13 results about "Throat swab sample" patented technology

The present invention provides a throat swab sampling device, comprising: a sampling head device for fixing and carrying a throat swab, a transfer platform for connecting the throat swab sampling device and an external component, and a sampling motion device for driving the sampling head device to move; the sampling motion device includes a housing, a fixed platform, a turntable motor installed between the fixed platform and the transfer platform, two side plates installed on the fixed platform, a rotating shaft installed between the two side plates, a cross beam installed on the rotating shaft, a tension spring installed between the fixed platform and the cross beam, a lead screw motor installed on the fixed platform, a top wheel installed at the front end of the lead screw of the lead screw motor, and an anti-rotation device installed on the fixed platform; the present invention is used to avoid infection between medical staff and the person being sampled during throat swab collection, improve the safety of throat swab collection; and meet the requirements of automation, lightweight, rapidity of collection action, collection comfort and safety, etc.

The utility model relates to the technical field of sampling devices, and discloses a disposable throat swab sampling device which comprises a main pipe, one side of the main pipe is connected with an extension pipe in a sliding mode, the surface of one side, away from a sampling screen, of a supporting seat is fixedly connected with a plurality of second teeth, and the surfaces of the second teeth are provided with an adjusting mechanism used for adjusting the sampling screen. Two third storage grooves are symmetrically formed in the surface of the side, away from the sampling screen, of the extension tube, restraining mechanisms used for restraining the extension tube are arranged in the two third storage grooves, a first storage groove is formed in the surface of the side, away from the extension tube, of the main tube, and a throat swab is slidably connected into the first storage groove; two first restraining grooves are symmetrically formed in the first containing groove, and limiting mechanisms used for limiting the throat swab are arranged in the two first restraining grooves. Through the arrangement of the extension tube, the infection probability of a sampler can be reduced.

The application discloses a throat swab sampling robot control system and method, the system comprises a main control module, a hardware control module, a visual control module and a comprehensive control module which are sequentially connected in communication; the main control module is used for receiving the visual tracking message sent by the visual control module, sending the prompt and running state message to the comprehensive control module, and interacting with the hardware control module to execute the instruction information; the hardware control module is used for interacting with the visual control module to sample the information of the mechanism, and delivering the voice playing information to the comprehensive control module; the visual control module is used for delivering the voice playing or text image prompt information to the comprehensive control module, and receiving the visual tracking activation message sent by the comprehensive control module, the flexibility and the expandability of the throat swab sampling robot are increased, and various uncertain problems possibly occurring in the sampling process can be intelligently coped with.

The invention provides a method for directly amplifying pathogens in a throat swab sample, which comprises the following steps of: preparing a throat swab sample nucleic acid releasing agent from NP-40, Tris-base, EDTA (Ethylene Diamine Tetraacetic Acid), Chelex-100 and KCl, collecting the throat swab sample in normal saline during direct amplification, fully oscillating, taking 1mL of the throat swab sample, centrifuging 12,000 g of the throat swab sample for 10 minutes, discarding supernatant, retaining precipitate, adding 100 microliters of the throat swab sample nucleic acid releasing agent according to claim 1, shaking for 30-60 seconds by hand, and detecting the pathogens in the throat swab sample. And standing for 1-2 minutes to obtain a nucleic acid template for PCR (Polymerase Chain Reaction) detection. The method greatly simplifies the nucleic acid purification process of a clinical sample, greatly shortens the detection time, and has the advantages of low cost and convenience in use.

The invention relates to the technical field of cell sampling, discloses a throat swab sampling device for infectious diseases, and aims to solve the problem that sampling operation is affected by oral closure and droplet pollution of a patient. Through the arrangement of the supporting piece and the tooth clamping piece, the supporting piece is used for supporting the oral cavity of a patient, meanwhile, the tooth clamping piece is used for fixing the relative position of the oral cavity of the patient and the supporting piece, the phenomenon that the oral cavity of the patient is closed is not likely to happen, in addition, spittle diffusion of the patient is limited through the supporting piece, spittle of the oral cavity of the patient can only move from the inner side of the supporting piece; through the action, the probability that the spittle pollutes a detector or a mechanical arm is reduced.

The disclosure provides a throat swab loaded with a reticular MOF black phosphorus nanocomposite for SERS detection and a preparation method thereof, the throat swab is composed of a throat swab sampling cotton swab and a reticular MOF coated sheet-shaped black phosphorus, the reticular MOF coated sheet-shaped black phosphorus is coated on the head of the throat swab sampling cotton swab; the foam hole density of the head of the throat swab sampling cotton swab is 300 ppi; the reticular MOF has a pore size of 200-300 nanometers and a nanoscale gap structure on the surface; the sheet-shaped black scale has a diameter of 1000-5000 nanometers; the black phosphorus has good biocompatibility with the reticular MOF, the throat swab sampling cotton swab is used as a bearing matrix, and the throat swab is simple to make and low in cost, and the open reticular foam structure of the throat swab is helpful for complete release of a sample into a culture solution, and a large number of protruding structures on the surface of the throat swab can further enhance the Raman signal of an adsorbed molecule.

The invention relates to influenza A and B virus nucleic acid detection primers and a kit, and belongs to the technical field of biological detection. The method aims at solving the problems that an existing virus detection method is long in consumed time, low in sensitivity, prone to pollution and incapable of adapting to automation. The primer, the fluorescent probe, the internal standard primer and the probe are designed for specific conserved regions of the influenza A virus and the influenza B virus, and the enzyme dosage, the primer and probe concentration and the like are optimized. The method is adaptive to automatic detection, operation transfer and aerosol pollution are reduced, and operation is simple, convenient and time-saving; the sensitivity of influenza A throat swab sample detection is 100%, the specificity is 99.65%, the sensitivity of influenza B detection is 100%, the specificity is 99.66%, cross reaction is avoided, and rapid and accurate detection is achieved.

The present disclosure provides a chameleon-like self-growing throat swab sampling robot, comprising: a robot body, formed by pneumatic self-growth of flexible material, with an internal channel connected to the atmosphere formed therein, which grasps and releases the throat swab according to the change in the gripping length of the throat swab through this internal channel; a drive storage mechanism connected to the front end of the robot body, which is used to store the flexible material required for the growth of the robot body and provide power for its growth and recovery; a pneumatic artificial muscle located on the surface of the robot body, which is used to control the position of the robot end; and an end actuator located at the end of the robot body, which includes a recovery structure and a data acquisition module. The recovery structure guides the flexible material through rolling friction to assist in the recovery of the robot body. The present disclosure imitates the chameleon's "aim-launch-swallow-withdraw" hunting process and fully utilizes the flexibility and transmission characteristics of the self-growing robot to achieve rapid and safe collection of throat swabs.

The application belongs to the technical field of biological detection, and particularly relates to an isothermal amplification detection reagent and kit for detecting varicella-zoster virus (VZV). The application designs a specific primer pair with a target of a conservative region of an ORF62 of a VZV genome, performs RPA reaction, combines a modified detection probe, and uses lateral flow chromatography test paper to realize a detection sensitivity of not higher than 1 copy / µL for a crude extract of a vesicle fluid or throat swab sample, realize rapid and high-sensitivity detection, and has good popularization and application value.

The present disclosure relates to the technical field of automatic sampling manipulators, and provides a throat swab sampling device, which includes a mounting part, a fixed part, and a movable part; one side of the mounting part is provided with a connection portion for connecting to an external device; the fixed part is fixedly connected to the other side of the mounting part through at least a first sensor and a second sensor; the movable part is connected to the side of the fixed part facing away from the mounting part through an elastic movable component, and a clamping mechanism for clamping the swab is provided on the other opposite side of the movable part; the first sensor and the second sensor are spaced apart on opposite sides of the fixed part, and can detect the pressure and / or tension between the fixed part and the mounting part; the elastic movable component can be compressed and deformed to drive the movable part and the swab to move parallel or tilted toward the fixed part. The throat swab sampling device can realize automatic and flexible collection of oral swabs, ensuring that the person being collected is safer and more comfortable during the collection process.

The application relates to a swab unpacking device and a throat swab sampling robot. The swab unpacking device is used for taking out swabs in a swab connected package, the swab connected package comprises a plurality of sequentially connected packaging bags, and the swab unpacking device comprises a rack, a cutting station arranged on the rack, a cutting mechanism configured to cut the packaging bag located at the cutting station, a conveying mechanism configured to convey the swab connected package so that the packaging bag in the swab connected package moves to the cutting station along a first direction, and an ejection mechanism comprising a first driving member and an ejecting member connected with the driving member, wherein the first driving member is configured to drive the ejecting member to move along a second direction so as to eject the swab in the packaging bag at the cutting station and cut by the ejecting member. The swab unpacking device in the application can replace manual work to complete the swab unpacking work, and can release medical staff from the heavy and tedious unpacking work, thereby reducing the work burden of the medical staff.

The invention relates to novel coronavirus nucleic acid detection primers and a kit, and belongs to the technical field of biological detection. The kit provided by the invention comprises a PCR (Polymerase Chain Reaction) premixed solution; positive control; performing negative control; specific primers and probes of the ORF1ab gene and the N gene of the SARS-CoV-2 virus as well as enzymes and auxiliary components required by RNA (Ribonucleic Acid) reverse transcription and DNA (Deoxyribose Nucleic Acid) amplification are covered in the PCR premixed solution. According to the kit disclosed by the invention, a one-tube PCR premixed solution, RNA reverse transcription and DNA amplification are carried out under the same system, the operation is extremely simple, convenient and time-saving, the kit can adapt to automatic detection, the transfer operation and aerosol pollution risks are effectively avoided, and the novel coronavirus RNA of various mutation types as low as 180 copies / mL can be detected within 60 minutes. The sensitivity of the kit for detecting a throat swab sample is 98.59%, and the specificity is 100%.

This invention relates to the field of sampling device technology, and in particular to a throat swab sampling robot and sampling method. The throat swab sampling robot includes a housing, an actuator, and a user operating unit. The actuator is housed within the housing, and the user operating unit includes a ventilation hood. The spaces within the ventilation hood and the housing are independently configured, connected by a perforation. The ventilation hood is equipped with an exhaust device to maintain a negative pressure environment and a collection port for extending a swab. During sampling, the user's mouth needs to be aligned with the collection port. The actuator picks up the swab and moves it to the collection port for sampling. The exhaust device maintains a negative pressure environment within the ventilation hood, expelling aerosols exhaled by the user and preventing contamination of the actuator. The independent configuration of the ventilation hood and housing space reduces the likelihood of contamination of the actuator by placing the sampling process and the actuator in separate spaces.