58 results about "Benzalkonium chloride solution" patented technology

A highly stable acidifed formula of Crotoxin comprising saline and benzalkonium chloride, and optionally Thiamine, is disclosed that facilitates the therapeutic use of Crotoxin. Also disclosed is a method of preparing a highly stable formula of Crotoxin.

The ophthalmic composition according to the present invention contains: (A) 0.01-0.5 w / w% of a copolymer having structural units represented by formulae (1a)-(1c), the molar ratio of the structural units being a: b: c = 100: 10-400: 2-50, and the weight-average molecular weight being 5,000-2,000,000; (B) from 0.001 w / w% to 0.02 w / w% (inclusive) of benzalkonium chloride; and / or (C) from 0.001 w / w% to 0.05 w / w% (inclusive) of chlorhexidine gluconate. According to the present invention, it is possible to provide an ophthalmic composition that protects corneal cells while exhibiting sufficient storage efficacy.

The invention discloses an oyster enzymolysis ultrafiltration extract nasal spray and a preparation method thereof, the nasal spray comprises the following components: 5-10 wt% of oyster extract, 0.1-0.3 wt% of preservative, 0.05-0.15 wt% of sodium chloride and 0.1-0.3 wt% of emulsifier, the pH value is 5.5-6.5, the content of the preservative is 0.1-0.3 wt%, the content of the sodium chloride is 0.05-0.15 wt%, the content of the emulsifier is 0.1-0.3 wt%, and the balance is water. The preservative is one of benzalkonium chloride, sorbic acid and potassium sorbate, and the emulsifier is polysorbate 80. Through definite raw material composition, a step-by-step process and quality control, the bioavailability of active components is improved, the flavor of the product is optimized, the effect of safely and efficiently improving sleep is achieved, the problems of low bioavailability, poor flavor and potential safety hazards of an existing sleep improving product are solved, the process repeatability is high, and the preparation method is suitable for industrial production. The long-term use of people with chronic insomnia is facilitated.

The application provides a content determination method of quaternary ammonium salt disinfectant: 1 mL is taken and placed in a 100 mL volumetric flask, diluted to the scale with a mobile phase, 1 mL is taken and placed in a 10 mL volumetric flask, diluted to the scale with a mobile phase, and a test sample solution is obtained; benzalkonium chloride control samples are taken, dissolved and quantitatively diluted with a mobile phase to prepare C12 substituted homologues and C14 substituted homologues solutions, which are used as benzalkonium chloride control sample solutions; decamethylquinolinium chloride control samples are taken, dissolved and quantitatively diluted with a mobile phase to prepare a solution, which is used as a decamethylquinolinium chloride control sample solution; the benzalkonium chloride and decamethylquinolinium chloride control sample solutions are taken, and a chromatogram is recorded; the logarithmic values of the control sample solution concentrations and the logarithmic values of the corresponding peak areas are calculated to obtain a corresponding linear regression equation; the test sample solution is taken, and the content of benzalkonium chloride and decamethylquinolinium chloride in the test sample is calculated by the linear regression equation.

This invention discloses a microcapsule, its preparation method, and its applications, belonging to the field of bioprotective materials. The microcapsule has a tertiary spherical or near-spherical particle structure, including a core layer, a shell layer covering the core layer, and satellite layers anchored to the outer surface of the shell layer. The core layer includes an active ingredient and a hydrophobic carrier medium. The shell layer is a cross-linked polyurethane-polyurea wall material formed by interfacial polymerization of polyisocyanate and polyols or polyamines containing hydrophilic segments. The satellite layers include active units and bridging and stabilizing units. The active units include benzalkonium chloride or benzyl chloride. The satellite layers exist in the form of nanoparticles or molecular clusters with a size of 10-150 nm. This invention, applied to bioprotective materials, solves the problem of efficient co-loading and intelligent sequential release of multipolar active substances in existing microcapsules. It possesses antiviral, antibacterial, antifungal, and anti-mite functions, a long service life, and features controllable and reproducible processes.

The invention relates to the technical field of hemostatic materials, in particular to composite hemostatic gel as well as a preparation method and application thereof. The composite hemostatic gel is prepared from the following components in percentage by mass: 0.5 to 3 percent of carboxymethyl chitosan, 0.5 to 5 percent of trehalose, 1 to 10 percent of glycerol, 0.1 to 2 percent of carbomer, 0.1 to 2 percent of recombinant blood coagulation factor III, 0.005 to 0.05 percent of benzalkonium chloride and the balance of Tris-HCl buffer solution. Based on the synergistic effect of a natural high polymer material carboxymethyl chitosan and a bioactive component recombinant blood coagulation factor III, the gel constructs a'physical adsorption-blood coagulation activation 'dual hemostasis pathway, realizes a rapid and multi-mechanism hemostasis function, has antibacterial and repair promoting characteristics, can be widely applied to various bleeding scenes such as cutting wounds and surgical wounds, and has wide application prospects. The wound healing is effectively promoted.

The invention relates to the technical field of disinfectants, in particular to a microorganism and nucleic acid removal material based on high-temperature stable sustained-release microspheres, a preparation method of the microorganism and nucleic acid removal material and application of the microorganism and nucleic acid removal material in a high-temperature condition. The microorganism and nucleic acid removal material based on the high-temperature stable sustained-release microspheres is prepared from an oil phase raw material, an inner water phase raw material and an outer water phase, the oil phase raw material comprises poly-L-lactic acid; the inner water phase raw material is a mixture of a cationic polymer and benzalkonium chloride; the cationic polymer comprises any two or three of polyhexamethylene biguanide, polyethyleneimine and chitosan. According to the invention, by optimizing the formula of the microorganism and nucleic acid removal material based on the high-temperature stable sustained-release microspheres, multiple advantages of high-temperature stability, efficient nucleic acid inactivation, accurate release, environmental friendliness, long-acting disinfection and the like are realized, and a brand-new, efficient and reliable solution is provided for the disinfection demand in a high-temperature environment.

The invention relates to a preparation method of brimonidine tartrate eye drops, particularly relates to a new technical scheme obtained by adjusting the rotating speed, the temperature and the material adding sequence, and solves the problems of non-uniform content of benzalkonium chloride and dissolution of polyvinyl alcohol. The brimonidine tartrate eye drops prepared by the preparation method disclosed by the invention are uniform in benzalkonium chloride content, clear in liquid medicine, stable in quality, low in requirements on production equipment and suitable for large-scale industrial production.

The invention relates to the technical field of defect detection, and discloses a benzalkonium chloride disinfectant bottle surface defect intelligent discrimination system, which comprises the following steps: firstly, collecting a bottle body surface image, extracting a bottle body area to generate a contour, and further determining an outer boundary to obtain a boundary characterization curve; then screening shoulder candidate points in the boundary characterization curve, establishing a local coordinate system at the position, and performing equal-interval sampling along the normal direction of the inner side to form a normal gray section; carrying out extreme point analysis on the section to position a bright peak and upstream and downstream stationary points, and further calculating an intensity geometric correlation index and a width asymmetry index; and finally, fusing the indexes to generate a discrimination index for distinguishing real scratches and liquid film artifacts, and realizing defect positioning based on bright peaks, so that the accuracy and the automation level of defect detection are improved.

The invention discloses a compound nysfungin ointment, which comprises an active component, a preservative, a humectant, a thickening agent, a grease matrix and an antibacterial agent, the active component is selected from one or more of self-made mycotoxin, neomycin sulfate, permethrin and triamcinolone acetonide, the preservative is selected from benzalkonium chloride, the humectant is selected from glycerol, the thickening agent is selected from glycerol, and the grease matrix is selected from a grease matrix. The humectant is selected from humectant, the thickening agent is selected from carbomer, the grease matrix is selected from liquid paraffin and / or wool fat, the antibacterial agent is selected from thymol, and the ratio of the humectant to the thickening agent is (2-7): (0.5-3) in parts by mass. By accurately controlling the proportion of the humectant to the thickener, the texture of the ointment can be optimized, so that the skin permeability is improved, the medicine absorption is promoted, the treatment effect is improved, in addition, the form of the ointment can be kept, the active ingredients are prevented from being degraded, and the shelf life of the preparation is prolonged.

The application discloses modified phosphogypsum with mildew-proof and antibacterial properties and a preparation method thereof, and belongs to the field of phosphogypsum mildew-proof and antibacterial treatment. The modified phosphogypsum with mildew-proof and antibacterial properties comprises the following raw materials in percentage by mass: 0.2%-0.5% of water-soluble quaternary ammonium salt bacteriostatic agent, 14%-24% of inorganic alkaline material, 46%-56% of phosphogypsum powder and 29.8%-35.8% of water; wherein the water-soluble quaternary ammonium salt bacteriostatic agent comprises 0.1%-0.3% of benzalkonium chloride and 0.1%-0.3% of cetyltrimethylammonium bromide; the inorganic alkaline material comprises 5%-20% of P.O 42.5 ordinary portland cement and 3%-9% of Ca(OH)2; the amount of the quaternary ammonium salt bacteriostatic agent and the inorganic alkaline material used for reducing the original single-doped modification to achieve the same mildew-proof effect is reduced through synergistic effect, the cost required for phosphogypsum resource treatment is reduced, and meanwhile, the optimal mildew-proof effect can be achieved without affecting the strength of the phosphogypsum.

The invention relates to the technical field of sterilization and antifogging, in particular to a microsphere-based antibacterial and antifogging additive, a preparation method thereof, a multifunctional coating and application. The microsphere-based antibacterial and antifogging additive is a liposome vesicle microsphere, and the liposome vesicle microsphere is prepared from an oil-phase raw material and a water-phase raw material; the oil phase raw material comprises one or more of distearoyl phosphatidylcholine, hydrogenated lecithin and cholesterol; the water-phase raw material is a mixture of polyhexamethylene biguanide, polyethyleneimine and benzalkonium chloride; in the water phase raw material, the content of the polyhexamethylene biguanide is 25wt%-45wt%. By optimizing the formula of the microspheres, the efficiency and effect of killing nucleic acid can be remarkably improved, and the fog-resistant and anti-fog effects are achieved.

The invention discloses a preparation method of eye sustained-release eye drops. The preparation method comprises the following steps: step 1, preparing cyclodextrin microspheres; step 2, preparing cyclodextrin microspheres loaded with atropine sulfate; and step 3, dispersing the atropine sulfate loaded cyclodextrin microspheres obtained in the step 2 in deionized water to obtain a mixed solution, then adding a thickening agent, mannitol and benzalkonium chloride, and stirring at room temperature for 20-30 minutes to obtain the eye sustained-release eye drops. The invention further discloses the eye sustained-release eye drops prepared by the preparation method and application of the eye sustained-release eye drops. The sustained-release eye drops for eyes have the advantages of high stability, high bioavailability, low irritation and controllable release rate.

The present invention provides a disinfectant composition comprising 0.01-5 parts by weight of a compound of formula (I), 1-10 parts by weight of benzalkonium chloride, and the remainder being pure water. By compounding ethylicin and benzalkonium chloride, the present invention can effectively eliminate environmental pathogens at a very low dosage, thereby achieving a good disinfection effect.

The invention relates to the technical field of disinfectants, in particular to a microorganism and nucleic acid removal composition as well as a preparation method and application thereof. The microorganism and nucleic acid removal composition comprises effective bactericidal components, and the effective bactericidal components are prepared from the following raw materials in parts by weight: 2 to 4 parts of polyethyleneimine, 2.5 to 5.5 parts of polyhexamethylene biguanide and 0.5 to 5 parts of benzalkonium chloride. According to the microorganism and nucleic acid removing composition, through the synergistic effect of polyethyleneimine, polyhexamethylene biguanide and benzalkonium chloride, nucleic acid of pathogens can be efficiently killed, and therefore the spreading risk of the pathogens is remarkably reduced. Compared with a traditional microorganism and nucleic acid removal composition, the microorganism and nucleic acid removal composition not only can destroy the external structure of a pathogen, but also can deeply act on nucleic acid to achieve a more thorough sterilization effect.

The application discloses a bubble-assisted benzalkonium chloride heterogeneous Fenton-like catalytic degradation method and belongs to the technical field of water treatment in environmental engineering. The method uses ferric nitrate, cobalt chloride, lanthanum nitrate and biochar as raw materials, synthesizes BC / LaFeCo-LDH through a hydrothermal method, uses the BC / LaFeCo-LDH as a heterogeneous Fenton-like catalyst, and is used for activating peroxymonosulfate. Meanwhile, a solid-liquid-gas heterogeneous Fenton-like catalytic system is constructed in combination with a hydrodynamic cavitation reactor. In the system, the exposure degree of benzalkonium chloride is increased by virtue of the bidirectional action of hydrophobic bubbles and the surface of hydrophilic catalysts, the activation rate of peroxymonosulfate is significantly improved, a large amount of singlet oxygen is generated, and the degradation efficiency and reaction rate of benzalkonium chloride are effectively improved. The method provides an effective way for green and efficient degradation of benzalkonium chloride.

The application discloses a composite bactericide and application, which comprises cetyltrimethylammonium bromide, 5-chloro-2-methyl-4-isothiazolin-3-one, tetramethylammonium phosphonium sulfate, benzalkonium chloride, wherein the mass concentration of the cetyltrimethylammonium bromide is 0.2-0.5 mg / L, the mass concentration of the tetramethylammonium phosphonium sulfate is 0.4-1 mg / L, the mass concentration of the 5-chloro-2-methyl-4-isothiazolin-3-one is 0.2-0.5 mg / L, and the mass concentration of the benzalkonium chloride is 0.2-0.5 mg / L. The composite bactericide can simultaneously effectively kill Acidithiobacillus ferrooxidans A. ferrooxidans and common desulfurization vibrio D. vulgaris with a sterilization rate of 98%, and has a synergistic sterilization effect.

This invention discloses a topical preparation of recombinant platelet-derived growth factor (PDGF) and its preparation method. In this invention, each milliliter of the topical preparation contains the following components and dosages: 40,000-85,000 IU of PDGF, 50-200 mg of polyvinyl alcohol, 10-100 mg of arginine hydrochloride, 54-60 mg of sodium chloride, 40-80 mg of disodium hydrogen phosphate, 0.5-2.5 mg of sodium dihydrogen phosphate, and 0.5-5 mg of benzalkonium chloride, diluted to 10 ml with water for injection. The pH of the solution is 7.0. The PDGF topical solution of this invention has optimized compatibility of its raw materials, exhibits good stability, and can promote wound healing effectively and rapidly, shortening wound healing time and improving wound healing efficiency, thus demonstrating good therapeutic efficacy.

The present invention relates to an ophthalmic aqueous composition for the decrease of intraocular pressure in patients with ocular hypertension or open angle glaucoma containing a combination of Brinzolamide and Brimonidine and a method for preparation thereof. The invention as currently presented has a significant advantage over ophthalmic compositions already known in the art. More particularly the present invention relates to a multi-dose ophthalmic aqueous composition comprising a borate, a single polyol and benzalkonium chloride as an antimicrobial agent.

An inkjet ink includes: a pigment, a preservative, a zwitterionic compound, and water. The zwitterionic compound is a zwitterionic compound that has a zwitterionic structure in an environment with a pH of 7.5 or more and 9 or less. The preservative includes at least one of 2-(2-hydroxy-5-methylphenyl)benzotriazole, orthophenylphenol, sodium dihydroxydimethoxybenzophenonedisulfonate, para-aminobenzoic acid, ferulic acid, benzalkonium chloride, or the like. In the inkjet ink, the content of orthophenylphenol is 4 mass % or less and the content of ferulic acid is 7 mass % or less.

The invention relates to the technical field of disinfectants, in particular to a microsphere sustained-release antibacterial material, a preparation method thereof and application of the microsphere sustained-release antibacterial material in human and livestock skin disinfection and wound hemostasis treatment. The microsphere slow-release antibacterial material is prepared from an oil-phase raw material and a water-phase raw material, the oil phase raw materials comprise distearoyl phosphatidylcholine, hydrogenated lecithin and cholesterol; the water-phase raw material is a mixture of a cationic polymer, benzalkonium chloride and dopamine; the cationic polymer is prepared from one or more of chitosan, polyhexamethylene biguanide and polyethyleneimine. The microsphere sustained-release antibacterial material provided by the invention has remarkable advantages in the aspects of sterilization speed, human body safety, wound protection and environmental friendliness by optimizing the formula of the microspheres, can also effectively reduce the infection rate and improve the public health level, and has wide application prospects.

The formula comprises the following components: polyhexamethylene biguanide hydrochloride, benzalkonium chloride, glycerol, propylene glycol, borneol, menthol, a folium artemisiae argyi extract, a pepper extract, an R301 miticide and the balance of water. According to the spray prepared by the invention, the herbal raw materials are used as main raw materials, and are matched with the interaction of other various components, so that the antibacterial and mite-killing performance of the spray can be greatly improved. By introducing the folium artemisiae argyi extract and the matching effect of the pepper extract extracted by a specific method, the spray can be endowed with unique herbal fragrance, meanwhile, a remarkable antibacterial effect can be achieved, most of common pathogenic bacteria including staphylococcus aureus, escherichia coli, candida albicans and the like can be effectively inhibited, and the spray has a good antibacterial effect. The pathogenic bacteria are inhibited and killed.

The invention discloses pranoprofen eye drops and a production process thereof. Comprising the following raw material components in parts by weight: 0.1 to 0.5 part of pranoprofen, 1 to 5 parts of vitamin E polyethylene glycol 1000 succinate, 2 to 6 parts of soybean phospholipid, 3 to 8 parts of polyoxyethylated castor oil EL-40, 0.1 to 0.3 part of histidine, 0.2 to 0.6 part of sodium dihydrogen phosphate, 0.3 to 0.7 part of disodium hydrogen phosphate, 2 to 5 parts of glycerol, 1 to 4 parts of polyethylene glycol 400, 0.05 to 0.2 part of sodium hyaluronate, 0.1 to 0.4 part of D-panthenol and 0.01 to 0.03 part of benzalkonium chloride. The injection comprises the following components in parts by weight: 0.05-0.15 part of potassium sorbate, 0.005-0.02 part of epsilon-polylysine, 0.01-0.05 part of edetate disodium, 0.02-0.08 part of vitamin E acetate, 0.005-0.015 part of L-cysteine and the balance of water for injection, and the total weight part of the water for injection is 100 parts. According to the invention, pranoprofen is taken as a core, and vitamin E polyethylene glycol 1000 succinate, soybean phospholipid and polyoxyethylated castor oil EL-40 are adopted for synergistic solubilization, so that the problem of poor water solubility of the medicine is solved; histidine and phosphate are compounded for buffering and are matched with multiple stabilizers, so that the stability of the preparation is improved.

The application relates to the technical field of oil field chemistry, and is a preparation method and application of an aminosulfonic betaine type surfactant. The aminosulfonic betaine surfactant and the preparation method thereof are simple in operation, high in product yield, green in biodegradation, and green in environmental protection; the product does not need to be separated and purified, and can be directly used, thereby reducing the cost. The cleanup aid for acid fracturing, which takes the surfactant as a main component, can effectively reduce the surface and interfacial tension of a fracturing fluid of an oil and gas field, and the surfactant in the cleanup aid is low in use amount, thereby reducing the use cost.

This invention provides an inkjet ink that can suppress pigment aggregation in a solvent, even when using an ionic preservative. [Solution] The inkjet ink contains a pigment, a preservative, a zwitterionic compound, and water. The zwitterionic compound is a zwitterionic compound that takes on a zwitterionic structure in an environment with a pH of 7.5 to 9. The preservative contains at least one of 2-(2-hydroxy-5-methylphenyl)benzotriazole, orthophenylphenol, sodium dihydroxydimethoxybenzophenone disulfonate, para-aminobenzoic acid, ferulic acid, and benzalkonium chloride. In the inkjet ink, the orthophenylphenol content is 4% by mass or less, and the ferulic acid content is 7% by mass or less.

This invention provides a protein-targeting bifunctional blue developing agent. Commercially available Prussian blue (Tianjin Zhonglian CAS: 14038-43-8) is used, with water as the solvent and benzalkonium chloride as the dispersant, and is ultrasonically dissolved to form a 4% (w / w) Prussian blue aqueous solution. It can be used to develop latent fingerprints or blood fingerprints containing grease on a sample using methods such as drop casting, spraying, and immersion. Under ambient light, the fingerprint turns blue under the action of the developing solution. This invention is applicable to most non-permeable samples and some semi-permeable samples. The dye formulation provided by this invention has low cost, simple preparation, rapid color development, easy operation, and is environmentally friendly. It can broaden new methods for fingerprint development in criminal investigations.

The invention discloses a benzalkonium chloride microbial limit control bacterium detection method, and relates to the technical field of microbial limit detection, and the specific steps are as follows: firstly, putting a benzalkonium chloride test sample into a sterile test tube, adding a diluent, and uniformly mixing to prepare a 1: 10 benzalkonium chloride test sample solution; inoculating the control strain into a casein tryptone liquid culture medium to prepare a control strain suspension; a test sample culture and a test sample positive culture containing control bacteria and a test sample are prepared through a film filtration method; finally, respectively inoculating the cultures into corresponding selective culture mediums, culturing according to regulations, and carrying out selection and isolated culture to obtain a positive culture of the test sample and a microbial colony of the culture of the test sample; the benzalkonium chloride microbial limit control bacterium detection method is higher in applicability, can solve the problem of strong antibacterial activity in microbial limit detection of high-concentration solid / semi-solid benzalkonium chloride, and is beneficial to improving the microbial detection efficiency of a benzalkonium chloride preparation.

The application discloses an antibacterial and antiviral agent, which comprises the following components in parts by weight: 100 parts of water, 0.04-0.1 parts of cetylpyridinium chloride, 0.2-0.6 parts of benzalkonium chloride, 0.1-0.3 parts of polyhexamethylene biguanide hydrochloride, 0.04-0.16 parts of phenoxyethanol, 0.5-5 parts of silica-supported metal silver nanoparticles, 0.4-1.0 parts of propylene glycol, 0.02-0.06 parts of glycerol and 0.02-0.06 parts of EDTA-2Na. The application further discloses a preparation method of the antibacterial and antiviral agent. The antibacterial and antiviral agent provided by the application can synergistically enhance the effect by compounding cetylpyridinium chloride, benzalkonium chloride, polyhexamethylene biguanide hydrochloride and silica-supported metal silver nanoparticles, reduces the active ingredients such as cetylpyridinium chloride and benzalkonium chloride, and maintains excellent bactericidal effect; and the combination of silica-supported metal silver nanoparticles with different particle sizes enables the sanitary wet wipe liquid to not only quickly kill bacteria but also kill bacteria for a long time, and effectively improves the bactericidal efficiency and bactericidal timeliness of the sanitary wet wipe liquid.

The invention discloses stable and low-irritation benzalkonium chloride contraceptive gel and a preparation method, and belongs to the technical field of biological medicine manufacturing, and the method comprises the following steps: dissolving hydroxypropyl methylcellulose in purified water, and then adding benzalkonium chloride and chlorhexidine gluconate to obtain an antibacterial matrix phase; in addition, beta-sitosterol and hydroxypropyl-beta-cyclodextrin are premixed, aloe gel freeze-dried powder, glycerin, an adjusting auxiliary material, undecylenic acid glyceride and Ectoin are added, and the mixture is homogenized to obtain an active enhanced phase; adding the activity enhancing phase into the antibacterial matrix phase, uniformly mixing, and sterilizing by ozone. Compared with the prior art, the bactericidal effect is remarkably enhanced while the dosage of the bactericide is reduced, and mucous membrane irritation is reduced; the stability of the product is effectively improved, a suitable subacid environment is created, and the unification of sterilization, protection and stability is realized.

The invention relates to an eye care solution capable of relieving eyeball aging, and belongs to the technical field of care solutions. The eye care solution capable of relieving eyeball aging is prepared from the following raw materials in percentage by mass: 1.5 to 2.5 percent of glycerol, 0.78 to 0.82 percent of sodium chloride, 0.01 to 0.02 percent of water-soluble lutein, 0.1 to 0.15 percent of taurine, 0.03 to 0.05 percent of hydrolyzed pearl, 0.2 to 0.28 percent of boric acid, 0.05 to 0.07 percent of borax, 0.02 to 0.04 percent of edetate disodium, 0.0035 to 0.0045 percent of benzalkonium chloride, 0.002 to 0.005 percent of borneol, 0.005 to 0.01 percent of menthol and the balance of purified water. The eye care solution disclosed by the invention aims at office workers who use eyes for a long time, middle-aged and elderly people who are susceptible to eyeball aging, asthenopia and dry eye surfaces, realizes mild moisturizing and relieving of the eye surfaces, supplements nutrients required by eye tissue metabolism, resists eyeball aging caused by light damage, and has the effects of relieving eye fatigue and relieving eye fatigue. Meanwhile, eyeball senescence related eye discomfort such as eye dryness, eye acerbity and blurred vision is relieved, bacteriostatic protection of the ocular surface microenvironment is considered, the physiological state of eye tissue can be improved after long-term use, and the eyeball senescence process is delayed.