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Preparation of shaolin plaster for rheumatism and wound and quality control method

A quality control method and Dieda cream technology, which is applied in ointment delivery, measuring devices, and pharmaceutical formulations, can solve problems such as loss of cohesive force, large loss of ingredients, and uncontrollable relative density of extracted medicinal extracts from finished medicinal materials.

Inactive Publication Date: 2008-10-08
张会林
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The advantages are aging resistance, strong performance, and good design performance. The disadvantage is that the stickiness is not as good as that of rubber plasters.
The solvent method can easily lead to the loss of volatile components. Now most of them are produced by hot pressing method. The Shaolin Fengshi Dieda Ointment recorded in the 2005 edition of the original "Chinese Pharmacopoeia" by Anyang Zhongzhi Pharmaceutical Co., Ltd. has (1) The power consumption of mastication is large; (2) The temperature of mastication rises quickly, and it is easy to lose its cohesive force due to aging; (3) It has been tried to soak rubber mastication with menthol, methyl salicylate, and borneol in the prescription, and the finished product is as above If the loss of components is too large, if vaseline is used to soak rubber for plastication, the problem of oil penetration of the finished product will be serious. (4) The relative density of the medicinal material extraction extract specified in the standard cannot be controlled, etc.

Method used

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  • Preparation of shaolin plaster for rheumatism and wound and quality control method
  • Preparation of shaolin plaster for rheumatism and wound and quality control method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1 The amount of medicinal materials in the formula (1000 preparation units): 16g of Aconitum aconitum, 16g of Aconitum aconitum, 16g of Aconitum, 16g of Baiji, 16g of Angelica dahurica, 16g of Baishui, 16g of ground beetle, 16g of papaya, 16g of trigonium, zedoary 16g, angelica 16g, red peony root 16g, cinnamon 16g, rhubarb 32g, forsythia 32g, dried blood 10g, frankincense (fried) 6g, myrrh (fried) 6g, Panax notoginseng 6g, catechu 6g, menthol 8g, salicylic acid Methyl ester 8g, borneol 8g

[0044] Substrate formula and dosage: natural rubber 540g, rosin 225g, lithopone, 664g vaseline 25g, lanolin 18g, glyceryl tristearate 12g, antioxidant 264 (2,6-di-tert-butyl-4-methyl Phenol) 8g

[0045] Preparation method: 15 flavors such as Shengchuanwu, Shengcaowu, Wuyao, Baiji, Baizhi, Baishui, ground beetle, papaya, Sanleng, curcuma, angelica, red peony, cinnamon, rhubarb, forsythia, etc., put in an extraction tank Add 4 times, 3 times, and 3 times the amount of water ...

Embodiment 2

[0085] Embodiment 2: The amount of prescription medicinal materials and the extraction and processing method of medicinal materials and the masticating and mixing method are the same as in Example 1

[0086] The matrix formula is: isoprene rubber 460g, hydrogenated rosin 200g, liquid terpene resin 30g, polyisobutylene PB1300 80g, kaolin 650g, antioxidant 1010 6g

Embodiment 3

[0087] Embodiment 3: The amount of prescription medicinal material and the extraction and processing method of medicinal material and the masticating and mixing method are the same as in Example 1

[0088] The matrix formula is: cis-1,4-polyisoprene rubber 320g, hydrogenated rosin glycidyl ester 260g, C9 petroleum resin 230g, vaseline 20g, lanolin 10g, glycerin 30g, titanium dioxide 350g, zinc oxide 300g, antioxidant Dosage 300 6g

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PUM

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Abstract

The invention relates to a preparation and quality control method of a Shaolin rheumatism trauma paste. The original production process of the Shaolin rheumatism trauma paste has the problems that (1) power consumption of plastication is great; (2) temperature rises quickly in the plastication, which results in easy aging and loss of cohesive force; (3) the menthol, menthyl salicylate and borneol in the prescription are once tried for soaking rubber to carry out the plastication, which leads to excessive loss of the components in finished products; when petrolatum is used for replacing the components to soak the rubber for carrying out the plastication, serious problem of oil permeation occurs in the finished products; (4) the relative density of the extract of medical material specified by the standards can not be controlled. The invention aims at providing the preparation and quality control method of the Shaolin rheumatism trauma paste, proposing a reasonable prescription of base materials and a production technique to ensure that finished products have clean and smooth appearance and good cohesive force and reducing the loss of active components of the finished products, particularly the volatile components such as menthol, menthyl salicylate and borneol. The quality standards essentially comprises thin layer identification of angelica, forsythia fruit, rhubarb root, root of common peony and resina draconis, limit tests on adhesion ability and aconitine and determination of the content of menthol, menthyl salicylate and borneol of the products by gas chromatography.

Description

technical field [0001] The invention relates to a preparation and quality control method of medicine, in particular to a preparation and quality control method of Shaolin Fengshi Dieda Ointment. Background technique [0002] Rubber plaster is a modern preparation, including two types of drug-containing and drug-free (adhesive plaster). The rubber plaster has strong adhesion, is easy to use and carry, can be pasted directly on the affected area without preheating and softening, does not pollute the clothes, and has almost no damage to the body; but because the plaster is thin and the drug load is limited, the extraction of drugs or medicinal materials should be controlled as much as possible amount of things. The preparation methods include ① solvent method: first extract the drug, then immerse the treated raw rubber in gasoline, swell it into a glue, then add tackifier, softener, filler, etc. to make a matrix, and then add medicinal materials The extract is mixed well to f...

Claims

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Application Information

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IPC IPC(8): A61K36/906A61K9/06A61K47/30G01N30/90G01N30/02A61P29/00A61K31/045A61K31/60A61K35/64
Inventor 董文玲岳安新骈卫国
Owner 张会林
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