2 results about "Naphazoline Hydrochloride" patented technology

The application belongs to the field of pharmaceutical preparations and discloses a soothing pharmaceutical preparation and a preparation method thereof. The preparation method comprises the following steps: firstly, preparing synthetic naphazoline hydrochloride by using compound 1 containing a cyano group, wherein a composite solvent composed of toluene and ethyl acetate is used for condensation reaction in the synthesis process, and dilute hydrochloric acid is used for salt formation; secondly, preparing synthetic pheniramine maleate by using compound 2 containing a halogen group and compound 3 containing a cyano group, wherein a weak base catalyst is used for condensation reaction in the synthesis process; finally, adding functional additives, naphazoline hydrochloride and pheniramine maleate into water, stirring and dissolving, and filling to obtain the soothing pharmaceutical preparation, wherein the pH of the soothing pharmaceutical preparation is 5.7-6.3. The soothing pharmaceutical preparation prepared by the above method can effectively avoid the adverse influence of impurities in naphazoline hydrochloride and pheniramine maleate on the soothing effect.

The invention belongs to the field of medicinal preparations, and discloses a medicinal soothing preparation and a preparation method thereof.The preparation method comprises the following steps that firstly, naphazoline hydrochloride is prepared and synthesized through a cyano-containing compound 1, a compound solvent formed by mixing methylbenzene and ethyl acetate is adopted for condensation reaction in the synthesis process, and a compound 2 is obtained; carrying out salt forming reaction by adopting diluted hydrochloric acid; the method comprises the following steps: firstly, synthesizing pheniramine maleate from a compound 2 containing a halogen group and a compound 3 containing a cyano group, and carrying out condensation reaction by using a weak base catalyst in the synthesis process; and finally, adding the functional additive, naphazoline hydrochloride and pheniramine maleate into water, stirring for dissolving, and filling to obtain the medicinal soothing preparation with the pH value of 5.7-6.3. The medicinal soothing preparation prepared by the method can effectively avoid adverse effects of impurities in naphazoline hydrochloride and pheniramine maleate on the soothing effect of the medicinal soothing preparation.