Photostimulation device of decision behaviors

Abstract

A photostimulation device of decision behaviors comprises a central control system, a barrier maze system, a photostimulation system, an infrared detection system and a video analysis system, wherein the central control system is respectively connected with the photostimulation system, the infrared detection system and the video analysis system and is used for controlling the photostimulation system, the infrared detection system and the video analysis system, the photostimulation system is used for applying photostimulation signals to animals to be tested, the infrared detection system is used for monitoring the moving process of the animals to be tested in the barrier maze system, and the video analysis system is used for recording and analyzing the moving state of the animals to be tested in the barrier maze system. According to the device, a reward-system-based and effort-based decision behavior testing model is established, the states of the animals before and after the choice and the reaction incubation period are judged, and people can have interference in the decision behaviors of the animals by combining optogenetics method.

Description

technical field [0001] The invention relates to a model for studying decision-making behavior, in particular to a light stimulation device for regulating animal decision-making behavior, which is used in the fields of medical biology, neuropharmacology and the like. Background technique [0002] "Decisionmaking" is a high-level cognitive activity of the central nervous system. The development of decision-making level has affected the evolutionary pressure of animals and humans to seek food and other rewards to a certain extent. Decision-making behavior is determined by the economic balance between the interests and costs of animals and humans for the environment, themselves and various alternative conditions. The study of the brain mechanism of decision-making behavior and related neural circuits is of great significance for revealing the cognitive function of the brain. Prompt function. [0003] Optogenetic technology is a combination of optics and genetics, and through g...

AI Technical Summary

Problems solved by technology

The main limitations of the above-mentioned active operation box are: (1) the operation box is airtight, the behavior of animals is not easy to observe, and the behavior of animals is limited; , optogenetics intervention; and, in the natural state, animals generally do not prefer to actively operate experiments. Compared with the operation box, the maze is more in line with the habit of animals to drill holes; (3) The active operation box can only pass the analysis twice Judging the reaction latency of the animal by the time of the pedal, but it is impossible to make a correct judgment on the state and time of the animal between the two choices, that is, the response latency between the animal choosing to eat delicious food and the period between choosing to eat rough food cannot be determined ; (4) To compare the decision-making behavior of animals, it is necessary to compare the amount of coarse grains and refined grains consumed by animals, so it is necessary to weigh the weights of coarse grains and refined grains before and after the experiment. , often scattered scattered, so the operation is more troublesome, wasting the time of the experimenter

In addition, the traditional T maze only chooses the left and right conditions of the position, and after reaching a certain accuracy rate, other molecular, pharmacological or genetic operations are performed, which cannot test the animal's trade-off in the face of selection and its own ability. compare with

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