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Methods and compositions for diagnosing conditions associated with specific DNA methylation patterns

The present invention provides a method for identification of differentially methylated genomic CpG dinucleotide sequences associated with cancer in an individual by obtaining a biological sample comprising genomic DNA from the individual measuring the level or pattern of methylated genomic CpG dinucleotide sequences for two or more of the genomic targets in the sample, and comparing the level of methylated genomic CpG dinucleotide sequences in the sample to a reference level of methylated genomic CpG dinucleotide sequences, wherein a difference in the level or pattern of methylation of the genomic CpG dinucleotide sequences in the sample compared to the reference level identifies differentially methylated genomic CpG dinucleotide sequences associated with cancer. As disclosed herein, the methods of the invention have numerous diagnostic and prognostic applications. The methods of the invention can be combined with a miniaturized array platform that allows for a high level of assay multiplexing and scalable automation for sample handling and data processing. Also provided by the invention are genomic targets and corresponding nucleic acid probes that are useful in the methods of the invention as they enable detection of differentially methylated genomic CpG dinucleotide sequences associated with cancer, for example, adenocarcenomas and sqamous cell carcinomas of the lung.
Owner:ILLUMINA INC

Determining situational patterns of use for computing systems

Techniques for determining situational patterns of use of computing systems are disclosed. A situational pattern of use can be determined based on the situations encountered by the computing system as the situations occur without having to predefine a set of situations. Generally, a situation can be determined and/or defined based on the context of use of the computing system when the use occurs. The context of use can, for example, be determined based on internal and external variables including the physical environment where a device is used and biological data associated with a person who uses the device. The state of use of the computing system can, for example, be determined based on the state (or status) of one or more components of the computing system (e.g., the state of one or more active applications that are being used by person). Similar to the context of use, the state of use can be determined as the use occurs without having to predefine potential uses of the computing system (e.g., there is no need to predefine or know the applications that will be used on a device). Moreover, the state of use can be connected to context of use defining a situation in which the state of use has occurred to allow determining a pattern of use of the computing system at least based on the association of the state of use with the situation effectively defined by the contextual usage data which can be obtained as and when the use occurs.
Owner:SAMSUNG ELECTRONICS CO LTD
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