Carteolol hydrochloride eye drops without bacteriostatic agent and preparation method thereof
A technology of hydrochloric acid card and eye drops, which can be applied to medical preparations containing active ingredients, pharmaceutical formulations, drug delivery, etc., can solve problems such as high risk, save costs, avoid toxic and side effects, and ensure sterility requirements. Effect
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Embodiment 1
[0047] prescription:
[0048]
[0049] Its preparation method:
[0050] a. Accurately weigh 20.0 g of carteolol hydrochloride, 1.0 g of sodium dihydrogen phosphate, and 7.0 g of sodium chloride, add 200 mL of water for injection to dissolve, stir evenly, and dilute to 1000 mL with water for injection to obtain a liquid medicine.
[0051] b. Filter the above medicinal solution once with a 0.45 μm microporous membrane, and then filter twice through a 0.22 μm microporous membrane under a Class 100 environment.
[0052] c. After the medicinal liquid is tested and passed, fill 0.4mL of the above medicinal liquid into a 1mL single-dose packaging plastic container in a class 100 environment, and seal it to obtain the finished product.
Embodiment 2
[0054] prescription:
[0055]
[0056]Its preparation method:
[0057] a. Accurately weigh 20.0g carteolol hydrochloride, 6.4g sodium dihydrogen phosphate, 1.9g disodium hydrogen phosphate, 10.0g glycerin, add 200mL water for injection to dissolve, after stirring evenly, dilute to 1000mL with water for injection, get liquid medicine.
[0058] b. Filter the above medicinal solution once with a 0.45 μm microporous membrane, and then filter twice through a 0.22 μm microporous membrane under a Class 100 environment.
[0059] c. After the medicinal liquid is tested and passed, fill 0.4mL of the above medicinal liquid into a 1mL single-dose packaging plastic container in a class 100 environment, and seal it to obtain the finished product.
Embodiment 3
[0061] prescription:
[0062]
[0063] Its preparation method:
[0064] a. Accurately weigh 20.0g carteolol hydrochloride, 5.6g sodium dihydrogen phosphate, 2.8g disodium hydrogen phosphate, 17.0g glucose, add 200mL water for injection to dissolve, stir evenly, dilute to 1000mL with water for injection, get liquid medicine.
[0065] b. Filter the medicinal solution prepared above with a 0.45 μm microporous membrane once, and then through a 0.22 μm microporous membrane once.
[0066] c. The filtered medicinal solution is sterilized at 121° C. for 8 minutes by autoclaving, and then cooled.
[0067] d. After the medicinal liquid is tested and passed, fill 0.4mL of the above medicinal liquid into a 1mL single-dose packaging plastic container in a class 100 environment, and seal it to obtain the finished product.
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