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Method for preparing antimicrobial medical polymer material

A technology of polymer materials and plasma, which is applied in the field of preparation of medical polymer materials, can solve the problems of unsustainable antibacterial effect, poor binding force of antibacterial agents, poor antibacterial persistence, etc., and achieve enhanced binding force and stable surface structure , the effect of simple operation

Inactive Publication Date: 2012-11-21
TAIYUAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, under the action of body fluids, if the binding force between the antibacterial agent and the material is poor, the antibacterial layer is easy to fall off, making the antibacterial effect difficult to last.
For example, the patented silver-containing polyurethane urea solution (US2009253826-A1; CN101555349-A) and the patented deposition product composite material and its production process (Deposition Products, Composite Materials and Processes for the Production Thereof, US2008233161-A1) adopt the method of dip coating to Silver or silver compounds of various valences are coated on the surface of polymer materials, but a large amount of silver falls off into body fluids, resulting in poor antibacterial durability

Method used

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  • Method for preparing antimicrobial medical polymer material
  • Method for preparing antimicrobial medical polymer material
  • Method for preparing antimicrobial medical polymer material

Examples

Experimental program
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Effect test

Embodiment 1

[0036] Implement the preparation method of a kind of antibacterial medical polymer material provided by the present invention, this method adopts plasma-self-assembled monolayer film and electroless plating combination technology to prepare antibacterial medical polymer material, carry out according to the following steps:

[0037] Cut the silica gel sheet with a thickness of 0.05mm into a 5cm×5cm sheet, place it in acetone solution, a certain concentration of alkali solution, an acid solution, and deionized water for a certain period of ultrasonic cleaning, take it out and dry it for later use; after that, the pretreatment The final silica gel sheet is placed on the processing table of the vacuum chamber of the plasma equipment, sealed, and vacuumized to 6×10 0 Pa; Preheat for 10 minutes, and then inject 20.0 SCCM of helium to finally maintain the vacuum degree in the vacuum chamber at 10 Pa. Turn on the plasma source, keep its power at 50W, and the processing time is 10min; ...

Embodiment 2

[0040] The antibacterial medical polymer material is prepared by combining plasma-self-assembled monolayer film and electroless plating, including the following steps:

[0041] Cut the silica gel sheet with a thickness of 1mm into a 5cm×5cm sheet, place it in acetone solution, a certain concentration of alkali solution, an acid solution, and deionized water for a certain period of time, and then take it out and dry it for later use; The treated silica gel sheet is placed on the processing table of the vacuum chamber of the plasma equipment, sealed, and evacuated to 2×10 -1 Pa; preheat for 15 minutes, feed 40.0 SCCM of helium to maintain the vacuum degree in the vacuum chamber at 30 Pa; turn on the plasma source, keep its power at 100W, and process for 10 minutes; Inject air to restore the air pressure in the treatment table to atmospheric pressure, take out the treated silica gel sheet; configure a certain concentration of silane coupling agent solution, put the treated silica...

Embodiment 3

[0044] The antibacterial medical polymer material is prepared by combining plasma-self-assembled monolayer film and electroless plating, including the following steps:

[0045] Cut the PVC material with a thickness of 1mm into 2.5cm×2.5cm thin slices, place them in acetone solution, a certain concentration of alkali solution, acid solution, and deionized water for a certain period of time, and then take them out and dry them for later use; Place the pretreated PVC on the processing table of the vacuum chamber of the plasma equipment, seal it, and evacuate it to 6×10 0 Pa; preheating for 10 minutes, injecting 20.0 SCCM of helium, and finally maintaining the vacuum degree in the vacuum chamber at 30 Pa; turn on the plasma source, keep its power at 50W, and process for 20 minutes; after the treatment, turn off the power of the processing table, Introduce air to restore the air pressure in the treatment table to atmospheric pressure; take out the treated silica gel sheet; configur...

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Abstract

The invention relates to a method for preparing an antimicrobial medical polymer material, comprising the following steps: fixing a medical polymer material into a vacuum chamber of plasma equipment, vacuumizing, preheating, introducing gas, starting the power supply of a treating platform, treating to obtain a medical polymer material with high surface activity, grafting a silane coupling agent to the surface of the modified surface with hyperreactivity to form an SAM (self-assembled monolayer), and capturing silver ions in the solution by the SAM in the following electroless plating process to prepare an antimicrobial coating which has strong binding force relative to the matrix of the polymer material. The method is easy to operate, can not affect the physical and chemical properties of the material and ensure that the antimicrobial coating can be firmly combined with the matrix of the polymer material. The obtained antimicrobial medical polymer material has a stable surface structure and durable antibacterial properties.

Description

technical field [0001] The invention relates to a method for preparing a medical polymer material, in particular to a method for preparing an antibacterial medical polymer material by adopting a technology combining plasma-self-assembled monolayer film surface modification and electroless plating. Background technique [0002] Medical polymer materials are an important part of biomedical materials. With its excellent performance, diverse structures and wide adaptability, it has become a trend to gradually replace traditional materials in various medical device industries. At present, there are 12 kinds of medical polymer materials widely used in medical devices in the world, and nearly 300 kinds of medical implants and artificial organs have been developed and applied using existing biomedical materials. In recent years, the polymer materials consumed in medicine in western countries have been increasing at a rate of 10% to 20% per year, while the domestic market has also g...

Claims

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Application Information

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IPC IPC(8): C08J7/12C08L7/02C08L83/04C08L23/06C08L23/12C08L27/06C08L75/04C08L67/02C08L77/00C08L27/18
Inventor 郭睿劼沙晓娟侯文娟魏丽乔许并社
Owner TAIYUAN UNIV OF TECH
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