6results about How to "Rapid reconstitution" patented technology

The invention discloses an iron protein succinate solid dispersion and a preparation method thereof, and belongs to the technical field of medicines. The solid dispersion is prepared from iron protein succinate and a solid dispersion matrix, wherein the solid dispersion matrix is polyethylene glycol or hydroxyethyl starch. The solid dispersion provided by the invention only adopts the iron protein succinate and the solid dispersion matrix as raw materials, and by adjusting the ratio of the iron protein succinate to the solid dispersion matrix, the dispersion has the following advantages: no preservative is added; few types of safe auxiliary materials are used in the prescription; the preparation is formed into a soluble solid form and is convenient to take and carry; the requirements on safety and compliance of pregnant women and infants are met; the adverse reaction of constipation caused by an iron supplement is reduced; the preparation method is easy to implement. The solid dispersion provided by the invention also has the characteristics of no obvious rust flavor and no irritation to the mouth and the tongue; the stability of the dispersoid and the stability of particles prepared from the dispersoid are equivalent to those of commercially available iron protein succinate oral solutions.

The invention discloses a protective agent for detecting freeze drying of an enzyme preparation at a constant temperature and application of the protective agent, and belongs to the technical field of freeze drying, the protective agent is formed by mixing saccharides, polymers and amino acid according to the weight ratio of 5: 2: 1; the saccharides comprise the following raw materials in percentage by weight: 75-100% of trehalose and 0-30% of maltose; the polymer is prepared from the following raw materials in percentage by weight: 0 to 100 percent of polyethylene glycol and 0 to 100 percent of polyvinylpyrrolidone; the amino acid is glycine. The invention also discloses an application of the protective agent in detecting freeze drying of the enzyme preparation at a constant temperature, the application comprises the following steps: protein solution pretreatment and freeze drying, and the freeze drying is divided into three stages: pre-freezing, sublimation drying and desorption drying. The method finally solves the technical problem that the constant-temperature detection enzyme preparation depends on temperature in transportation and storage, the storage and transportation cost is reduced, and the storage life of the constant-temperature detection enzyme preparation product is prolonged.

This application relates to the technical field of bioassay, specifically disclosing a combined detection kit for pepsinogen I and pepsinogen II and its application. The disclosed combined detection kit for pepsinogen I and pepsinogen II includes: a sample pad, a conjugate pad, a coating membrane, and an absorbent pad; the coating membrane is an NC membrane coated with antibody; the conjugate pad is prepared by pretreating and drying a fiber membrane, followed by spraying time-resolved fluorescent microspheres labeled with antibody; the pretreating solution is a solution of pH 8.0-8.4 + 8-12mM BS + 0.8-1.2% BSA + 0.8-1.2% PEG4000 + 0.02-0.03% surfactant + 4-6% sucrose. Using the detection kit and method provided in this application for the combined detection of pepsinogen I / pepsinogen II exhibits high sensitivity, accuracy, and repeatability.

The invention relates to the technical field of biological products, in particular to a preparation method of a myocardial marker composite quality control substance, which comprises the following steps: firstly, treating serum to prepare a quality control substance matrix liquid, further testing the concentration of myocardial markers in the quality control substance matrix liquid, screening out low-concentration-value human serum and high-concentration-value human serum, and determining the concentration of the myocardial markers in the quality control substance matrix liquid. Selecting a positive myocardial marker pure product to prepare a myocardial marker substance control solution without pure product addition and a myocardial marker substance control solution with pure product addition, synthesizing the corresponding myocardial marker substance control solution, adding disodium hydrogen phosphate dodecahydrate and sodium dihydrogen phosphate dihydrate, adjusting the pH value, sequentially adding corresponding elements, and uniformly mixing to obtain the myocardial marker substance. According to the myocardial marker substance control substance provided by the invention, the matrix effect in different detection methodologies can be effectively reduced; the stability of a detection result can be remarkably improved, and the preparation method has the characteristics of good stability and uniformity, high redissolution speed, low viscosity, small matrix effect and simplicity and convenience in preparation.

The invention belongs to the field of pharmaceutical preparations, and particularly relates to a cetrorelix acetate preparation composition for injection and a preparation method thereof.According to the preparation composition, through a specific freeze-drying process including a slow freezing stage, an annealing stage, primary drying and secondary drying, it is effectively guaranteed that the in-batch quality uniformity of a preparation is good, and the long-term stability is excellent; and industrial mass production is facilitated.

The application relates to the tobacco essence and flavor preparation technical field, in particular to a fenugreek extract freeze-dried powder and a preparation method and application thereof. The application is prepared by reverse osmosis coupling low-temperature vacuum concentration on fenugreek seeds, and then freeze-drying to obtain the fenugreek extract freeze-dried powder. The freeze-dried powder can be directly used as a tobacco fenugreek flavor, or can be used by being dissolved in a solvent to obtain a tobacco fenugreek flavor. The reverse osmosis coupling low-temperature vacuum concentration and freeze-drying technology adopted by the method can separate and concentrate ethanol and most of the water, so that the concentration time is shortened, and the overall time of flavor preparation is further reduced; meanwhile, the process can maximally reduce the volatilization loss of heat-sensitive flavor substances, and effectively retains the aroma components in the fenugreek.