Method for treating metronidazole waste water

A treatment method and technology for metronidazole are applied in the field of treatment of metronidazole wastewater, can solve problems such as the failure of effective recycling of various useful substances, and achieve the effects of preventing pollution, mild reaction conditions and low cost

Active Publication Date: 2012-02-08
HUBEI HONGYUAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims at the problem that the waste water produced in the existing metronidazole production process contains a variety of highly polluting organic substances and salts, which are directly discharged to cause environmental pollution, and a variety of useful substances have not been effectively recycled and utilized, and provides a The treatment method of metronidazole production wastewater can signific

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Take 1200ml of centrifuged waste water of crude metronidazole, put it in a 2L flask, spin evaporate to the remaining 400ml of solution, crystallize at a temperature of 55°C, filter to obtain anhydrous sodium sulfate and sodium formate, and dry to obtain 106.3g. The filtrate was adjusted to PH=5 with sulfuric acid to precipitate 9 g of nitrated compounds, stirred at room temperature, filtered and dried. Then the filtrate was concentrated by rotary evaporation to 280g viscous solution, added 280g of anhydrous methanol and reacted at 40°C for 1.5 hours, filtered to obtain anhydrous sodium sulfate and sodium formate, and dried to obtain 145g. Two times of anhydrous sodium sulfate and sodium formate are combined (analyzing the content of sodium formate is 37.42%), first adding 70g content is 88% formic acid to make it dissolve, then slowly add 73g concentrated sulfuric acid to react, after the reaction, maintain the reaction temperature at 100 ℃ for 1 hour, and recovered und...

Embodiment 2

[0025] Take 1200ml of centrifuged wastewater of crude metronidazole, put it in a 2L flask, spin evaporate until the remaining 300ml of solution, crystallize at 45°C, filter the concentrate to obtain anhydrous sodium sulfate and sodium formate, and dry to obtain 115g. The filtrate was adjusted to PH=3 with sulfuric acid to precipitate 8 g of nitrates, stirred at room temperature, filtered and dried. Then the filtrate was concentrated by rotary evaporation to 271g viscous solution, and 406.5g of anhydrous methanol was added to react at 30°C for 2 hours, then filtered to obtain anhydrous sodium sulfate and sodium formate, and dried to obtain 145g. Two times of anhydrous sodium sulfate and sodium formate are combined (analyzing the content of sodium formate is 37.69%), first adding 80g content is 88% formic acid to make it dissolve, then slowly add 77g concentrated sulfuric acid to react, after the reaction, maintain the reaction temperature at 60 ℃ for 3 hours, and recovered unde...

Embodiment 3

[0027] Take 1200ml of centrifuged wastewater of crude metronidazole, put it in a 2L flask, spin evaporate to the remaining 240ml of solution, crystallize at 100°C, filter the concentrate to obtain anhydrous sodium sulfate and sodium formate, and dry to obtain 124g. The filtrate was adjusted to PH=6 with sulfuric acid to precipitate 10 g of nitrated compounds, stirred at room temperature, filtered and dried. Then the filtrate was concentrated by rotary evaporation to 260g viscous solution, and 650g of anhydrous methanol was added to react at 50°C for 0.5 hours, then filtered to obtain anhydrous sodium sulfate and sodium formate, and dried to obtain 143g. Two times of anhydrous sodium sulfate and sodium formate are combined (analyzing the content of sodium formate is 38.11%), first adding 90g content is 88% formic acid to make it dissolve, then slowly add the concentrated sulfuric acid reaction of 80g, after the reaction, maintain the reaction temperature at React at 120°C for 0...

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Abstract

The invention relates to a method for treating metronidazole waste water, which comprises the following steps of: concentrating the metronidazole waste water into 1/3-1/5 of total amount, and crystallizing and filtering the concentrated metronidazole waste water at 45-100 DEG C to obtain anhydrous sodium sulfate and sodium formate; adjusting the PH to 3-6 by using sulfuric acid or formic acid, and precipitating 2-methy-5-nitro imidazole; concentrating the filter liquid to anhydrous sticky state, dissolving organic matter by using methanol or ethanol, and filtering the solution to obtain anhydrous sodium sulfate and sodium formate; merging the sodium formate and the anhydrous sodium sulfate obtained in two times, successively adding formic acid and sulfuric acid, and recovering the formic acid to obtain anhydrous sodium sulfate; and rectifying and separating the organic mixture extract of methanol or ethanol to obtain methanol or ethanol and glycol. The method for treating metronidazole waste water provided by the invention is simple and convenient to operate, the content of polluting organic matter and inorganic slats in the metronidazole waste water can be obviously reduced, environmental pollution can be preveneted, various kinds of useful organic matter and inorganic matter can be recovered, raw materials are saved, and the production cost is lowered.

Description

technical field [0001] The invention relates to a method for treating metronidazole wastewater, which belongs to the technical field of industrial wastewater treatment and recovery. Background technique [0002] With the development of the pharmaceutical industry, the wastewater produced in the pharmaceutical process has become one of the serious pollution sources. Due to the use of various raw materials in the pharmaceutical production process, the production process is complicated, the water quality and water volume fluctuate greatly, and the composition of the wastewater is very complex. One of the more difficult industrial wastewater, especially the antibiotic industrial wastewater in pharmaceutical wastewater, is a kind of high-concentration organic wastewater with high chroma, refractory substances and many biological toxic substances. [0003] Metronidazole is an antibiotic raw material widely used in the pharmaceutical and chemical industry. Chemical methods such as ...

Claims

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Application Information

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IPC IPC(8): C02F9/10C01D5/00C07D233/92C07C53/02C07C51/02C07C31/04C07C31/08C07C31/20C07C29/80
Inventor 周拥军段小六张雷吕智国鲍应元晏浩哲
Owner HUBEI HONGYUAN PHARMA
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