Production method of enteric-coated kitasamycin for feed

Abstract

The invention discloses a production method of enteric-coated kitasamycin for feed, which comprises the following process steps: step one, the preparation of drug-loaded pellets; step two, inner layer sustained-release coating of the drug-loaded pellets, which prolongs the release and acting time of kitasamycin; and steps three, outer layer enteric coating of the drug-loaded pellets, which ensures the release in succus entericus and small or no release in gastric juice. The method has the advantages that the kitasamycin is subjected to pellets pelletizing and 99 percent of the prepared granulums can pass through 24 meshes, so the dust is greatly reduced and the fluidity is increased; the coating of the inner layer sustained-release agent (HPMC) prolongs the release and acting time of the kitasamycin, reduces medication times and reduces the medication cost; and a layer of enteric substance, namely acrylic resin-III is sprayed and coated on the outer layer of particles. The substance protects the kitasamycin which is a weakly alkaline antibiotic from being damaged by gastroc acid in stomach, quickly disintegrates after entering enteric canal and releases the kitasamycin; and then the kitasamycin is absorbed by gastrointestinal mucosa into blood drug to play a role of restraining the reproduction of pathogenic microorganism and preventing diarrhea. Insoluble in the stomach, kitasamycin coating formulations have no pessimal stimulation on the stomach, and cannot result in regurgitation and vomiting. In addition, the sustained-release formulation, namely the kitasamycin prolongs the acting time so the medication times is reduced, the medication cost of farmers is reduced, and the economic benefit is improved.

Description

Technical field [0001] The invention relates to a production method of enteric-coated kitasamycin coating for feed. It belongs to the technical field of feed and feed additives. Background technique: [0002] Kitasamycin, also known as Leucomycin, is a multi-component sixteen-membered macrolide antibiotic produced by Strepotomyces kitasatoensis. It is composed of A 1 , A 2 , A 3 , A 4 , A 5 , A 6 And A 7 And other composition, where A 1 And A 5 It has the strongest antibacterial activity and has a strong inhibitory effect on gram-positive bacteria, some gram-negative bacteria, mycoplasma, rickettsiae and spirochetes. Kitasamycin is the only antibiotic that can be added to animal feed prescribed by the Ministry of Agriculture of the macrolides. Its role is to prevent and treat respiratory diseases in pigs and chickens, and has a certain growth-promoting effect. In the veterinary drug quality standards promulgated by the Ministry of Agriculture, there are two content specification...

AI Technical Summary

Problems solved by technology

As early as the early 1980s, it was introduced into my country as a feed additive via Japan, but it has not been widely used in compound feeds. The reason is that there are three major disadvantages of kitasamycin raw powder: 1) The effect of preventing intestinal diarrhea is not ideal. Mycin is absorbed quickly in the intestinal tract of animals and is absorbed at the front end of the intestinal tract. It can only inhibit the pathogenic bacteria in the local (front) intestinal tract, and it is difficult to evenly cover the entire intestinal tract, so it is difficult to treat pathogenic bacteria in the intestinal tract of the entire animal. Microorganisms play a better role in inhibiting

2) Strong bitter taste, irritating to the stomach, directly affecting the animals' food intake, excessive addition will cause adverse reactions in animals, such as nausea, vomiting and food refusal

Due to the above influencing factors, gemtamycin has not been well applied in my country's feed industry.

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