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Composition for preparing antibacterial polyurethane, antibacterial polyurethane and preparation method of antibacterial polyurethane

A technology for polyurethane and composition is applied in the field of preparing antibacterial polyurethane composition, which can solve the problems of bacteria being prone to drug resistance, environmental pollution, decline in antibacterial activity, etc., and achieves efficient and easy process, avoiding environmental pollution, and antibacterial activity. high effect

Active Publication Date: 2017-12-22
南京邦鼎生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these direct application or physical doping schemes have disadvantages such as a sharp decline in antibacterial activity over time, pollution to the environment, and bacteria are prone to drug resistance.

Method used

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  • Composition for preparing antibacterial polyurethane, antibacterial polyurethane and preparation method of antibacterial polyurethane
  • Composition for preparing antibacterial polyurethane, antibacterial polyurethane and preparation method of antibacterial polyurethane
  • Composition for preparing antibacterial polyurethane, antibacterial polyurethane and preparation method of antibacterial polyurethane

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preparation example Construction

[0047] The present invention also provides a kind of preparation method of antibacterial polyurethane, comprises the following steps:

[0048] (1) Weigh each raw material in the above-mentioned composition for preparing antibacterial polyurethane; mix polymer diol and diisocyanate at normal temperature, and under nitrogen protection, heat up to 60~90°C such as 60°C, 70°C ℃, 80℃ or 90℃ for stirring reaction;

[0049] (2) Cool the mixture after step (1) to 35-50°C, such as 35°C, 38°C, 40°C, 43°C, 45°C or 50°C, etc., and add an appropriate amount of dimethylformamide (technical Technicians can determine the appropriate amount according to actual needs), chain extender I, chain extender II and chain extender III, and then heat up to 60-90°C such as 60°C, 65°C, 70°C, 75°C, 80°C, React at 85°C or 90°C;

[0050] (3) cooling the mixture reacted in step (2) to normal temperature, adding alkynyl-modified 1,2-benzisothiazolin-3-one and a first catalyst for reaction to obtain antibacter...

Embodiment 1

[0065] (1) Preparation of alkynyl-modified 1,2-benzisothiazolin-3-one (BIT-Al):

[0066] Add 10 g of BIT (66 mmol), appropriate amount of potassium carbonate and 50 ml of dry DMF into a 100 ml single-necked round bottom flask. Then, 7.87 g of propyne bromide (66 mmol) was slowly added dropwise at room temperature, and after the drop was completed, the reactant was continuously stirred at room temperature for 16-24 h. Then add an appropriate amount of saturated brine, and extract three times with ethyl acetate; combine the organic phases, wash three times with saturated brine, dry the organic phases with anhydrous magnesium sulfate, concentrate, and recrystallize in ethanol to obtain 7.61 g of a light yellow solid , the yield of alkynyl-modified 1,2-benzisothiazolin-3-one (BIT-Al) was about 61%.

[0067] (2) Preparation of polyurethane (PU-N) containing azide functional group 3 ):

[0068] Dehydrate the polyether diol PPG (Mn=1000) in vacuum for 1.5h at 100°C, drop to room t...

Embodiment 2

[0072] The difference between this embodiment and embodiment 1 is that step (3) prepares antibacterial polyurethane:

[0073] Under magnetic stirring, add 24g of the above PU-N to a 100ml three-necked bottle 3 solution and 20ml of water and DMF mixed solution containing BIT-Al (0.8g) (V DMF :V H2O =9:1). Then 2 ml of copper sulfate water-DMF solution (containing 0.02 g of copper sulfate pentahydrate) was added, the mixture was degassed with nitrogen for 20 minutes, 0.06 g of sodium ascorbate was added, and reacted at room temperature for 1 h. Then, take 5 g of the reactant solution into a polytetrafluoroethylene petri dish with a diameter of 4 cm, dry at 75° C. for 24 h, cool, and remove the film to obtain an antibacterial polyurethane film (PU-BIT2).

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Abstract

The invention discloses a composition for preparing antibacterial polyurethane, the antibacterial polyurethane and a preparation method of the antibacterial polyurethane. The composition comprises the following raw materials in molar percentages: 20% to 55% of polymer dihydric alcohol, 55% to 70% of diisocyanate, 2% to 15% of a chain extender I, 5% to 20% of a chain extender II, 5% to 25% of a chain extender III and 0.05% to 25% of alkynyl modified 1,2-benzisothiazolin-3-ketone. The antibacterial polyurethane prepared with the method has selectivity, gram positive bacteria such as staphylococcus aureus can be selectively killed, the capacity of selective contact sterilization provides convenience for sterilization requirement at specific scenes, beneficial bacteria can be prevented from being killed, and the possibility is provided for accurate sterilization; and moreover, the antibacterial polyurethane adopts impermeable contact sterilization, and can avoid environmental pollution and inhibit the generation of bacterial resistance.

Description

technical field [0001] The invention relates to the technical field of chemical materials, in particular to a composition for preparing antibacterial polyurethane, antibacterial polyurethane and a preparation method thereof. Background technique [0002] In view of the negative impact of microorganisms on public health and the economy, controlling and preventing the proliferation of microorganisms has become a global concern and urgent problem. Although more than half of nosocomial infections in the United States are related to medical devices, points of infection still originate in areas such as water purification systems, sanitation facilities, and health care products. All material surfaces that are frequently touched by the public provide opportunities for the reproduction and spread of disease-causing bacteria. Therefore, the development of antibacterial materials that can effectively inhibit the reproduction and spread of bacteria is in line with the needs of the publ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G18/48C08G18/75C08G18/32C08G18/38C08G18/66C08G18/12C08G18/83C08J5/18C07D275/04A01N47/18A01P1/00C08L75/08
CPCA01N47/18C07D275/04C08G18/12C08G18/4825C08G18/6666C08G18/755C08G18/833C08J5/18C08J2375/08C08G18/3206C08G18/3819
Inventor 胡剑青郭宏伟邓建
Owner 南京邦鼎生物科技有限公司
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