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Spectinomycin hydrochloride and lincomycin hydrochloride freeze-dried powder injection and preparation method of spectinomycin hydrochloride and lincomycin hydrochloride freeze-dried powder injection

A technology of lincomycin hydrochloride and spectinomycin hydrochloride, which is applied in freeze-drying transportation, powder transportation, pharmaceutical formulations, etc., can solve the problems of poor drug stability and high production costs, achieve drug stability, keep pH unchanged, and reduce The effect of production costs

Inactive Publication Date: 2017-02-22
LESHAN RECONDEX BIOPHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The invention provides spectinomycin hydrochloride, lincomycin hydrochloride freeze-dried powder injection and preparation method thereof, which solves the problems of high industrial production cost and poor drug stability in the prior art

Method used

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  • Spectinomycin hydrochloride and lincomycin hydrochloride freeze-dried powder injection and preparation method of spectinomycin hydrochloride and lincomycin hydrochloride freeze-dried powder injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1 (taking spectinomycin hydrochloride as mass ratio benchmark),

[0026] component name Material name mass ratio spectinomycin hydrochloride spectinomycin hydrochloride 1 Lincomycin Hydrochloride Lincomycin Hydrochloride 1 freeze-dried proppant lactose 1 Antioxidants sodium bisulfite 0.1

[0027] Wherein, the solid content in the solution after constant volume in step (2) is 15%, the antioxidant content in the solution after constant volume in step (2) is 0.5wt%, and the volume of water for injection in step (1) is controlled at 5mL~20mL.

Embodiment 2

[0028] Embodiment 2 (taking spectinomycin hydrochloride as mass ratio benchmark),

[0029] component name Material name mass ratio spectinomycin hydrochloride spectinomycin hydrochloride 4 Lincomycin Hydrochloride Lincomycin Hydrochloride 4 freeze-dried proppant lactose 10 Antioxidants sodium bisulfite 1

[0030] Wherein, the solid content in the solution after constant volume in step (2) is 15%, the antioxidant content in the solution after constant volume in step (2) is 0.5wt%, and the volume of water for injection in step (1) is controlled at 5mL~20mL.

Embodiment 3

[0031] Embodiment 3 (taking spectinomycin hydrochloride as mass ratio benchmark),

[0032] component name Material name mass ratio spectinomycin hydrochloride spectinomycin hydrochloride 4 Lincomycin Hydrochloride Lincomycin Hydrochloride 2 freeze-dried proppant lactose 4 Antioxidants sodium bisulfite 0.5

[0033] Wherein, the solid content in the solution after constant volume in step (2) is 15%, the antioxidant content in the solution after constant volume in step (2) is 0.5wt%, and the volume of water for injection in step (1) is controlled at 5mL~20mL.

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Abstract

The invention relates to a spectinomycin hydrochloride and lincomycin hydrochloride freeze-dried powder injection and a preparation method of the spectinomycin hydrochloride and lincomycin hydrochloride freeze-dried powder injection, and solves the problems of high cost of industrial production and low drug stability in the prior art. The preparation method comprises the steps of firstly preparing a freeze-dried propping agent and antioxidant mixed solution, then preparing a to-be-freeze-dried sample of spectinomycin hydrochloride and lincomycin hydrochloride, and finally preparing the white loose block or powder spectinomycin hydrochloride and lincomycin hydrochloride freeze-dried powder injection in a freeze drying box. According to the spectinomycin hydrochloride and lincomycin hydrochloride freeze-dried powder injection and the preparation method of the spectinomycin hydrochloride and lincomycin hydrochloride freeze-dried powder injection, the drug stability and the bioavailability are high, and the industrial production is realized.

Description

technical field [0001] The invention relates to spectinomycin hydrochloride and lincomycin hydrochloride freeze-dried powder injections and a preparation method thereof, belonging to the technical field of veterinary drug preparation. Background technique [0002] At present, spectinomycin hydrochloride and lincomycin hydrochloride are used as injections or soluble powders on the market. Spectinomycin hydrochloride and lincomycin hydrochloride have poor oral absorption effect, low bioavailability, and have special smell and taste. It affects the feed intake of animals, which in turn affects the therapeutic effect. The injection has good absorption effect, high bioavailability, wide tissue distribution and rapid onset of effect when used by injection. Become worse, the potency of spectinomycin hydrochloride in the liquid medicine, the pH value drops rapidly, and the color deepens and becomes dark yellow. [0003] In the prior art, CN101829082B discloses a preparation method ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K47/26A61K31/357A61K31/7056
CPCA61K9/19A61K9/0019A61K31/357A61K31/7056A61K47/26A61K2300/00
Inventor 王莉田刚李竹张天洋赵强
Owner LESHAN RECONDEX BIOPHARM CO LTD
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