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Core-shell type nano medical granule, preparation method and application thereof

A nano-drug and particle technology, applied in the field of anti-tumor drugs, can solve the problems of killing normal cells and cannot overcome the drug resistance of tumor cells, and achieve the effects of improving sensitivity, inhibiting growth, and reducing cytotoxicity.

Active Publication Date: 2013-05-15
SHENZHEN INST OF ADVANCED TECH
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Problems solved by technology

[0010] At present, there are many researches on nano-encapsulation of conventional chemotherapy drugs, but they still cannot well overcome the problem of drug resistance of tumor cells and the killing of normal cells by conventional chemotherapy drugs, especially at high doses.
Combining chemotherapeutic drugs and epigenetic drugs can greatly increase the sensitivity of tumor cells to conventional chemotherapeutic drugs, but there is no report on how to simultaneously entrap the two in nanocarriers to form a nano-loaded drug delivery system. Simultaneous efficient delivery of two drugs to tumor tissue remains to be resolved

Method used

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  • Core-shell type nano medical granule, preparation method and application thereof
  • Core-shell type nano medical granule, preparation method and application thereof
  • Core-shell type nano medical granule, preparation method and application thereof

Examples

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Embodiment 1

[0051] Embodiment 1-Preparation of Nano-Drug Particles Encapsulating DOX and Aza

[0052] Preparation of hydrophobic liquid I: Mix an acetonitrile solution containing 2 mg / ml PLGA with doxorubicin (DOX) and 5-aza-2'-deoxycytidine (Aza), the sum of the mass of DOX and Aza is equal to the mass of PLGA 10%, the ratio of DOX and Aza O.2:1.

[0053] Preparation of Hydrophilic Liquid II: Mix the aqueous solutions containing 1 mg / ml lecithin and 25 mg / ml DSPE-PEG2000-COOH at a lecithin: DSPE-PEG2000-COOH molar ratio of 6:4, and dilute in 4% ethanol solution , the total mass of lecithin and DSPE-PEG2000-COOH is 20% of the mass of PLGA.

[0054] Prepare the mixed solution: After the hydrophilic solution II was incubated at 65°C for 3 minutes, add the drug-containing PLGA hydrophobic solution I dropwise under gentle stirring, shake vigorously for 3 minutes after mixing, and then mix and stir at 65°C for 4 hours. A solution of nanoparticles encapsulating the drug is obtained.

[0055]...

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Abstract

The invention relates to a core-shell type nano medical granule targeting to tumor cells. The core-shell type nano medical granule comprises an inner hydrophobic polymer with chemotherapeutics medicines and epigenetics medicines in an adsorbing manner, a single-layer lipid molecule layer wrapping the inner hydrophobic core, and an hydrophilic outer shell targeting to the tumor cells. The invention further relates to a preparation method of the core-shell type nano medical granule and the application of the core-shell type nano medical granule to preparing anti-tumor medicines. The core-shell type nano medical granule combines the nano wrapping, the chemotherapeutics medicines and the epigenetics medicines, thereby having the advantages of improving the medicine delivery targeting, improving the sensitivity of the tumor cells to the chemotherapeutics medicines, suppressing the medicine resistance of the tumor cells, and the like.

Description

【Technical field】 [0001] The invention relates to the field of antitumor drugs, in particular to a core-shell nano drug particle targeting tumor cells, a preparation method and application thereof. 【Background technique】 [0002] Traditional tumor treatment methods mainly include surgical resection, radiotherapy and chemotherapy. Surgical resection and radiotherapy are mainly used to remove or kill the primary tumor and other visible tumor tissues. Due to the metastatic and invasive ability of tumor cells acquired in the late stage of tumor development, the systemic distribution of tumor cells becomes difficult to track, which greatly limits the therapeutic effect of surgical resection and radiotherapy for advanced cancer. [0003] Chemotherapy-based drug therapy has the characteristics of non-invasive and systemic treatment, and it also has a killing effect on the spreading tumor cells, so it is undoubtedly the most potential treatment method. However, despite the continu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K45/06A61K47/34A61P35/00
Inventor 蔡林涛王朝晖李力力苏献伟龚萍郑明彬
Owner SHENZHEN INST OF ADVANCED TECH
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