80results about How to "Rapid reconstitution" patented technology

The invention relates to a freeze-dried powder injection of L-oxiracetam and a process for preparing the freeze-dried powder injection. The freeze-dried powder injection comprises, by weight, 1 part of the L-oxiracetam, 0.1 to 10 parts of an excipient, 0.01 to 1 part of an antisticking agent and 0.01 to 0.5 part of a pH regulator, wherein polyethylene glycol (PEG) series of products serve as the antisticking agent preferably. The freeze-dried powder injection which is prepared on the basis of a prescription according to the process has the advantages of being short in freeze-drying time, attractive in appearance, short in redissolving time and high in stability.

The invention relates to a ceftizoxime sodium drug injection powder and a preparation method thereof, as well as a synthetic method of bulk drug ceftizoxime sodium. The ceftizoxime sodium drug injection powder consists of 100% ceftizoxime sodium, wherein the ceftizoxime sodium is pretreated, and the pretreatment is aseptic refining and/or grinding. The ceftizoxime sodium drug has the advantages of high purity, almost no impurity, better and more stable quality, better clarity and the like; and the synthetic method of bulk drug ceftizoxime sodium has lower bulk cost, less synthesis technology difficulty, mild reaction condition, stable and reliable yield and quality, and high purity and yield of products.

The invention discloses a preparation method of a human coagulation factor VIII. The human coagulation factor VIII prepared by the method does not contain human serum albumin or other animal-derived protein, does not contain sugar or sugar alcohol, does not have the risk for transmitting other viruses or pathogene, and is wide in applicable crowd scope, and can be used by diabetic patients; the human coagulation factor VIII prepared by the method is fast to redissolve and good in redissolving effect, and still keeps high titer and high specific activity which are respectively larger than 80 percent and 40 IU/mg; in addition, the preparation method is simple, the cost is low, the human coagulation factor VIII is safe and effective, and has a good industrial application prospect.

The invention relates to a cefodizime sodium proliposome preparation and a preparation method thereof. The proliposome preparation comprises cefodizime sodium, egg yolk lecithin, cholesterol, antioxidant and supporting agent, wherein the cefodizime sodium proliposome preparation comprises the following components by weight portion: 1 to 20 portions of the cefodizime sodium, 5 to 50 portions of the egg yolk lecithin, 3 to 30 portions of the cholesterol, 0.5 to 20 portions of the antioxidant and 3 to 50 portions of the supporting agent.

A fosaprepitant dimeglumine freeze-dried preparation prepared by adopting the invention has the characteristics of porosity, stable quality, high redissolution speed, good clarity and the like. The invention provides a preparation method of a fosaprepitant dimeglumine freeze-dried preparation for injection, which comprises the following steps: (A) pre-freezing: firstly, cooling a fosaprepitant dimeglumine injection to (-12)-(-14) DEG C, and freezing through temperature oscillation; and then, cooling to (-32)-(-35) DEG C, and oscillating and freezing for 42-62 minutes; (B) sublimating: vacuumizing in a box body until the air pressure is 12-17 Pa, heating a product to (-35)-(-37) DEG C, and preserving the temperature for 8-10 hours; and intermittently injecting nitrogen gas, oscillating for 1-1.5 hours by taking air pressure (17-22 Pa) in the box body as an amplitude, heating the product to (-25)-(-29) DEG C, and preserving the temperature for 15-18 hours; and (C) drying: gradually heating the medicament to 38-42 DEG C, and preserving the temperature for 1-2 hours.

The invention relates to an adenine arabinoside monophosphate freeze-dried powder injection and a preparation method thereof. The freeze-dried powder injection is formed by freeze-drying an adenine arabinoside monophosphate drug solution. The adenine arabinoside monophosphate drug solution comprises 100g of adenine arabinoside monophosphate, 25g of mannitol, 3g of disodium hydrogen phosphate, 0.3gof monosodium orthophosphate, 1g of disodium ethylene diamine tetraacetate and 2,000ml of water for injection. The freeze-drying process in the preparation method comprises pre-freezing, sublimationand heating for drying. Compared with the common water injections in the prior art, the freeze-dried powder injection and the preparation method thereof have obvious advantages on storage and transportation.

The invention relates to the field of pharmacy, in particular to a terlipressin acetate injection and a preparation method thereof. The preparation method of the terlipressin acetate injection comprises the following steps that a terlipressin acetate freeze-dried powder injection and a sodium chloride solution with the pH of 3.0 to 4.0 are mixed to obtain the injection, wherein after a medicine solution is subjected to staged pre-freezing, staged first drying and staged second drying are conducted in sequence. By means of the reparation method of the terlipressin acetate injection, the eruption phenomenon can be effectively improved, moreover, the fact that the prepared terlipressin acetate freeze-dried powder injection is good in stability, intact in sample appearance and capable of fastredissolving is guaranteed, meanwhile, the sodium chloride solution with the pH of 3.0 to 4.0 is adopted for redissolving, the injection stability is improved, and the safety and the effectiveness ofclinical medication are guaranteed.

The invention discloses a preparation method of a vitamin complex freeze-dried powder injection. The method comprises the following steps of: weighing 12 types of vitamins; adding a part of principle medicaments into polysorbate 80, stirring for dissolving, adding 40 percent water for injection and stirring for dissolving; adding the remaining principle medicaments into the solution, stirring for dissolving and replenishing water for injection to 80 percent of the total amount of the water for injection; measuring the pH of the solution and filtering by using a filter membrane; pre-freezing, namely, lowering the temperature of the injection to 15 DEG C below zero and oscillating and refrigerating at the temperature of between 6 DEG C below zero and 15 DEG C below zero; lowering the temperature to 33 DEG C below zero and 35 DEG C below zero and oscillating and refrigerating at the temperature of between 25 DEG C below zero and 35 DEG C below zero for 40 to 60 minutes; performing sublimation drying; drying once again; and gradually raising the temperature of a medicament to 40 DEG C and preserving heat for 1 to 2 hours. A product prepared by the method has full appearance, looseness, high dissolubility, quick re-dissolution, high clarity and high stability.

The invention discloses a freeze-drying and dry heat treatment protecting agent for human coagulation factor VIII. The freeze-drying and dry heat treatment protecting agent for human coagulation factor VIII does not contain human serum albumin or other animal-source proteins, sugar or sugar alcohol, is composed of soluble salt, amino acid and a surface active agent, is free from the risk of spreading other viruses or causative agents, and is applicable to a wide crowd range, including diabetics; after being freeze-dried, a product of the human coagulation factor VIII using the protecting agent is quick in redissolving and has a good redissolving effect, still keeps high potency and high specific activity, and has the potency higher than 80 percent and the specific activity higher than 40 IU/mg; in addition, the freeze-drying and dry heat treatment protecting agent for human coagulation factor VIII is low in cost, simple to prepare, has an obvious protecting effect, is safe and effective, and has an excellent industrial application prospect.

The invention relates to an acyclovir lyophilized formulation for injection and a preparation method of the acyclovir lyophilized formulation. The acyclovir lyophilized formulation for injection comprises acyclovir, sodium hydroxide, mannitol and a pH value stabilizing agent, wherein the weight ratio of the acyclovir to the mannitol is 1;(1-10). The acyclovir lyophilized formulation is advanced in prescription and good in product formability; the solution before being frozen is clear in appearance; the lyophilized product is good in solubility; and the re-dissolved solution is good in clarity, low in impurity content, good in stability and controllable in quality.

The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a taxol freeze-dried powder preparation containing an excipient and a preparation method of the taxol freeze-dried powder preparation. The preparation takes taxol as a medicinal active ingredient and mPEG-PLA-lysine as a matrix and contains the excipient; and the excipient is selected from one or more of lactose, mannitol, dextran, glycine and glucose. The preparation method comprises the following steps: (1) mixing mPEG-PLA-lysine with taxol; (2) fully dissolving the mixture by using an organic solvent; (3) removing the organic solvent; (4) adding water for hydration to form a micellar liquid; and (5) adding the excipient of which the weight is not more than 5% of the total weight of the fed materials in the step (1) into the drug-loaded micellar liquid, dissolving the excipient fully, and then performing freeze-drying on the mixed micellar liquid according to a conventional freeze-drying process, thereby obtaining the taxol freeze-dried powder preparation. The preparation method provided by the invention is simple; the formula is simple, and the safety is high; and the freeze-dried powder preparation is good in solubility, can be re-dissolved quickly in water, has a relatively small average particle size after re-dissolution, and can give play to an ERP effect more easily.

The invention belongs to the technical field of medicinal preparations, and relates to an excipient-free lyophilized paclitaxel powder preparation and a preparation method thereof. The lyophilized paclitaxel powder does not contain excipients, adopts paclitaxel as a medicinal effective component, and adopts mPEG- PLA-glutamic acid as a matrix. The preparation method is simple; the excipient-free lyophilized paclitaxel powder preparation adopts mPEG-PLA-glutamic acid with low cytotoxicityas as a carrier, and other auxiliary components are not needed, so the preparation has simple formula and high safety; the excipient-free lyophilized paclitaxel powder preparation has good solubility in water, and can be rapidly re-dissolved in water; and the re-dissolved lyophilized paclitaxel powder preparation has small average particle size, and easily performs an ERP effect.