Pharmaceutical composition containing polymyxin and application thereof

A technology of polymyxin and composition, applied in the field of pharmaceutical compositions including polymyxin and its synergist, can solve the problem of difficulty in meeting demand, low success rate, long development cycle of new antibiotic drugs, etc. problem, to achieve good therapeutic effect, increase bioavailability, and reduce the effect of drug dosage
CN112089824APending Publication Date: 2020-12-18ARTIVILA BIOPHARMA
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
ARTIVILA BIOPHARMA
Publication Date
2020-12-18

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Abstract

The invention discloses a pharmaceutical composition containing polymyxin and application thereof, and belongs to the field of biological medicine. The pharmaceutical composition comprises C507-0440 and polymyxin, the C507-0440 and the polymyxin are combined for use so that the activity of the polymyxin in gram-negative bacteria can be effectively improved, and the drug resistance of the polymyxinis inhibited; and meanwhile, the C507-0440 can significantly reduce the use dosage of the polymyxin, and is conductive to reducing side effects caused by drug use.
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Description

technical field

[0001] The invention relates to a pharmaceutical composition containing polymyxin and its application, in particular to a pharmaceutical composition comprising polymyxin and its synergist, which is applied to resist Gram-negative bacteria and belongs to the field of biomedicine. Background technique

[0002] According to the statistics of the World Health Organization, about 700,000 people die from bacterial infections every year in the world. In the treatment of various bacterial infections or diseases caused by pathogenic microorganisms, antibiotics are the main drugs used, but with the use of antibiotics, bacteria can strengthen their drug resistance through various ways, including secreting a variety of antibiotic hydrolytic enzymes (super Broad-spectrum β-lactamase, carbapenemase, etc.), gene mutations of drug targets, loss or translocation of membrane porins, active efflux pump system, etc., the above pathways have caused bacterial antibiotic resistance...

Claims

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