Antibacterial medical catheter and preparation method thereof

A medical catheter and antibacterial agent technology, applied in the field of antibacterial medical catheters and their preparation, can solve the problems of easily causing economic losses in medical accidents, easily multiplying bacteria, threatening the recovery of patients, etc. Effect

Inactive Publication Date: 2013-02-13
RESEARCH INSTITUTE OF TSINGHUA UNIVERSITY IN SHENZHEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] According to the clinical application experience of medical catheters at home and abroad, there is an important problem to be considered in the medical process of using medical catheters. The existing medical catheters lack strong antibacterial properties. I

Method used

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Examples

Experimental program
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Effect test

preparation example Construction

[0028] On the other hand, the present invention also provides the preparation method of above-mentioned antibacterial medical catheter, comprises the following steps:

[0029] Medical catheter surface treatment step: immerse the medical catheter in the surface treatment solution for 15 to 40 minutes, take it out and ultrasonically clean it with deionized water, and then dry it for use. This step is to modify the medical catheter, which can not only prolong the medical The service life of the catheter itself also makes it safer and more reliable during use;

[0030] Preparation of carrier solution steps: Soak the polymer masterbatch in absolute ethanol, then ultrasonically clean it with deionized water, then dry it for use, take the processed polymer masterbatch and organic solvent in grams: ml The mass volume ratio of 1:15~1:40 is completely dissolved to obtain the carrier solution. In this step, the organic solvent used is tetrahydrofuran, chloroform, acetonitrile, dimethylfo...

Embodiment 1

[0038] Embodiment 1--Preparation has the polyurethane medical conduit of silver-loaded antibacterial coating

[0039]Pretreatment steps for medical catheters: dissolve 7g of chromium trioxide in 500ml of distilled water, then add 65g of concentrated sulfuric acid with a concentration of 98% by mass, stir evenly in ice water at 0°C, and put the polyurethane medical catheters that need to be coated with antibacterial coating Immerse in the prepared solution for 30 minutes, stir at an appropriate speed, then ultrasonically clean the treated polyurethane medical catheter in deionized water for 0.5 hour, and then dry it at 60°C for use.

[0040] Preparation of carrier solution steps: Soak the polyurethane masterbatch in absolute ethanol for 3 hours, then ultrasonically clean it with deionized water for half an hour, and dry it at 60°C for later use; then take 5g of the treated polyurethane masterbatch and dissolve it at room temperature In 100ml of tetrahydrofuran, and stirred at a...

Embodiment

[0044] Embodiment 2--Preparation of PVC medical catheter with silver-loaded antibacterial coating

[0045] Medical catheter pretreatment steps: Dissolve 8g of chromium trioxide in 500ml of distilled water, then add 65g of concentrated sulfuric acid with a concentration of 98% by mass, stir evenly in ice water at 0°C, and dip the PVC medical catheter in the prepared solution After 30 minutes, stir at an appropriate speed, then ultrasonically clean the treated PVC medical catheter in deionized water for 0.5 hours, and dry it at 60°C for use.

[0046] Steps for preparing the carrier solution: Soak the polyvinylpyrrolidone masterbatch in absolute ethanol for 3 hours, then ultrasonically clean it with deionized water for half an hour, and dry it at 60 degrees Celsius for use. At room temperature, take 5g of the treated polyvinylpyrrolidone masterbatch and dissolve it in 150ml of chloroform (chloroform). Stir with a magnetic stirrer at a speed of 500 rpm until completely dissolved ...

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Abstract

The invention relates to an antibacterial medical catheter. The antibacterial medical catheter comprises a catheter body; an antibacterial coating is coated on inner and outer surfaces of the catheter body respectively and comprises an antibacterial agent and high polymer used as an antibacterial agent carrier, wherein the antibacterial agent accounts for 0.05 to 10 percent based on the total mass of the antibacterial coating. The invention also provides a preparation method for the antibacterial medical catheter. The method comprises the following steps of: treating the surface of a medical catheter; preparing a carrier solution; preparing an antibacterial solution, namely adding the antibacterial agent into the carrier solution, and stirring until a mixture is dispersed uniformly to obtain the antibacterial solution; forming a film, namely immersing the medical catheter of which the surface is treated in the antibacterial solution, and then lifting the medical catheter slowly to ensure that the antibacterial solution naturally flows along the surface of the medical catheter to form the uniform and smooth antibacterial coating; and drying. The antibacterial coating containing antibacterial components is deposited on the surface of the medical catheter and can effectively inhibit the growth of bacteria and exert the good antibacterial capacity for a long time.

Description

technical field [0001] The invention relates to the field of biomedical materials, more precisely, the invention relates to an antibacterial medical catheter and a preparation method thereof. Background technique [0002] With the development of the economy and the improvement of people's living standards, the level of medical care is also improving day by day. The emergence of new medical devices has greatly changed the traditional diagnosis and treatment and diagnosis modes, and has also greatly improved the level of medical treatment and the rehabilitation of patients' physical fitness and physiological functions after recovery. Among them, medical catheters have developed rapidly and have been widely used in the diagnosis and treatment of various diseases, or to perform some auxiliary medical operations. Some traditional diagnosis and treatment methods with complex operations, many complications and high risks have been fundamentally improved. [0003] According to the...

Claims

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Application Information

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IPC IPC(8): A61L29/10A61L29/08A61L29/16A61M25/02
Inventor 王明波佘振定谭荣伟
Owner RESEARCH INSTITUTE OF TSINGHUA UNIVERSITY IN SHENZHEN
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