Dragon blood nano medicament crystallized preparation and preparation method thereof

A technology of nano-drug crystallization and dried blood, which can be used in drug combinations, pharmaceutical formulations, antipyretics, etc., can solve the problems of inability to meet the bioavailability of treatment requirements, difficult to prepare preparations for intravenous administration, and limited drug application. , to achieve the effect of improving bioavailability, reducing administration volume and enhancing therapeutic effect

Inactive Publication Date: 2012-07-18
TAISHAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the insolubility of drugs has become one of the main obstacles in the research and development of new drugs and the improvement of pharmacological activity. The traditional preparation method often cannot meet the bioavailability required for treatment after oral administration, or it is difficult to make preparations for intravenous administration. This greatly limits the application of the drug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Preparation of dried blood nanomedicine crystal preparation, formula quantity: dried dried blood 0.5g, poloxamer 188 0.5g, polyvinyl alcohol 0.1g, absolute ethanol 2g.

[0036] Preparation Process:

[0037] (1) Dissolve 0.5 g of dried blood in 2 g of absolute ethanol, and apply it under 300-600w ultrasound for 5 minutes to disperse the dried dried blood to form a uniform solution A;

[0038] (2) Dissolving 0.5g poloxamer 188 and 0.1g polyvinyl alcohol in 100ml double distilled water to obtain solution B;

[0039] (3) Add solution A to solution B, and under the low temperature condition of 4°C, disperse it uniformly through ultrasonic treatment with a power of 600w for 15 minutes, and apply the uniformly dispersed dried blood suspension on a high-speed shearing machine at 20000rpm Disperse at low temperature for 2 minutes, and disperse 5 times to obtain a uniform suspension system C;

[0040] (4) Homogenize 5 times at 500 bar and 1000 bar with a high-pressure homogenizer...

Embodiment 2

[0042] Preparation of dried blood nanomedicine crystal preparation, formula quantity: blood dried blood 2g, glyceryl monostearate 1.0g, hydroxypropyl methylcellulose 0.5g, polyethylene glycol 400 2g.

[0043] Preparation Process:

[0044] (1) Dissolve 2 g of dried blood in 2 g of polyethylene glycol 400, and apply it under 300-600w ultrasound for 5 minutes to disperse the dried blood to form a uniform solution A;

[0045] (2) 1.0g glyceryl monostearate and 0.5g hydroxypropyl methylcellulose were dissolved in 100ml double distilled water to obtain solution B;

[0046] (3) Add solution A to solution B. Under the low temperature condition of 4°C, disperse it evenly through ultrasonic treatment with a power of 800w for 20 minutes, and apply the uniformly dispersed dried blood suspension on a high-speed shearing machine at 20000rpm Disperse at low temperature for 2 minutes, and disperse 5 times to obtain a uniform suspension system C;

[0047] (4) Homogenize 5 times at 500 bar an...

Embodiment 3

[0049] A lyophilized preparation of dried blood nanomedicine was prepared, and the formula quantity was: 0.5 g of dried blood, 0.5 g of poloxamer 188, 0.1 g of polyvinyl alcohol, and 2 g of absolute ethanol.

[0050] Preparation Process:

[0051] (1) Dissolve 0.5g of dried blood in 2g of absolute ethanol, and apply it under 300-600w ultrasound for 5 minutes to disperse the dried blood to form a uniform solution A;

[0052] (2) Dissolving 0.5g poloxamer 188 and 0.1g polyvinyl alcohol in 100ml double distilled water to obtain solution B;

[0053] (3) Add solution A to solution B, and under the low temperature condition of 4°C, disperse it uniformly through ultrasonic treatment with a power of 600w for 15 minutes, and apply the uniformly dispersed dried blood suspension on a high-speed shearing machine at 20000rpm Disperse at low temperature for 2 minutes, and disperse 5 times to obtain a uniform suspension system C;

[0054] (4) Homogenize 5 times at 500 bar and 1000 bar resp...

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PUM

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Abstract

The invention discloses a dragon blood nano medicament crystallized preparation and a preparation method thereof, and relates to the field of medicinal preparation, and contains a dragon blood, a stabilizing agent and a mixed solvent, wherein the stabilizing agent contains a surfactant and a suspending agent, and the weight ratio of each component is as follows: the dragon blood 0.01-5.0g; the surfactant 0.01-2.0 g; the suspending agent 0.002-1.0 g; the mixed solvent 0.01-5.0g. The preparation technology of the dragon blood nano medicament crystallized preparation has the advantages of easy enlargement, simple prescription, improved medicament stability after freeze drying and reduced administration volume; the medication is prepared into an oral nanometer crystallized suspension for improving bioavailability, reducing administration dosage and saving resource effectively.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a dried blood nanomedicine crystal preparation and a preparation method thereof. Background technique [0002] Dried blood, also known as dried unicorn, is one of the famous and precious traditional Chinese medicines. It has been recorded and applied in Chinese medicine for more than 1,500 years. It has the effects of promoting blood circulation and removing blood stasis, removing putrefaction and promoting muscle growth, stopping bleeding and astringent, reducing swelling and relieving pain, etc. It is known as the holy medicine for promoting blood circulation in "Compendium of Materia Medica". Modern medical research has proved that dried blood has the functions of improving microcirculation, adjusting metabolism, and enhancing immune function. Blood stasis and many other aspects have significant effects, so that blood dried blood has broad application prospects in t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/889A61K36/896A61K9/10A61K9/19A61P29/00A61P7/04A61P17/02
Inventor 郝吉福王晓丹郭丰广王建筑李菲毕研平
Owner TAISHAN MEDICAL UNIV
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