Production method of enteric-coated kitasamycin for feed

A guitarmycin and production method technology, applied in animal feed, animal feed, application, etc., can solve the problems of stomach irritation, nausea, inhibition of difficult pathogenic microorganisms, etc., to prolong the release and action time, and reduce the cost of medication , the effect of reducing the frequency of medication

Active Publication Date: 2009-12-30
WUXI ZHENGDA POULTRY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As early as the early 1980s, it was introduced into my country as a feed additive via Japan, but it has not been widely used in compound feeds. The reason is that there are three major disadvantages of kitasamycin raw powder: 1) The effect of preventing intestinal diarrhea is not ideal. Mycin is absorbed quickly in the intestinal tract of animals and is absorbed at the front end of the intestinal tract. It can only inhibit the pathogenic bacteria in the local (front) intestinal tract, and it is

Method used

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  • Production method of enteric-coated kitasamycin for feed

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Add 55.5kg starch, 6.5kg dextrin, and 3kg mannitol enzyme with 35kg of kitasamycin and mix evenly through a 60-mesh sieve, add 8% water to make a soft material, and extrude into a diameter equivalent through an extrusion sieve plate (0.8mm in aperture). strips. Then enter the spheronizer to make the granules completely spheroidized, dry at 40°C, and take 24-mesh pellets for coating. First use 3.0% HPMC (hydroxypropyl methylcellulose) aqueous solution as slow-release coating, and dry at 40°C for about 10 minutes. Then use 7kg acrylic resin (enteric-coating type) as coating material to carry out enteric-coating, all with fluidized bed coating machine coating. The coating process conditions are as follows: blower frequency: 27.5 Hz; air spray pressure: 0.2 MPa; liquid spray flow rate: 1 ml / min; fluidization temperature: 33°C.

Embodiment 2

[0020] Add 60kg starch, 6.5kg dextrin, and 3.5kg mannitol enzyme with 30kg kitasamycin and mix evenly through a 60-mesh sieve, add 7% water to make a soft material, and extrude it into a diameter equivalent through an extrusion sieve plate (0.8mm in aperture). strips. Then enter the spheronizer to make the granules completely spheroidized, dry at 40°C, and take 24-mesh pellets for coating. First use 3.0% HPMC (hydroxypropyl methylcellulose) aqueous solution as slow-release coating, and dry at 40°C for about 10 minutes. Then use 6kg acrylic resin (enteric-coating type) as coating material to carry out enteric-coating, all with fluidized bed coating machine coating. The coating process conditions are as follows: blower frequency: 27.5 Hz; air spray pressure: 0.2 MPa; liquid spray flow rate: 1 ml / min; fluidization temperature: 33°C.

Embodiment 3

[0022] Add 64kg starch, 7.5kg dextrin, and 3.5kg mannitol enzyme with 25kg of kitasamycin and mix evenly through a 60-mesh sieve, add 6% of water to make a soft material, and extrude through an extrusion sieve (aperture 0.8mm) into a diameter equivalent strips. Then enter the spheronizer to make the granules completely spheroidized, dry at 40°C, and take 24-mesh pellets for coating. Use 3.0% HPMC (hydroxypropyl methylcellulose) aqueous solution as the slow-release coating, and dry at 40° C. for about 10 minutes. Use 5kg acrylic resin (enteric-coated type) as coating material to carry out enteric-coated coating, all coat with fluidized bed coating machine. The coating process conditions are as follows: blower frequency: 27.5 Hz; air spray pressure: 0.2 MPa; liquid spray flow rate: 1 ml / min; fluidization temperature: 33°C.

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Abstract

The invention discloses a production method of enteric-coated kitasamycin for feed, which comprises the following process steps: step one, the preparation of drug-loaded pellets; step two, inner layer sustained-release coating of the drug-loaded pellets, which prolongs the release and acting time of kitasamycin; and steps three, outer layer enteric coating of the drug-loaded pellets, which ensures the release in succus entericus and small or no release in gastric juice. The method has the advantages that the kitasamycin is subjected to pellets pelletizing and 99 percent of the prepared granulums can pass through 24 meshes, so the dust is greatly reduced and the fluidity is increased; the coating of the inner layer sustained-release agent (HPMC) prolongs the release and acting time of the kitasamycin, reduces medication times and reduces the medication cost; and a layer of enteric substance, namely acrylic resin-III is sprayed and coated on the outer layer of particles. The substance protects the kitasamycin which is a weakly alkaline antibiotic from being damaged by gastroc acid in stomach, quickly disintegrates after entering enteric canal and releases the kitasamycin; and then the kitasamycin is absorbed by gastrointestinal mucosa into blood drug to play a role of restraining the reproduction of pathogenic microorganism and preventing diarrhea. Insoluble in the stomach, kitasamycin coating formulations have no pessimal stimulation on the stomach, and cannot result in regurgitation and vomiting. In addition, the sustained-release formulation, namely the kitasamycin prolongs the acting time so the medication times is reduced, the medication cost of farmers is reduced, and the economic benefit is improved.

Description

technical field [0001] The invention relates to a production method of enteric kitasomycin coating for feed. The invention belongs to the technical field of feed and feed additives. Background technique: [0002] Kitasamycin, also known as Leucomycin, is a multi-component sixteen-membered macrolide antibiotic produced by Strepotomyces kitasatoensis. 1 、A 2 、A 3 、A 4 、A 5 、A 6 and A 7 and so on, where A 1 and A 5 The antibacterial activity is the strongest, and it has a strong inhibitory effect on Gram-positive bacteria, some Gram-negative bacteria, Mycoplasma, Rickettsia, and spirochetes. Kitamycin is the only macrolide antibiotic that can be added to animal feed as stipulated by the Ministry of Agriculture. Its function is to prevent and treat respiratory diseases in pigs and chickens, and it has a certain growth-promoting effect. In the veterinary drug quality standards promulgated by the Ministry of Agriculture, kitasamycin premix (in the form of powder) has two...

Claims

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Application Information

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IPC IPC(8): A23K1/17A23K20/195
Inventor 周玲叶锋先
Owner WUXI ZHENGDA POULTRY
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