45results about How to "Guaranteed sterility requirements" patented technology

The invention discloses bacteriostat-free sodium hyaluronate eye drops and a preparation method thereof. The bacteriostat-free sodium hyaluronate eye drops comprise sodium hyaluronate, a pH regulator, an isotonic agent, a stabilizing agent, and the like; and the preparation method adopts a bacteria-free bottling process or an autoclaving process. In addition, the eye drops are independently packaged in disposable single dose, thereby the sterility performance of products is guaranteed and the products are more safe, reliable, simple, convenient, and sanitary.

The present invention discloses sodium cromoglicate eye drops which do not contain bacteriostat and a preparing method thereof, wherein the sodium cromoglicate eye drops comprise sodium cromoglicate, pH modifying agent, isoosmotic agent, stabilizing agent, thickening agent, algefacient, etc. The preparing method adopts an aseptic manipulation filling technique or hot pressing sterilizing technique. Furthermore the eye drops of the invention adopt a disposable single-dose independent packaging. The sterilized performance of product is guaranteed. The product is safer, more reliable, easier and more sanitary.

The present invention disclose a tropicamide eye drops without bacteria inhibitor and the preparation method thereof, which comprises tropicamide, pH regulating agent, isotonic agent and stabiliser etc. sterile operation loading process or heat pressing sterilizing process is adopted in the preparation, and disposable single dose independent packaging is used in the eye drop through the present invention, so that sterilized performance is guaranteed to make product more secure, reliable, sanitary, simple and convenient.

The invention belongs to the field of pharmaceutical preparations and provides levofloxacin single-dose eye drops. The levofloxacin single-dose eye drops comprise an active component, namely levofloxacin, an isotonic regulator selected from sodium chloride, disodium hydrogen phosphate and sodium citrate, a pH regulator selected from hydrochloric acid, sodium dihydrogen phosphate and citric acid, and water for injection. The invention further provides a preparation method of the single-dose eye drops. The levofloxacin single-dose eye drops prepared by the preparation method provided by the invention do not contain preservatives, so that potential danger and toxic and side effects to eyes caused by the preservatives are avoided, and the levofloxacin eye drops which are safer and more reliable are provided for patients.

The invention discloses copper-containing ferrite nanoparticles as well as a preparation method and antibacterial effect thereof. A structural formula of the copper-containing ferrite nanoparticles isCu0.5Fe<(II)>0.5Fe<(III)>2O4. 1/2 of ferrous iron in Fe3O4 nanoparticles is replaced with divalent copper, so that the electron coupling effect in the Cu0.5Fe<(II)>0.5Fe<(III)>2O4 is eliminated. Theobtained nanoparticles Cu0.5Fe<(II)>0.5Fe<(III)>2O4 have a very excellent antibacterial effect, can effectively avoid the progress of bacteria to drug-resistant bacteria, and have a wide application prospect.

The invention discloses instant compound oleum lithospermi dressing and a preparation method thereof. The dressing is prepared from the following components in parts by mass: 55-65 parts of radices lithospermi, 75-85 parts of polygonum cuspidatum, 2-8 parts of borneol, 40-60 parts of vitamin E oil, 1-3 parts of inositol hexaphosphate and 900-1100 parts of olive oil. The preparation method combinesthe negative pressure drying technology and micron sterilization technology, can be used for furthest ensuring efficient extraction of medicinal material and sterile requirement for later medicinal oil dressing.

The invention discloses an enclosed bioreactor. The enclosed bioreactor comprises a solution container, a collection container, a bioreaction tank, a liquid inlet pipeline and a liquid outlet pipeline, wherein the liquid inlet pipeline and the liquid outlet pipeline are provided with one four-way joint respectively. The invention further discloses a cell culturing method of the enclosed bioreactor. The cell culturing method comprises pre-culturing, bioreactor cell inoculation, bioreactor cell perfusion culture, bioreactor virus vaccination, bioreactor washing and replacement as well as bioreactor virus perfusion culture. By adopting the enclosed bioreactor, bioreactor perfusion culture can be realized, rapid liquid exchanging is realized, high-pressure cleaning is facilitated, repeated used is realized, the production cost is reduced, the pollution risk can be lowered, and the working efficiency is improved. By adopting the enclosed bioreactor and the cell culturing method thereof disclosed by the invention, the production operation of the bioreactor with a single pipeline in the existing method is substituted, and the aseptic requirement in vaccine production is effectively ensured. The enclosed bioreactor is easy and convenient to operate, and is suitable for fixed bed bioreactor large-scale culture.

The invention relates to the technical field of medicine preparations. The hydrochloric acid melphalan is very unstable in water, and a large amount of medicine degrades after several hours to generate impurities causing toxic or side effect, so the hydrochloric acid melphalan is not suitable for being prepared into medicine water solution to be stored for a long time. The invention provides stable hydrochloric acid melphalan injection liquid, which consists of hydrochloric acid melphalan, injection-use solvents and pH value regulating agents, wherein the injection-use solvents are anhydrous solvents obtained through dewatering treatment. The hydrochloric acid melphalan injection liquid of the invention has the advantages of stable preparation, low cost, autoclaving capability and small toxic or side effect.

The present invention provides a cultivation method of grifola frondosa. The cultivation method includes: step S1, proportioning of production materials; step S2, pretreatment of raw materials of a culture medium; step S3, mechanical agitation and bottling; step S4, sterilizing and cooling; step S5, inoculation; step S6, mycelium cultivation; and step S7, cultivation for fruiting, namely transferring a cultivation bottle for cultivating mycelia in step S6 into a cultivation room, and adjusting and setting parameters including illumination, temperature, humidity and carbon dioxide concentrationin the cultivation room to ensure that the mycelia in the cultivation bottle further complete growth until fruiting. By using the cultivation method of grifola frondosa, provided by the present invention, the yield of the grifola frondosa may be effectively increased, and the quality of a finished product of the grifola frondosa produced by using an existing cultivation technology may be remarkably improved, so that the cultivation method is very suitable for industrial popularization.

The invention discloses a method for utilizing mash waste heat during an alcohol production process. The method comprises the following steps: (1) pumping 80 DEG C liquid mash into a heat exchanger for heat exchanging; (2), pumping 80 DEG C liquid vinasse into a heat exchanger for heat exchanging; (3), leading 68 DEG C liquid mash and 68 DEG C liquid vinasse which are produced after heat exchanging out for the next process; and (4), mixing the recycled heat quantity, and leading the mixed heat quantity into a circulating cooling water system through an electric control system. According to the method, the 80 DEG C liquid mash and the 80 DEG C liquid vinasse produced during the alcohol production process are utilized; an HR waste heat recovery system which is domestic professional equipment is adopted; the part of heat quantity is recovered to produce 18 DEG C chilled water, so as to control the fermentation temperature to be 30 to 32 DEG C; not only the temperature controlling ensuring annual normal alcohol fermentation but also waste heat utilization are realized; the refrigeration cost is reduced; and the production benefit is improved stably.

The invention relates to a living body sampler of which a sampling head is replaceable. The living body sampler of which the sampling head is replaceable comprises a handheld frame, wherein a samplinginserting pipe is mounted on the handheld frame; a sampling inserting rod is mounted in the sampling inserting pipe; the sampling inserting pipe can move in an axial direction relative to the sampling inserting rod; the sampling head is mounted at the end of the sampling inserting rod in a replaceable manner; and the sampling head is provided with an accommodating space for accommodating tissue samples. According to the living body sampler of which the sampling head is replaceable disclosed by the invention, after each sampling is completed, the sampling head is replaced, so that the occurrence of the situation that cross-infection is generated between different living bodies is avoided; the replaced sampling head can be integrally put in a freezing vessel for storage, so that in the removing process, the sterile requirements are guaranteed, and an operator can easily collect the desired tissue samples; and the living body sampler is very practical.

The invention discloses a disposable integral midwifery drape. The disposable integral midwifery drape forms a sterile operation area for midwifery at the perineum of a puerpera; the sterile operation area is composed of a middle part arranged between the two legs and used for covering the perineum and leg protecting parts arranged on the two sides of the middle part and used for covering the legs; and the middle part and the leg protecting parts on the two sides are connected into a whole. The middle part comprises a belly protecting part covering the belly and a midwifery extending part covering the table top; the abdomen protecting part, the midwifery extending part and the leg protecting parts on the two sides define a sterile midwifery operation area at the perineum of the puerpera. The invention further relates to a folding method and the application of the drape. According to the paving towel, preparation of the whole paving towel can be completed only by opening the paving towel in several simple steps, and due to the overall design, the paved paving towel does not slip off; the leg is quickly and simply fixed and protected on the leg, so that the time for paving the towel is saved; and after the whole drape is folded, the drape surface layer is clamped in the drape block, so that the sterile requirement of the drape is ensured.