Titanium alloy containing antibacterial coating as well as preparation method and application thereof

A technology of antibacterial coating and titanium alloy, which is applied in the direction of coating, metal material coating technology, prosthesis, etc., can solve the problems of complex processing equipment and high preparation cost, and achieve low preparation cost, promote application, and broad-spectrum antibacterial effect of ability

Inactive Publication Date: 2015-02-18
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In view of this, the object of the present invention is to provide a titanium alloy containing an antibacterial coating, the coating of this titanium alloy takes polydopamine as an intermediate layer, and utilizes polydopamine to reduce the adsorbed silver ions to silver nanoparticles in situ and fix them. On the surface of the substrate; the present invention also provides the preparation method and application of the titanium alloy, which overcomes the disadvantages of complex equipment and high preparation cost of the existing processing method

Method used

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  • Titanium alloy containing antibacterial coating as well as preparation method and application thereof
  • Titanium alloy containing antibacterial coating as well as preparation method and application thereof
  • Titanium alloy containing antibacterial coating as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The preparation method of the titanium alloy containing antibacterial coating is as follows:

[0032] 1. Pretreatment

[0033] Polish the titanium sheet with 400, 1000 and 2000 mesh sandpaper to a bright surface, and then use tap water, ethanol, and acetone to ultrasonically clean it for 10 minutes each time; after cleaning, put it in an oven at 60°C for drying. After drying, put the titanium sheet into a sterile tube, wrap it with newspaper, put it in a high-pressure sterilizer for 20 minutes, and then take it out and put it in an oven to dry for later use;

[0034] 2. Polydopamine deposition

[0035] Soak the titanium alloy treated in step (1) in 2 mg / mL dopamine hydrochloride solution for 12 hours to obtain a titanium alloy with a polydopamine film layer deposited on the surface;

[0036] 3. Nano silver coating preparation

[0037] The titanium alloy treated in step (2) was immersed in a 12.5mmol / L silver nitrate solution for 12 hours to obtain a titanium alloy wi...

Embodiment 2

[0039] The preparation method of the titanium alloy containing antibacterial coating is as follows:

[0040] 1. Pretreatment

[0041] With embodiment 1;

[0042] 2. Polydopamine deposition

[0043] Soak the titanium alloy treated in step (1) in a 5 mg / mL dopamine hydrochloride solution for 24 hours to obtain a titanium alloy with a polydopamine film layer deposited on the surface;

[0044] 3. Nano silver coating preparation

[0045] Immerse the titanium alloy treated in step (2) in a 5 mmol / L silver nitrate solution for 24 hours to obtain a titanium alloy with nano-silver antibacterial coating deposited on the surface.

Embodiment 3

[0047] The preparation method of the titanium alloy containing antibacterial coating is as follows:

[0048] 1. Pretreatment

[0049] With embodiment 1;

[0050] 2. Polydopamine deposition

[0051] Soak the titanium alloy treated in step (1) in a 10 mg / mL dopamine hydrochloride solution for 36 hours to obtain a titanium alloy with a polydopamine film layer deposited on the surface;

[0052] 3. Nano silver coating preparation

[0053] The titanium alloy treated in step (2) was immersed in a 100mmol / L silver nitrate solution for 36 hours to obtain a titanium alloy with a nano-silver antibacterial coating deposited on the surface.

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Abstract

The invention discloses a titanium alloy containing an antibacterial coating as well as a preparation method and application thereof. The titanium alloy deposited with nano-silver antibacterial coating on the surface is prepared by the following steps: preprocessing and sterilizing the surface of titanium alloy; then soaking the titanium alloy in a dopamine hydrochloride solution with mass-volume concentration of 1-10mg/mL for 12-36h to obtain titanium alloy deposited with a polydopamine thin film layer on the surface; and finally soaking the titanium alloy in a silver nitrate solution which is 5-100mmol/L in concentration for 12-36h. According to the titanium alloy disclosed by the invention, the titanium alloy is connected to silver nanoparticles by virtue of adhesion from self-polymerization of dopamine and adsorbed silver ions are reduced into nano-silver in situ through weak reducibility of the dopamine. Because of broad-spectrum antibacterial capacity of the nano-silver, an excellent antibacterial effect can be achieved with relatively low effect concentration. The invention provides new thinking for antibacterial modification of the titanium alloy, and can effectively promote application of a titanium alloy implant material in the fields of bone tissue repair and regeneration.

Description

technical field [0001] The invention belongs to the field of medical metal materials, and in particular relates to a titanium alloy containing an antibacterial coating and a preparation method and application thereof. Background technique [0002] Titanium alloy has excellent mechanical properties and corrosion resistance, and is widely used in orthopedics and dentistry as an excellent implant material. However, because the plaque on the surface of titanium alloy implants is easy to accumulate, the host immunity on the surface of the implant is poor, which makes it easy to cause bacterial infection after titanium alloy enters the human body. Bacterial adhesion and biofilm formation on the surface of implanted materials are the main pathological basis of its associated infection. Infection caused by the material interface often causes premature loosening and falling off of the implant, and leads to infection or even necrosis of adjacent tissues and organs, thus bringing pain...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C23C18/42B22F9/24B82Y40/00A61L27/06A61L27/54A61L27/28
Inventor 刘鹏赵永春
Owner CHONGQING UNIV
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