56results about How to "Increase alkaline phosphatase activity" patented technology

The invention provides a Chinese herbal medicinal feed additive for improving the quality of carp flesh, and the Chinese herbal medicinal feed additive is prepared from the following raw material drugs in parts by weight: 2 to 4 parts of eucommia, 2 to 4 parts of dandelion, 3 to 5 parts of angelica root, 3 to 5 parts of yam, and 3 to 5 parts of chrysanthemum. A preparation method of the additive comprises the following steps: weighing the eucommia, the dandelion, the angelica root, the yam and the chrysanthemum Chinese herbal medicinal slices in weight proportion, and respectively crushing into coarse powder; collecting volatile oil from the chrysanthemum coarse powder by using a distillation method; immersing the eucommia, dandelion, angelica root and yam Chinese herbal medicinal coarse powders with water, and decocting for three times with the distilled chrysanthemum dreg with slow fire; combining the three filtrates, and heating to obtain concentrated liquid; and combining the volatile oil and the concentrated liquid, adding antiseptic and water quantitatively, uniformly stirring, filtering, filling and sterilizing to obtain the Chinese herbal medicinal feed additive. The Chinese herbal medicinal feed additive is used for improving the quality of carp flesh, and has the advantages of convenient use, low cost, good effect, safety and non toxic or side effect.

The invention belongs to the field of biomedical materials and in particular relates to a preparation method of a co-crosslinked double network hydrogel scaffold for promoting osteogenic growth. The preparation method comprises the following steps: (1) preparation of GelMA; (2) preparation of photo-crosslinkable OGP; and (3) preparation of the hydrogel scaffold: dissolving 50mg of the GelMA prepared in the step (1) and 20mg of the photo-crosslinkable OGP prepared in the step (2) in 1mL of PBS, uniformly mixing the two, adding 10mg of a light initiator, uniformly mixing the mixture, and irradiating the mixture by ultraviolet rays to prepare the hydrogel scaffold. The hydrogel scaffold prepared by the invention plays obvious roles of promoting increase of bone density and union of bone defects, and can regulate proliferation and differentiation of osteoblast and mineralization of a matrix and improve the alkaline phosphatase activities. The hydrogel scaffold is of a porous structure, so that OGP is co-crosslinked to the surface of the porous scaffold to induce OGP to slowly release, and therefore, actions of the biological scaffold in the fields of orthopedics department such as bone defects and bone graft fusion are achieved.

The invention belongs to the technical field of medicine, and relates to the application of an iridoid compound in the preparation of anti-osteoporosis drugs. The application of the iridoid compound of general formula I of the present invention in the preparation of medicines for treating and / or preventing osteoporosis. The experiment found that the extract of iridoids with the general formula I was tracked and separated based on the ALP activity in UMR106 cells, and the effects of the extract and the separated components on osteoblast proliferation and antioxidant activity Research has been carried out, showing that the iridoid compounds with the general formula I can significantly promote the activity of alkaline phosphatase and promote the differentiation of osteoblasts, so this type of compound has an anti-osteoporosis effect and can be used to prepare Medicines to treat or prevent osteoporosis. Among them, privetin and compound G13 have the effect of significantly promoting the activity of alkaline phosphatase and promoting the differentiation of osteoblasts, and the effect of privetin can also significantly promote the proliferation of UMR-106 cells, which is used for anti-osteoporosis When the effect is better.