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Preparation method of copper-iron oxide and mixed nanoparticles and antibacterial application

A copper-iron oxide and nanoparticle technology, which is applied in the fields of botanical equipment and methods, chemical instruments and methods, and applications, can solve the problems of toxicity of human cells, and achieve the effects of low toxicity, high sterilization efficiency, and rapid sterilization ability.

Active Publication Date: 2019-08-02
赵奕平 +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In summary, the existing problems in the prior art are: the existing silver nanoparticles or copper oxide nanoparticles are toxic to human cells

Method used

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  • Preparation method of copper-iron oxide and mixed nanoparticles and antibacterial application
  • Preparation method of copper-iron oxide and mixed nanoparticles and antibacterial application
  • Preparation method of copper-iron oxide and mixed nanoparticles and antibacterial application

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Embodiment Construction

[0033] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0034] The present invention now passes the cuprous oxide (Cu 2 O), iron oxide (Fe 2 o 3 ) and copper iron oxide (CuFeO 2 ) nanoparticles (called Cu x Fe y o z NPs) have high antibacterial activity against many Gram-positive and negative bacteria. The material can also inhibit the growth of bacteria in the growth medium. Cytotoxicity assays on mouse fibroblasts showed that these nanoparticles were less toxic to mammalian cells at low working concentrations (≤1 mg / ml).

[0035] The application principle of the present invention will be described in detail below in conjunction with the accompanying drawings.

[0036...

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Abstract

The invention belongs to the technical field of preparation of nanoparticles, and discloses a preparation method of copper-iron oxide and mixed nanoparticles and an antibacterial application. Cu(NO3)2.3H2O and Fe(NO3)3.9H2O in a certain ratio are dissolved in deionized water; a NaOH solution is dropwise added to the mixture under continuous stirring condition; formaldehyde is added to the mixture,the obtained solution is transferred into a SiC reaction tube and subjected to a reaction in a microwave chamber, and copper-iron oxide and mixed nanoparticles are produced; after cooling, a synthesized sample is centrifuged and washed with deionized water; the collected sample is placed in a drying oven and dried overnight. An experiment indicates that the nanoparticles have efficient antibacterial performance on at least nine important human pathogenic bacteria, for example, the nanoparticles can kill escherichia coli at a 10<9>-log reduction speed within 15 min; after incubation is performed for 4 h, about 10<8>-log reduction of klebsiella pneumoniae strains with multidrug resistance is realized .

Description

technical field [0001] The invention belongs to the technical field of nanoparticle preparation, and in particular relates to a preparation method and antibacterial application of copper iron oxide and mixed nanoparticle. Background technique [0002] Currently, the state of the art in the industry is that infectious disease is the second leading cause of death in the world (and third in the United States) and the leading cause of disability-adjusted life years globally. Infections caused by bacteria, including those caused by Salmonella, E. coli or Shigella, make up a large proportion of infectious diseases. For example, recent outbreaks of Listeria infection in ham and Salmonella infection in ground beef have seen Penicillin and other antibiotics essential to treating infections caused by the bacteria, but increased antibiotic resistance that has been observed in many pathogens has become a very serious public health problem. Even if resistance is not a factor limiting t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N59/20A01N59/16A01P1/00B01J23/745C02F1/72A61K33/34A61K9/12A61P31/04A61P17/02A61L15/18A61L15/46A61L31/08A61L31/16A61K33/26C02F101/30C02F101/34C02F101/38
CPCA01N59/20A01N59/16B01J23/745B01J23/002C02F1/725C02F1/72A61K33/34A61K33/26A61K9/12A61K9/0014A61P31/04A61P17/02A61L15/18A61L15/46A61L31/088A61L31/16C02F2101/308C02F2101/34C02F2101/38C02F2101/40C02F2305/023A61L2300/102A61L2300/404A61L2300/606B01J35/39A61K2300/00Y02A50/30
Inventor 赵奕平朱露
Owner 赵奕平
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