Core-shell type nano medical granule, preparation method and application thereof

Abstract

The invention relates to a core-shell type nano medical granule targeting to tumor cells. The core-shell type nano medical granule comprises an inner hydrophobic polymer with chemotherapeutics medicines and epigenetics medicines in an adsorbing manner, a single-layer lipid molecule layer wrapping the inner hydrophobic core, and an hydrophilic outer shell targeting to the tumor cells. The invention further relates to a preparation method of the core-shell type nano medical granule and the application of the core-shell type nano medical granule to preparing anti-tumor medicines. The core-shell type nano medical granule combines the nano wrapping, the chemotherapeutics medicines and the epigenetics medicines, thereby having the advantages of improving the medicine delivery targeting, improving the sensitivity of the tumor cells to the chemotherapeutics medicines, suppressing the medicine resistance of the tumor cells, and the like.

Description

【Technical field】 [0001] The invention relates to the field of antitumor drugs, in particular to a core-shell nano drug particle targeting tumor cells, a preparation method and application thereof. 【Background technique】 [0002] Traditional tumor treatment methods mainly include surgical resection, radiotherapy and chemotherapy. Surgical resection and radiotherapy are mainly used to remove or kill the primary tumor and other visible tumor tissues. Due to the metastatic and invasive ability of tumor cells acquired in the late stage of tumor development, the systemic distribution of tumor cells becomes difficult to track, which greatly limits the therapeutic effect of surgical resection and radiotherapy for advanced cancer. [0003] Chemotherapy-based drug therapy has the characteristics of non-invasive and systemic treatment, and it also has a killing effect on the spreading tumor cells, so it is undoubtedly the most potential treatment method. However, despite the continu...

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Problems solved by technology

[0010] At present, there are many researches on nano-encapsulation of conventional chemotherapy drugs, but they still cannot well overcome the problem of drug resistance of tumor cells and the killing of normal cells by conventional chemotherapy drugs, especially at high doses.

Combining chemotherapeutic drugs and epigenetic drugs can greatly increase the sensitivity of tumor cells to conventional chemotherapeutic drugs, but there is no report on how to simultaneously entrap the two in nanocarriers to form a nano-loaded drug delivery system. Simultaneous efficient delivery of two drugs to tumor tissue remains to be resolved

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