116 results about "Phase imaging" patented technology

The invention relates to the technical field of large-aperture telescope construction, in particular to a large-aperture spliced telescope progressive generation method, which comprises the following steps of S1, constructing a local co-phase region at the edge of a large-aperture telescope by using spliced sub-mirrors through assistance of a small-aperture secondary mirror, and forming local co-phase imaging capability; s2, the step S1 is repeated, and equal-area local co-phase regions are constructed at the symmetrical positions of the edge of the large-aperture telescope; s3, constructing an interference imaging system through optical path difference adjustment, zero interference elimination and two symmetrical local co-phase regions; s4, repeating the steps S1 to S3, constructing more symmetrical and equal-area local co-phase regions at the edge of the large-aperture telescope, and constructing interference imaging in which the plurality of symmetrical local co-phase regions participate; and S5, constructing local co-phase regions in sequence from the edge to the center until the construction of the whole large-aperture telescope is completed.

A method, a system, and computer program product for optical systems including a metasurface that supports quantitative phase imaging are provided. Optical system characteristics of an optical system are received. The optical system characteristics include an optical path, the optical system comprising a light source and an imaging system. Optical parameters of at least one metasurface are received. A location of the metasurface is selected within the optical path of the optical system to modulate an incident wavefront generated by the light source. An image acquired by the imaging system is processed, based on the optical parameters of the at least one metasurface and based on the location of the metasurface within the optical path, to determine one or more image properties.

Snapshot phase-shifting diffraction modules and associated systems and methods are described that enable high spatial and temporal resolution phase imaging with high immunity to environmental factors such as vibrations and temperature changes. One example optical diffraction phase module includes a polarization grating to produce two circularly polarized light beams with opposite polarizations, a first lens to receive the two circularly polarized beams, and a spatial filter positioned at a focal plane of the first lens. The spatial filter includes two openings, one to spatially filter one of the two circularly polarized light beams, and another opening to allow another circularly polarized light beam to pass. The module also includes a second lens to focus the received light onto an image plane and to enable a phase measurement based a plurality of interferograms. The phase module can be incorporated into a microscope system that operates a reflection or a transmission mode.

The invention relates to a thick-wall pressure vessel inner wall damage detection method based on a low-frequency ultrasonic phase control imaging algorithm, which comprises the following steps: calculating to obtain an ultrasonic Lamb wave frequency dispersion curve of a thick-wall plate-shaped structure, and selecting a low-frequency guided wave frequency; determining parameter configuration of array elements of the phased array according to the low-frequency guided wave frequency, and arranging the array elements on the outer wall of the pressure vessel; exciting a low-frequency Lamb wave signal, and collecting FMC data through phased array elements, including echo signal data of each array element; frequency dispersion compensation processing is carried out on the acquired FMC data, and a phase coherence factor of each imaging pixel point is calculated; and adopting a TFM (Time Frequency Modulation) algorithm based on phase coherence factor weighting to carry out delay weighted reconstruction on the compensated FMC data to obtain an imaging and positioning result of the damage defect of the inner wall of the pressure vessel. Compared with the prior art, the problems of guided wave propagation frequency dispersion effect, complex mode, low signal-to-noise ratio and the like can be solved, and high-precision imaging positioning of inner wall damage defects is realized.

The invention discloses a variable view field Linnik interference microscopic system and a measurement method thereof, and belongs to the field of laser measurement instruments, and a variable diaphragm is introduced into a reference arm of an interference system to realize matching of objective lenses of different test arms, so that light field spatial correlation under speckle illumination is maintained; meanwhile, a light source system with a delay line structure is adopted to accurately compensate the optical path difference introduced by the asymmetric objective lens configuration, so that the acquisition of a high-contrast interference pattern is realized. The method can effectively improve the quality of an interference image, has a depth selection function, and is suitable for dynamic phase imaging in different view field ranges. The technical scheme of the invention shows good imaging effect and adaptability in the aspects of dynamic imaging and depth layering.

The invention discloses a single-pixel phase imaging method based on an untrained physical driving neural network, and belongs to the field of single-pixel imaging and computational optics. According to the method, by adding a physical diffraction layer and an Admn optimizer, direct reconstruction from a single-pixel detection intensity sequence to a phase object image is realized. According to the method, pre-training is not needed, and the dependency on a large data set is remarkably reduced; by introducing the total variation loss of the output phase, the influence of noise and optical distortion is effectively suppressed; and when the sampling rate is as low as 30%, the phase distribution can still be efficiently reconstructed, and the required sampling number is reduced.

The invention belongs to the technical field of optical measurement, and particularly relates to a digital holographic microscopy system phase distortion correction method based on adaptive optics, which has the advantage that optical wave complex amplitude information can be acquired in a wide field by means of digital holographic microscopy, and uses a distortion phase image measured by a digital holographic microscopy system as input to correct phase distortion of the digital holographic microscopy system. And iterating the image by using an optimization algorithm until the image evaluation function converges, and obtaining a correction pattern for removing phase distortion. And uploading the correction pattern to a self-adaptive correction device and modulating the wavefront of the light wave to finally realize accurate compensation of phase distortion. The method can provide an in-situ, accurate and rapid phase distortion correction mode and means for the field of optical microscopic imaging, especially the field of quantitative phase imaging.

An ultra-high flux quantitative phase imaging (QPI) system incorporates a real-time rotating cell detection based platform with concentric annular cell chambers (20). Each chamber (20) has a detection region (22) and a pair of access channels (24) with openings (25) between the ends. The access channel (24) serves to deliver a fluid containing the cell sample introduced into the opening (25) to the detection region (22). The opening (25) faces an inner radial position of the rotating platform compared to the detection area (22) so as to prevent liquid within the detection area (22) from being squeezed out by centrifugal force when the platform rotates, while communicating with the external environment before, during and after rotation.

The invention discloses a microfluidic image flow cytometry identification system and a microfluidic image flow cytometry identification method based on multi-modal phase imaging and deep learning, relates to a microfluidic image flow cytometry detection technology, and belongs to the crossing field of microfluidics, optical imaging and artificial intelligence. The cell deformation chip is used for inducing a cell sample to generate controllable deformation through the cell deformation chip and discharging deformed cells; the optical imaging unit is used for scanning the deformed cells and collecting multi-modal phase images of the deformed cells; the data processing and analysis unit is used for preprocessing the multi-modal phase image and performing cell intelligent identification analysis on the preprocessed multi-modal phase image by using a deep learning feature extraction network, so that accurate identification and classification of cells are realized, and a leukocyte subpopulation identification model is constructed; and generating a cell imaging result and a cell mechanical parameter thermodynamic diagram. According to the invention, label-free identification of leukocyte subgroups is realized, and the problems of tedious operation and cell damage of traditional fluorescence labeling are solved.

The invention discloses a 30-40GHz near-field millimeter wave imaging method based on phase imaging, and relates to the field of nondestructive testing. According to the near-field millimeter wave phase imaging method, a phase imaging technology and a near-field millimeter wave imaging method are combined, the characteristics of a detected sample are reconstructed through the phase effect, and the limitation that the detected sample is inversed only from the amplitude in a traditional near-field millimeter wave imaging method is overcome. The method is based on a phase imaging technology, and utilizes a near-field millimeter wave synthetic aperture technology and the phase imaging technology to convert back scattering data into wrapped phase data. And then, carrying out de-noising processing on the wrapped phase data through the corrected mean filter. Then, the wrapped phase data is converted into absolute phase data through the near-field millimeter wave phase unwrapping technology; the multi-frequency near-field millimeter wave technology is adopted to reduce the influence of Gaussian noise, so that a better imaging result is obtained.

To provide an X-ray phase imaging apparatus and an image processing method for improving contrast and visibility of an image photographed by a phase contrast method.SOLUTION: According to an aspect of the present invention, there is provided an X-ray phase imaging apparatus comprising an X-ray source, a detector configured to detect X-rays emitted from the X-ray source to a subject, and an image processing unit configured to generate an image of the subject, the image processing unit includes a storage unit in which a plurality of noise correction images for correcting a luminance variation between pixels are stored separately for brightness and darkness, and an image generation unit that generates a luminance image of the subject by irradiating the subject with X-rays, generates a plurality of corrected images of the subject by correcting the luminance image according to the noise correction image, and generates one subject image by selecting the plurality of corrected images according to a threshold value.SELECTED DRAWING: Figure 5

The present application relates to the field of optical interferometry, and aims at the phase distortion problem in off-axis interferometric quantitative phase imaging, and provides an interferometric microscopic phase distortion elimination method based on PACUNeXt3+ network. The method comprises the following steps: 1. using Zernike polynomials and test target pictures to simulate and generate a data set; 2. establishing and training a PACUNeXt3+ neural network model; 3. inputting the interference graph I or of the sample to be measured into the trained neural network, and outputting the background interference graph I' r corresponding to the sample without sample information; 4. using the two interference graphs I or and I' r to reconstruct the sample phase distribution φ o (x, y) without phase distortion. The present application has high precision and speed, can eliminate the secondary or high-order phase distortion in interferometric quantitative phase imaging, and has great application prospect in the field of phase imaging.

The application relates to a kind of quantitative imaging methods of living cells based on digital holographic microscopic sequential displacement aberration correction, and belongs to the field of optical measurement, comprising: collecting three holograms by sequentially displacing living cells; obtaining three original phase maps by phase demodulation; obtaining total mask map; sequentially displacing phase map in reverse direction; performing difference calculation to obtain global phase system aberration difference data; obtaining local system aberration difference data by using total mask map; performing difference processing on Chebyshev polynomial to obtain local polynomial difference data by using total mask map; fitting global system aberration by calculating corresponding coefficients from difference data; subtracting global system aberration from three original phase maps to obtain phase map of living cells after aberration correction. The application realizes high-precision quantitative phase imaging of living cells while retaining high-frequency information, has excellent displacement distance robustness, does not need to be equipped with high-precision displacement mechanism, and greatly reduces the hardware cost of measurement system.

The present disclosure provides a pathology sample virtual staining apparatus and method that can easily acquire virtual staining sample images for unlabeled samples as well as decolorized samples, by including a sample image acquisition module that irradiates near-infrared light toward a placed sample to acquire a near-infrared-based phase image of the sample, and a virtual staining module that receives the near-infrared-based phase image and performs neural network computation to acquire a virtual staining image similar to an image of a stained sample in which the sample is stained.

This invention discloses a heterodyne digital holographic microscopic phase imaging scheme based on a moving grating. The scheme includes an optical imaging device and a measurement method. The optical imaging device includes a light source system, an amplification system, a heterodyne interferometry system, and an image acquisition system. A light beam emitted from the light source penetrates the object under test, carrying the object's optical phase information. This information is amplified by the amplification system and then passed through a moving grating in the heterodyne microscopy system, splitting the incident light into multiple beams of different frequencies. An aperture is used to select the 0th and +1st order beams, which interfere on the camera's detection surface to generate continuous moving interference fringes. The measurement method mainly includes: optical path adjustment, image data acquisition, image processing, and phase-height calibration. This invention achieves higher reconstruction accuracy compared to traditional single-image reconstruction schemes, and features low cost and good stability, providing a new measurement scheme and approach for digital holographic microscopy.

A quantitative phase contrast imaging system comprises a light source configured to generate light and to direct the light to a sample, wherein the light comprises nonlinearly polarized light; a first lens configured to receive light from the sample; a phase filter, wherein the first lens is configured to focus the light from the sample onto the phase filter, and the phase filter is configured to modulate multiple components of the nonlinearly polarized light simultaneously (e.g., geometric phase interferometry); a second lens configured to receive light from the phase filter; and a polarized camera, wherein the second lens is configured to collimate the light beam from the phase filter to the polarized camera and the polarized camera is configured to image the sample in response to the light from the phase filter. In absence of the second lens, the camera can be placed at the image plane.

The invention discloses an SPR phase imaging system based on a four-polarization filtering array, and the system comprises an incident light path which is used for generating area array laser; the SPR module is used for receiving the area array laser and carrying out SPR sensing to obtain an area array laser modulation result related to a to-be-detected substance; and the imaging light path is used for carrying out amplification and filtering modulation on the area array laser modulation result so as to carry out imaging on a four-polarization array, and carrying out matched filtering and double-differential phase resolving on a four-polarization image so as to obtain an imaging result. According to the invention, through polarization virtual image generation and cross-channel block matching, and in combination with four-dimensional collaborative filtering, the noise suppression efficiency is improved; and through double differential phase resolving, the dynamic range is expanded to 0.06 RIU, and the resolution ratio is superior to that of the RIU. The invention solves the problem of mutual restriction of dynamic range and resolution in the traditional SPR technology, and is suitable for high-sensitivity biomolecule interaction detection.

Mesoscopic imaging systems and methods comprise or utilize a light source configured to generate an illumination light; an optical system configured to direct the illumination light toward a sample; an objective lens having a numerical aperture (NA) of 0.2 to 0.6, the objective lens being configured to receive a response light emitted by the sample in response to the illumination light; a filter wheel comprising a plurality of emission filters configured to filter the response light to generate a filtered light; a tube lens configured to provide an optical magnification to the filtered light; and an image sensor having 40 megapixels or more and a pixel size of less than or equal to 4 μm, the image sensor being configured to receive the filtered light and generate image data based on the received filtered light.

The application discloses a kind of single-pixel phase imaging method, system, device and storage medium, imaging system includes light source, pre-processing module, first spatial modulator, second spatial modulator, lens, detector, data acquisition card and processor, light emitted by light source collimates and attenuates after pre-processing module, in turn after first spatial modulator, measured object, second spatial modulator and lens, to detector;Imaging method includes: obtaining the first hologram and second hologram of phase difference preset phase shift, according to first hologram, second hologram and pre-design formula, the hologram of measured object is calculated, according to the hologram of measured object and preset algorithm, the reconstructed image of measured object is calculated.The efficiency of the embodiment of the application improves phase shift holographic imaging, and can be widely applied to imaging technical field.

The application relates to the technical field of mine evaluation, in particular to a mine available resource evaluation method and system.The method comprises the following steps: obtaining mine resource geological exploration data; performing data preprocessing on the mine resource geological exploration data to generate standard mine resource geological exploration data; performing three-dimensional geological modeling based on the standard mine resource geological exploration data to generate mine resource reserve distribution data; obtaining a surface deformation monitoring image through a synthetic aperture radar; performing time sequence slicing on the surface deformation monitoring image to generate surface deformation slice data; and performing stress change and microseismic phase imaging on the surface deformation slice data, so that time sequence stress data and microseismic phase data are obtained.The application improves the accuracy, dynamic nature and geological risk early warning capability of mine resource evaluation through multi-source dynamic data fusion and three-dimensional modeling, and improves the precision of mine available resource evaluation.

The application discloses an imaging sensor based on a full-Stokes polarization superlens, and relates to the field of optical sensing.The imaging sensor comprises a sensing excitation light source, an adjustable attenuator, a polarizer, a coupling prism, a sensing chip, a first objective lens, a full-Stokes polarization superlens, a second objective lens, an imaging lens and a CCD imaging camera; the sensing excitation light source emits monochromatic light as system incident light, which sequentially passes through the adjustable attenuator and the polarizer, and is incident onto the surface of the sensing chip to generate surface plasmon resonance after passing through the coupling prism; reflected light is converged onto the polarization superlens by the first objective lens, and then converged onto the second objective lens; subsequently, the imaging lens is used for imaging to the CCD camera; the property change of a to-be-measured sample leads to surface plasmon resonance of the sensing chip, which causes the analysis information of the full-Stokes polarization superlens to change, and further causes the image obtained by the CCD imaging camera to change.The application can perform single-shot phase imaging on a refractive index sample.

The utility model provides microscopic imaging equipment. The microscopic imaging equipment comprises a base, a supporting piece, a light source assembly, an object carrying platform, an objective lens assembly, a fluorescence imaging module and a quantitative phase imaging module, the supporting piece is arranged on the base, the light source assembly is arranged at the top of the supporting piece, the light source assembly is connected with a first light source, and the light source assembly comprises a second light source; the object carrying platform and the objective lens assembly are both arranged on the supporting piece, the object carrying platform is used for carrying a to-be-observed sample, and the objective lens assembly is located below the object carrying platform; the fluorescence imaging module is arranged on the base and comprises a fluorescence light source and a first camera; the quantitative phase and the fluorescence imaging module are arranged adjacently. The microscopic imaging equipment provided by the utility model can provide quantitative phase imaging, fluorescence imaging and bright field imaging, the imaging cost of a sample is saved, the use convenience is improved, the modules on the microscopic imaging equipment are compactly connected, and the size of the microscopic imaging equipment is reduced.

This invention discloses a lensless fiber bundle phase imaging method. The method includes: acquiring a single-exposure image of a sample through an optical fiber under multi-wavelength illumination; obtaining light intensity data for reconstruction by multi-channel separation and correction of the image; reconstructing the diffraction image of the sample based on the obtained light intensity data by removing the fiber bundle structure; establishing a lensless fiber bundle imaging model and correlating the diffraction image with the complex amplitude distribution of the sample; constructing an objective function for optimization and solving to obtain the amplitude image and phase image of the sample. This invention eliminates the need for lenses in the fiber bundle, offering advantages such as simple structure and suitability for miniaturized systems, and enables stable quantitative phase imaging under single exposure.

The invention discloses a use method of a scanning splicing large-view-field fundus phase imaging device. The scanning splicing large-view-field fundus phase imaging device comprises an illumination light path and a zoom light path. The illumination light path comprises a scanning mirror, a spectroscope and a fundus objective lens, the front side of the scanning mirror is a collimation light source, the rear side of the scanning mirror is the spectroscope, the left side of the spectroscope is the fundus objective lens and a patient fundus, and the right side of the spectroscope is a zoom lens group of a zoom light path and a fundus camera. The scanning mirror is rotated and the focal length of the zoom lens group is adjusted in sequence according to the plurality of scanning sequence groups, so that the fundus camera acquires a plurality of groups of positive defocus state, focusing state and negative defocus state images, then a plurality of local fundus phase diagrams are obtained according to the images, and a complete fundus phase distribution diagram is obtained, namely, the fundus phase distribution diagram has the phase information acquisition capability; and observing microscopic important pathological features according to the fundus phase distribution diagram. Therefore, the design has the capability of acquiring phase information, and microscopic important pathological features can be observed.

An apparatus, system, and related methods for the conversion of a regular bright-field microscope into a PS-QPI (Polarization-Sensitivity and Quantitative Phase Imaging) microscope system. A regular bright-field microscope is converted by insertion of a polarizing element in the illumination path and a Fresnel biprism in the image space of the system. The converted system is suitable for real-time quantitative PS phase imaging in a broad number of biological applications aimed at understanding cell growth and dynamic changes occurring during physiological processes, as well as identification of cell / tissue screening and diagnosis.

The invention belongs to the technical field of optical detection, and particularly relates to the field of optical wavefront detection, in particular to a lateral shear interference wavefront detection system and method based on an orthogonal polarization birefringent crystal. The system comprises a laser light source, wherein a polarizer and a beam splitter prism are sequentially arranged on an emergent light path of the laser light source; the invention discloses a polarization birefringent crystal, a reflector and a polarization camera. The method comprises the following steps: processing four phase shift interferograms, and extracting a wavefront gradient by using an arc tangent function; solving the system of linear equations to determine wavefront phase distribution by adopting an integral algorithm based on a least square method; and based on the extracted wavefront gradient, performing quantitative phase imaging by using a phase recovery algorithm. The device is simple in structure, high in stability and high in light energy utilization rate; the method is good in real-time performance, high in precision, capable of effectively restraining noise influences, capable of improving the precision of wavefront measurement, capable of meeting the requirement for high-precision optical system detection and wide in application range.

This invention discloses a quantitative phase imaging system and method for embryos based on dual liquid zoom lenses, which is installed in a time-difference incubator. It includes an illumination module, an imaging module, and a quantitative phase imaging module arranged sequentially along the optical path. The illumination module includes an LED light source, an illumination slit modulation structure, and a liquid zoom focusing system. The liquid zoom focusing system dynamically adjusts the numerical aperture of the illumination by changing the focal length. The imaging module includes an objective lens, a polarizer, a Nomaski prism, an analyzer, and a liquid imaging lens. The polarizer is positioned in the output optical path of the objective lens, the Nomaski prism is positioned between the polarizer and the analyzer, and the liquid imaging lens is positioned in the output optical path of the analyzer. The quantitative phase imaging module includes a spatial light modulator and an image acquisition unit. The spatial light modulator is used to perform phase-shift modulation on the optical path.

The invention provides a lensless amplitude phase imaging method and system suitable for axial scanning of polychromatic light. The method comprises the following steps: respectively acquiring diffraction data of an optical diffraction element and sample diffraction data at different positions through a lensless imaging device; randomly selecting a sample plane, transmitting a probe function of the optical diffraction element plane to the sample plane, transmitting a transmission function of the sample plane to a detector plane, and updating the transmission function through sample diffraction data; reversely transmitting the updated transmission function back to the sample plane, respectively updating the probe function and the object function of the sample, and transmitting the probe function back to the optical diffraction element plane; transmitting the probe function to a detector plane, performing amplitude constraint on the probe function by using diffraction data of the optical diffraction element, and then transmitting the probe function back to the plane of the optical diffraction element; and repeating the above steps to complete iteration, and finally obtaining a structure diagram through reconstruction. According to the invention, data volume is reduced and imaging quality is improved.

A synthetic aperture quantitative phase imaging method based on a hybrid of digital holography and Fourier ptychography. A programmable LED array which is annularly arranged is mounted on an off-axis digital holographic system for providing oblique illumination at varying angles; accurate noise-containing low-frequency information of an object is obtained by means of digital holography and is used as initial estimation; and then, high-frequency information of the object is reconstructed by means of a Fourier ptychographic algorithm based on intensity measurement, so as to realize synthetic aperture quantitative phase imaging. Using the accurate low frequency provided by holography as initial estimation ensures the accuracy of phase retrieval and wavefront aberration reconstruction, without strictly meeting matching illumination conditions, and reduces the number of intensity graphs required by Fourier ptychography; and a non-interferometric phase retrieval method based on Fourier ptychography improves the imaging resolution to an incoherent diffraction limit, and also effectively solves the problem of inherent speckle noise in digital holography.

The invention discloses a microfluidic quantitative phase imaging system and method based on an event camera, and the method employs the event camera to replace a frame camera in a conventional imaging system, and employs a working mechanism that the event camera is only sensitive to light intensity changes and asynchronously outputs event streams. Foreground extraction of a moving sample in the micro-fluidic chip and inhibition of a static background are realized, and background redundancy is eradicated from the source of data acquisition. According to the method, the inherent contradiction between high throughput and data explosion in the traditional technology is solved, and a brand new implementation way with zero data redundancy and high time resolution can be provided for high-precision, high-throughput and long-time dynamic quantitative phase measurement and analysis.