Copper-containing ferrite nanoparticles as well as preparation method and antibacterial effect thereof

A nanoparticle, copper-iron technology, applied in the medical field of nanomaterials, can solve the problems of limited antibacterial effect and inhibition, achieve excellent antibacterial effect, simple synthesis process, and wide application prospects

Pending Publication Date: 2020-10-16
GANNAN MEDICAL UNIV +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, pure Fe3O4 nanoparticles (Fe 3 o 4 NPs) due to the presence of The electronic coupling effect makes Fe 2+ Oxidation activity is inhibited
Therefore, pure Fe 3 o 4 The antibacterial effect of NPs is very limited

Method used

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  • Copper-containing ferrite nanoparticles as well as preparation method and antibacterial effect thereof
  • Copper-containing ferrite nanoparticles as well as preparation method and antibacterial effect thereof
  • Copper-containing ferrite nanoparticles as well as preparation method and antibacterial effect thereof

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Embodiment 1

[0033] 1. Preparation and identification of copper-containing ferrite nanoparticles Cu@Fe NPs of the present invention.

[0034] CuCl 2 , FeCl 2 , FeCl 3 Dissolve in 100ml of water so that the concentration of CuCl is 0.1mM 2 , 0.1mM FeCl 2 , 0.4mM FeCl 3 , and add 500mg polyvinylpyrrolidone (K40), mix well to get Cu 2+ , Fe 2+ , Fe 3+ Cu-Fe precursor solution with a molar ratio of 1:1:4. Dissolve NaOH in a three-necked round-bottomed flask filled with 100mL of deionized water, so that the concentration of NaOH is 1.6mM, and add 500mg of polyvinylpyrrolidone (K40), and mix evenly at a speed of 800rpm to 1200rpm. Heat to 85°C to 90°C. according to figure 1 As shown, assemble the condenser tube B, flask A, thermometer C and syringe D on the iron stand, and put the copper-iron precursor solution into the flask under the condenser tube. When the temperature of the NaOH solution reaches 85°C to 90°C, use a syringe to add the copper-iron precursor solution dropwise at a r...

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Abstract

The invention discloses copper-containing ferrite nanoparticles as well as a preparation method and antibacterial effect thereof. A structural formula of the copper-containing ferrite nanoparticles isCu0.5Fe<(II)>0.5Fe<(III)>2O4. 1/2 of ferrous iron in Fe3O4 nanoparticles is replaced with divalent copper, so that the electron coupling effect in the Cu0.5Fe<(II)>0.5Fe<(III)>2O4 is eliminated. Theobtained nanoparticles Cu0.5Fe<(II)>0.5Fe<(III)>2O4 have a very excellent antibacterial effect, can effectively avoid the progress of bacteria to drug-resistant bacteria, and have a wide application prospect.

Description

Technical field: [0001] The invention belongs to the medical field of nanomaterials, and in particular relates to a copper-containing ferrite nanoparticle, a preparation method thereof and antibacterial effect. Background technique: [0002] Reactive oxygen species (Reactive Oxygen Species, ROS) is a general term for a class of molecules with oxidative activity produced by cells in energy metabolism under aerobic conditions, including hydroxyl radicals (OH), superoxide anions (O - ) and hydrogen peroxide (H 2 o 2 )Wait. ROS has dual activities: under physiological conditions, an appropriate amount of ROS can promote immunity, repair, survival and growth, etc. When ROS generation exceeds the scavenging capacity of the antioxidant system, ROS will cause oxidative damage to cell lipids, proteins and DNA, and even lead to cell death. Therefore, ROS play a very important role in the physiological and pathological development of bacteria. [0003] Studies have shown that most...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/34A61P31/04A61P31/02A01N59/20A01N59/16A01P1/00C01G49/00B82Y5/00B82Y30/00
CPCA61K33/34A61P31/04A61P31/02A01N59/20A01N59/16C01G49/0018B82Y5/00B82Y30/00C01P2002/72C01P2004/04C01P2004/64C01P2004/80C01P2004/82
Inventor 田原僮陈冠宇陈智鹏钟毅段少峰
Owner GANNAN MEDICAL UNIV
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