41 results about "Naphazoline Hydrochloride" patented technology

The present invention discloses a naphazoline hydrochloride, chlorphenamine maleate and vitamin B12 eye drops which do not contain bacteriostat and a preparing method thereof, wherein the naphazoline hydrochloride, chlorphenamine maleate and vitamin B12 eye drops comprise naphazoline hydrochloride, chlorphenamine maleate, vitamin B12, pH modifying agent, isoosmotic agent, stabilizing agent, thickening agent, etc. The preparing method adopts an aseptic manipulation filling technique. Furthermore the eye drops of the invention adopt a disposable single-dose independent packaging. The sterilized performance of product is guaranteed. The product is safer, more reliable, easier and more sanitary.

The invention provides a method for measuring the high efficiency liquid chromatography by the content of triamcinolone acetonide chloramphenicol solution, which can simultaneously measuring the content of three active ingredients comprising acetic acid triamcinolone acetonide, chloramphenicol and naphazoline hydrochloride. The method is characterized in high accuracy, good specificity, high sensitivity, easy operation and low cost. Compared with the prior art, the content measuring method provided in the invention not only increases the method for controlling the content of the naphazoline hydrochloridem but also brings a better effect of each component separation and more sensitive and accurate measuring which can avoid the complicated and time-consuming operation, less specificity and no content measuring of the naphazoline hydrochloride prescribed in the active standard, and guarantees the advancement and accuracy of the quality standard, thus further effectively ensure the safe and effective use of the medicine for the people.

The invention discloses a contact lens care solution, and relates to the technical field of care solutions. The preparation method of the contact lens care solution comprises the steps that sodium citrate, sodium pyrrolidonecarboxylate, sodium chloride and deionized water are heated according to the proportion in a formula by 45 DEG C, even mixing is conducted for dissolution, polyhexamethylene guanidine, alga active enzymes, N-[3-(dimethylamino)propyl]myristamide and naphazoline hydrochloride are slowly added at the speed of 70-85 revolutions / min, chrysanthemum flower extract, vitamin B6 and fructus lycii essence are added then, evenly mixing is conducted for 5-10 min, after the mixture is placed at room temperature for 10-12 h, the solution is loaded into a sterile eye drop bottle, inspection is conducted, and the contact lens care solution is put in storage. The contact lens solution comprises multiple natural ingredients, toxic and side effects on human bodies do not exist, on the premise that the good moisturizing and antibacterial effects are guaranteed, asthenopia is relieved, eye nourishing is achieved, wearing comfort is kept, and lipid and protein sediments on contact lenses can be effectively removed; due to the fact that naphazoline hydrochloride is added, the care solution has the effect of resisting hyperemia of the eyes.

The invention discloses a compound rupatadine bioadhesion nasal gel product and a preparation method. The compound rupatadine bioadhesion nasal gel product is characterized by being prepared from, 10-100 parts of rupatadine and salts thereof, 5-20 parts of xylometazoline hydrochloride / naphazoline / pseudoephedrine hydrochloride, 1-4 parts of furacilin, 300-5000 parts of polymer gel materials, 2-200 parts of a biological adhesive, 180-200 parts of a buffer salt, 800-1600 parts of a wetting agent and 20000 parts of sterile water for injection. The wetting agent is dissolved into 2 / 3 of the sterile water for injection to obtain a solution A; the polymer gel material is stirred and added into the solution A to obtain a gel system B; the biological adhesive is dispersed into the gel system B to obtain a gel system C; the rupatadine and salts thereof, the xylometazoline hydrochloride / naphazoline / pseudoephedrine hydrochloride, the furacilin and the buffer salt are successively added into 1 / 3 of the sterile water for injection, and sonication is performed to obtain a solution D; the solution D is dispersed into the gel system C, and stirring is performed to obtain the final product.

The invention relates to a nasal drop for treatment of acute and chronic rhinitis, sinusitis and allergic rhinitis and a preparation method thereof. The nasal drop comprises neomycin sulfate, chlorpheniramine maleate, naphazoline hydrochloride, auxiliary ingredients and solvents. Specifically, per 1000ml of the nasal drops comprise 0.975-5 million units of neomycin sulfate, 0.3-1.0g of chloropheniramine maleate and 0.3-1.0g of naphthozoline hydrochloride. The nasal drop provided by the invention has anti-bacterial, anti-inflammation and anti-allergy effects, at the same time can constrict blood vessels and improve the nasal obstruction symptom caused by rhinitis, is atraumatic, and has the characteristics of easy carrying, convenient use, quick action, shortening of the course of disease,good patient compliance, and high cure rate, and has good efficacy on acute and chronic rhinitis, sinusitis and allergic rhinitis and the like. The preparation method of the nasal drop provided by theinvention has the advantages of simple and feasible processing technology and good repeatability, and is convenient for industrial production.

The invention discloses a compound asparticitin gutta and making method, which comprises the following parts: aspartic acid, vitamin B6, glycyrrhizin dipotassium, naphazoline hydrochloride, neostigmine methylsulfate, maleic chlorobenzenenamin, polysorbate 80, sodium chloride, menthol, benzachloridamine, sodium hydroxide solution and injecting water. The invention paves basis for scaling manufacturing of the compound asparticitin gutta further, which improves the productivity with stable content of maleic chlorobenzenenamin.

The invention provides nasal spray for treating allergic rhinitis. The nasal spray comprises cromolyn sodium, naphazoline hydrochloride, chlorpheniramine maleate and a pharmaceutically acceptable excipient selected from a buffering agent, an osmotic pressure regulator, an absorption enhancer, a pH regulator and the like. Active ingredients in the preparation can take effect rapidly by being rapidly adsorbed through mucosa of nasal cavity. The nasal spray has the advantages of high bioavailability, high compliance, convenience in carrying and use, and the like.

The invention relates to separation and detection methods for related substances in naphazoline hydrochloride, chlorphenamine maleate and vitamin B12 eye drops, and belongs to the field of pharmaceutical analysis. The separation method comprises the following steps of: injecting the naphazoline hydrochloride, chlorphenamine maleate and vitamin B12 eye drops into a high performance liquid chromatograph, and carrying out separation under the following conditions: a chromatographic column is a C8 or C18 chromatographic column; the mobile phase comprises a mobile phase A and a mobile phase B, themobile phase A is disodium hydrogen phosphate, and the mobile phase B is an alcohol compound and / or acetonitrile; and the elution time and the volume content of the mobile phase B in the elution timeare as follows: 0-25 min, 18%-20%; 25-70 min, 20%-45%; 70-80 min, and 45%; 80-85 min, and 45%-18%. The separation method can be used for separating related substances corresponding to three effectivecomponents in the naphazoline hydrochloride, chlorphenamine maleate and vitamin B12 eye drops. The detection method comprises the following steps of: taking the naphazoline hydrochloride, chlorphenamine maleate and vitamin B12 eye drops as a test solution, preparing reference solutions, respectively carrying out chromatographic detection on the test solution and the reference solutions, and calculating the content of each related substance according to a recorded chromatogram. The detection method can be used for rapidly and accurately detecting the contents of related substances correspondingto the three effective components in the naphazoline hydrochloride, chlorphenamine maleate and vitamin B12 eye drops.

The invented naristillae is composed of naphazoline hydrochloride nose drop 3-8 ml. contianing 0.1% naphazoline hydrochloride, lincomycin hydrochloride solution 2-6 ml. containing 0.6-1.8 gm licomycin hydrochloride, prednisolone aectate solution 1-5 ml. containing prednisolone acetate 25-125 mg. Advantages include: apparent therapeutic effect quick action, easy to use it, no recurrence etc.

The invention provides a pharmaceutical composition for treating rhinitis, which comprises sodium cromolyn, naphazoline hydrochloride and chlorpheniramine maleate. The composition is a spray, and the active ingredient in the preparation can be quickly absorbed through the nasal mucosa to take effect quickly, and has the advantages of high bioavailability, good compliance, convenient carrying and use, and the like.

The invention provides a sodium cromoglycate, naphazoline hydrochloride and chlorpheniramine maleate nasal spray for treating allergic rhinitis. The sodium cromoglycate, naphazoline hydrochloride and chlorpheniramine maleate nasal spray comprises sodium cromoglycate, naphazoline hydrochloride, chlorpheniramine maleate, and pharmaceutically acceptable excipients, wherein the pharmaceutically acceptable excipients are selected from a buffering agent, an osmotic pressure regulator, a preservative, an absorption enhancer, a pH (Power of Hydrogen) regulator and the like. According to the sodium cromoglycate, naphazoline hydrochloride and chlorpheniramine maleate nasal spray, the active ingredients can be quickly absorbed through mucosa of nasal cavity and then acts quickly; the sodium cromoglycate, naphazoline hydrochloride and chlorpheniramine maleate nasal spray has the advantages of high bioavailability, outstanding compliance, and convenience in carrying and use, etc.