the purposes of protecting, transferring and releasing the functional grease are achieved. According to the margarine prepared by the preparation method disclosed by the invention, in-vitro simulated digestion result analysis shows that oil drops of a test sample are gradually reduced along with the action of stomach and intestine digestive juice, and the total fatty acid content is reduced. According to the phenomenon, positive regulation and control of a system on fat digestion and normal metabolism of fat are optimized, the controllability of fat digestion and absorption is achieved, the requirements of special crowds for slow release of nutritional ingredients of sugar-controlled and fat-controlled people and the like are met, and experimental and theoretical support is provided for functional application.
Owner:SHANDONG ACADEMY OF AGRICULTURAL SCIENCES

Edible or feed glucose oxidase double gel microspheres and a method for preparing the same

The application relates to a preparation method of glucose oxidase double-layer gel microspheres with a slow and continuous significant increase in enzyme release amount in the intestinal digestion stage, and simultaneously provides a product with high encapsulation efficiency, good sustained-release effect in the whole gastrointestinal period, good high-temperature resistance, excellent storage stability and swelling degree. The application effectively utilizes sodium alginate, sodium carboxymethyl cellulose, chitosan and calcium ions to perform secondary coating on glucose oxidase, changes the mechanical strength, thickness and pore size of the film, and further improves the sustained-release performance. Compared with single-layer gel microspheres, the double-layer gel microspheres can still be continuously and significantly linearly released at a release amount of 0.15-0.2% per minute (P<0.05) within 210-240 minutes in the intestinal digestion stage of human or animals; after being placed at 80 DEG C for 10 minutes, the double-layer gel microspheres still have 39.76% of enzyme activity; after being stored for 30 days, the double-layer gel microspheres still have 80.52% of activity; and the glucose oxidase gel microspheres have wide application prospects in the field of food and feed processing.
Owner:QIQIHAR UNIVERSITY

Alpha-glucosidase inhibitory peptide and application thereof

The invention discloses an alpha-glucosidase inhibitory peptide and application thereof, and belongs to the technical field of biological medicine and functional food. And the sequence of the alpha-glucosidase inhibitory peptide is Ser-Pro-Tyr-Leu-Gly (SPYLG) or Tyr-Leu-Pro-Lys-Gly (YLPKG). The invention further discloses a preparation method of the alpha-glucosidase inhibitory peptide. The alpha-glucosidase inhibitory peptide has excellent biological safety. Experiments prove that the polypeptide has a remarkable inhibition capability on alpha-glucosidase and shows good gastrointestinal digestion stability. In-vivo and in-vitro studies show that the polypeptide can significantly reduce fasting blood-glucose and improve insulin resistance, the fasting blood-glucose level of diabetic mice after administration is reduced by about 50%, and liver and kidney injury caused by diabetes is effectively relieved. The polypeptide disclosed by the invention is suitable for being used as a core component for developing pharmaceutical preparations for preventing or treating type 2 diabetes and functional foods for assisting in reducing blood glucose.
Owner:QINGDAO UNIV

Single-cell nano-encapsulated probiotic microcapsules and methods of making same

This invention discloses a single-cell nanoencapsulated probiotic microcapsule and its preparation method. The probiotic microcapsule consists of a core material encapsulated by a wall material. The wall material comprises two layers: an outer layer of methacrylate copolymer and an inner layer of metal-polyphenol network loaded with small-molecule oligosaccharides. The core material is probiotics. This probiotic microcapsule utilizes a single-cell nanoencapsulation method, which is simple and easy to operate, and can form a nanoscale functional coating on the surface of a single probiotic. The single-cell nanoencapsulated probiotic microcapsule provided by this invention not only has a particle size almost similar to that of a single probiotic, but also, through the synergistic effect of the inner and outer wall materials, endows the probiotic with excellent resistance to gastrointestinal digestion and intestinal targeted adhesion and colonization capabilities. Furthermore, the addition of small-molecule oligosaccharides makes the network structure of the coating denser and enhances the stability of the probiotics during storage and transportation.
Owner:SOUTH CHINA UNIV OF TECH

Method for predicting feedstuff raw material digestion kinetics parameters based on near infrared spectroscopy

This application discloses a method for predicting feed ingredient digestibility kinetic parameters based on near-infrared spectroscopy, relating to the field of animal nutrition science and technology. The method includes collecting various feed ingredients to form a calibration sample set; acquiring raw near-infrared spectral data of the calibration sample set using a near-infrared spectrometer; determining the cumulative release of glucose, nitrogen, and total amino acids during small intestinal digestion through in vitro simulated digestion experiments, and calculating the release rates during rapid digestion, non-rapid digestion, and the final release rate of the entire digestion process to obtain standard reference values ​​for nine digestibility kinetic parameters; establishing a standard prediction model for each parameter, using spectral data as the independent variable and the standard reference values ​​for the nine digestibility kinetic parameters as the dependent variable; for unknown feed ingredient samples, acquiring their near-infrared spectra and preprocessing them, inputting the processed data into the established model, and outputting the predicted values ​​for the nine digestibility kinetic parameters.
Owner:CHINA AGRI UNIV