A kind of Erchen extract with anti-tumor activity and its preparation method

A technology of anti-tumor activity and extract, which is applied in the field of preparation of Erchen extract and its preparations, can solve the problems of large volume and dosage, poor taste, inconvenient to carry, etc., achieve convenience in taking, increase compliance, and process easy-to-use effects

Active Publication Date: 2021-03-02
YANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Existing traditional Chinese medicine decoctions have large volume and dosage, poor taste, and are not easy to carry. There is no Erchen extract and its preparations with antitumor activity mainly composed of Erchen polysaccharides.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Mix 30 kg of pinellia, 30 kg of tangerine peel, 18 kg of poria cocos and 9 kg of licorice, put them into a frying pan, add water to decoct at a material-to-liquid ratio of 1:8 (W / V), and cook at a temperature of 85°C for 1 hour each time. Cook for a total of 2 times. Filter the decoction and concentrate under reduced pressure to a concentrated solution with a specific gravity of 1.15. Slowly add ethanol to the concentrated solution and stir rapidly. The final concentration of ethanol is 60%. After standing for 4 hours, pour off the supernatant and centrifuge to obtain a precipitate. Dissolve the precipitate with distilled water, filter, discard the insoluble matter, obtain the aqueous solution after the precipitate is dissolved in distilled water, adjust the specific gravity of the aqueous solution to 1.10, and then place the aqueous solution in a dialysis bag with a molecular weight cut-off of 8000 for routine dialysis for 12 hours, and dialyze The inner liquid (aqueou...

Embodiment 2

[0032]Mix 15 kg pinellia, 15 kg tangerine peel, 9 kg poria cocos and 4.5 kg licorice, add them to the frying pan, add water to decoct at a material-to-liquid ratio of 1:10 (W / V), and cook at a temperature of 88°C for 0.5 hours each time , decocted 3 times in total. Filter the decoction and concentrate under reduced pressure to a concentrated solution with a specific gravity of 1.20. Slowly add ethanol to the concentrated solution and stir rapidly. The final concentration of ethanol is 70%. After standing for 3 hours, pour off the supernatant and centrifuge to obtain a precipitate. Dissolve the precipitate with distilled water, filter, discard the insoluble matter, obtain the aqueous solution after the precipitate is dissolved in distilled water, adjust the specific gravity of the aqueous solution to 1.12, and then place the aqueous solution in a dialysis bag with a molecular weight cut-off of 7000 for routine dialysis for 18 hours, and dialyze The inner liquid (aqueous solutio...

Embodiment 3

[0034] Mix 7.5 kg pinellia, 7.5 kg tangerine peel, 4.5 kg poria cocos and 2.25 kg licorice, add them to the frying pan, add water to decoct at a material-to-liquid ratio of 1:12 (W / V), and cook at a temperature of 90°C for 1 hour each time , A total of 2 decoctions. Filter the decoction and concentrate under reduced pressure to a concentrated solution with a specific gravity of 1.30. Slowly add ethanol to the concentrated solution and stir rapidly. The final concentration of ethanol is 80%. After standing for 2 hours, pour off the supernatant and centrifuge to obtain a precipitate. Dissolve the precipitate with distilled water, filter, discard the insoluble matter, obtain the aqueous solution after the precipitate is dissolved in distilled water, adjust the specific gravity of the aqueous solution to 1.15, and then place the aqueous solution in a dialysis bag with a molecular weight cut-off of 6000 for routine dialysis for 24 hours, and dialyze The inner liquid (aqueous soluti...

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Abstract

The invention relates to a preparation method of Erchen extract with antitumor activity and its preparation, which belongs to the technical field of traditional Chinese medicine pharmacy. The Erchen Decoction composed of Pinellia, Tangerine Peel, Poria, and Licorice is formulated according to the dosage ratio of ancient Chinese medicine, decocted with water, filtered, concentrated decoction under reduced pressure, adding ethanol to the decoction concentrated solution, dissolving the ethanol precipitate and dialyzing , Concentrate the dialysate under reduced pressure and then dry it in vacuum to obtain Erchen extract with anti-tumor activity. Through the present invention, the extract has a high yield, its polysaccharide content is higher than 75%, and its antitumor activity is better than that of Erchen Decoction. Erchen extract is added to excipients to make Erchen extract preparations with anti-tumor activity. Compared with the traditional water decoction of Erchen Decoction, the preparation made by adding Erchen extracts to excipients is more effective. The anti-tumor effect is good, and it is convenient to take, which increases the compliance of patients and can be widely used. The inventive process is simple and easy to implement, and is suitable for large-scale industrial production.

Description

technical field [0001] The invention relates to a preparation method of Erchen extract with antitumor activity and its preparation, which belongs to the technical field of traditional Chinese medicine pharmacy. Background technique [0002] Erchen Decoction originated from the "Daping Huimin Heji Bureau Prescription" in the Song Dynasty. It is composed of four traditional Chinese medicines: pinellia, tangerine peel, poria cocos and licorice. In the prescription, pinellia is the king, which is good at drying dampness and phlegm, and can reduce adverse events and harmonize the stomach, dissipate stagnation and eliminate swelling; tangerine peel is the minister, regulates qi and stagnation, dries dampness and eliminates phlegm, makes qi smooth and phlegm disappears; adjuvant with Poria cocos, expelling dampness and invigorating the spleen , with the source of Du Shengphlegm; with licorice as an adjuvant medicine, to reconcile the properties of the medicine and to invigorate the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8888A61K9/48A61P35/00
CPCA61K9/48A61K36/076A61K36/484A61K36/752A61K36/8888A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 陈华圣孙建许爱华夏子豪凌子成袁田宇
Owner YANGZHOU UNIV
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