Chloromycetin eyedrops without bacteriostatic agent and preparation method thereof

A technology of chloramphenicol and eye drops, which is applied to medical preparations containing active ingredients, antibacterial drugs, pharmaceutical formulations, etc., can solve problems such as high risk, save costs, avoid potential risks, and ensure no The effect of bacteria requirements

Inactive Publication Date: 2009-06-24
HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Especially for eye drops that need to be used frequently, the potential danger is greater

Method used

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  • Chloromycetin eyedrops without bacteriostatic agent and preparation method thereof
  • Chloromycetin eyedrops without bacteriostatic agent and preparation method thereof
  • Chloromycetin eyedrops without bacteriostatic agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] prescription:

[0046]

[0047] Its preparation method:

[0048] a. Accurately weigh 2.5g of chloramphenicol, 16.0g of boric acid, and 2.0g of borax, add 200mL of water for injection to dissolve, stir evenly, and dilute to 1000mL with water for injection to obtain a medicinal solution.

[0049] b. The above medicinal liquid is filtered once with a 0.45 μm microporous membrane, and then filtered twice with a 0.22 μm microporous membrane under a class 100 environment.

[0050] c. After the medicinal liquid is tested and passed, fill 0.4mL of the above medicinal liquid into a 1mL single-dose packaging plastic container in a class 100 environment, and seal it to obtain the finished product.

Embodiment 2

[0052] prescription:

[0053]

[0054]

[0055] Its preparation method:

[0056]a. Accurately weigh 2.5g of chloramphenicol, 12.0g of boric acid, 0.6g of borax, and 2.2g of sodium chloride, add 200mL of water for injection to dissolve, stir and mix, and dilute to 1000mL with water for injection to obtain a liquid medicine.

[0057] b. Filter the medicinal solution prepared above with a 0.45 μm microporous membrane for one time, and then with a 0.22 μm microporous membrane for one time.

[0058] c. The filtered medicinal solution is sterilized at 121° C. for 8 minutes by autoclaving, and then cooled.

[0059] d. After the medicinal liquid is tested and passed, fill 0.5mL of the above medicinal liquid into a 1mL single-dose packaging plastic container in a class 100 environment, and seal it to obtain the finished product.

Embodiment 3

[0061] prescription:

[0062]

[0063] Its preparation method:

[0064] a. Accurately weigh 2.5g chloramphenicol, 4.0g sodium dihydrogen phosphate, 4.7g disodium hydrogen phosphate, 4.2g sodium chloride, 1.0g sodium hyaluronate, add 250mL water for injection to dissolve, stir and mix, and use water for injection Dilute to 1000mL to obtain liquid medicine.

[0065] b. Filter the medicinal solution prepared above with a 0.45 μm microporous membrane for one time, and then with a 0.22 μm microporous membrane for one time.

[0066] c. The filtered medicinal solution is sterilized at 121° C. for 8 minutes by autoclaving, and then cooled.

[0067] d. After the medicinal liquid is tested and passed, fill 0.8mL of the above medicinal liquid into a 1mL single-dose packaging plastic container in a class 100 environment, and seal it to obtain the finished product.

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PUM

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Abstract

The invention discloses bacteriostat-free chloromycetin eye drops and a preparation method thereof. The bacteriostat-free chloromycetin eye drops comprise chloromycetin, a pH regulator, an isotonic agent, a stabilizing agent, a thickening agent, and the like; and the preparation method adopts bacteria-free bottling process or autoclaving process. In addition, the eye drops are independently packaged in disposable single dose, thereby the sterility performance of products is guaranteed and the products are more safe, reliable, simple, convenient, and sanitary.

Description

technical field [0001] The invention belongs to the field of pharmacy, in particular to chloramphenicol eye drops without bacteriostatic agent and a preparation method thereof. Background technique [0002] Chloramphenicol eye drops are used to treat eye infections such as trachoma, conjunctivitis, corneal inflammation, blepharitis, etc. Chloramphenicol eye drops that have been on the market all contain antibacterial agents and are packaged in multiple doses for repeated use. Once the preparation is opened, it is easy to be contaminated by tears and microbes in the air during use and storage, thereby causing safety hazards. In order to prevent ophthalmic preparations from being contaminated by microorganisms during repeated use after opening, bacteriostatic agents (preservatives) are added to ophthalmic preparations, which are used in almost all eye drop prescriptions in the "Chinese Hospital Preparation Specifications" antibacterial agent. Bacteriostatic agents, also kn...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/165A61P27/02A61P31/04
Inventor 姚军
Owner HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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