High-barrier medical film

Abstract

The invention relates to a high-barrier medical film which is prepared from five layers of resin materials through coextrusion, wherein the first layer is a heat sealing layer as an inner layer A and comprises the components of high-melting-point metallocene polypropylene and ethylene-octene copolymer (EOC) through mixing, and the addition quantity of the EOC in the mixture is 10%-30%; the second layer is a barrier layer as a secondary inner layer B and comprises the component of cycloolefin copolymer; the third layer is a core layer as an intermediate layer C and comprises the components of polypropylene and styrene-ethylene-butylene-styrene (SEBS) through mixing, and the addition quantity of the SEBS in the mixture is 20%-40%; the fourth layer is an adhesion layer as a secondary outer layer D and comprises the component of anhydride modified polypropylene copolymer; and the fifth layer is a weather-proof layer as an outer layer E and comprises the component of a segmented copolymer of polyethylene naphthalate and polyethylene terephthalate. A soft bag made of the medical film has good barrier performance, optical performance and safety performance, and is especially suitable for being used as a packaging material of therapeutic transfusions, nutrition transfusions, powder injections and small-volume injections.

Description

technical field [0001] The invention relates to a medical film made of polymer material, more specifically a high-barrier medical film, which can be used as the packaging material for injection medicine, replacing PVC infusion film, glass bottle, plastic bottle, and ordinary non-PVC infusion film , ampoules and vials. technical background [0002] At present, most of the infusion packages used in hospitals in our country are glass bottles, and there are also very few plastic bottles, PVC infusion films, and ordinary non-PVC infusion film packages. Because glass bottles or plastic bottles are rigid, air must be added to make the liquid instilled smoothly. Microorganisms (mycobacterium tuberculosis, SARS virus, etc.) and dust in the air can easily contaminate the medicine, and microorganisms can cause cross-infection. Block the capillaries with a thickness of several microns, cause thrombus, and seriously cause phlebitis and pulmonary arteritis, which will have a huge impact ...

AI Technical Summary

Problems solved by technology

The main disadvantages of PVC infusion film are: (1) PVC infusion film contains polyvinyl chloride monomer, which is not conducive to human health

(2) In the production process of PVC infusion film, plasticizer (DEHP) is added to change its performance. During its use, DEHP may be dissolved. DEHP is a harmful substance and can release estrogen. Exposure to DEHP may cause reproductive system Dysplasia, seriously endangering human health

(3) PVC infusion membrane has poor heat resistance, and the disinfection temperature can only be controlled below 110°C. If the temperature rises, the bag will easily deform and burst, which cannot meet the sterility guarantee requirements (F 0 <12) (sterilization standard stipulated in the Chinese Pharmacopoeia), it is also easy to cause the deterioration of the drug and the pyrogen reaction of the patient

(4) During the storage of the medicines packed in the PVC infusion film, part of the liquid medicine may react with the PVC infusion film, causing the medicine to deteriorate and cannot be used. In addition, the PVC infusion film will adsorb the medicine and reduce the efficacy.

(5) The permeability of PVC infusion film to oxygen and water vapor is extremely large, and the barrier property is very poor, so the validity period of the packaged medicine is only 3 months

(6) After the PVC infusion film is burned, it will form hydrochloric acid, which will cause respiratory damage to humans and animals and corrosion of buildings. In addition, it will easily produce dioxins when burned, which will have a profound impact on the environment.

[0003] Ordinary non-PVC infusion membranes have a high permeation rate of oxygen and water vapor, so they cannot be used in nutritional infusions, plasma substitute infusions, therapeutic infusions, etc., resulting in a very low market share for the above-mentioned infusion solutions, which cannot meet people's needs in health care and treatment. need

Internationally, only Polysinian of Germany and Sealed Air of the United States produce this kind of high-barrier infusion membrane, but so far there is no domestic enterprise that can produce high-barrier infusion membrane

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