Novel voriconazole broad-spectrum antifungal medicine compound, broad-spectrum antifungal medicine composition and application thereof

A compound and composition technology, applied in antifungal agents, medical preparations containing active ingredients, organic chemistry, etc., can solve problems such as unclear mechanism of action, and achieve strong antifungal activity, enhanced drug efficacy, and pharmacokinetics Good properties and safety effects
CN101575330AActive Publication Date: 2009-11-11LIVZON PHARM GRP INC
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Applications(China)
Current Assignee / Owner
LIVZON PHARM GRP INC
Publication Date
2009-11-11

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Abstract

The invention relates to a novel broad-spectrum antifungal medicine compound, a broad-spectrum antifungal medicine composition, an application of the compound or the composition in the preparation of a broad-spectrum antifungal medicine, and an application of the compound or the composition in the preparation of a medicine used for treating severe invasive infection (comprising Candida krusei) caused by invasive aspergillosis and / or Fluconazole-resistant Monilia and / or severe infection caused by Scedosporium and fusarium. The novel broad-spectrum antifungal medicine compound and the broad-spectrum antifungal medicine composition have extensive and strong antifungal activity and better dynamic property and safety. For deep mycotic infection, the novel broad-spectrum antifungal medicine compound and the broad-spectrum antifungal medicine composition are better than the original voriconazole in the aspects of the antibiotic activity and the medicine resistance and is better than amphotericin B in the aspects of safety and effectiveness; and compared with the formerly applied voriconazole, Fluconazole, itraconazole and amphotericin B, the novel broad-spectrum antifungal medicine compound and the broad-spectrum antifungal medicine composition have reinforced medicine effect, less adverse reaction and good safety.
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Description

technical field

[0001] The invention belongs to the technical field of medicinal chemistry. Specifically, the present invention relates to a new broad-spectrum antifungal drug compound, a broad-spectrum antifungal drug composition, the application of the compound or composition in the preparation of a broad-spectrum antifungal drug, and the compound or composition In the preparation for the treatment of invasive aspergillosis and / or serious invasive infections caused by fluconazole-resistant Candida species (including Candida krusei) and / or severe infections caused by Actinomycetes and Fusarium species application in medicines. Background technique

[0002] In view of the current global incidence of severe fungal infections continues to rise, especially the high mortality of fungal infections in immunocompromised populations (such as cancer patients, AIDS patients, organ transplant patients, etc.), the epidemiology of global pathogens has undergone significant changes: Cand...

Claims

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