The invention belongs to the technical field of medical devices, and discloses a puncture part pressing device for cardiovascular intervention operation. The puncture part pressing device is providedwith a base, fixing holes, a first bracket, a limb placing groove, a second bracket, a second threaded clamping pin, a third bracket, a third threaded clamping pin, a cross beam, a slider, a connecting block, a rubber bag, a column-shaped cotton ball, an air inlet hole, an air pipe, an inflating pump, a first telescopic rod, a second telescopic rod, a third telescopic rod and a first threaded clamping pin; the base is fixedly connected with the first telescopic bracket, and the limb placing groove is fixedly connected to the top of the first telescopic bracket; the cross beam is fixedly connected to the second bracket and the third bracket; the slider is mounted on the cross beam, the connecting block is fixedly connected to the lower part of the slider, the rubber bag is connected insidethe connecting block in a hollow manner, and the rubber bag is adhered to the column-shaped cotton ball. For the whole device provided by the invention, the artificial pressing which is time-saving and labor-saving is saved, meanwhile, the structure setting is simple, the operation is convenient, and the column-shaped cotton ball capable of being replaced is more sanitary.