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Compounds and methods for diagnosis and treatment of leishmaniasis

A technology for leishmaniasis and leishmania, which is applied in the field of serum diagnosis and can solve problems such as decreased sensitivity and low reactivity

Inactive Publication Date: 2009-06-24
INFECTIOUS DISEASE RES INST IN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in Sudan, Ethiopia, and Kenya, the sensitivity of the strip test dropped to 67%, and negative responses to the strip test by ELISA appeared to be associated with lower reactivity

Method used

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  • Compounds and methods for diagnosis and treatment of leishmaniasis
  • Compounds and methods for diagnosis and treatment of leishmaniasis
  • Compounds and methods for diagnosis and treatment of leishmaniasis

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Abstract

Compounds and methods are provided for diagnosing, preventing, treating and detecting leishmaniasis infection and stimulating immune responses in patients are disclosed. The compounds disclosed are include polypeptides and fusion proteins that contain at least one immunogenic portion of one or more Leishmania antigens, or a variant thereof. Additionally, methods of screening a screening library for tandem repeat proteins that have immunogenic properties are disclosed. Vaccines and pharmaceutical compositions comprising polynucleotides, polypeptides, fusion proteins and variants thereof that may be used for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmaniasis infection are described.

Description

[0001] priority claim [0001] This application claims priority to US non-provisional application 11 / 733,440, filed April 10,2007. The foregoing applications are incorporated herein by reference in their entirety. [0002] This application claims priority to US Provisional Application 60 / 744,798, filed April 13,2006. The foregoing applications are incorporated herein by reference in their entirety. [0003] This application claims priority to US Provisional Application 60 / 791,226, filed April 10,2006. The foregoing applications are incorporated herein by reference in their entirety. field of invention [0004] The present invention relates generally to serodiagnosis of Leishmania infection. More particularly the present invention relates to the use of one or more Leishmania polypeptides in methods and diagnostic kits to screen for Leishmania from organisms and blood supplies and to identify those with the potential to develop acute visceral Those individuals with leishman...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/00C07K4/12C07K2/00C07K19/00A61K39/008G01N33/53
CPCY02A50/30
Inventor S·G·里德后藤康之
Owner INFECTIOUS DISEASE RES INST IN
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