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Chinese material medica preparation in use for treating infection of influenza virus, and preparation method

A technology of traditional Chinese medicine preparations and solvents, applied in antiviral agents, pharmaceutical formulas, medical preparations containing active ingredients, etc., to achieve the effect of simple preparation process, economical preparation process and high safety

Inactive Publication Date: 2008-10-01
TIANJIN INSTITUTE OF PHARMA RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the total flavonoids extract of Scutellaria barbata as an effective part, its antiviral research and the research on the main components of total flavonoids and total alkaloids in the extract of Scutellaria barbata have not been reported in the literature.

Method used

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  • Chinese material medica preparation in use for treating infection of influenza virus, and preparation method
  • Chinese material medica preparation in use for treating infection of influenza virus, and preparation method
  • Chinese material medica preparation in use for treating infection of influenza virus, and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Crush the whole herb of Scutellaria barbata, weigh 1 kg, heat and extract twice with 18 times the amount of water to obtain the crude extract (A) of Scutellaria barbata. Separation on a macroporous resin column (D101 type or AB8), receiving the unadsorbed drug solution, concentrating to obtain 12 g, and eluting with water and ethanol (30-90%) of different concentrations. Collect each part, wash part with water and dry to obtain 26g, 30-60% ethanol part to obtain dry paste 67g, 80-90% ethanol part to obtain 8g of ethanol part. The total flavonoids were measured, and the content of scutellarin eluted with 30-60% ethanol was the highest (4.2%). The obtained mixture contains 33.8% of total flavonoids, 1.5% of total alkaloids, 1.8% of steroids and 10.2% of sugars.

Embodiment 2

[0057] Crush the whole herb of Scutellaria barbata, weigh 1 kg, extract twice with 18 times the amount of 50% ethanol (heating or percolation) to obtain the crude extract (B) of Scutellaria barbata. Separation on a macroporous resin column (D101 type or AB8), receiving the unadsorbed drug solution, concentrating to obtain 15g (F), and eluting with water and different concentrations of ethanol (30-90%). Collect each part, wash part with water and dry to obtain 35g (G), 30-60% ethanol part to obtain dry paste 79g (H), 80-90% ethanol part to obtain 14g ethanol part. The total flavonoids were measured, and the content of scutellarin eluted with 30-60% ethanol was the highest (10.5%). 35 g of the mixture was obtained, and the mixture contained 63.1% of total flavonoids, 2.1% of total alkaloids, 1.0% of steroids and 5.2% of carbohydrates.

Embodiment 3

[0059] The whole herb of Scutellaria barbata is crushed, weighed 1 kg, extracted (heated or percolated) twice with 18 times the amount of 50% ethanol, the two extracts are combined, the ethanol is recovered under reduced pressure, and the crude extract of Scutellaria barbata is obtained. The dregs were discarded. The crude extract is adjusted to pH 7-8 with 5% NaOH solution to obtain an alkaline liquid, which is extracted with chloroform (or petroleum ether). Separate the solvent layer, discard it, adjust the pH of the water layer to 2-4 with 5% sulfuric acid, place it, centrifuge, and acidify the precipitate for later use. After drying, 30g (C) is obtained, and the solution is extracted with chloroform (or petroleum ether). The layers were separated, the water layer was concentrated to obtain 86g of (E), and the solvent layer was concentrated to obtain an extract, which was dried to obtain 40g of (D), which was uniformly mixed with the acidic precipitate to obtain 70g of the ...

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Abstract

A Chinese medicine in the form of injection or orally taken medicines for treating the infection of influenza virus is prepared from the extract of barbat skullcap herb and medicinal auxiliaries. Said extract composed of flavone, alkaloid, steroid and saccharide is prepared from barbat skullcap herb through extracting in water or alcohol, separating and concentrating.

Description

technical field [0001] The present invention relates to the preparation process and preparation method of traditional Chinese medicine, more specifically, an extract of Scutellaria barbata for preventing and treating influenza virus infection and its preparation method, and various traditional Chinese medicines made of the extract as the main component preparation. Background technique [0002] Influenza, also known as influenza, is an acute respiratory infectious disease caused by influenza virus. Every year in our country, influenza will break out and constantly mutate, so there is no ideal drug for the treatment of it at present. The existing traditional Chinese medicine preparations for treating influenza virus are mostly compound preparations, such as Shuanghuanglian, Yinqiao, Antelope, Sangju, etc. Although they have certain curative effects, the quality is difficult to repeat due to multiple ingredients, and the production controllability is poor. . Therefore, ther...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/53A61K9/08A61K9/16A61K9/20A61K9/48A61P31/16
Inventor 徐为人马素珍周福军华洁阎立萍林巳龙刘跃鹏
Owner TIANJIN INSTITUTE OF PHARMA RESEARCH
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