Medicament for treating skin diseases and preparation method thereof

Abstract

The invention provides a medicament for treating skin diseases and a preparation method thereof. The medicament comprises rabdosia rubescens powder, salicylic acid, benzoic acid, procaine, lidocaine and borneol. Preparing powder by combining talcum powder; preparing an ointment by combining with medical albolene; preparing a tincture by combining alcohol and water; the raw materials are low in obtaining cost, skin diseases can be rapidly and effectively treated in a short time, the special effect is achieved especially for fungal diseases, and various preparations can prevent and treat local body surface inflammation, redness, swelling, pain, severe itching and other symptoms caused by local body surface inflammation, redness and swelling of a patient in multiple aspects; the medicament has a remarkable curative effect on acne, psoriasis, eczema, fungal skin infection and mild skin inflammation.

Description

Technical Field

[0001] The present invention relates to the field of positioning traditional Chinese medicine preparations, and specifically to a medicament for treating skin diseases and a preparation method thereof. Background Art

[0002] Diseases caused by pathogenic fungi, such as tinea corporis, tinea cruris, tinea manus, tinea pedis, etc. Among them, tinea pedis is the most common among all fungal diseases, followed by tinea manus. Sometimes, 30% - 70% of people in the population have tinea pedis. For erosive type patients: it is prone to occur between the fingers (toes), especially common between the 3rd - 4th and 4th - 5th toes of tinea pedis. It is manifested as skin maceration and whitening, forming itchy white rotten skin. The epidermis is soft and easy to exfoliate. After wiping off the white rotten skin, a flushing and erosive surface is exposed, with exudate, often accompanied by severe itching, seriously affecting people's normal work and rest.

[0003] Tinea pedis is recorded in "Medical Masterpieces of the Golden Mirror, Surgical Heart Methods" as follows: "The foot is broken, the disease is very small, the itching cannot be relieved by rubbing, and the skin must be rubbed until it is rotten, and smelly water oozes out. When it hurts, the itching stops. The next day, it still does not heal for years, and it is extremely lingering."

[0004] Modern medicine believes that: Tinea pedis is caused by fungal infection of the epidermis, with maceration, rupture, exudate, and unbearable itching. The skin will be rubbed until the red wound surface is exposed, and the itching will stop only when accompanied by severe pain.

[0005] At present, some western medicine antifungal drugs used clinically have problems such as long medication cycle time, increasing drug resistance, fewer varieties, more adverse reactions, and higher prices. So far, the problems of local body surface inflammation, redness, swelling, pain and severe itching of patients have not been well solved. Summary of the Invention

[0006] The purpose of the present invention is to provide a medicament for treating skin diseases and a preparation method thereof to solve the above problems.

[0007] The present invention provides the following technical solutions: A medicament for treating skin diseases, including 10 - 40 grams of Rabdosia rubescens powder, 10 - 60 grams of salicylic acid, 60 - 120 grams of benzoic acid, 10 - 20 grams of procaine, 10 - 30 grams of lidocaine, and 5 - 10 grams of borneol.

[0008] Furthermore, a preparation method of a powder for treating skin diseases includes the following steps: a. Harvest Rabdosia rubescens leaves, remove impurities and select, dry in the sun, and store for later use; b. Wash the selected and sun - dried Rabdosia rubescens leaves with clean water; c. Dry the Rabdosia rubescens leaves in an oven at a constant temperature of 65 - 75 °C, and the moisture content after drying is 0 - 6%; d. Grind the dried Rabdosia rubescens leaves into fine powder, mix evenly and sieve through a 100-mesh sieve for later use; e. Weigh 10 - 40 g of Rabdosia rubescens powder, 10 - 60 g of salicylic acid, 60 - 120 g of benzoic acid, 10 - 20 g of procaine, 10 - 30 g of lidocaine, 5 - 10 g of borneol, and add talcum powder to make up 1000 g; f. Mix and grind the above drugs evenly to make a powder, sieve through a 100-mesh sieve, and fill into a quantitative medical plastic bottle.

[0009] Furthermore, a preparation method of an ointment for treating skin diseases includes the following steps: a. Harvest Rabdosia rubescens leaves, remove impurities and select, dry in the sun, and store for later use; b. Wash the selected and sun-dried Rabdosia rubescens leaves clean with pure water; c. Dry the Rabdosia rubescens leaves at a constant temperature of 65 - 75 °C, and the moisture content after drying is 0 - 6%; d. Crush the dried Rabdosia rubescens leaves into fine powder; e. Filter the Rabdosia rubescens powder through a 100-mesh sieve for later use; f. Weigh 10 - 40 g of Rabdosia rubescens powder filtered through a 100-mesh sieve, 10 - 60 g of salicylic acid, 60 - 120 g of benzoic acid, 10 - 20 g of procaine, 10 - 30 g of lidocaine, 5 - 10 g of borneol, and add medical white vaseline to make up 1000 g; g. Use an ointment mixer to fully stir and mix the above drugs evenly to make an ointment, and fill into different medical containers with inner packaging for ointments respectively.

[0010] Furthermore, a preparation method of a tincture for treating skin diseases includes the following steps: a. Harvest Rabdosia rubescens, remove impurities and select, dry in the sun, and store for later use; b. Make the selected and sun-dried Rabdosia rubescens into coarse powder for later use: c. Weigh 10 - 40 g of Rabdosia rubescens powder and place it in a covered container, add 800 ml of 95% alcohol, soak at room temperature, stir once a day, filter through a 100-mesh sieve after 8 days, collect the filtered liquid for later use; d. Add 10 - 60 g of salicylic acid, 60 - 120 g of benzoic acid, 10 - 20 g of procaine, 10 - 30 g of lidocaine, 5 - 10 g of borneol to the filtered liquid, and then add pure water to make up 1000 ml.

[0011] Furthermore, the Rabdosia rubescens is a wild and precious genuine Chinese medicinal material in the Taihang Mountains and Wangwu Mountains in Jiyuan City, Henan Province, and is also called Binglingcao.

[0012] Furthermore, the Rabdosia rubescens leaves are selected as fresh leaves that are pollution-free and free of pests and diseases and produced from May to September every year.

[0013] Furthermore, the medicament is used for treating acne, psoriasis, eczema, skin fungal infections, and mild skin inflammations.

[0014] Compared with the prior art, the beneficial effects of the present invention are as follows: The raw materials of the present invention are low in acquisition cost, can quickly and effectively treat skin diseases in a short period of time, especially have a special effect on fungal diseases, and various preparations can prevent and treat various symptoms such as local body surface inflammation, redness, swelling, pain, and severe itching of patients in many aspects.

[0015] This medicament has a significant curative effect in the treatment of acne, psoriasis, eczema, skin fungal infections, and mild skin inflammations. Specific Embodiments

[0016] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0017] The details of the medication in the present invention are as follows: Rabdosia rubescens: Recorded in the first volume of the 1977 edition of the Pharmacopoeia of the People's Republic of China: Rabdosia rubescens has the effects of clearing heat and detoxifying, promoting blood circulation and relieving pain. "Pharmacology and Application of Traditional Chinese Medicine", People's Medical Publishing House, pages 360 - 370: Rabdosia rubescens has functions such as antibacterial, anti-inflammatory, and bactericidal. "The Magical Anti-cancer Ice Grass - Rabdosia rubescens", page 171, line 9 from the top: Washing the face with Rabdosia rubescens tea water also has a beauty effect; using strong Rabdosia rubescens tea can cure athlete's foot. Rabdosia rubescens also contains 24 trace elements, 17 amino acids and other components beneficial to the human body, which is conducive to promoting the repair of damaged cells.

[0018] Salicylic acid, benzoic acid: Kill fungi. After using salicylic acid drugs, the fungi parasitizing on the epidermal cutin layer can usually be exfoliated within 3 to 5 days; completely eliminate the living conditions of fungi parasitizing in the epidermal cutin layer. "Summary of Modern Dermatology", People's Medical Publishing House, page 133, line 9 from the top: Skin fungi can decompose keratin to produce amino acids for the fungi to utilize, so skin fungi mostly parasitize in the epidermal cutin layer.

[0019] Procaine, lidocaine, borneol: They have analgesic and antipruritic effects and reduce cell damage caused by skin rubbing. On the first line from the top on page 16 of the "Pharmacology" textbook compiled and tried out by the cooperation of national higher medical colleges: Injecting procaine solution locally can relieve the symptoms of inflamed and damaged parts to a certain extent, which is often called block therapy. Generally, it is explained that procaine can block the noxious stimuli transmitted from the lesion to the central nervous system, which is beneficial to the nutritional process of local diseased tissues.

[0020] The present invention provides a medicament for treating skin diseases and its preparation method, including 10 - 40 grams of Rabdosia rubescens powder, 10 - 60 grams of salicylic acid, 60 - 120 grams of benzoic acid, 10 - 20 grams of procaine, 10 - 30 grams of lidocaine, and 5 - 10 grams of borneol. Examples

[0021] Weigh 40 grams of Rabdosia rubescens powder, 40 grams of salicylic acid, 90 grams of benzoic acid, 10 grams of procaine, 10 grams of lidocaine, 5 grams of borneol, and add talcum powder to 1000 grams, then mix evenly to make a powder.

[0022] Weigh 40 grams of Rabdosia rubescens powder sieved through a 100 - mesh sieve, 40 grams of salicylic acid, 90 grams of benzoic acid, 10 grams of procaine, 10 grams of lidocaine, 5 grams of borneol, and add medical white petrolatum to 1000 grams, then mix and stir to make an ointment.

[0023] Weigh 40 grams of Rabdosia rubescens powder and place it in a covered container, add 800 milliliters of 95% alcohol, soak at room temperature, stir once a day, after 8 days, filter through a 100 - mesh sieve, collect the filtered liquid for standby; add 40 grams of salicylic acid, 90 grams of benzoic acid, 10 grams of procaine, 10 grams of lidocaine, and 5 grams of borneol to the filtered liquid, then add purified water to 1000 milliliters, and mix and stir evenly to make a tincture.

[0024] Clinical trials: There were 50 patients, including 30 males and 20 females, aged 15 - 65 years old.

[0025] The 50 patients were divided into 3 groups: blister - scale type, hyperkeratotic type, and maceration - erosion type.

[0026] 1. Blister - scale type: It is prone to occur between the fingers (toes), on the palms, soles, and the lateral margins of the feet. The skin lesions are deep - seated blisters the size of a pinhead, the blisters are clear, thick - walled, scattered or clustered, and flaky scales exfoliate after the blisters dry up.

[0027] 2. Hyperkeratotic type: It is prone to occur on the heels and the palms and soles. The main manifestations are thickening, rough desquamation, and fissures of the skin on the palms and soles, and it can spread to the dorsum of the hands and feet.

[0028] 3. Immersion and erosion type: It is prone to occur in the interdigital spaces, especially between the 3rd and 4th fingers and between the 4th and 5th fingers (toes). The main manifestations are immersion, whitening, and after peeling off the epidermis, a red erosive surface is exposed.

[0029] Treatment method: Spray the affected area with the medicament twice a day; Observe after 10 days.

[0030] Observe the changes in the skin lesions between the fingers (toes) and the changes in the skin lesions on the palms and soles.

[0031] If the skin lesions such as blisters, scales, immersion, erosion, or chapping are relieved, it indicates that the treatment is effective.

[0032] If the skin lesions such as erythema, blisters, scales, immersion, hyperkeratosis of the skin, or chapping subside, leaving only pigmentation, it can be judged as clinical cure.

[0033] Results: Blister and scale type: 10 cases, 7 cured, 3 effective, cure rate 70%, effective rate 100%.

[0034] Hyperkeratosis type: 10 cases, 8 cured, 2 effective, cure rate 80%, effective rate 100% Immersion and erosion type: 30 cases, 27 cured, 3 effective, cure rate 90%, effective rate 100%. Examples

[0035] Weigh 50 grams of Rabdosia rubescens powder, 60 grams of salicylic acid, 120 grams of benzoic acid, 10 grams of procaine, 10 grams of lidocaine, 10 grams of borneol, and add talcum powder to 1000 grams, mix evenly to make a powder.

[0036] Weigh 50 grams of Rabdosia rubescens powder sieved through a 100-mesh sieve, 60 grams of salicylic acid, 120 grams of benzoic acid, 10 grams of procaine, 10 grams of lidocaine, 10 grams of borneol, and add medical white petrolatum to 1000 grams, mix and stir to make an ointment.

[0037] Weigh 50 grams of Rabdosia rubescens powder and place it in a covered container, add 800 ml of 95% alcohol, soak at room temperature, stir once a day, filter with a 100-mesh sieve after 8 days, collect the filtered liquid for standby;. Add 60 grams of salicylic acid, 120 grams of benzoic acid, 10 grams of procaine, 10 grams of lidocaine, and 10 grams of borneol to the filtered liquid, then add purified water to 1000 ml, mix and stir evenly to make a tincture.

[0038] Clinical trial: 50 patients, including 30 males and 20 females, aged 15 - 65 years.

[0039] Divide the 50 cases into 3 groups: blister and scale type, hyperkeratosis type, immersion and erosion type.

[0040] 1. Vesicular and scaling type: It is prone to occur between the fingers (toes), on the palms, soles, and the lateral margins of the feet. The skin lesions are deep vesicles the size of a pinhead, with clear, thick-walled vesicles that are scattered or clustered. After the vesicles dry up, flaky scales will fall off.

[0041] 2. Hyperkeratotic type: It is prone to occur on the heels and the palms and soles. The main manifestations are thickening of the skin on the palms and soles, rough desquamation, chapping, and it can spread to the back of the hands and feet.

[0042] 3. Macerated and erosive type: It is prone to occur between the fingers (toes), especially between the 3rd and 4th fingers and the 4th and 5th fingers (toes). The main manifestations are maceration, whitening, and after peeling off the epidermis, a red erosive surface will be exposed.

[0043] Treatment method: Apply the medicament to the affected area twice a day; Observe after 10 days.

[0044] Observe the changes in the skin lesions between the fingers (toes), and the changes in the skin lesions on the palms and toes.

[0045] If the skin lesions such as vesicles, scales, maceration, erosion, or chapping are relieved, it indicates that the treatment is effective.

[0046] If the skin lesions such as erythema, vesicles, scales, maceration, hyperkeratosis of the skin, and chapping subside, leaving only pigmentation, it can be judged as clinical cure.

[0047] Results: Vesicular and scaling type: 10 cases, 9 were cured, 1 was effective, the cure rate was 90%, and the effective rate was 100%.

[0048] Hyperkeratotic type: 10 cases, 10 were cured, 0 were effective, the cure rate was 100%, and the effective rate was 100%. Macerated and erosive type: 30 cases, 28 were cured, 2 were effective, the cure rate was 93%, and the effective rate was 100%. Although the technical solutions of the present invention have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions, and variations can be made to these embodiments without departing from the principle and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A medicament for treating skin diseases, characterized in that, It includes 10 - 40 grams of Rabdosia rubescens powder, 10 - 60 grams of salicylic acid, 60 - 120 grams of benzoic acid, 10 - 20 grams of procaine, 10 - 30 grams of lidocaine, and 5 - 10 grams of borneol.

2. The preparation method of a medicament for treating skin diseases according to claim 1, characterized in that, It includes the following steps: a. Harvest the leaves of Rabdosia rubescens, remove impurities and select, dry in the sun, and store for later use; b. Wash the selected and sun - dried leaves of Rabdosia rubescens with clean water; c. Dry the leaves of Rabdosia rubescens at a constant temperature of 65 - 75 °C, and the moisture content after drying is 0 - 6%; d. Crush the dried leaves of Rabdosia rubescens into fine powder for later use; e. Weigh 10 - 40 grams of Rabdosia rubescens powder, 10 - 60 grams of salicylic acid, 60 - 120 grams of benzoic acid, 10 - 20 grams of procaine, 10 - 30 grams of lidocaine, 5 - 10 grams of borneol, and add talcum powder to make up to 1000 grams; f. Grind the above - mentioned drugs into fine powder, mix evenly, pass through a 100 - mesh sieve to make a powder, and pack it into quantitative medical plastic bottles.

3. The preparation method of a medicament for treating skin diseases according to claim 2, characterized in that: The Rabdosia rubescens powder is weighed after being filtered through a 100 - mesh sieve, the talcum powder is replaced with the same weight of medical white petrolatum, and after being fully stirred and mixed evenly with an ointment mixer, an ointment is made and packed into different medical containers with ointment inner packaging.

4. The preparation method of a medicament for treating skin diseases according to claim 2, characterized in that: Put 10 - 40 grams of the Rabdosia rubescens powder into a covered container, add 800 ml of 95% alcohol, soak at room temperature, stir once a day, after 8 days, filter with a 100 - mesh sieve to collect the filtrate, add 10 - 60 grams of salicylic acid, 60 - 120 grams of benzoic acid, 10 - 20 grams of procaine, 10 - 30 grams of lidocaine, and 5 - 10 grams of borneol to the filtrate, then filter with a 100 - mesh sieve to collect the filtrate and add pure water to make up to 1000 ml, and make a tincture after mixing evenly and fill it into medical plastic bottles.

5. The preparation method of a medicament for treating skin diseases according to any one of claims 2-4, characterized in that, The Rabdosia rubescens is a wild and precious genuine traditional Chinese medicine in the Taihang Mountains and Wangwu Mountains in Jiyuan City, Henan Province, and is also called Binglingcao.

6. The preparation method of a medicament for treating skin diseases according to any one of claims 2-4, characterized in that, The leaves of Rabdosia rubescens are selected as fresh leaves produced from May to September each year without pollution and pests.

7. The preparation method of a medicament for treating skin diseases according to any one of claims 2-4, characterized in that, The medicament is used for treating acne, psoriasis, eczema, skin fungal infections, and mild skin inflammation.