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Method for preparing biomedical titanium and titanium alloy surface antibacterial coatings

A surface antibacterial, titanium alloy technology, applied in the direction of surface reaction electrolytic coating, metal material coating process, coating, etc., can solve the problems of silver content reduction, difficult antibacterial effect, etc., achieve high production efficiency, avoid bacterial infection, adaptable effect

Active Publication Date: 2012-10-31
NORTHWEST INSTITUTE FOR NON-FERROUS METAL RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, some existing studies adopt the method of reducing the concentration of silver salt incorporation, which greatly reduces the silver content entering the film layer, and it is difficult to form an effective antibacterial effect, especially after implant postoperative infection presents a certain periodicity and long-term nature. Too low silver content will not effectively solve these problems

Method used

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  • Method for preparing biomedical titanium and titanium alloy surface antibacterial coatings
  • Method for preparing biomedical titanium and titanium alloy surface antibacterial coatings
  • Method for preparing biomedical titanium and titanium alloy surface antibacterial coatings

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Step 1. Preparation of TiO on the surface of the medical pure titanium sample to be treated 2 Nanotube Precoat:

[0030] 101. Polish the medical pure titanium sample to be treated to the mirror surface, then ultrasonically clean the polished medical pure titanium sample with distilled water, acetone and absolute ethanol in sequence, and then vacuum dry the medical pure titanium sample after ultrasonic cleaning with absolute ethanol ;

[0031] 102. Completely immerse the medical pure titanium sample after vacuum drying in 101 in the 4 In the ethylene glycol aqueous solution of F, the anodic oxidation treatment was carried out under the condition of 50V constant potential for 1h; the said containing NH 4 The mass concentration of ethylene glycol in the ethylene glycol aqueous solution of F is 95%, and the NH 4 The mass concentration of F is 2%, and the balance is water;

[0032] Step 2, TiO 2 Nanotube pre-coating surface silver-loaded treatment:

[0033] 201. AgNO ...

Embodiment 2

[0042] Step 1. Preparation of TiO on the surface of the Ti6Al4V titanium alloy sample to be treated 2 Nanotube Precoat:

[0043] 101. Polish the surface of the medical Ti6Al4V titanium alloy sample to be treated to a mirror surface, then ultrasonically clean the polished medical Ti6Al4V titanium alloy sample with distilled water, acetone and absolute ethanol in sequence, and then clean the medical Ti6Al4V titanium alloy after ultrasonic cleaning with absolute ethanol. Alloy samples were dried in vacuum;

[0044] 102. Completely immerse the medical Ti6Al4V titanium alloy sample after vacuum drying in 101 in the ethylene glycol aqueous solution containing KF, and perform anodic oxidation treatment under 30V constant potential condition for 1h; the ethylene glycol aqueous solution containing KF The mass concentration of alcohol is 85%, the mass concentration of KF is 5%, and the balance is water;

[0045] Step 2, TiO 2 Nanotube pre-coating surface silver-loaded treatment:

[...

Embodiment 3

[0055] Step 1. Preparation of TiO on the surface of the Ti6Al7Nb titanium alloy sample to be treated 2 Nanotube Precoat:

[0056] 101. Polish the surface of the medical Ti6Al7Nb titanium alloy sample to be treated to a mirror surface, then ultrasonically clean the polished medical Ti6Al7Nb titanium alloy sample with distilled water, acetone and absolute ethanol in sequence, and then clean the medical Ti6Al7Nb titanium alloy after ultrasonic cleaning with absolute ethanol Alloy samples were dried in vacuum;

[0057] 102. Completely immerse the medical Ti6Al7Nb titanium alloy sample after vacuum drying in 101 in the 4 In the ethylene glycol aqueous solution of F and KF, under the condition of 40V constant potential, anodic oxidation treatment 4h; Said containing NH 4 The mass concentration of ethylene glycol in the ethylene glycol aqueous solution of F and KF is 90%, NH 4 The mass concentration of F is 2.5%, the mass concentration of KF is 2.5%, and the balance is water;

[...

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Abstract

The invention discloses a method for preparing biomedical titanium and titanium alloy surface antibacterial coatings. The method comprises steps of firstly, processing the surface of a biomedical titanium or titanium alloy sample to be processed, immersing the biomedical titanium or titanium alloy sample in a glycol aqueous solution containing soluble fluoride and performing an anode oxidation treatment; secondly, immersing the biomedical titanium or titanium alloy sample after being subjected to the anode oxidation treatment in a silver nitrate solution, taking out the biomedical titanium or titanium alloy sample, using ultraviolet light radiation to process the biomedical titanium or titanium alloy sample and obtaining the silver-carrying biomedical titanium or titanium alloy sample; and performing a micro-arc oxidation treatment for the silver-carrying biomedical titanium or titanium alloy sample, performing ultrasonic cleaning and vacuum drying and obtaining the antibacterial coatings. The nano precoating layer preparation, the silver-carrying treatment and a micro-arc oxidation technology are combined, then a large amount of silver can be fixed on the biomedical titanium and titanium alloy sample surfaces and can be released slowly for a long time, the antibacterial performance of titanium and titanium alloys is greatly improved, the antibacterial effect can be kept for a long time, and the bacterial infection caused by the fact that a titanium and titanium alloy apparatus is embedded in a human body is greatly reduced or avoided.

Description

technical field [0001] The invention belongs to the technical field of surface modification of surgically implanted titanium and titanium alloys, in particular to a method for preparing an antibacterial coating on the surface of medical titanium and titanium alloys. Background technique [0002] Due to their excellent biocompatibility, corrosion resistance and comprehensive mechanical properties, titanium and titanium alloys have gradually become the materials of choice for human hard tissue substitutes and restorations such as dental implants, orthopedic trauma products, and artificial joints. However, with the widespread application of medical titanium and titanium alloys, biomaterial centered infections (BCI) have become a very difficult clinical problem. It has been reported in the literature that the incidence of screw tract infection of titanium alloy implants is not the same, and the incidence of severe screw tract infection requiring hospitalization for antibiotic tr...

Claims

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Application Information

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IPC IPC(8): C23C28/00C25D11/26C23C18/42A61L27/06A61L27/30
Inventor 于振涛余森张强韩建业牛金龙刘春潮
Owner NORTHWEST INSTITUTE FOR NON-FERROUS METAL RESEARCH
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