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Method for preparing biomedical titanium and titanium alloy surface antibacterial coatings

A surface antibacterial, titanium alloy technology, applied in the direction of surface reaction electrolytic coating, metal material coating process, coating, etc., can solve the problems of difficult antibacterial effect, silver content reduction, etc., to prevent surgical infection, high production efficiency, The effect of reducing bacterial infection

Active Publication Date: 2014-05-07
NORTHWEST INSTITUTE FOR NON-FERROUS METAL RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, some existing studies adopt the method of reducing the concentration of silver salt incorporation, which greatly reduces the silver content entering the film layer, and it is difficult to form an effective antibacterial effect, especially after implant postoperative infection presents a certain periodicity and long-term nature. Too low silver content will not effectively solve these problems

Method used

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  • Method for preparing biomedical titanium and titanium alloy surface antibacterial coatings
  • Method for preparing biomedical titanium and titanium alloy surface antibacterial coatings
  • Method for preparing biomedical titanium and titanium alloy surface antibacterial coatings

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Step 1: Prepare TiO on the surface of medical pure titanium sample to be processed 2 Nanotube pre-coating:

[0030] 101. Polish the medical pure titanium sample to be processed to a mirror surface, then ultrasonically clean the polished medical pure titanium sample with distilled water, acetone and absolute ethanol, and vacuum dry the medical pure titanium sample after ultrasonic cleaning with absolute ethanol ;

[0031] 102. The medical pure titanium sample after vacuum drying in 101 is completely immersed in NH 4 F in the ethylene glycol aqueous solution, anodic oxidation treatment under 50V constant potential conditions for 1h; the containing NH 4 The mass concentration of ethylene glycol in the glycol aqueous solution of F is 95%, NH 4 The mass concentration of F is 2%, and the balance is water;

[0032] Step two, TiO 2 Nanotube pre-coating surface treatment with silver loading:

[0033] 201 The AgNO 3 Evenly dispersed in deionized water to obtain AgNO with a concentration ...

Embodiment 2

[0042] Step 1: Prepare TiO on the surface of the medical Ti6Al4V titanium alloy sample to be processed 2 Nanotube pre-coating:

[0043] 101. Polish the surface of the medical Ti6Al4V titanium alloy sample to be processed to a mirror surface, and then the polished medical Ti6Al4V titanium alloy sample is ultrasonically cleaned with distilled water, acetone, and absolute ethanol, and then the medical Ti6Al4V titanium after ultrasonic cleaning with absolute ethanol Vacuum drying of alloy samples;

[0044] 102. The medical Ti6Al4V titanium alloy sample after vacuum drying in 101 was completely immersed in the ethylene glycol aqueous solution containing KF, and anodized for 1 hour under the condition of 30V constant potential; the ethylene glycol in the ethylene glycol aqueous solution containing KF The mass concentration of alcohol is 85%, the mass concentration of KF is 5%, and the balance is water;

[0045] Step two, TiO 2 Nanotube pre-coating surface treatment with silver loading:

[...

Embodiment 3

[0055] Step 1: Prepare TiO on the surface of the medical Ti6Al7Nb titanium alloy sample to be processed 2 Nanotube pre-coating:

[0056] 101. Polish the surface of the medical Ti6Al7Nb titanium alloy sample to be processed to a mirror surface, and then the polished medical Ti6Al7Nb titanium alloy sample is ultrasonically cleaned with distilled water, acetone and absolute ethanol in turn, and then the medical Ti6Al7Nb titanium after ultrasonic cleaning with absolute ethanol Vacuum drying of alloy samples;

[0057] 102. The medical Ti6Al7Nb titanium alloy sample after vacuum drying in 101 is completely immersed in NH 4 F and KF in ethylene glycol aqueous solution, anodizing treatment under 40V constant potential conditions for 4h; said containing NH 4 The mass concentration of ethylene glycol in the ethylene glycol aqueous solution of F and KF is 90%, NH 4 The mass concentration of F is 2.5%, the mass concentration of KF is 2.5%, and the balance is water;

[0058] Step two, TiO 2 Nanot...

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Abstract

The invention discloses a method for preparing biomedical titanium and titanium alloy surface antibacterial coatings. The method comprises steps of firstly, processing the surface of a biomedical titanium or titanium alloy sample to be processed, immersing the biomedical titanium or titanium alloy sample in a glycol aqueous solution containing soluble fluoride and performing an anode oxidation treatment; secondly, immersing the biomedical titanium or titanium alloy sample after being subjected to the anode oxidation treatment in a silver nitrate solution, taking out the biomedical titanium or titanium alloy sample, using ultraviolet light radiation to process the biomedical titanium or titanium alloy sample and obtaining the silver-carrying biomedical titanium or titanium alloy sample; and performing a micro-arc oxidation treatment for the silver-carrying biomedical titanium or titanium alloy sample, performing ultrasonic cleaning and vacuum drying and obtaining the antibacterial coatings. The nano precoating layer preparation, the silver-carrying treatment and a micro-arc oxidation technology are combined, then a large amount of silver can be fixed on the biomedical titanium and titanium alloy sample surfaces and can be released slowly for a long time, the antibacterial performance of titanium and titanium alloys is greatly improved, the antibacterial effect can be kept for a long time, and the bacterial infection caused by the fact that a titanium and titanium alloy apparatus is embedded in a human body is greatly reduced or avoided.

Description

Technical field [0001] The invention belongs to the technical field of surface modification of surgically implanted titanium and titanium alloy, and specifically relates to a preparation method of an antibacterial coating on the surface of medical titanium and titanium alloy. Background technique [0002] Titanium and titanium alloys have gradually become the first choice materials for human hard tissue substitutes and restorations such as dental implants, bone trauma products and artificial joints due to their excellent biocompatibility, corrosion resistance and comprehensive mechanical properties. However, with the widespread application of medical titanium and titanium alloys, biomaterial centered infections (BCI) have become a very difficult clinical problem. It is reported in the literature that the incidence of nail tract infection of titanium alloy implants is not the same, and the incidence of serious nail tract infection that requires hospitalization for antibiotic treat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C23C28/00C25D11/26C23C18/42A61L27/06A61L27/30
Inventor 于振涛余森张强韩建业牛金龙刘春潮
Owner NORTHWEST INSTITUTE FOR NON-FERROUS METAL RESEARCH
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