174 results about "Intestinal digestion" patented technology

The invention discloses a preparation method and application of a lactoferrin-sodium alginate hydrogel system, and the preparation method of the lactoferrin-sodium alginate hydrogel system comprises the following steps: S1, preparing a lactoferrin subunit solution; s2, preparing a lactoferrin-active substance co-assembly; s3, purifying; s4, preparing a sodium alginate solution; and S5, preparing the lactoferrin-sodium alginate hydrogel loaded with the active substance. According to the method disclosed by the invention, small-molecule active substances are encapsulated on the basis that lactoferrin has a natural cage-shaped structure and a self-assembly characteristic, and lactoferrin is modified by utilizing good gel characteristic and gastrointestinal digestion resistance characteristic of sodium alginate, so that a lactoferrin-sodium alginate co-protected active substance hydrogel system is constructed; the constructed system shows obvious superiority in processing adaptability and bioaccessibility, and the problems of poor stability, low bioavailability and the like of natural small-molecule active substances in the food processing process are solved.

The invention provides the nano-liposome for embedding the cod bone peptide calcium chelate, so that the digestion stability of the cod bone peptide calcium chelate is enhanced, targeted release of Ca < 2 + > in small intestines is facilitated, and the bioavailability of the cod bone peptide calcium chelate is further improved. The amino acid sequence of the cod bone calcium chelating active peptide is SSGPGGERGPp. The nano-liposome disclosed by the invention can ensure the structural integrity in the stomach to protect the cod bone peptide calcium chelate from being damaged, and can release the peptide calcium chelate in the intestinal digestion process, so that the digestion stability of the cod bone peptide calcium chelate is improved, and the targeted delivery of the cod bone peptide calcium chelate is realized.

The invention discloses tartary buckwheat insoluble dietary fiber additive type biscuits capable of reducing methylglyoxal and a preparation method of the tartary buckwheat insoluble dietary fiber additive type biscuits. According to the method disclosed by the invention, the tartary buckwheat bran is used as a raw material for continuous enzymolysis, so that the tartary buckwheat insoluble dietary fiber bound phenol with relatively high purity is obtained. Various phenolic substances are detected by the obtained tartary buckwheat insoluble dietary fiber combined phenol, so that the tartary buckwheat insoluble dietary fiber combined phenol has remarkable methyl glyoxal removal capacity, and most of methyl glyoxal removal capacity of residues digested by the stomach and the intestine can still be reserved, so that the tartary buckwheat insoluble dietary fiber combined phenol can continuously play a removal role in the gastrointestinal tract. The tartary buckwheat insoluble dietary fiber combined phenol is properly added into the biscuit, so that the content of methylglyoxal in the biscuit can be reduced, the intake of harmful substances in food by a human body is reduced, the occurrence of chronic diseases is slowed down, and the tartary buckwheat biscuit is beneficial to the health of the human body.

The invention provides a hypoglycemic peptide which is prepared by taking bovine whey protein as a raw material and is stable in gastrointestinal digestion and absorption. In an in-vitro cell experiment, the peptide fragment can improve the uptake of insulin-resistant HepG2 hepatocytes and synthesize glycogen by using glucose, can promote intestinal endocrine cells NCI-H716 to secrete GLP-1, has a certain synergistic effect, and can further play the effects of promoting GLP-1 secretion and activating a GLP-1 receptor through combined use. An insulin resistance mouse model is constructed by utilizing high-fat diet, and the peptide fragment is adopted for intervention, so that the hypoglycemic peptide is further proved to have obvious effects on losing weight, reducing lipid accumulation and assisting in reducing blood fat, and meanwhile, the hypoglycemic peptide can be used for improving insulin resistance related symptoms. The milk peptide provided by the invention has gastrointestinal digestion stability and hypoglycemic activity, can be used as a functional milk base material for developing food, medicines or health care products with the effect of regulating blood sugar, and is wide in application prospect.

The invention discloses a nutrition improvement nursing method for a gastrointestinal digestion patient, and relates to the field of medical monitoring, and the method comprises the following steps: analyzing to obtain the current absorption amount of to-be-supplemented nutrient elements of the gastrointestinal digestion patient; analyzing to obtain a health influence coefficient of the to-be-supplemented nutrient elements on the gastrointestinal digestion patient; acquiring an absorption promotion coefficient between the to-be-supplemented nutrient elements and other to-be-supplemented nutrient elements; forming a to-be-updated recipe of the current recipe; calculating a health contribution value of the to-be-updated recipe to the gastrointestinal digestion patient; and calculating the coincidence proportion of the to-be-updated recipe relative to the current recipe, and performing recipe change on the current recipe. According to the method, the health influence coefficient is obtained through analysis, the absorption promotion coefficient is obtained, the to-be-updated recipe is formed, the corresponding health influence is obtained according to the deficiency of different to-be-supplemented nutrient elements, and the mutual influence condition existing between the different to-be-supplemented nutrient elements is also considered, so that the prediction result of nutrient absorption is closer to the reality.

The invention discloses a method for improving gastrointestinal tolerance of probiotics and a probiotic liquid core gel ball, the probiotic liquid core gel ball is prepared by adopting a calcium alginate cross-linked reverse spheroidizing method, and various indexes influencing the characteristics of the probiotic liquid core ball after re-culture are optimized, the process is simple in preparation, raw materials are natural and safe, the cost is low, and the method is suitable for industrial production. The tolerance and the survival rate of the probiotics in gastrointestinal digestion can be well improved, and the probiotic liquid core gel ball prepared by the method disclosed by the invention has good mechanical property, swelling rate and storage survival rate; by optimizing various parameters, such as re-culture time, core material liquid viscosity, polysaccharide molecular weight and a storage solution, which influence the characteristics of the probiotic liquid core ball after re-culture, the re-cultured liquid core ball has better mechanical properties, swelling rate and survival rate, and by combining with a gastric acid-cholate resistance reaction result, the survival rate of the liquid core ball is improved. The invention provides the preparation process of the re-culture solution core ball capable of effectively improving the gastrointestinal tolerance of the probiotics whether the core ball is broken or not.

The invention belongs to the field of food processing, and discloses a preparation method and application of a targeted colon delivery polyunsaturated fatty acid grease microcapsule. 11S globulin in soybeans and Arabic gum are used as wall materials of the microcapsule, complex coacervation of the 11S globulin in the soybeans and the Arabic gum is induced under a certain pH condition, so that oil drops are wetted by a coacervate, a core-shell structure is formed, a coacervate phase is further stabilized through glucan to inhibit coalescence, and on the basis, the microcapsule is prepared. And tannic acid, polysaccharide and protein can form hydrogen bonds and generate hydrophobic interaction to further crosslink the condensed phase to obtain the microcapsule capable of resisting digestion of the stomach and the small intestine, so that colon delivery of polyunsaturated fatty acid is realized.

The invention discloses epigallocatechin gallate starch nanoparticles as well as a preparation method and application thereof, and belongs to the technical field of medicinal chemistry. According to the method, high-proportion branched-chain cassava starch is used as a raw material, ultrasonic microwave assistance is adopted, in the nanometer starch alcohol precipitation process, epigallocatechin gallate is synchronously packaged to form nanometer-level epigallocatechin gallate starch nanometer particles, and embedding of epigallocatechin gallate is completed. The embedding rate of the epigallocatechin gallate starch nanoparticles can reach 50.20%, the drug loading capacity can reach 311mg / g, the drug slow release performance is obvious in the process of simulating gastrointestinal digestion, the sustained release time can be 20 hours, the drug release capacity can reach 72.33% and 90.10% respectively, and the preparation process is simple, easy to operate, low in preparation cost and suitable for large-scale production and application.

The invention belongs to the technical field of aquaculture, and particularly relates to a pearl grouper fry rearing method. According to the method, firstly, after the roes are hatched, the fries are soaked with a bactericide, harmful bacteria on the surfaces of the roes and in a hatching pond can be effectively killed, and a bacteria solution of lactobacillus brevis serves as the bactericide, so that the use of antibiotics is reduced while the growth of pathogenic bacteria is inhibited; the culture pond is divided into 1m * 1m spaces by the partition plates, so that the phenomenon that the fries kill each other or snatch for food due to insufficient spaces is avoided, and uniform growth of the fries is facilitated; culture is carried out in stages according to nutritional requirements of different growth stages, and the Weissella microbial inoculum and the lactococcus lactis microbial inoculum are added to the feed in each stage, so that the intestinal microecological balance of the fry is adjusted, the growth and reproduction of harmful bacteria are inhibited, the intestinal digestion and absorption functions of the fry are enhanced, and the utilization rate of the feed is increased.

The invention belongs to the technical field of drug delivery and food medicine, and particularly relates to resistant starch of intestinal targeted slow-release polyphenol and a preparation method and application of the resistant starch of the intestinal targeted slow-release polyphenol. Performing annealing recrystallization on the heat-dispersed high-amylose corn starch in an ethanol solution to obtain single-spiral structure resistant corn starch; and self-assembling the resistant corn starch with the single-spiral structure and the quinoa polyphenol extract in an alcohol-water system to obtain the intestinal targeted slow-release polyphenol resistant starch. According to the resistant starch of the intestinal targeted slow-release polyphenol prepared by the method disclosed by the invention, the specific starch spiral structure can realize the intestinal targeted controlled release of the polyphenol contained in the intestinal targeted slow-release polyphenol, so that the loss of phenolic compounds in the gastrointestinal digestion process is reduced, and the accurate and continuous release of the polyphenol compounds in the intestinal digestion stage is realized; the residence time of the polyphenol in the intestinal tract is prolonged, so that the bioavailability of the polyphenol is improved.

The stability of polyphenol is improved based on steric hindrance of the nanoparticles, the slow-release characteristic of the polyphenol in the gastrointestinal digestion process is improved, and the problems that traditional starch is easy to digest and hydrolyze, and the like are solved. And the problems of complex preparation steps or unstable polyphenol inhibition digestion caused by resistant starch and slowly digestible starch are solved. And the activity of amylase can be effectively inhibited by continuously releasing polyphenol, so that the digestibility of starch is reduced. And secondly, the polyphenol used in the invention has biological activity, and the prolamin nanoparticles show excellent mucous membrane adhesiveness in gastrointestinal digestion and absorption processes, so that the bioaccessibility of the encapsulated bioactive compound is increased, and the preparation method has higher application value and is suitable for wide popularization and application.

The invention discloses a tilapia skin DPP-IV inhibitory peptide as well as a preparation method and application thereof, and belongs to the technical field of food-borne active peptide development. The preparation method comprises the following steps: taking tilapia skin as a raw material, extracting gelatin from the tilapia skin through an acid-alkali treatment method, and then performing simulated gastrointestinal digestion on the gelatin by utilizing simulated digestive juice prepared from pepsin, trypsin and chymotrypsin to obtain a digestion product with DPP-IV inhibitory activity; the tilapia skin active peptide with relatively high DPP-IV inhibitory activity is obtained through further ultrafiltration and identification, amino acid sequences of the tilapia skin active peptide are AKVELLK, VPGPMGPMGPR and DGIR respectively, and the three inhibitory peptides have good DPP-IV inhibitory activity and can be used for developing food, health care products or medicines for assisting in regulating blood sugar.

The invention discloses a core-shell microcapsule containing high-activity plant lactobacillus as well as a preparation method and application of the core-shell microcapsule, and belongs to the technical field of microcapsules. According to the preparation method, the plant lactobacillus KLDS 1.0328-EGCG microcapsule is prepared through an electrostatic spraying technology, WPC and beta-CD are used as packaging carriers, EGCG is added, lac is used as a shell layer, and the plant lactobacillus KLDS 1.0328-EGCG coaxial electrostatic spraying microcapsule with a core-shell structure is prepared. Simulated gastrointestinal digestion experiments prove that the coaxial electrostatic spraying capsule disclosed by the invention efficiently protects the biological activity of the probiotics. The invention provides a new thought for improving the biological activity of the probiotics, establishes a new method for improving the physiological characteristics and probiotic functions of the probiotics under environmental stress, has potential to play a probiotic role on human health through a synergistic effect in vivo, and provides a new thought for developing a novel probiotic protective agent.

According to the probiotic gel microspheres disclosed by the invention, probiotics are wrapped by the gel microspheres, so that the probiotics are protected from being absorbed or the influence of gastric acid and intestinal digestive juice is reduced, and the release of the probiotics in intestinal tracts is promoted. When the probiotics adopt functional coatings, after the probiotics gel microspheres reach the intestinal tract and release the probiotics, the coating layers on the surfaces of the probiotics can promote the probiotics to adhere to the intestinal mucosa, and the problem that traditional probiotics are difficult to colonize in the intestinal tract is solved. The probiotic gel microspheres disclosed by the invention have an obvious radiation injury protection effect after being orally taken, and can be used for relieving whole-body radiation injury or local radiation injury (such as radioactive intestinal injury) caused by whole-body radiation or local radiation (such as abdominal radiotherapy).

The invention belongs to the field of fish breeding, and discloses a construction method and primers of a fast-growing red crucian carp homozygous strain, and the construction method comprises the following steps: preparing gRNA of a red crucian carp acvr2b gene, microinjecting a mixture of the gRNA and Cas9 protein into a one-cell stage fertilized egg of the red crucian carp, and screening to obtain an F0-generation gene knockout mutant; carrying out selfing on the F0-generation gene knockout mutant to obtain an F1-generation mutant, and screening to obtain a homozygous mutant; and selfing and propagating the homozygous mutant to obtain the product. The acvr2b homozygous knockout strain is successfully established in the red crucian carp through a CRISPR / Cas9 gene editing technology for the first time, the body weight of the obtained acvr2b mutant red crucian carp at the age of 12 months is increased by 30.68% compared with that of a wild type, the muscle protein content is increased by 13.81%, the intestinal digestion and absorption capacity is obviously improved, high-quality germplasm resources are provided for fish genetic breeding, and the acvr2b mutant red crucian carp has a good application prospect.

The invention discloses a natto peptide sea cucumber polysaccharide liposome for synergistically improving cardiovascular health and a preparation method and application thereof, belongs to the field of active peptide delivery systems, and aims to solve the stability problem of natto oligopeptide in gastrointestinal digestive tracts. The phytosterol and the vitamin E are filled between phospholipid double layers of the liposome to support a gap between the phospholipid double layers, and the ratio of the phytosterol to the vitamin E is (1-3): 1, so that the natto oligopeptide liposome has the effects that the storage of the natto oligopeptide and the stability of the natto oligopeptide in gastrointestinal and digestive tracts can be improved, the bioavailability of the natto oligopeptide liposome is improved, and the bioavailability of the natto oligopeptide liposome is improved. The traditional Chinese medicine composition has synergistic effects in the aspects of anticoagulation, thrombolysis and blood fat reduction, and has a good cardiovascular protection effect.

The invention discloses bifidobacterium adolescentis from longevity dogs and cats and application thereof, and belongs to the technical field of microorganisms. Bifidobacterium adolescentis with the effect of prolonging the life of mice is separated from fresh feces of longevity dogs and cats, and after mutagenesis, the bifidobacterium adolescentis for dogs and cats, which is more suitable for gastrointestinal environments of dogs and cats, is bred by taking growth speed, gastrointestinal digestion resistance and oxygen resistance as indexes. The mutant strain is preserved in the China Center for Type Culture Collection (CCTCC) on August 5, 2024, and the preservation number of the mutant strain is CCTCC NO: M20241747 and the preservation number of the mutant strain is CCTCC NO: M20241746. The bifidobacterium adolescentis disclosed by the invention can be applied to food (feed) of dogs and cats, and has the effects of reducing the food change stress rate of the dogs and the cats and improving the senescence index (NAD < + >).

The invention belongs to the field of food nutrition and functional factors, and particularly relates to a method for preparing ovotransferrin hydrolysate with high immunocompetence based on an adult gastrointestinal simulated digestion system. According to the method, ovotransferrin is treated through the stomach and intestine of a simulated adult, OVT hydrolysate is prepared, and the OVT hydrolysate contains HTEGSTT, TTSY and / or RTAGWVIPMG. The invention finds that the immunomodulatory activity of OVT is enhanced after gastrointestinal digestion and hydrolysis, the OVT is more easily hydrolyzed in simulated adult digestive juice than in infant digestive juice, and a contrast experiment shows that the nutrition intervention of OVT adult and infant simulated digestion products can promote the generation of short-chain fatty acids such as acetic acid, propionic acid and butyric acid; the swelling injury caused by inflammation to small intestine mucous membrane tissues is effectively relieved, so that the intestinal barrier immune function is obviously improved, and the OIA shows higher intestinal immune activity than the OIB.

The invention belongs to the technical field of biological small molecule active peptides, and more specifically relates to a uric acid reducing active peptide, a preparation method and an application thereof. The uric acid reducing activity LQKW has remarkable XOD inhibitory activity, IC50 is 2.70 mg / mL, and the IC50 is superior to that of many known natural source XOD inhibitory peptides; good gastrointestinal digestion stability is shown, and the activity retention rate after in-vitro simulated gastrointestinal digestion is (61.84 + / -0.82)%. According to the invention, a specific binding mechanism of uric acid reduction activity and XOD active sites (Ile648, Phe649 and the like) is clarified through molecular docking, and a basis is provided for rational design based on a structure. According to the invention, the method for efficiently preparing the active peptide fragment from the white spirit vinasse is established, and the high-valued utilization of the wine brewing byproducts is realized. The uric acid reducing activity LQKW provided by the invention can be prepared through solid-phase synthesis, the process is mature, the quality is controllable, and a foundation is laid for industrialization. In addition, as the XOD inhibitor of a natural source, the uric acid reducing activity LQKW has good safety.

The invention discloses a glycinin compound for preventing hyperlipemia as well as a preparation method and application of the glycinin compound, and belongs to the field of biological medicines. The preparation method comprises the following steps: stirring and mixing resveratrol and a soybean 7S globulin solution at 40-60 DEG C for 1.5-2.5 h, so that resveratrol and soybean 7S globulin are fully combined to obtain a glycinin compound; the mass ratio of the soybean 7S globulin to the resveratrol is (250: 50)-(250: 45). Experimental results show that the glycinin compound disclosed by the invention can inhibit the weight increase of a hyperlipemia rat, remarkably reduce the fat index and the liver index, effectively improve the abnormal change of the blood fat factor level and show an obvious lipid-lowering effect. In-vitro simulated digestion experiments show that the glycinin compound shows peptide fragments with different strength from soybean 7S protein after gastrointestinal digestion, and meanwhile, the glycinin compound improves the in-vitro cholate binding capacity.

The invention discloses a method for adjusting functional properties and oxidation resistance of potato protein, and relates to the technical field of food processing. The method comprises the following steps: extracting potato protein by adopting an alkali-solution and acid-isolation method, and modifying the potato protein by utilizing an ultrasonic technology; the ultrasonic frequency is set to be 20 kHz, the amplitude is set to be 40%, the ultrasonic time is 0-10 min, and the change rule of the potato protein structure and the functional property under different ultrasonic time is analyzed. After ultrasonic treatment, the particle size and polydispersity index of the potato protein are obviously reduced, the Zeta-potential is increased, but main strips are not changed; after 6 minutes of ultrasonic treatment, the particle size is 266.90 + / -2.26 nm, the PDI is 0.27 + / -0.03, and the Zeta-potential is-26.25 + / -0.93 mV. After 6 minutes of ultrasonic treatment, the solubility of potato protein is the highest, the foamability is improved by 1.18 times, the emulsifying activity is improved by 1.54 times, and the digestibility of simulated intestines is remarkably improved. Under the condition, the reducing power of the potato protein and the scavenging rates of DPPH, superoxide anions and hydroxyl radicals reach the maximum value.

The invention discloses a preparation method of a red rice bran protein peptide compound with antioxidant and hypoglycemic effects. According to the method, red rice bran protein is extracted through an alkali-solution and acid-isolation method; hydrolyzing the red rice bran protein with alkaline protease to obtain a red rice bran protein hydrolysate; the red rice bran protein hydrolysate prepared by the invention has the functional characteristics of excellent emulsibility, foamability and oil absorbency, and has excellent antioxidant and hypoglycemic functional activities after being subjected to in-vitro simulated gastrointestinal digestion. The red rice bran protein hydrolysate can be used in plant-based food and dairy product substitutes and functional food with a hypoglycemic effect.

The present invention relates to the technical field of whey protein hydrolysis, and particularly to a preparation method and application of buffalo colostrum-derived bioactive peptides. The present invention optimizes the enzymatic hydrolysis process of buffalo colostrum whey protein through single-factor experiments to obtain an enzymatic hydrolysis method of buffalo colostrum whey protein suitable for large-scale production. In addition, the enzymatic hydrolysis process of buffalo colostrum whey protein is optimized by the response surface method. Three factors, namely the pH value, enzymatic hydrolysis time, and enzyme addition amount during enzymatic hydrolysis with neutral protease, are selected as corresponding variables, and the ABTS radical scavenging rate is used as the response value. Multiple fittings are performed on each factor to obtain the optimal enzymatic hydrolysis process conditions for whey protein. The buffalo colostrum-derived bioactive peptides obtained by this enzymatic hydrolysis method have the technical advantages of high ABTS radical scavenging rate and good immune function. At the same time, the stability of the enzymatic hydrolysis product is further studied through gastrointestinal digestion experiments, providing a more comprehensive theoretical reference for the further research of whey protein.

The application discloses a South China Sea Decapterus maruadsi polypeptide with uric acid reducing and antioxidant activities and an application thereof, and relates to the technical field of biology. The polypeptide with high uric acid reducing activity and antioxidant activity is screened through activity prediction and molecular docking, and the amino acid sequence is FYDWWK. The polypeptide can be stably combined with the active center of xanthine oxidase, forms multiple hydrogen bonds and hydrophobic interaction, significantly inhibits the generation of uric acid, and has an in-vitro xanthine oxidase inhibition IC 50 of 3.068±0.2547 mmol / L. Meanwhile, the polypeptide has excellent DPPH free radical scavenging capacity, and an IC 50 of 5.033±0.5476 mmol / L. The polypeptide has good stability, still has high efficient inhibitory activity after simulated gastrointestinal digestion, and has oral development potential. The polypeptide is a natural marine small molecule active peptide, is safe and easy to absorb, and can be applied to the preparation of products related to uric acid reducing and / or antioxidant.

The invention discloses a preparation method and application of 7-hydroxyisoflavone acetylferulate, relating to the technical field of feed additives. The preparation method comprises the following steps: adding acetylferulic acid, 7-hydroxyisoflavone, 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride, and N,N-dimethyl-4-pyridinamine to a reactor; using dichloromethane as a solvent; stirring at room temperature for 5 hours; adding water after the reaction is complete; and then extracting with dichloromethane; and concentrating and crystallizing the product to obtain a target product. The product prepared by this method has good fat solubility and stability, and can be added as an additive to livestock, poultry, and aquatic animal feed to significantly improve the growth performance, antioxidant capacity, immunity, and intestinal digestion capacity of the animal.

The present invention belongs to the field of feed additives, and specifically relates to a Chinese medicine composition having the function of improving the intestinal health of rabbits, and a preparation method and application thereof. The present invention provides a Chinese medicine formula for improving the intestinal health of rabbits, comprising 2-5 parts of astragalus; 1-3 parts of evodia rutaecarpa; 1-3 parts of dried orange peel; and 1-3 parts of liquorice. The Chinese medicine composition and feed provided by the present invention can improve the growth performance of rabbits, regulate fat metabolism and energy metabolism, improve the body's immunity, enhance the digestive capacity and antioxidant capacity of the intestines, and improve the intestinal morphology.

1. The name of the design product: ultrasonic digestive endoscope. 2. The use of the design product: for gastrointestinal digestive examination diagnosis and treatment. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

The present invention provides a package of a micronutrient supplement for promoting the digestive function of the intestinal tract of a body, the micronutrient supplement consisting of two types of unit dosage forms in one package for sale to a purchaser wherein the first type of unit dosage form contains VB6 and a compound thereof, and the second type of unit dosage form contains VB6 and a compound thereof. The first type of unit dosage form contains Zn and compounds thereof, the second type of unit dosage form contains Zn and compounds thereof or VD and compounds thereof, and the first type of unit dosage form does not contain Zn and VD, and the second type of unit dosage form does not contain VB6, the micronutrient supplement being provided in a manner of administration twice a day, the first type of unit dosage form is taken in an awakening period, and the second type of unit dosage form is taken in a sleep period. The packaging product can be matched with the biological clock rhythm of an organism, the absorption and utilization rate of micronutrients is increased, and then the intestinal digestion function is improved.

The invention belongs to the technical field of whey protein processing, and particularly relates to a preparation method of a hydrolyzed whey protein digestion product with high immunocompetence and low sensitization. The preparation method comprises the following steps: by taking hydrolyzed whey protein as a raw material, carrying out simulated gastrointestinal digestion treatment under specific conditions to obtain a whey protein digestion product; the product can effectively exert immunoregulation and anti-inflammatory effects, solves the problem of sensitization of a traditional whey protein product, and has a good application prospect.

The invention discloses a preparation method of a whey protein / pullulan / sugar astaxanthin nano-dispersion, WPC / PUL compounds are adopted to construct different carriers to embed AST, the carriers are respectively a nano-dispersion loaded with AST, emulsion gel and microcapsule powder, the three carriers have good embedding efficiency and protection effect on AST, the simulated gastrointestinal digestion stability of AST is remarkably improved, and the stability of AST is improved. And the method has great significance in expanding the preparation of an AST embedding delivery system and the application of AST in industries such as food and the like.